Journal
BIOMEDICAL OPTICS EXPRESS
Volume 10, Issue 8, Pages 4075-4096Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.10.004075
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Funding
- Ministry of Science and Technology of the People's Republic of China [2015CB755602]
- National Natural Science Foundation of China [61721092, 81671374]
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Elucidating connectivity and functionality at the whole-brain level is one of the most challenging research goals in neuroscience. Various whole-brain optical imaging technologies with submicron lateral resolution have been developed to reveal the fine structures of brain-wide neural and vascular networks at the mesoscopic level. Among them, micro-optical sectioning tomography (MOST) is attracting increasing attention, as a variety of technological variations and solutions tailored toward different biological applications have been optimized Here, we summarize the recent development of MOST technology in whole-brain imaging and anticipate future improvements. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.
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