Article
Medical Laboratory Technology
Qipan Zhang, Lun Guo, Xuxiang Song, Chengna Lv, Pan Tang, Yan Li, Qunli Ding, Mingcai Li
Summary: The study revealed significantly higher levels of IL-36 alpha and IL-36 gamma in CTD-ILD and IPF patients compared to healthy controls, while IL-36Ra levels did not differ significantly. Increased IL-36 levels were associated with disease severity in IPF patients, with high diagnostic value demonstrated by ROC curve analysis for IL-36 alpha in both IPF and CTD-ILD patients.
CLINICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Lei Fang, Wei-Chih Chen, Peter Jaksch, Antonio Molino, Alessandro Saglia, Michael Roth, Christopher Lambers
Summary: Treprostinil was found to reduce mitochondrial damage and improve mitochondrial function in IPF cells, which may explain its therapeutic effects in IPF patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Respiratory System
Noriyuki Enomoto, Sakae Homma, Naohiko Inase, Yasuhiro Kondoh, Takeshi Saraya, Hajime Takizawa, Yoshikazu Inoue, Hiroshi Ishii, Yoshio Taguchi, Shinyu Izumi, Yasuhiko Yamano, Yoshinori Tanino, Yasuhiko Nishioka, Mikio Toyoshima, Koshi Yokomura, Shiro Imokawa, Naoki Koshimizu, Takehisa Sano, Taisuke Akamatsu, Hiroshi Mukae, Motoyasu Kato, Naoki Hamada, Hirofumi Chiba, Shinobu Akagawa, Shigeo Muro, Hironori Uruga, Hiroyuki Matsuda, Yusuke Kaida, Miho Kanai, Kazutaka Mori, Masafumi Masuda, Hironao Hozumi, Tomoyuki Fujisawa, Yutaro Nakamura, Noriyoshi Ogawa, Takafumi Suda
Summary: This nationwide multicentre study prospectively evaluated 376 patients with IIP, finding that 18.6% of them met the IPAF criteria. Patients with IPAF were more likely to develop systemic autoimmune diseases, had fewer acute exacerbations of IIP, and showed better survival outcomes. Cluster analysis identified a subgroup with more autoimmune features, predominantly female, and with a better prognosis.
Review
Biochemistry & Molecular Biology
Giuliana Cerro Chiang, Tanyalak Parimon
Summary: CTD-ILD is a group of systemic autoimmune disorders that cause lung interstitial abnormalities or lung fibrosis. The pathogenesis of CTD-ILD is not well understood, but it shares common risk factors with idiopathic pulmonary fibrosis. The primary mechanism involves dysfunction of alveolar type II cells, triggering inflammatory cascades and leading to abnormal lung remodeling and fibrosis. Understanding these mechanisms is important for developing targeted therapies and identifying disease biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Toyoshi Yanagihara, Kazuya Tsubouchi, Mahsa Gholiof, Sy Giin Chong, Kenneth E. Lipson, Quan Zhou, Ciaran Scallan, Chandak Upagupta, Jussi Tikkanen, Shaf Keshavjee, Kjetil Ask, Martin R. J. Kolb
Summary: Idiopathic pulmonary fibrosis is a fatal lung disease characterized by the accumulation of myofibroblasts. The study found that connective-tissue growth factor (CTGF) plays a key role in pulmonary fibrosis. Increased levels of CTGF exacerbate lung fibrosis and CTGF expression is upregulated in patients with idiopathic pulmonary fibrosis. Different cells contribute to the maintenance of the fibrotic phenotype during fibrogenesis.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Medicine, General & Internal
Jonathan H. Chung, Ayodeji Adegunsoye, Brenna Cannon, Rekha Vij, Justin M. Oldham, Christopher King, Steven M. Montner, Prahasit Thirkateh, Scott Barnett, Ronald Karwoski, Brian J. Bartholmai, Mary Strek, Steven D. Nathan
Summary: A study comparing quantitative imaging data between IPF and CTD-ILD in a UIP setting found that VRS was higher in IPF patients. VRS showed an inverse correlation with DLCO%, while the total volume of normal lung was associated with both DLCO% and FVC% in multivariable analysis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Nana Akiyama, Masaru Shimura, Taro Yamazaki, Hiroko Harashima, Takuya Fushimi, Tomoko Tsuruoka, Tomohiro Ebihara, Keiko Ichimoto, Ayako Matsunaga, Megumi Saito-Tsuruoka, Yukiko Yatsuka, Yoshihito Kishita, Masakazu Kohda, Akira Namba, Yoshimasa Kamei, Yasushi Okazaki, Shinji Kosugi, Akira Ohtake, Kei Murayama
Summary: The study aimed to clarify the status of prenatal genetic diagnosis of mitochondrial diseases caused by nDNA defects in Japan. A comprehensive genomic analysis was performed on over 400 patients, with 13 families (16 cases) requesting prenatal diagnoses. Results showed that for cases with wild type homozygous or heterozygous variants, continuing the pregnancy led to healthy babies, while cases with severe phenotypes tended to choose pregnancy termination.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Takuya Kotani, Masaki Ikemoto, Shogo Matsuda, Ryota Masutani, Tohru Takeuchi
Summary: In this study, it was found that the hybrid protein hMIKO-1 can suppress the abnormal activation of macrophages, reduce lung fibrosis in mice, and decrease the expression of related inflammation factors, indicating its potential as a therapeutic candidate for ILD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Amelie Riviere, Clement Picard, Cristina Berastegui, Victor Manuel Mora, Vincent Bunel, Laurent Godinas, Elena Salvaterra, Valeria Rossetti, Laurent Savale, Dominique Israel-Biet, Xavier Demant, Julien Bermudez, Federica Meloni, Peter Jaksch, Jesper Magnusson, Laurence Beaumont, Michael Perch, Jean-Francois Mornex, Christiane Knoop, John-David Aubert, Baptiste Hervier, Hilario Nunes, Marc Humbert, Jens Gottlieb, Yurdagul Uzunhan, Jerome Le Pavec
Summary: This study aimed to evaluate the survival rate and prognostic factors in lung transplant recipients with interstitial lung disease complicating idiopathic inflammatory myopathy (IIM-ILD). The study found that the post-transplant survival rate in IIM-ILD was similar to that in international all-cause transplantation registries and worse in patients with classical IIM. Muscle involvement was identified as the main factor associated with worse survival.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Erika Rubi Luis-Garcia, Carina Becerril, Alfonso Salgado-Aguayo, Omar Emiliano Aparicio-Trejo, Yair Romero, Edgar Flores-Soto, Criselda Mendoza-Milla, Martha Montano, Victoria Chagoya, Jose Pedraza-Chaverri, Mohammed El Hafidi, Marisol Orozco-Ibarra, Annie Pardo, Moises Selman
Summary: IPF fibroblasts exhibit resistance to apoptosis induced by mitomycin C, potentially due to inhibition of mPTP and mitochondrial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rafaela C. Cordeiro, Camila N. C. Lima, Gabriel R. Fries, Giovana Zunta-Soares, Jair C. Soares, Joao Quevedo, Giselli Scaini
Summary: This study investigates the impact of mitochondrial dysfunction on bipolar disorder (BD). The study finds that BD patients have a lower mitochondrial health index (MHI) compared to non-psychiatry controls, with a negative correlation between MHI and cell-free mtDNA levels. The study further reveals that MHI is related to the expression of mitochondria quality control (MQC) proteins, and a longer illness duration, worse functional status, and higher depressive symptoms are associated with lower MHI and higher cell-free mtDNA levels.
MOLECULAR PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Patrizia Bottoni, Giulia Gionta, Roberto Scatena
Summary: Mitochondrial myopathies are a heterogeneous group of diseases caused by genetic mutations in proteins involved in mitochondrial oxidative metabolism. These myopathies show significant differences in their evolution, but some physiological and pathophysiological aspects of mitochondria reveal other potential molecular mechanisms that may play a significant role in their clinical progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Goncalo Boleto, Silje Reiseter, Anna-Maria Hoffmann-Vold, Adrien Mirouse, Patrice Cacoub, Marco Matucci-Cerinic, Manuel Silverio-Antonio, Joao Eurico Fonseca, Ana Catarina Duarte, Jorge Pestana Lopes, Valeria Riccieri, Alain Lescoat, Erwan Le Tallec, Ivan Castellvi Barranco, Jose Luis Tandaipan, Paolo Airo, Masataka Kuwana, Hoda Kavosi, Jerome Avouac, Yannick Allanore
Summary: This study compared predictive factors for interstitial lung disease (ILD) in patients with mixed connective tissue disease (MTCD) and found different factors associated with ILD. The study also found that MCTD-ILD patients have increased mortality and that digital ulcers (DU) are associated with progressive lung disease.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Biochemistry & Molecular Biology
Haruna Tani, Kaori Ishikawa, Hiroaki Tamashiro, Emi Ogasawara, Takehiro Yasukawa, Shigeru Matsuda, Akinori Shimizu, Dongchon Kang, Jun-Ichi Hayashi, Fan-Yan Wei, Kazuto Nakada
Summary: This study established a mouse model carrying a pathogenic mutation in the mitochondrial tRNA gene, associated with metabolic syndrome-like symptoms. The mutation led to decreased protein levels and reduced Complex I activity in mitochondria, providing insights into the molecular basis of mutation-mediated mitochondrial disorders.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Medicine, General & Internal
Hee-Young Yoon, Su-Jin Moon, Jin Woo Song
Summary: The study found that the composition of the microbiome in lung tissues differed between patients with idiopathic pulmonary fibrosis (IPF) and controls, and was associated with the diagnosis, mortality, and disease severity of IPF. Specific bacterial abundances can serve as predictive indicators for the development and prognosis of IPF in patients.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Luca Tamo, Kleanthis Fytianos, Fabienne Caldana, Cedric Simillion, Anis Feki, Izabela Nita, Manfred Heller, Thomas Geiser, Amiq Gazdhar
Summary: Macrophages play vital role in tissue repair and regeneration, and iPSC-CM has shown potential in reducing lung fibrosis and regulating macrophage phenotype. Through gene network analysis, this study identified AAP and ELAVL-1 in iPSC-CM as key components in regulating macrophage phenotype. Experimental confirmation demonstrated that AAP and ELAVL1 can change macrophage phenotype and reduce profibrotic characteristics, highlighting the antifibrotic and regenerative potential of iPSC-CM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Nuria Bosch-Guiteras, Tina Uroda, Hugo A. Guillen-Ramirez, Rahel Riedo, Amiq Gazdhar, Roberta Esposito, Carlos Pulido-Quetglas, Yitzhak Zimmer, Michaela Medova, Rory Johnson
Summary: Research shows that delaying NHEJ relative to DSB formation is a simple and effective means of enhancing the efficiency and accuracy of CRISPR-deletion, improving the success rate of DNA deletion.
Article
Rheumatology
Maria-Grazia Lazzaroni, Emiliano Marasco, Corrado Campochiaro, Jeska DeVries-Bouwstra, Montserrat-Ixchel Gonzalez-Perez, Jorge Rojas-Serrano, Eric Hachulla, Elisabetta Zanatta, Simone Barsotti, Federica Furini, Konstantinos Triantafyllias, Giuseppina Abignano, Marie-Elise Truchetet, Giacomo De Luca, Ellen De Langhe, Roger Hesselstrand, Francesca Ingegnoli, Eugenia Bertoldo, Vanessa Smith, Silvia Bellando-Randone, Hadi Poormoghim, Enrico Colombo, Angela Ceribelli, Alessio Furloni, Stefania Zingarelli, Ilaria Cavazzana, Franco Franceschini, Francesco Del Galdo, Christopher P. Denton, Lorenzo Cavagna, Oliver Distler, Yannick Allanore, Paolo Airo
Summary: The study evaluated clinical associations of anti-PM/Scl antibodies in SSc patients, showing that patients with isolated anti-PM/Scl+ had a more severe disease phenotype, while those with both anti-PM/Scl and SSc-specific antibodies exhibited more typical SSc features.
Article
Rheumatology
Simone Arnold, Veronika K. Jaeger, Almut Scherer, Adrian Ciurea, Ulrich A. Walker, Diego Kyburz
Summary: This study aimed to identify predictors of successful discontinuation of bDMARD therapy in patients with rheumatoid arthritis (RA) in a real-world cohort. The majority of patients who discontinued bDMARD treatment lost remission within <1 year. Fulfillment of more rigorous remission criteria and csDMARD treatment increased the chance of maintaining bDMARD-free remission.
Article
Rheumatology
Michele Iudici, Matthias Jarlborg, Kim Lauper, Ulf Mueller-Ladner, Vanessa Smith, Yannick Allanore, Alexandra Balbir-Gurman, Andrea Doria, Paolo Airo, Ulrich A. Walker, Valeria Riccieri, Madelon C. Vonk, Armando Gabrielli, Anna-Maria Hoffmann-Vold, Gabriella Szucs, Thierry Martin, Oliver Distler, Delphine S. Courvoisier
Summary: The objective of this study was to assess the extent of ineligibility and determine the reasons for it in SSc patients included in the EUSTAR database. The study found that the representativeness of patients in SSc-RCTs varies greatly, and is more influenced by treatment and safety factors rather than demographic criteria.
Article
Pharmacology & Pharmacy
Paulius Ruzgys, Stephan Bohringer, Ayse Sila Dokumaci, Yvonne Hari, Christian M. Schurch, Frido Bruhl, Stefan Schurch, Sonke Szidat, Carsten Riether, Saulius Satkauskas, Thomas Geiser, David Hradetzky, Amiq Gazdhar
Summary: Targeted drug delivery by electrospray is shown to be efficient in the subcutaneous mouse model of lung cancer and holds promise for further development towards clinical application.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Health Care Sciences & Services
Ralf Krumkamp, Benno Kreuels, Veronika K. Jaeger, Juergen May, Rafael Mikolajczyk, Andre Karch
Summary: This study simulated the increase in infectious individuals over time in asymptomatic individuals following a negative SARS-CoV-2 test using a Monte Carlo approach. The results showed that the false negative rates of PCR tests or rapid antigen tests, as well as the time since testing, play a crucial role in determining the number of infectious individuals. The simulated results were comparable to mathematically predicted case numbers, highlighting the importance of these factors in testing population groups.
BMC MEDICAL RESEARCH METHODOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Petra Khan, Kleanthis Fytianos, Sabrina Blumer, Julien Roux, Amiq Gazdhar, Spasenija Savic, Lars Knudsen, Danny Jonigk, Mark P. Kuehnel, Sofia Mykoniati, Michael Tamm, Thomas Geiser, Katrin E. Hostettler
Summary: This study confirmed the presence of basal-like cells in peripheral lung tissue of patients with idiopathic pulmonary fibrosis (IPF) and investigated their paracrine effects on fibroblasts. The findings suggest that basal-like cells may play a role in limiting aberrant fibroblast activation and differentiation in IPF through paracrine mechanisms.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biology
Giuseppe Bombaci, Mayuresh Anant Sarangdhar, Nicola Andina, Aubry Tardivel, Eric Chi-Wang Yu, Gillian M. Mackie, Matthew Pugh, Vedat Burak Ozan, Yara Banz, Thibaud Spinetti, Cedric Hirzel, Esther Youd, Joerg Schefold, Graham Taylor, Amiq Gazdhar, Nicolas Bonadies, Anne Angelillo-Scherrer, Pascal Schneider, Kendle M. Maslowski, Ramanjaneyulu Allam
Summary: The protein RNH1 has been found to inhibit the activation of inflammasomes, reducing inflammation. Deletion of RNH1 in macrophages leads to increased production of IL-1β and activation of caspase-1. Furthermore, RNH1 protein levels were negatively correlated with disease severity and inflammation in COVID-19 patients.
LIFE SCIENCE ALLIANCE
(2022)
Article
Immunology
Johannes Mischlinger, Veronika K. Jaeger, Adrian Ciurea, Cem Gabay, Paul Hasler, Ruediger B. Mueller, Claire Ann Siegrist, Peter Villiger, Ulrich A. Walker, Christoph Hatz, Silja Buehler
Summary: This study found that patients with rheumatic diseases have lower long-term antibody persistence after receiving the diphtheria/tetanus vaccine, which may be influenced by the presence of rheumatic diseases and its treatment on plasma cells in the immune system.
Article
Obstetrics & Gynecology
Kerry L. M. Wong, Amy Gimma, Enny S. Paixao, Christel Faes, Philippe Beutels, Niel Hens, Christopher I. Jarvis, W. John Edmunds
Summary: During the COVID-19 pandemic, pregnant women had slightly fewer social contacts compared to non-pregnant women, with fewer work contacts but marginally more contacts in non-essential social settings. A significant proportion of both pregnant and non-pregnant individuals reported being in isolation or quarantine for a large part of the study period. COVID-19 vaccine coverage in pregnant women was initially higher than in non-pregnant women, but the situation reversed since May 2021.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Pharmacology & Pharmacy
Kleanthis Fytianos, Ronja Schliep, Sofia Mykoniati, Petra Khan, Katrin E. Hostettler, Michael Tamm, Amiq Gazdhar, Lars Knudsen, Thomas Geiser
Summary: The overexpression of SDF-1 beta can reduce collagen deposition, improve lung histology, and induce apoptosis of myofibroblasts. Additionally, it increases alveolar epithelial cell numbers and proliferation, showing potential as a new approach for the treatment of lung fibrosis.
Article
Pediatrics
Imeke Goldschmidt, Evgeny Chichelnitskiy, Nicole Ruebsamen, Veronika K. Jaeger, Andre Karch, Lorenzo D'Antiga, Angelo Di Giorgio, Emanuele Nicastro, Deirdre A. Kelly, Valerie McLin, Simona Korff, Dominique Debray, Muriel Girard, Loreto Hierro, Maja Klaudel-Dreszler, Malgorzata Markiewicz-Kijewska, Christine Falk, Ulrich Baumann
Summary: Soluble cytokines levels were found to be elevated in children suspected to have T-cell-mediated acute rejection (TCMR) after liver transplantation. However, the diagnostic accuracy of these cytokines for TCMR is poor.
Article
Infectious Diseases
Geraldine Engels, Anna-Lisa Oechsle, Anne Schlegtendal, Christoph Maier, Sarah Holzwarth, Andrea Streng, Berit Lange, Andre Karch, Astrid Petersmann, Hendrik Streeck, Sabine Blaschke-Steinbrecher, Christoph Haertel, Horst Schroten, Ruediger von Kries, Reinhard Berner, Johannes Liese, Folke Brinkmann, Nicole Toepfner
Summary: The study evaluates the effects of the Omicron variant on the sero-immunity, health status, and quality of life of children and adolescents in Germany. The results show that a majority of children and adolescents have immunity against SARS-CoV-2, with differences in vaccination rates and infection rates across age groups. Overall, the health status and quality of life of children were good.
Article
Biochemical Research Methods
Shozen K. Dan, Yu Chen, Yining Chen, Melodie Monod, Veronika E. Jaeger, Samir E. Bhatt, Andre E. Karch, Oliver Ratmann
Summary: The study develops a model-based approach to estimate fine-age contact patterns from coarse-age data and measure real-time effective reproduction numbers. The model can also adjust for reporting fatigue and time trends, and is applicable to modern survey data with coarsely reported age information.
PLOS COMPUTATIONAL BIOLOGY
(2023)