CEP120 interacts with C2CD3 and Talpid3 and is required for centriole appendage assembly and ciliogenesis

Myosin-Va is required for preciliary vesicle transportation to the mother centriole during ciliogenesis

(2018) Chien-Ting Wu et al.   NATURE CELL BIOLOGY

Super-resolution architecture of mammalian centriole distal appendages reveals distinct blade and matrix functional components

(2018) T. Tony Yang et al.   Nature Communications

Disease-Associated Mutations in CEP120 Destabilize the Protein and Impair Ciliogenesis

(2018) Nimesh Joseph et al.   Cell Reports

CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium

(2018) Maren Mönnich et al.   Cell Reports

A novel Cep120-dependent mechanism inhibits centriole maturation in quiescent cells

(2018) Ewelina Betleja et al.   eLife

Characterization of three ciliopathy pedigrees expands the phenotype associated with biallelic C2CD3 variants

(2018) Nicole J. Boczek et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A distal centriolar protein network controls organelle maturation and asymmetry

(2018) Lei Wang et al.   Nature Communications

Building the right centriole for each cell type

(2017) Jadranka Loncarek et al.   JOURNAL OF CELL BIOLOGY

Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles

(2017) Hsin-Yi Chen et al.   Nature Communications

CEP295 interacts with microtubules and is required for centriole elongation

(2016) Ching-Wen Chang et al.   JOURNAL OF CELL SCIENCE

Mutations inCEP120cause Joubert syndrome as well as complex ciliopathy phenotypes

(2016) Susanne Roosing et al.   JOURNAL OF MEDICAL GENETICS

Cilium assembly and disassembly

(2016) Irma Sánchez et al.   NATURE CELL BIOLOGY

Mutations in human C2CD3 cause skeletal dysplasia and provide new insights into phenotypic and cellular consequences of altered C2CD3 function

(2016) Claudio R. Cortés et al.   Scientific Reports

Mutations in KIAA0586 Cause Lethal Ciliopathies Ranging from a Hydrolethalus Phenotype to Short-Rib Polydactyly Syndrome

(2015) Caroline Alby et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Two Polo-like kinase 4 binding domains in Asterless perform distinct roles in regulating kinase stability

(2015) Joseph E. Klebba et al.   JOURNAL OF CELL BIOLOGY

Binding of STIL to Plk4 activates kinase activity to promote centriole assembly

(2015) Tyler C. Moyer et al.   JOURNAL OF CELL BIOLOGY

Mutations in human homologue of chickentalpid3gene (KIAA0586) cause a hybrid ciliopathy with overlapping features of Jeune and Joubert syndromes

(2015) May Christine V Malicdan et al.   JOURNAL OF MEDICAL GENETICS

Erratum: Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation

(2015) Quanlong Lu et al.   NATURE CELL BIOLOGY

STIL binding to Polo-box 3 of PLK4 regulates centriole duplication

(2015) Christian Arquint et al.   eLife

Plk4-dependent phosphorylation of STIL is required for centriole duplication

(2015) A.-S. Kratz et al.   Biology Open

Plk4 Phosphorylates Ana2 to Trigger Sas6 Recruitment and Procentriole Formation

(2014) Nikola S. Dzhindzhev et al.   CURRENT BIOLOGY

A founder CEP120 mutation in Jeune asphyxiating thoracic dystrophy expands the role of centriolar proteins in skeletal ciliopathies

(2014) Ranad Shaheen et al.   HUMAN MOLECULAR GENETICS

The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly

(2014) Tetsuo Kobayashi et al.   JOURNAL OF CELL BIOLOGY

The oral-facial-digital syndrome gene C2CD3 encodes a positive regulator of centriole elongation

(2014) Christel Thauvin-Robinet et al.   NATURE GENETICS

Talpid3-Binding Centrosomal Protein Cep120 Is Required for Centriole Duplication and Proliferation of Cerebellar Granule Neuron Progenitors

(2014) Chuanqing Wu et al.   PLoS One

Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo

(2014) H. Bazzi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals

(2014) Xuan Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole

(2014) Midori Ohta et al.   Nature Communications

CEP120 and SPICE1 Cooperate with CPAP in Centriole Elongation

(2013) David Comartin et al.   CURRENT BIOLOGY

Discovering Regulators of Centriole Biogenesis through siRNA-Based Functional Genomics in Human Cells

(2013) Fernando R. Balestra et al.   DEVELOPMENTAL CELL

Human microcephaly protein CEP135 binds to hSAS-6 and CPAP, and is required for centriole assembly

(2013) Yu-Chih Lin et al.   EMBO JOURNAL

Centriole distal appendages promote membrane docking, leading to cilia initiation

(2013) B. E. Tanos et al.   GENES & DEVELOPMENT

CEP120 interacts with CPAP and positively regulates centriole elongation

(2013) Yi-Nan Lin et al.   JOURNAL OF CELL BIOLOGY

CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base

(2013) Won-Jing Wang et al.   NATURE CELL BIOLOGY

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Generation of mice with functional inactivation of talpid3, a gene first identified in chicken

(2011) F. Bangs et al.   DEVELOPMENT

The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation

(2011) Chieh-Ju C Tang et al.   EMBO JOURNAL

The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries

(2011) Erich A. Nigg et al.   NATURE CELL BIOLOGY

Building the Centriole

(2010) Juliette Azimzadeh et al.   CURRENT BIOLOGY

Cep120 is asymmetrically localized to the daughter centriole and is essential for centriole assembly

(2010) Moe R. Mahjoub et al.   JOURNAL OF CELL BIOLOGY

Control of Centriole Length by CPAP and CP110

(2009) Thorsten I. Schmidt et al.   CURRENT BIOLOGY

Cep76, a Centrosomal Protein that Specifically Restrains Centriole Reduplication

(2009) William Y. Tsang et al.   DEVELOPMENTAL CELL

hPOC5 is a centrin-binding protein required for assembly of full-length centrioles

(2009) Juliette Azimzadeh et al.   JOURNAL OF CELL BIOLOGY

CPAP is a cell-cycle regulated protein that controls centriole length

(2009) Chieh-Ju C. Tang et al.   NATURE CELL BIOLOGY

C2cd3 is required for cilia formation and Hedgehog signaling in mouse

(2008) A. N. Hoover et al.   DEVELOPMENT

Molecular Architecture of the Centriole Proteome: The Conserved WD40 Domain Protein POC1 Is Required for Centriole Duplication and Length Control

(2008) Lani C. Keller et al.   MOLECULAR BIOLOGY OF THE CELL