Article
Biochemistry & Molecular Biology
Jean-Baptiste Domergue, Cinzia Bocca, Rosine De Paepe, Guy Lenaers, Anis M. Limami, Guillaume Tcherkez
Summary: Disruption of mitochondrial complex I (CI) has been found to cause multiple changes in cellular lipids, including leaf, pollen, and seed lipids. This suggests that mitochondrial homeostasis plays a crucial role in regulating the whole cellular lipidome through specific signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Cell Biology
Macarena S. Arrazola, Felipe A. Court
NEURAL REGENERATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Orianne Serri, Magalie Boguenet, Juan Manuel Chao de la Barca, Pierre-Emmanuel Bouet, Hady El Hachem, Odile Blanchet, Pascal Reynier, Pascale May-Panloup
Summary: Male infertility has been on the rise in the past decade, and the pathophysiologic mechanisms behind extreme oligospermia (EO) are not fully understood. In this metabolomics study, we identified metabolites associated with EO and found clear evidence of epididymal dysfunction in cases of testicular damage. This study highlights the complexity of metabolic dysfunction in male infertility and underscores the importance of metabolomics in understanding this condition.
Article
Cell Biology
Macarena S. Arrazola, Matias Lira, Felipe Veliz-Valverde, Gabriel Quiroz, Somya Iqbal, Samantha L. Eaton, Douglas J. Lamont, Hernan Huerta, Gonzalo Ureta, Sebastian Bernales, J. Cesar Cardenas, Waldo Cerpa, Thomas M. Wishart, Felipe A. Court
Summary: Age is a major risk factor for neurodegenerative diseases, with axonal degeneration being an early event in the aged brain. This study found that inhibiting necroptosis, a form of cell death, delayed age-associated axonal degeneration and neuroinflammation, protecting against cognitive decline in mice. Inhibition of necroptosis also improved the hippocampal proteome and its associated functions, such as synaptic plasticity. These findings suggest that necroptosis plays a role in age-related brain degeneration and targeting it could be a potential strategy to treat memory impairment and cognitive decline.
Letter
Medical Laboratory Technology
Charles R. Lefevre, Elise Sacaze, Lena Damaj, Paul Rollier, Marie Lenski, Camille Le Stradic, Claude Bendavid, Pascal Reynier, Xavier Dieu, Delphine Prunier, Caroline Moreau, Chadi Homedan
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Clinical Neurology
M. Khamaysa, M. Lefort, M. Pelegrini-Issac, A. Lackmy-Vallee, A. Preuilh, D. Devos, A. -S. Rolland, C. Desnuelle, M. Chupin, V. Marchand-Pauvert, G. Querin, Pierre-Francois Pradat
Summary: This study aimed to evaluate the predictive value of cervical spinal cord MRI parameters for motor capacity in ALS compared to clinical prognostic factors. Structural MRI measurements were significantly correlated with the ALSFRS-R score and its sub-scores. Multiple linear regression models combining spinal multimodal MRI and clinical factors could predict motor capacity in ALS.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Arnaud Chevrollier, Adeline Alice Bonnard, Lyse Ruaud, Naig Gueguen, Laurence Perrin, Valerie Desquiret-Dumas, Fabien Guimiot, Pierre-Hadrien Becker, Jonathan Levy, Pascal Reynier, Pauline Gaignard
Summary: This study presents a case of severe developmental defect due to MFN2 deficiency with clumped mitochondria. The study confirms that the loss of MFN2 function leads to the inability of mitochondria to fuse.
Article
Biochemistry & Molecular Biology
Pierre Nivoit, Thomas Mathivet, Junxi Wu, Yann Salemkour, Devanarayanan Siva Sankar, Veronique Baudrie, Jennifer Bourreau, Anne-Laure Guihot, Emilie Vessieres, Mathilde Lemitre, Cinzia Bocca, Jeremie Teillon, Morgane Le Gall, Anna Chipont, Estelle Robidel, Neeraj Dhaun, Eric Camerer, Pascal Reynier, Etienne Roux, Thierry Couffinhal, Patrick W. F. Hadoke, Jean-Sebastien Silvestre, Xavier Guillonneau, Philippe Bonnin, Daniel Henrion, Joern Dengjel, Pierre-Louis Tharaux, Olivia Lenoir
Summary: Dysregulated autophagy is associated with cardiovascular and metabolic diseases. Our study reveals the complex mechanisms by which autophagy regulates endothelial functions and demonstrates its crucial role in flow-mediated outward arterial remodeling, prevention of neointima formation, and recovery after myocardial infarction. These findings highlight the fundamental role of autophagy in endothelial function and its connection to cellular proteostasis and mechanosensing.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xavier Dieu, Sophie Tamareille, Aglae Herbreteau, Lucie Lebeau, Juan Manuel Chao de la Barca, Floris Chabrun, Pascal Reynier, Delphine Mirebeau-Prunier, Fabrice Prunier
Summary: This study used machine learning to analyze metabolite data and found changes in heart metabolism following a stroke. The post-stroke heart exhibited increased collagen turnover, increased arginase activity, decreased nitric oxide synthase activity, and altered amino acid metabolism. These results demonstrate that stroke-induced metabolic remodeling in the heart may be involved in the pathophysiology of stroke heart syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
G. Urbanski, F. Chabrun, C. Lavigne, C. Lacout, E. Delattre, P. Reynier, J. Requin
Summary: This study found a linear relationship between serum ferritin and C-reactive protein, while transferrin saturation was not correlated with C-reactive protein. The serum ferritin/CRP ratio accurately predicted iron deficiency, with ROC-AUC values ranging from 0.85 to 0.92 for different definitions of iron deficiency. A threshold of <= 6 demonstrated the highest Youden index (0.61). In the validation cohort, the serum ferritin/CRP ratio had an ROC-AUC of 0.88 [95% CI: 0.85-0.90], with an odds ratio of 37.9 [95% CI: 20.3-68.9] for the threshold of <= 6.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Neurosciences
Djamaa Atamena, Venu Gurram, Petnoi Petsophonsakul, Farnoosh Khosrobakhsh, Macarena S. Arrazola, Marlene Botella, Bernd Wissinger, Marion Szelechowski, Pascale Belenguer
Summary: Dominant optic atrophy (DOA) is caused by OPA1 mutations and results in the degeneration of retinal ganglion cells (RGCs). The expressivity of DOA varies greatly and might be influenced by modifying genetic and/or environmental factors. A study on the influence of genetic background found that switching the background of the DOA mouse model led to a negative effect on RGC connectivity, indicating the importance of secondary genetic factors in DOA expressivity.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Chemistry, Medicinal
Rima Kamel, Delphine Baetz, Naig Gueguen, Lucie Lebeau, Agnes Barbelivien, Anne-Laure Guihot, Louwana Allawa, Jean Gallet, Justine Beaumont, Michel Ovize, Daniel Henrion, Pascal Reynier, Delphine Mirebeau-Prunier, Fabrice Prunier, Sophie Tamareille
Summary: This study demonstrates that KYNA has cardioprotective effects by enhancing mitophagy and antioxidant defense. These findings contribute to the identification of potential therapeutic targets for myocardial infarction and their translation into clinical practice.
Article
Neurosciences
Trinovita Andraini, Lionel Mouledous, Petnoi Petsophonsakul, Cedrick Florian, Sebastien Gauzin, Marlene Botella-Daloyau, Macarena Arrazola, Kamela Nikolla, Adam Philip, Alice Leydier, Manon Marque, Laetitia Arnaune-Pelloquin, Pascale Belenguer, Claire Rampon, Marie -Christine Miquel
Summary: Mitochondrial defects and their dynamics play a crucial role in neurodegenerative diseases and may contribute to cognitive impairments. A study using a mouse model showed that mild mitochondrial defects affected adult neurogenesis and resulted in early impairments in spatial memory, which could be restored by exercise and pharmacological treatment. These findings suggest that enhancing mitochondrial function at an early stage is beneficial for late-onset neurodegenerative diseases.
Article
Nanoscience & Nanotechnology
Nicolas Santos, Santiago Valenzuela, Camilo Segura, Igor Osorio-Roman, Macarena S. Arrazola, Concepcion Panadero-Medianero, Paula A. Santana, Manuel Ahumada
Summary: This study synthesized carbon dots based on PEI and CS using different methods and characterized their surface properties and biological activity. The choice of synthesis method was found to impact the optical and biological properties of the carbon dots.
Letter
Obstetrics & Gynecology
M. Boguenet, V Desquiret-Dumas, P. Reynier, P. May-Panloup
HUMAN REPRODUCTION OPEN
(2022)