Journal
BIOMEDICAL OPTICS EXPRESS
Volume 10, Issue 7, Pages 3522-3532Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.10.003522
Keywords
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Funding
- National Institutes of Health [R01EY027833, R01 EY024544, P30 EY010572]
- William & Mary Greve Special Scholar Award from Research to Prevent Blindness (New York, NY)
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Optical coherence tomography angiography (OCTA) allows us to noninvasively investigate foveal ischemia, a key feature of diabetic retinopathy (DR). However, the sizes of the foveal avascular zone (FAZ) have a significant Variation in a normal population, preventing the objective assessment of pathological enlargement of FAZ due to capillary dropout. Based on the relationship between FAZ and ganglion cell complex (GCC) thickness in normal eyes, we defined a theoretical baseline FAZ (tbFAZ) on structural OCT and measured 2D and 3D vessel density in its vicinity on the simultaneously acquired OCTA in normal and diabetic eyes. We found that the structure-based tbFAZ was a reliable reference to identify foveal ischemia and that the 3D vessel density demonstrated ischemia more effectively than the 2D method. The proposed 3D para-FAZ vessel density correlates well with DR severity and potentially is a useful diagnostic biomarker, especially in the early stages of DR. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement
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