Article
Environmental Sciences
Barakat M. ALRashdi, Hassan A. Elgebaly, Mousa O. Germoush, Moath M. Qarmush, Mona S. Azab, Reem S. Alruhaimi, Ahmad F. Ahmeda, Mohammad H. Abukhalil, Emadeldin M. Kamel, Hany H. Arab, Mohammed A. Alzoghaibi, Mohammed F. Alotaibi, Ayman M. Mahmoud
Summary: This study investigated the effects of Monolluma quadrangula extract (MQE) on hyperuricemic rats and found that MQE exhibited renoprotective properties by inhibiting xanthine oxidase activity, reducing oxidative stress and inflammation, and modulating urate transporters.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jinfen Chen, Lieqiang Xu, Linyun Jiang, Yulin Wu, Long Wei, Xiaoli Wu, Shihong Xiao, Yuhong Liu, Changjun Gao, Jian Cai, Ziren Su
Summary: Sonneratia apetala seeds have been found to have potential nutraceutical benefits in lowering uric acid levels and protecting against renal injury through modulation of anti-oxidant status and inflammatory responses. These seeds also show promise in reversing hyperuricemia-induced kidney damage by activating the Nrf2 pathway and suppressing the TXNIP/NLRP3 inflammasome.
Article
Peripheral Vascular Disease
Masato Furuhashi, Yukimura Higashiura, Masayuki Koyama, Marenao Tanaka, Takayo Murase, Takashi Nakamura, Seigo Akari, Akiko Sakai, Kazuma Mori, Hirofumi Ohnishi, Shigeyuki Saitoh, Kazuaki Shimamoto, Tetsuji Miura
Summary: The study found that plasma XOR activity is independently associated with hypertension in nondiabetic individuals who are not taking any medications. The activity is positively correlated with mean arterial pressure and significantly higher in the hypertension group compared to the non-hypertension group.
HYPERTENSION RESEARCH
(2021)
Article
Agriculture, Multidisciplinary
Xiaofen Qi, Haoran Chen, Kaifang Guan, Rongchun Wang, Ying Ma
Summary: The study found that whey protein hydrolysate (WPH) can alleviate hyperuricemia (HUA) by inhibiting uric acid production and promoting uric acid excretion, improving renal dysfunction caused by HUA.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Food Science & Technology
Lin Xiang, Yuting Huang, Rong Li, Yexing Tao, Ting Wu, Siyi Pan, Xiaoyun Xu
Summary: Artemisia selengensis Turcz. (AST) leaves extract (ASTLE), rich in caffeoylquinic acids (CQAs), showed inhibitory activity against xanthine oxidase (XOD), modulated the expression of renal uric acid transporters, and improved metabolic disorders in hyperuricemia (HUA) mice. These findings suggest that ASTLE may be a promising natural resource for ameliorating HUA.
Article
Agriculture, Multidisciplinary
Ze-Rui Sun, Hua-Rong Liu, Di Hu, Mao-Si Fan, Ming-Yue Wang, Meng-Fei An, Yun-Li Zhao, Ze-Min Xiang, Jun Sheng
Summary: Ellagic acid (EA) has been shown to effectively regulate hyperuricemia by inhibiting xanthine oxidase and superoxide anion, reducing uric acid levels through the NLRP3 signaling pathway, and improving histopathology in animal models.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Food Science & Technology
Simin Feng, Sijie Wu, Fei Xie, Chung S. Yang, Ping Shao
Summary: This review highlights the potential activities of natural compounds from food and other plants in lowering blood uric acid levels and discusses their molecular mechanisms. Flavonoids, saponins, terpenoids, and alkaloids have shown uric acid-lowering effects by inhibiting xanthine oxidoreductase and regulating uric acid transporters. A dietary approach is proposed for the management of hyperuricemia, either as an adjuvant or replacement for current uric acid-lowering drugs, based on the information provided in the review.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Liuyi Wei, Hongwu Ji, Wenkui Song, Shuo Peng, Suhong Zhan, Yushan Qu, Ming Chen, Di Zhang, Shucheng Liu
Summary: ATO can reduce serum uric acid levels in hyperuricemic mice by decreasing uric acid production and promoting renal excretion. It also exhibits hepatoprotective and nephroprotective activities.
Article
Endocrinology & Metabolism
Austin G. Stack, David Han, Ronald Goldwater, Susanne Johansson, Nalina Dronamraju, Jan Oscarsson, Eva Johnsson, Joanna Parkinson, Fredrik Erlandsson
Summary: The study found that combining dapagliflozin with verinurad and febuxostat can effectively lower sUA levels without increasing urinary uric acid excretion, indicating that this combination therapy does not adversely affect kidney function.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Tianshu Gao, Jin Xu, Yuxiao Xiao, Jiaqi Li, Weifeng Hu, Xiaoyu Su, Xudong Shen, Wan Yu, Zhen Chen, Baosheng Huang, Honglei Li, Xing Wang
Summary: The study found that N-(9,10-anthraquinone-2-ylcarbonyl) xanthine oxidase inhibitors (NAY) can reduce the levels of uric acid by inhibiting xanthine oxidase activity, regulating the uric acid transporter, and inhibiting inflammation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Yuqing Zhou, Yupeng Zeng, Zhijun Pan, Yufeng Jin, Qing Li, Juan Pang, Xin Wang, Yu Chen, Yan Yang, Wenhua Ling
Summary: This study found that resveratrol supplementation for 8 weeks had no significant effect on lipid profile but decreased uric acid in a dose-response manner in individuals with dyslipidemia. It also demonstrated an inhibitory effect on xanthine oxidase activity. However, there were no significant differences in glucose, insulin, or oxidative stress biomarkers between the resveratrol groups and placebo.
Article
Biochemistry & Molecular Biology
Yixiang Liu, Naixin Liu, Wenxin Bian, Yue Zhang, Yutong Wu, Ying Peng, Zeqiong Ru, Zhe Fu, Yinglei Wang, Chao Li, Xinwang Yang, Ying Wang
Summary: A short peptide (NCTX15) from Nephila clavata spider toxin gland homogenates was found to lower uric acid levels, inhibit inflammatory responses, and alleviate renal injury, showing potential for treating gout and hyperuricemia.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Liyan Yuan, Zhijie Bao, Tiecheng Ma, Songyi Lin
Summary: The study investigated the hypouricemic effect of corn silk flavonoids on mice with potassium oxonate-induced hyperuricemia, showing that CSF-B had the best effect by inhibiting XO activity and promoting UA excretion. It also identified five major flavonoids in CSF-B that may contribute to its hypouricemic activity. The findings suggest that corn silk flavonoids could be a potential dietary supplement for managing hyperuricemia.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yoshiro Tanaka, Tomohisa Nagoshi, Akira Yoshii, Yuhei Oi, Hirotake Takahashi, Haruka Kimura, Keiichi Ito, Yusuke Kashiwagi, Toshikazu D. Tanaka, Michihiro Yoshimura
Summary: Accumulating evidence suggests that high serum uric acid is associated with left ventricular dysfunction, and xanthine oxidase activation plays a critical role in this process. In a study on doxorubicin-induced cardiotoxicity, it was found that cardiac tissue xanthine oxidase activation led to impaired left ventricular function, which was attenuated by xanthine oxidase inhibitors through reduction of oxidative stress and modulation of purine metabolism.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ming Chen, Hongwu Ji, Wenkui Song, Di Zhang, Weiming Su, Shucheng Liu
Summary: This study found that anserine can reduce hepatorenal injury and serum uric acid levels by regulating the gene expressions related to uric acid metabolism. Anserine can also reduce inflammatory cell infiltration and has anti-inflammatory effects.
