Article
Medicine, General & Internal
Amal F. Gharib, Emad M. Eed, Amany S. Khalifa, Nermin Raafat, Somaia Shehab-Eldeen, Hany R. Alwakeel, Ehab Darwiesh, Abdallah Essa
Summary: This study explored the effectiveness of miRNA-96-5p and miRNA-99a-5p as diagnostic tools in HCC. The results showed increased expression levels of miRNA-96-5p in HCC patient sera, while miRNA-99a-5p levels were reduced. Combining circulating miRNA-96-5p, miRNA-99a-5p, and AFP improved the accuracy of HCC diagnosis. Higher serum miRNA-96-5p levels were linked to larger tumors and metastasis, while lower serum miRNA-99a-5p levels were exclusively linked to HCC metastasis.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Review
Oncology
Chenbin Liu, Han Wu, Yinqi Mao, Wei Chen, Shuying Chen
Summary: Exosomal microRNAs play a crucial role in hepatocellular carcinoma, holding significant value in the early diagnosis and treatment of this disease.
CANCER CELL INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Laura Gramantieri, Francesca Fornari, Catia Giovannini, Davide Trere
Summary: miRNAs in HCC play a bidirectional role in both immune-related pathways and oncogenic pathways. Understanding their function can help identify patient subgroups and design personalized treatment strategies.
Review
Oncology
Ting Song, Li Li, Shaobo Wu, Yan Liu, Caiping Guo, Wen Wang, Lili Dai, Tong Zhang, Hao Wu, Bin Su
Summary: Hepatocellular carcinoma (HCC) is a common and highly lethal cancer, and genetic biomarkers are increasingly playing a crucial role in early diagnosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Takeshi Matsui, Susumu Hamada-Tsutsumi, Yutaka Naito, Masanori Nojima, Etsuko Iio, Akihiro Tamori, Shoji Kubo, Tatsuya Ide, Yasuteru Kondo, Yuichiro Eguchi, Atsumasa Komori, Yuji Morine, Mitsuo Shimada, Tohru Utsunomiya, Ken Shirabe, Koichi Kimura, Yoichi Hiasa, Natthaya Chuaypen, Pisit Tangkijvanich, Aya Naiki-Ito, Satoru Takahashi, Takahiro Ochiya, Yasuhito Tanaka
Summary: The miRNA clusters miR-183/96/182 and miR-217/216a/216b are significantly upregulated in nonviral hepatocellular carcinoma (NBNC-HCC). High levels of miR-182-5p and miR-217-5p, but low levels of miR-96-5p, in tumor tissues are associated with poor recurrence-free survival of NBNC-HCC patients. Further upregulation of miR-96-5p in tumors may have an inhibitory effect on recurrence, suggesting its potential as a tumor suppressor in NBNC-HCC patients at high risk of recurrence. Transfection of miR-96-5p mimic induced apoptosis of HepG2 cells and suppressed proliferation and invasion, indicating its potential antitumor effects.
HEPATOLOGY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Karina Maciak, Angela Dziedzic, Elzbieta Miller, Joanna Saluk-Bijak
Summary: miR-155 plays a crucial role in regulating inflammation and autoimmune responses in multiple sclerosis, impacting processes such as blood-brain barrier disruption and neuropathic pain. Its dysregulation has also been linked to neuropsychiatric symptoms associated with the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Sharad Khare, Tripti Khare, Raghu Ramanathan, Jamal A. Ibdah
Summary: This review discusses the role and involvement of microRNAs (miRs) in the heterogeneity and metastasis of hepatocellular carcinoma, with a special emphasis on their potential as diagnostic and prognostic tools in the risk prediction, early detection, and treatment of hepatocellular carcinoma.
Review
Oncology
Laura Gramantieri, Catia Giovannini, Fabio Piscaglia, Francesca Fornari
Summary: miRNAs play crucial roles in hepatocellular carcinoma as both biomarkers and therapeutic targets. However, discrepancies between preclinical and clinical findings need to be carefully considered when translating miRNA-based approaches for clinical use.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2021)
Article
Oncology
Ganji Purnachandra Nagaraju, Begum Dariya, Prameswari Kasa, Sujatha Peela, Sujatha Peela Bassel F. El-Rayes
Summary: HCC is the most common primary malignancy of the liver, with a high fatality rate. Genetic and epigenetic aberrations are commonly observed in HCC, including chromatin remodeling, histone alterations, DNA methylation, and ncRNA expression. In-depth understanding of the epigenetics of HCC is critical for developing rational clinical strategies, improving overall survival, and predicting therapeutic outcomes.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Medical Laboratory Technology
Rongkang Li, Chong Lu, Weiqiang Yang, Yaqi Zhou, Jiatao Zhong, Xuan Chen, Xinji Li, Guocheng Huang, Xiqi Peng, Kaihao Liu, Chunduo Zhang, Hongyi Hu, Yongqing Lai
Summary: MicroRNAs are stable in serum and specific to different tumor types, making them a potential non-invasive biomarker for cancer detection. A three-miRNA panel has been shown to have high diagnostic efficiency for nasopharyngeal carcinoma. Further analysis suggests potential target genes for this miRNA panel.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Chemistry, Analytical
Lorico D. S. Lapitan Jr, Mariusz Pietrzak, Marek Krawczyk, Elzbieta Malinowska
Summary: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death globally in 2020. The complexity of the disease and the low survival rate are due to late-stage diagnosis. Therefore, developing simple, sensitive, and rapid screening methods for early detection is necessary. Recent studies have shown promising HCC biomarkers and ultrasensitive biosensor technologies that could significantly improve diagnosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Gastroenterology & Hepatology
Xiaochang Wu, Renrui Wan, LingYan Ren, Yong Yang, Yuan Ding, Weilin Wang
Summary: In this study, circulating microRNAs were used as a diagnostic tool to segregate hepatocellular carcinoma patients from healthy subjects. The study identified three microRNAs, miR-206, miR-222, and miR-126, that were significantly differentially expressed in hepatocellular carcinoma patients compared to healthy subjects. Combining these microRNAs with alpha-fetoprotein improved the diagnostic accuracy of hepatocellular carcinoma.
TURKISH JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Jiantao Wang, Jinbiao Che
Summary: The study showed that circTP63 is significantly upregulated in HCC tissues and cell lines, and its high expression is associated with advanced tumor stages, lymph node metastasis, and poor prognosis in HCC patients. Mechanistically, circTP63 acts as a sponge for miR-155-5p to regulate ZBTB18 expression, which is negatively correlated with the survival rate of HCC patients, highlighting a critical regulatory network in HCC progression.
CANCER CELL INTERNATIONAL
(2021)
Review
Oncology
Jose D. Debes, Pablo A. Romagnoli, Jhon Prieto, Marco Arrese, Angelo Z. Mattos, Andre Boonstra
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer death worldwide. Late diagnosis and limited treatment options contribute to the low survival rate of patients with HCC. Currently, combining ultrasound with the biomarker AFP is a commonly used screening method, but its clinical utility and operator-dependence are controversial.
Article
Cell Biology
Jingwen Yang, Weiwei Dong, He Zhang, Huixia Zhao, Zhiyan Zeng, Fengyun Zhang, Qiuwen Li, Xiaohong Duan, Yanyan Hu, Wenhua Xiao
Summary: This study revealed that the exosomal microRNA panel has high accuracy in diagnosing HCC and has important clinical significance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Haizhou Liu, Zihan Zhang, Yi Huang, Wene Wei, Shufang Ning, Jilin Li, Xinqiang Liang, Kaisheng Liu, Litu Zhang
Summary: The study demonstrated the association of pre-treatment plasma HSP90AA1 with the risk of breast cancer onset and metastasis, showing that combining with other markers could conveniently predict patients' risk.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wene Wei, Jiahui Zhou, Lipeng Chen, Haizhou Liu, Fuyong Zhang, Jilin Li, Shufang Ning, Shirong Li, Chen Wang, Yi Huang, Chang Zou, Litu Zhang
Summary: The study showed that plasma Hsp90 alpha levels were significantly higher in colorectal cancer patients and were associated with disease progression, certain tumor biomarkers, and immune cells. However, plasma Hsp90 alpha failed to demonstrate a prognostic value in progression-free survival for colorectal cancer.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yi Chen, Haizhou Liu, Shufang Ning, Changhong Wei, Jilin Li, Wene Wei, Litu Zhang
Summary: This study aims to explore the diagnostic and prognostic value of plasma miRNA in colorectal cancer (CRC) patients and establish a prognostic model. The results showed that miR-96/miR-99b can be used as a promising biomarker for early detection of metastatic CRC (mCRC) patients, and the nomogram based on 5 characteristics has satisfactory prognostic value.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Zihan Zhang, Qian Lin, Yi Chen, Chenlin Su, Wuye Lin, Daoyu Wei, Litu Zhang, Haizhou Liu
Summary: This study found that peripheral blood parameters play an important role in predicting distant metastasis and prognosis of breast cancer patients. The lymphocyte to monocyte ratio (LMR) is an independent prognostic factor for DFS in HER2-negative breast cancer patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Baoyue Huang, Jinmiao Pan, Haizhou Liu, Yamei Tang, Shirong Li, Yingzhen Bian, Shufang Ning, Jilin Li, Litu Zhang
Summary: This study investigates the significance of eHSP90 alpha in small cell lung cancer and finds that it is positively correlated with NSE, and can better predict overall survival and progression in patients, as well as the effectiveness of chemotherapy.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Multidisciplinary Sciences
Jinmiao Pan, Haizhou Liu, Shirong Li, Wene Wei, Jinling Mai, Yingzhen Bian, Shufang Ning, Jilin Li, Litu Zhang
Summary: This study focused on the role of serum thymidine kinase 1 (STK1) in predicting the prognosis of T4-stage lung squamous cell carcinoma (LUSC) with immunotherapy. A total of 180 LUSC patients were enrolled and divided into different T stages. The optimal cutoff value for predicting overall survival (OS) outcomes was determined using receiver operating characteristic (ROC) curves. STK1 was found to be over-expressed in T3-4 stage LUSC patients and correlated with other clinicopathological factors. Immunotherapy was identified as an independent prognostic factor in patients with T4 stage LUSC. In T4 LUSC patients receiving PD-1/PD-L1 inhibitor treatment, high levels of STK1 were associated with an increased risk of death. In conclusion, STK1 may serve as an effective prognostic marker for advanced LUSC immunotherapy patients, especially in T4 stage.
Article
Oncology
Shirong Li, Wene Wei, Zhaorong Feng, Yingzhen Bian, Jinmiao Pan, Jinling Mai, Shufang Ning, Jinglei Huang, Xiangyang Gao, Litu Zhang
Summary: This study aimed to clarify the diagnostic and prognostic value of serum Cytokeratin-19 fragments (CYFRA 21-1) in colorectal cancer (CRC). The results showed that CYFRA 21-1 can better differentiate colorectal liver metastases (CRLM) patients from the whole CRC patients and has unique prognostic value for CRLM patients.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Xinqiang Liang, Wenting Xu, Siyi Li, Mekhrdod S. Kurboniyon, Kunying Huang, Guilan Xu, Wene Wei, Shufang Ning, Litu Zhang, Chen Wang
Summary: A synergistic magnetic and photothermal therapeutic nanoplatform was constructed by synthesizing well-dispersed mSiO2-SmCox nanoparticles. These nanoparticles showed promising potential for hyperthermia-induced tumor therapy due to the magnetic and photothermal effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cell & Tissue Engineering
Shufang Ning, Yusha Chen, Shirong Li, Mengshu Liu, Haizhou Liu, Mengling Ye, Chen Wang, Jinmiao Pan, Wene Wei, Jilin Li, Litu Zhang
Summary: This study revealed that exosomal miR-99b-5p derived from human bone marrow mesenchymal stem cells can suppress the progression of colorectal cancer by targeting FGFR3. Exosomal miR-99b-5p may serve as a novel diagnostic marker for CRC and provide a therapeutic target for its treatment.
STEM CELL REVIEWS AND REPORTS
(2023)