Article
Nanoscience & Nanotechnology
Lu Xia, Jinjing Lu, Zhilin Chen, Xiaoyu Cui, Shuo Chen, Dongmei Pei
Summary: The study showed that utilizing blood serum SERS technique in combination with PLS-LDA method can effectively differentiate between healthy individuals and patients with thyroid nodules, as well as between benign and malignant nodules. This approach could potentially aid in more accurate diagnosis and treatment for patients with thyroid nodules.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Biochemical Research Methods
Shuo Chen, Hao Lin, He Zhang, Fuchang Guo, Shanshan Zhu, Xiaoyu Cui, Zhe Zhang
Summary: Adrenal tumors, both functioning and nonfunctioning, require accurate diagnosis and classification for precise treatment. Surface-enhanced Raman spectroscopy shows great potential in distinguishing different types of tumors.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Review
Engineering, Environmental
Lifang Xie, Kedong Gong, Yangyang Liu, Liwu Zhang
Summary: Nanoplastics, at sizes smaller than 1000 nm, are found ubiquitously in various environmental media and pose a potential health risk due to their ability to easily enter cells. In this review, we summarize the prevalent analytical techniques for identifying nanoplastics, with a focus on the advantages and disadvantages of surface-enhanced Raman spectroscopy (SERS). We discuss the principles of SERS, advances in nanoplastic detection using SERS, and the application of SERS in real environmental samples. Furthermore, we highlight the importance of efficient SERS substrates and pretreatment methodologies to enable practical nanoplastic detection and identify future research needs in this field.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Spectroscopy
Shanshan Zhu, Yanjian Li, Han Gao, Gang Hou, Xiaoyu Cui, Shuo Chen, Chen Ding
Summary: In this study, blood serum surface-enhanced Raman spectroscopy (SERS) method was investigated for the identification and assessment of pulmonary C. neoformans infection, showing great clinical potential for accurate diagnosis and evaluation.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Spectroscopy
Haiwei Li, Songqi Zhang, Ruochen Zhu, Zheng Zhou, Lu Xia, Hao Lin, Shuo Chen
Summary: The study investigated the potential prognostic role of serum SERS technique in the early assessment of HCC chemotherapeutic response. It was found that circulating nucleic acids and collagen levels, as well as their changes, could serve as potential serum markers for HCC prognosis.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Spectroscopy
H. F. Nargis, H. Nawaz, H. N. Bhatti, K. Jilani, M. Saleem
Summary: This study utilized SERS and RS for the classification of breast cancer patients and healthy individuals based on serum samples, finding that SERS showed higher sensitivity, specificity, and AUROC values compared to RS in distinguishing breast cancer from healthy samples. The study demonstrated the potential of SERS as a more effective analytical tool for understanding the progression of breast cancer.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Spectroscopy
Dayu Hu, Xiaosong Xu, Zeyin Zhao, Changqi Li, Ye Tian, Qiang Liu, Bo Shao, Shuo Chen, Yue Zhao, Ling Li, Huan Bi, Ang Chen, Cheng Fu, Xiaoyu Cui, Yu Zeng
Summary: The study utilized SERS technology to detect metabolites in urine, reflecting the cancer status. Combining results from urine supernatant and sediment, SERS showed high diagnostic sensitivity and specificity for BCa.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biochemistry & Molecular Biology
Eric Boateng Osei, Liliia Paniushkina, Konrad Wilhelm, Juergen Popp, Irina Nazarenko, Christoph Krafft
Summary: Extracellular vesicles (EVs) ranging in size from 60 to 800 nm were isolated from plasma of control and prostate cancer patients using differential centrifugation and ultrafiltration techniques. Spontaneous Raman and surface-enhanced Raman spectroscopy (SERS) were employed to identify fractions that best discriminate between control and cancer patients, with results showing that EV12 and EV120 fractions provide the most effective separation.
Article
Spectroscopy
Peng Wang, Jiansheng Chen, Xiaodong Wu, Yubing Tian, Rui Zhang, Jiaojiao Sun, Zhiqiang Zhang, Ce Wang, Pengli Bai, Liangsheng Guo, Jing Gao
Summary: A system using echelle Raman spectrometer combined with surface enhanced Raman spectroscopy (SERS) was proposed for accurate blood species identification of human and animals with high accuracy and reliability.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Spectroscopy
Peng Wang, Jiansheng Chen, Xiaodong Wu, Yubing Tian, Rui Zhang, Jiaojiao Sun, Zhiqiang Zhang, Ce Wang, Pengli Bai, Liangsheng Guo, Jing Gao
Summary: This study proposed a system using echelle Raman spectrometer combined with surface enhanced Raman spectroscopy (SERS) for blood species identification, with an accuracy rate of over 94%. The technology combines the advantages of echelle Raman spectrometer and the spectral sensitivity of SERS.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Shuyun Bi, Yue Yuan, Fengming Zhang, Yuting Wang, Jia Liu, Bin Yang, Daqian Song
Summary: This study established detection methods for two aminoglycoside antibiotics, gentamicin (GEN) and tobramycin (TOB), utilizing surface-enhanced Raman spectroscopy (SERS) based on gamma-Al2O3-modified silver nanoparticles (AgNPs) coated with bovine serum albumin (BSA). The pH, the addition amounts for the substrate and coagulant, as well as the mixing time were optimized. The methods were successfully used for the determination of GEN and TOB in commercial drugs and meat products.
Article
Nanoscience & Nanotechnology
Hongyang Qian, Yiqiu Wang, Zehua Ma, Lei Qian, Xiaoguang Shao, Di Jin, Ming Cao, Shupeng Liu, Haige Chen, Jiahua Pan, Wei Xue
Summary: Surface-enhanced Raman spectroscopy analysis of pretreated plasma samples can accurately predict disease recurrence in bladder cancer patients after neoadjuvant chemotherapy and radical cystectomy. SERS analysis showed higher levels of circulating free nucleic acid components and lower levels of tryptophan in recurrent patients, which are independent predictors of recurrence. Combining SERS analysis with clinicopathological parameters significantly improves the predictive model, and the diagnostic model based on SERS spectra has a high accuracy in predicting disease recurrence.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Shu Hu, Jingyu Wang, Yue-Jiao Zhang, Bao-Ying Wen, Si-Si Wu, Petar M. Radjenovic, Zhilin Yang, Bin Ren, Jian-Feng Li
Summary: In this study, the shell and structural effect of shell-isolated nanoparticle-enhanced Raman spectroscopy (SHINERS) were investigated. It was found that the field enhancement loss due to the shell could be overcome by optimizing the coupling geometry of the shell-isolated nanoparticles (SHINs), and signal enhancement could be further optimized by altering the aggregation geometries of the nanoparticles.
Article
Spectroscopy
Jia Lei, Dafu Yang, Rui Li, ZhaoXia Dai, Chenlei Zhang, Zhanwu Yu, Shifa Wu, Lu Pang, Shanshan Liang, Yi Zhang
Summary: This study utilized SERS technology to analyze lung cancer and normal serums, revealing biochemical differences between them and establishing an identification model, which offers a new approach for clinical diagnosis.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Multidisciplinary Sciences
Linfei Li, Jeremy F. Schultz, Sayantan Mahapatra, Zhongyi Lu, Xu Zhang, Nan Jiang
Summary: By using ultrahigh vacuum tip-enhanced Raman spectroscopy (UHV-TERS), single oxygen adatoms on a boron monolayer (borophene) can be identified and mapped with a spatial resolution of approximately 4.8 angstrom and single bond sensitivity. This technique enables the atomically defined, chemically homogeneous, and thermally reversible oxidation of borophene via atomic oxygen in UHV. Additionally, it reveals the propensity of borophene towards molecular oxygen activation at room temperature and phase-dependent chemical properties. Overall, this work demonstrates the powerful utility of UHV-TERS in probing the local chemistry of surface adsorbates in the atomic regime and has important applications in heterogeneous catalysis, on-surface molecular engineering, and low-dimensional materials.
NATURE COMMUNICATIONS
(2022)
Article
Biochemical Research Methods
Shuo Chen, Hao Lin, He Zhang, Fuchang Guo, Shanshan Zhu, Xiaoyu Cui, Zhe Zhang
Summary: Adrenal tumors, both functioning and nonfunctioning, require accurate diagnosis and classification for precise treatment. Surface-enhanced Raman spectroscopy shows great potential in distinguishing different types of tumors.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Geochemistry & Geophysics
Fengdi Zhang, Zhuoyu Zhang, Liwa Wei, Wenbin Xu, Xiaoyu Cui, Shuo Chen
Summary: By coding a convolutional neural network based on the spectral transmittance of a programmable optical filter, optical imaging can be seen as equivalent to the results of hyperspectral data postprocessed by the CNN. This enables simultaneous implementation of hyperspectral data acquisition and CNN postprocessing, leading to more intelligent, informative, and real-time optical detection and sensing in remote sensing applications.
IEEE GEOSCIENCE AND REMOTE SENSING LETTERS
(2021)
Article
Biotechnology & Applied Microbiology
Shuo Chen, Chunmeng Wang, Ruochen Zhu, Shanshan Zhu, Guojun Zhang
Summary: The study utilized surface-enhanced Raman spectroscopy to analyze bone marrow samples of AML patients, identifying significant differences in amino acid, saccharide, and lipid levels between AML patients with good and poor prognoses. A prognostic model was established with an accuracy of 84.78%, suggesting the potential of SERS as a diagnostic tool for timely and precise AML prognosis prediction.
Article
Radiology, Nuclear Medicine & Medical Imaging
Shiyuan Wang, Jiaming Chen, Fengdi Zhang, Mingyang Zhao, Xiaoyu Cui, Shuo Chen
Summary: For the first time, GAN was utilized to expedite the computation time of MC simulation of light propagation. By using the pix2pix network, the method reconstructed precise MC simulation results from roughly modeled results with a small number of photons, resulting in an acceleration of the simulation process by approximately 102 times.
Article
Optics
Fengdi Zhang, Wenbin Xu, Zhuoyu Zhang, Yuning Gao, Zheng Zhou, Xiaoyu Cui, Hao Lei, Shuo Chen
Summary: Programmable hyperspectral imaging is an efficient technique for fast target classification, with a novel splitting strategy proposed to reduce the number of filters while maintaining classification performance. Numerical simulation experiments showed that the proposed splitting strategy can achieve similar classification performance with a reduced number of filters by 25% to 80%.
Article
Biochemical Research Methods
Ruochen Zhu, Yuanjun Jiang, Zheng Zhou, Shanshan Zhu, Zhuoyu Zhang, Zhilin Chen, Shuo Chen, Zhe Zhang
Summary: This study explored a preoperative serum surface-enhanced Raman spectroscopy-based prognostic protocol to predict the postoperative prognosis for patients with non-muscle-invasive bladder cancer (NMIBC). The results suggested potential prognostic markers related to DNA/RNA, protein substances, trehalose, and collagen. The proposed prognostic models achieved high accuracies in predicting future postoperative recurrence and recurrent type. This method has great potential in early and accurate prediction of postoperative prognosis in NMIBC patients.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Spectroscopy
Haiwei Li, Songqi Zhang, Ruochen Zhu, Zheng Zhou, Lu Xia, Hao Lin, Shuo Chen
Summary: The study investigated the potential prognostic role of serum SERS technique in the early assessment of HCC chemotherapeutic response. It was found that circulating nucleic acids and collagen levels, as well as their changes, could serve as potential serum markers for HCC prognosis.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Endocrinology & Metabolism
Yunfeng Song, Zheng Zhou, Henan Liu, Runyu Du, Yaoyao Zhou, Shanshan Zhu, Shuo Chen
Summary: This study investigated the potential of using the tortuosity of branch retinal artery as an indicator for early detection and accurate assessment of diabetic retinopathy (DR). The results showed that the tortuosity of retinal arteries, especially branch retinal vessels, was significantly associated with DR genesis and progress. Therefore, branch arterial tortuosity can serve as a specific indicator for early detection and assessment of DR severity, guiding timely management to prevent visual impairment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemical Research Methods
Chang-Chun Xiong, Shan-Shan Zhu, Deng-Hui Yan, Yu-Dong Yao, Zhe Zhang, Guo-Jun Zhang, Shuo Chen
Summary: Early, express, and reliable detection of cancer using surface-enhanced Raman scattering (SERS) combined with deep learning can provide a rapid, reliable, and non-invasive approach. This study collected serum samples from healthy controls and cancer patients and used 1D-CNN for precise identification, achieving high accuracy of 98.27%. The contributions of SERS peaks indicated potential biomarkers for different types of cancer, providing insights into the intelligent diagnosis of cancers based on label-free serum SERS. The integration of label-free SERS and deep learning has great potential to significantly improve precise diagnosis in clinical practice.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Spectroscopy
Shuo Chen, Haotian Wu, Chen Chen, Daheng Wang, Yaru Yang, Zheng Zhou, Ruochen Zhu, Xiaoning He, Yaping Pan, Chen Li
Summary: This study explored a pre-treatment saliva SERS based prognostic protocol to predict the prognosis of periodontal non-surgery therapy in periodontitis patients. Significant differences in the levels of ascorbic acid, uric acid, and glutathione were observed between good prognosis group and poor prognosis group, which can serve as potential prognostic markers. The proposed prognostic model achieved high accuracy, sensitivity, and specificity. The excellent performance of this method demonstrated its potential for fast, accurate, and non-invasive prognostic prediction in periodontal non-surgery therapy, benefiting timely and rational guidance on clinical interventions.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Biochemical Research Methods
Shanshan Zhu, Yanjian Li, Fengdi Zhang, Changchun Xiong, Han Gao, Yudong Yao, Wei Qian, Chen Ding, Shuo Chen
Summary: A Raman spectroscopic method is proposed for fast and label-free genotype screening. The method is validated using spontaneous Raman measurements of wild-type Cryptococcus neoformans and its mutants. Accurate identification of different genotypes is achieved using a one-dimensional convolutional neural network (1D-CNN), and correlations between metabolic changes and genotypic variations are revealed. Genotype-specific regions of interest are localized using a gradient-weighted class activation mapping (Grad-CAM) method, and the contribution of each metabolite to genotypic decision making is quantified. The proposed method shows great potential for genotype screening and analysis of pathogens.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Biochemical Research Methods
Denghui Yan, Changchun Xiong, Qingshan Zhong, Yudong Yao, Shuo Chen, Xi Mei, Shanshan Zhu
Summary: The serum surface-enhanced Raman spectroscopy (SERS) technique is proposed to identify late-life depression (LDD) and mild cognitive impairment (MCI) patients by analyzing biomarkers such as ascorbic acid, saccharide, cell-free DNA, and amino acids. The combination of SERS and multivariate statistical analysis has shown a high accuracy rate for the identification of healthy controls, LDD, and MCI, which has the potential for early diagnosis and timely intervention of age-related neuropsychiatric disorders.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Engineering, Electrical & Electronic
Zheng Zhou, Jiao Lu, Wei Wang, Yaoyao Zhou, Shuo Chen
Summary: Depth sensitive fluorescence spectroscopy can extract the depth dependent distribution of fluorophores, which is closely associated with disease progresses in layered tissues. However, conventional contact fiber-optic probe or non-contact lens setup based fluorescence measurements often lack sufficient depth sensitivity for precise diagnosis. In this study, a programmable cone shell configuration based depth-sensitive fluorescence spectroscopy was proposed and tested on a two-layered agar phantom. The results showed that the target depth can be altered arbitrarily by digitally tuning the ring beam radius and its capability of flexibly narrowing the ring beam width can promote further improvement on depth sensitivity.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2023)
