Inhibition of the thioredoxin system by PX-12 (1-methylpropyl 2-imidazolyl disulfide) impedes HIV-1 infection in TZM-bl cells

How Are Proteins Reduced in the Endoplasmic Reticulum?

(2018) Lars Ellgaard et al.   TRENDS IN BIOCHEMICAL SCIENCES

The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation

(2018) Jonathan Muri et al.   Nature Communications

Thioredoxin (Trx1) regulates CD4 membrane domain localization and is required for efficient CD4-dependent HIV-1 entry

(2016) Naazneen Moolla et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Cellular Thioredoxin-1/Thioredoxin Reductase-1 Driven Oxidoreduction Represents a Chemotherapeutic Target for HIV-1 Entry Inhibition

(2016) Kathrin Reiser et al.   PLoS One

Disulfide Reduction in CD4 Domain 1 or 2 Is Essential for Interaction with HIV Glycoprotein 120 (gp120), which Impairs Thioredoxin-driven CD4 Dimerization

(2014) Nichole Cerutti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Induces the Formation of Stable Microtubules to Enhance Early Infection

(2013) Yosef Sabo et al.   Cell Host & Microbe

Thioredoxin-1 and protein disulfide isomerase catalyze the reduction of similar disulfides in HIV gp120

(2012) Kathrin Reiser et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Redox Regulation of Actin by Thioredoxin-1 Is Mediated by the Interaction of the Proteins via Cysteine 62

(2010) Xiaogang Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Reduced Monomeric CD4 Is the Preferred Receptor for HIV

(2010) Lisa J. Matthias et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emergence of Drug Resistance in HIV Type 1–Infected Patients after Receipt of First‐Line Highly Active Antiretroviral Therapy: A Systematic Review of Clinical Trials

(2008) Ravindra Gupta et al.   CLINICAL INFECTIOUS DISEASES

Human glutaredoxin-1 catalyzes the reduction of HIV-1 gp120 and CD4 disulfides and its inhibition reduces HIV-1 replication

(2008) Joeri Auwerx et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

2-[(1-Methylpropyl)dithio]-1H-imidazole inhibits tubulin polymerization through cysteine oxidation

(2008) K. Huber et al.   MOLECULAR CANCER THERAPEUTICS