Review
Pharmacology & Pharmacy
Wenhua Chen, Jiemiao Lu, Jiahao Zhang, Jianjun Wu, Lilong Yu, Luping Qin, Bo Zhu
Summary: Dendrobium officinale is a well-known plant used as a medicinal and food homologous product, containing various bioactive components and exhibiting diverse biological functions. The review summarizes research progress and aims to better understand the botany, traditional use, phytochemistry, pharmacology, quality control, and safety of D. officinale, providing references and potential directions for further studies.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wang Zhang, Xinjie Liu, Xun Sun, Rongchun Han, Nianjun Yu, Juan Liang, An Zhou
Summary: The study compared the antioxidant properties of fresh and dried Dendrobium officinale and their polysaccharides. Results showed that fresh Dendrobium officinale had greater effects in scavenging radicals and protecting against liver damage. The differences in antioxidant activities were attributed to the differences in polysaccharide composition and molecular weight arrangement.
Review
Biochemistry & Molecular Biology
Wen-hua Chen, Jian-jun Wu, Xue-fei Li, Jie-miao Lu, Wei Wu, Yi-qi Sun, Bo Zhu, Lu-ping Qin
Summary: Dendrobium officinale polysaccharides exhibit a variety of biological effects, including immunomodulatory, anti-tumor, and gastro-protective effects. Further research is needed to explore extraction, purification, and structural characteristics of these polysaccharides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Environmental Sciences
Yan Fu, Quansheng Wang, Liang Zhang, Shuping Ling, Huiyan Jia, Yinliang Wu
Summary: Based on the investigation of 12 pesticides in Dendrobium officinale, it was found that the residues were within acceptable limits at different pre-harvest intervals, indicating a low dietary risk.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Jianzhong Yu, Zhenlan Xu, Ji Sun, Xiaoyan Xu, Yuyong Wu, Fengting Sun, Ningning Sang, Xinwang Lv, Changpeng Zhang, Xueping Zhao, Tao Tang
Summary: Bioaccessibility (BA) is a crucial factor for evaluating the absorption of pollutants in the human digestion system, which is of vital importance for risk assessment of pollutants via food intake. Multi-pesticides were detected in Dendrobium officinale Kimura et Migo (D. officinale), a popular dual-use plant with both botanical medicine and food applications. Nevertheless, the BA of pesticides in D. officinale remains unknown, restricting its market size.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Yuhong Liu, Ke Bei, Weiran Zheng, Guoguang Yu, Caixia Sun
Summary: This study investigated pesticide residues in Dendrobium officinale stems and leaves and assessed the associated risk of human exposure. The results showed that although multiple pesticide residues were detected, the short-term, long-term, and cumulative risks to human health were negligible.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Applied
Zhenlan Xu, Lingxiangyu Li, Yi Xu, Shanshan Wang, Xiaoxia Zhang, Tao Tang, Jianzhong Yu, Huiyu Zhao, Shenggan Wu, Chunrong Zhang, Xueping Zhao
Summary: A method to detect multiple pesticide residues in D. officinale was developed and validated, with analysis of real samples showing no potential health risks from pesticide residues in fresh or dried D. officinale for human consumption.
Article
Biochemistry & Molecular Biology
Da Yang, Yeyang Song, Anjin Lu, Lin Qin, Daopeng Tan, Qianru Zhang, Yuqi He, Yanliu Lu
Summary: This study collected samples of Dendrobium officinale grown through different cultivation methods and analyzed their chemical composition through chemical analysis and metabolomics. The results showed that stone epiphytic cultivation and greenhouse cultivation had higher polysaccharide content compared to live tree epiphytic cultivation. Metabolomic analysis revealed differential metabolite production among the three cultivation methods, with stone epiphytic cultivation showing the highest number of differential metabolites.
Article
Pharmacology & Pharmacy
Shengchang Tao, Zhiyao Ren, Zerui Yang, Shuna Duan, Zhongxian Wan, Jiahui Huang, Chenxing Liu, Gang Wei
Summary: Our study demonstrated that the fraction of Dendrobium officinale polysaccharides with a molecular weight of 389.98 kDa exhibited the strongest antitumor effect against colorectal cancer; the specific fraction DOPW-1 could potentially be developed as a clinical agent for treating CRC; and DOPW-1 inhibits the proliferation of HT-29 cells by regulating the apoptosis pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Chengchong Huang, Jiali Yu, Jingjing Da, Rong Dong, Lu Dai, Yuqi Yang, Yiyao Deng, Jing Yuan
Summary: DOP, a primary active component of Dendrobium officinale Kimura & Migo, has been found to have a significant therapeutic effect on renal fibrosis in diabetic kidney disease (DKD). It can protect renal function by inhibiting fibrosis and also has hypoglycemic and anti-inflammatory effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Di Zhou, Ying Zhao, Zhilin Chen, Xiuxiang Yan, Yanqiang Zhao, Lu Gao, Lixin Yang
Summary: This study analyzed and compared the chemical composition of fresh stems of Dendrobium officinale and processed D. officinale stems, and investigated the impact of processing on the medicinal efficacy. The results showed that processed D. officinale stems had higher levels of certain metabolites with anti-inflammatory activity compared to fresh stems, supporting its traditional usage for inflammation treatment.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Xian-Mei Piao, Ming-Feng Feng, Wei-Ping Zhao, Zhi-Hang Wu, Wen-Wen Zhang, Hui-Min Hou, Jin-Hui Wang, Li-Bo Wang, Jian Huang, Yan Zhang
Summary: This study found that dendrocandin U, isolated from Dendrobium officinale, has significant anti-inflammatory activity and acts by inhibiting M1 polarization through the TLR4/MyD88/NF-kappa B signaling pathway.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Nutrition & Dietetics
Xiaoyu Guo, Mingguan Yang, Changlu Wang, Shaoping Nie, Steve W. Cui, Qingbin Guo
Summary: In this study, the structural features, conformational properties, functional properties, and immunomodulatory activities of Dendrobium Officinale polysaccharides (DOP) were investigated after ultrasound and mild base treatment. The results showed that ultrasound treatment decreased the molecular weight and viscosity, while mild base treatment reduced the degree of acetylation and water solubility. The immune-regulatory effects of DOP were highest after 200 minutes of sonication. However, the immunomodulatory effects were compromised after de-acetylation.
FRONTIERS IN NUTRITION
(2022)
Article
Plant Sciences
Kaixin Zheng, Yuchen Cai, Weijie Chen, Yadi Gao, Jingjing Jin, Huizhong Wang, Shangguo Feng, Jiangjie Lu
Summary: A specific DNA marker was developed for the rapid and accurate authentication of Dendrobium officinale, which can help ensure the quality of medicinal preparations and protect the germplasm of this important medicinal species.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Agronomy
Yuan Lei, Yuqin Luo, Nan Fang, Yanjie Li, Xiangyun Wang, Hongmei He, Jinhua Jiang, Jianzhong Yu, Changpeng Zhang, Xueping Zhao
Summary: The widespread use of pesticides poses significant risks to food and environmental safety. This study developed a rapid and efficient method for determining the residue of the neonicotinoid insecticide imidacloprid in four minor crops. The results showed that the imidacloprid residues in Chinese agricultural products were far below safety limits, indicating low health risk for consumers.
Article
Chemistry, Multidisciplinary
Chunhua Zhou, Zhenshan Xie, Zhouxi Lei, Yuechun Huang, Gang Wei
CHEMISTRY CENTRAL JOURNAL
(2018)
Article
Biochemistry & Molecular Biology
Wenxia Yu, Zhiyao Ren, Xiaofeng Zhang, Shangping Xing, Shengchang Tao, Chenxing Liu, Gang Wei, Yuan Yuan, Zhouxi Lei
Article
Integrative & Complementary Medicine
Xiaofeng Zhang, Yingyi Luo, Gang Wei, Yunrong Li, Yuechun Huang, Jiahui Huang, Chenxing Liu, Runping Huang, Guoxiong Liu, Zhaofeng Wei, Shuxiu Du
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Biotechnology & Applied Microbiology
Zhiyao Ren, Fangning Qiu, Yinjie Wang, Wenxia Yu, Chenxing Liu, Yangyang Sun, Yawen Wang, Xiaofeng Zhang, Shangping Xing, Shengchang Tao, Yuechun Huang, Guoxiong Liu, Zhaofeng Wei, Baiyin Yu, Shuxiu Du, Zhouxi Lei, Gang Wei
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Plant Sciences
Zhiyao Ren, Xiaoyu Ji, Zhenbin Jiao, Yingyi Luo, Guo-Qiang Zhang, Shengchang Tao, Zhouxi Lei, Jing Zhang, Yuchen Wang, Zhong-Jian Liu, Gang Wei
HORTICULTURE RESEARCH
(2020)
Article
Food Science & Technology
Xiaofeng Zhang, Shuna Duan, Shengchang Tao, Jiahui Huang, Chenxing Liu, Shangping Xing, Zhiyao Ren, Zhouxi Lei, Yunrong Li, Gang Wei
JOURNAL OF FUNCTIONAL FOODS
(2020)
Article
Biochemical Research Methods
Yawen Wang, Xian Liao, Chujuan Zhou, Li Hu, Gang Wei, Yuechun Huang, Zhouxi Lei, Zhiyao Ren, Zhixia Liu, Zhihua Liu
Summary: This study identified 25 previously undescribed flavones in Dendrobium nobile from various habitats, and revealed that the habitats of D. nobile can be distinguished by significant differences in their flavone content. C-glycosyl flavones were found to be characteristic compounds for evaluating D. nobile from different habitats. Flavones acylated with 3-hydroxy-3-methylglutaryl were specific compounds detected only in samples from Yunnan.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2021)
Article
Biochemical Research Methods
Li Hu, Zhiyun Liang, Yawen Wang, Gang Wei, Yue-Chun Huang
Summary: The study identified various types of flavones in different species of Dendrobium, providing valuable information for quality assessment and utilization of these plants in traditional Chinese medicine. The results may also serve as a reference for identifying flavones in other Chinese herbs.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2022)
Article
Food Science & Technology
Shengchang Tao, Chunlei Huang, Zhihong Tan, Shuna Duan, Xiaofeng Zhang, Zhiyao Ren, Chunhua Zhou, Jiahui Huang, Chenxing Liu, Gang Wei
Summary: The study demonstrated that Dendrobium officinale polysaccharides (DOPW-1) have strong anti-tumor effects on HT-29 cells, and significantly enhance the anticancer activities of 5-Fu in vitro and in vivo. Additionally, DOPW-1 effectively inhibited tumor metastasis in a zebrafish model, suggesting its potential as a natural polysaccharide source for colorectal cancer therapy.
Article
Biotechnology & Applied Microbiology
Huan Wang, Jinyan Li, Xiaoxia Liang, Shengchang Tao, Zhanghua Wu, Gang Wei
Summary: This study investigated the microbial communities associated with the medicinal plant Dendrobium officinale in the stressful environment of Danxia Habitat. The results showed that different microbes in different plant niches have diverse functional potentials to support the growth and development of D. officinale in the stressful environment. Metabolic pathways related to carbohydrate metabolism, amino acid metabolism, and energy metabolism were found to be significantly abundant, indicating their importance for the survival of D. officinale in the stressful environment.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shengchang Tao, Zhiyao Ren, Zerui Yang, Shuna Duan, Zhongxian Wan, Jiahui Huang, Chenxing Liu, Gang Wei
Summary: Our study demonstrated that the fraction of Dendrobium officinale polysaccharides with a molecular weight of 389.98 kDa exhibited the strongest antitumor effect against colorectal cancer; the specific fraction DOPW-1 could potentially be developed as a clinical agent for treating CRC; and DOPW-1 inhibits the proliferation of HT-29 cells by regulating the apoptosis pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qiqian Lan, Chenxing Liu, Zhanghua Wu, Chen Ni, Jinyan Li, Chunlei Huang, Huan Wang, Gang Wei
Summary: This study identified differential metabolites in Dendrobium officinale stems of different origins using a widely-targeted metabolomics approach. Flavonoids were found to be the main differentiating metabolites, and a quantitative analysis of four main flavonoids was conducted. These findings provide a scientific basis for further research on the quality evaluation of Dendrobium officinale.
