Article
Otorhinolaryngology
Jung M. Park, Min J. Kim, Jae S. Han, So Y. Park, Shi N. Park
Summary: Middle ear myoclonic tinnitus (MEMT) is a disease caused by abnormal movement of middle ear muscles. This study proposes intratympanic botulinum toxin (IT-BTX) injection as a new therapeutic option for MEMT, which has shown promising results in animal experiments and clinical trials.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Medicine, Research & Experimental
Liam Simani, Shahaf Shilo, Yahav Oron, Rani A. Eta, Ophir Handzel, Nidal Muhanna, Anton Warshavsky, Gilad Horowitz, Omer J. Ungar
Summary: The risk of residual tympanic membrane perforation after intratympanic steroidal treatment administered via transtympanic injection compared with trans-tympanostomy tube was found to be similar in this study, suggesting no significant difference in the two techniques. This indicates that both treatment methods are equally effective in preventing residual tympanic membrane perforation.
Review
Medicine, General & Internal
Katie E. Webster, Ambrose Lee, Kevin Galbraith, Natasha A. Harrington-Benton, Owen Judd, Diego Kaski, Otto R. Maarsingh, Samuel MacKeith, Jaydip Ray, Vincent A. Van Vugt, Brian Westerberg, Martin J. Burton
Summary: This study evaluated the benefits and harms of intratympanic corticosteroids in the treatment of Meniere's disease. The results showed that the effectiveness of this treatment in improving vertigo is uncertain, while it may slightly reduce the frequency of vertigo episodes. The impact on serious adverse events is also uncertain. The overall certainty of evidence for these outcomes is low or very low.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2023)
Article
Multidisciplinary Sciences
Zhengnan Luo, Yi Du, Shuting Li, He Zhang, Muya Shu, Di Zhang, Shunji He, Guangqin Wang, Falong Lu, Zhiyong Liu
Summary: This study reveals the cooperative action of three distinct enhancers in regulating Atoh1 during hair cell development in the inner ear. Deleting one or two of these enhancers impairs hair cell development, while simultaneous deletion of all three enhancers results in almost complete absence of hair cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
Yang Li, Sho Kanzaki, Shinsuke Shibata, Masaya Nakamura, Masahiro Ozaki, Hideyuki Okano, Kaoru Ogawa
Summary: This study investigated the pharmacokinetic behaviors of combination therapy in the inner ear of mice, finding that combination therapy had the longest reaching-peak time and largest AUC value in the inner ear of mice.
FRONTIERS IN NEUROLOGY
(2021)
Review
Cell Biology
Zhong Zhang, Renjie Chai
Summary: This paragraph discusses the importance of G protein-coupled receptors (GPCRs) in the cochlea, highlighting their role in cochlear development, hearing disorders, and the treatment of hearing loss. Several GPCRs, such as Frizzleds and Lgrs, have been identified to regulate stem cell self-renewal abilities and cochlear planar cell polarity (PCP). Mutations in specific GPCRs, such as Vlgr1, Gpr156, S1P2, and Gpr126, can cause hearing loss. Additionally, activation of A1, A2A, and CB2 receptors has a protective effect against noise- or drug-induced hearing loss.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yuxin Deng, Sen Chen, Jun Hu
Summary: Diabetes is closely related to hearing loss, although the exact mechanism is still unclear. Pathological research shows that diabetes damages various parts of the inner ear. Clinical studies have found a correlation between the duration and severity of diabetes and the occurrence and severity of hearing loss.
MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Makoto Hosoya, Masato Fujioka, Ayako Y. Murayama, Hideyuki Okano, Kaoru Ogawa
Summary: Cochlear development is a complex process crucial for understanding congenital hearing loss and regenerative medicine. The common marmoset, a New World monkey species, is suggested as an effective alternative for studying primate cochlear development, with similarities to humans and mice in general stages but differences in certain protein expression related to supporting cell processes and neuronal development. Human fetal samples for primate-specific cochlear development studies are rare, particularly for late developmental stages.
Article
Pharmacology & Pharmacy
So-Young Jung, Subin Kim, Zion Kang, Soonmin Kwon, Juhye Lee, Joo Won Park, Kab Sig Kim, Dong-Kee Kim
Summary: Dexamethasone nanosuspensions administered via intratympanic injection demonstrated efficient and safe delivery of dexamethasone to the cochlea, with superior hearing-protective effects compared to Dex-SP.
Article
Cell Biology
Maria Beatriz Duran Alonso, Victor Vendrell, Iris Lopez-Hernandez, Maria Teresa Alonso, Donna M. Martin, Fernando Giraldez, Laura Carramolino, Giovanna Giovinazzo, Enrique Vazquez, Miguel Torres, Thomas Schimmang
Summary: Meis2 gene plays a crucial role in controlling the development of the inner ear, particularly in the formation of the cochlea. The expression of Meis2 in tissues required for inner ear induction and the hindbrain is essential for otic vesicle formation. Inactivation of Meis2 in the inner ear results in an aberrant coiling of the cochlear duct, suggesting its importance in proper cochlear morphogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemical Research Methods
Betsy Szeto, Chris Valentini, Aykut Aksit, Emily G. Werth, Shahar Goeta, Lewis M. Brown, Elizabeth S. Olson, Jeffrey W. Kysar, Anil K. Lalwani
Summary: Glucocorticoids are the first-line treatment for sensorineural hearing loss, but the mechanism of their protective effect and the impact of route of administration are still poorly understood. Using hollow microneedles for proteomic analysis, our study found that dexamethasone administration route affects changes in perilymph proteome, with intraperitoneal route inducing more significant changes in protein expression related to neuroprotection, inflammatory pathway, and protein synthesis compared to intratympanic administration.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Neurosciences
Yi Pan, Shuting Li, Shunji He, Guangqin Wang, Chao Li, Zhiyong Liu, Mingliang Xiang
Summary: The study generated a new knock-in strain Fgf8(GFP/+) that accurately reflects the expression of Fgf8 and can be used to obtain high-purity embryonic and neonatal inner hair cells. Furthermore, the study revealed that inner hair cells can also be derived from inner ear progenitors expressing Insm1, a marker previously regarded as specific to outer hair cells.
NEUROSCIENCE BULLETIN
(2023)
Article
Medicine, General & Internal
Thi Phuc Le, Yang Yu, Ik Sung Cho, Eun Yeong Suh, Hyuk Chan Kwon, Sun-Ae Shin, Yong-Ho Park, Kang Moo Huh
Summary: This study prepared and evaluated an injectable poloxamer (P407) hydrogel formulation for intratympanic (IT) delivery of dexamethasone (DEX). The P407 hydrogel effectively solubilized hydrophobic DEX and demonstrated sustained release compared to hydrophilic DEX formulation. The in vivo study showed that the hydrogel formulation delivered considerable drug concentrations to the inner ear and displayed a favorable safety profile without apparent cytotoxicity or inflammation.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Genetics & Heredity
Shasha Zhang, Ying Dong, Ruiying Qiang, Yuan Zhang, Xiaoli Zhang, Yin Chen, Pei Jiang, Xiangyu Ma, Leilei Wu, Jingru Ai, Xia Gao, Pengjun Wang, Jie Chen, Renjie Chai
Summary: Strip1 is a core component of the STRIPAK complex and its knockout in mice is embryonic lethal, indicating its importance in cochlear hair cell development and maturation. Studies on Strip1 expression and function in the mammalian cochlea are still needed for further understanding its roles.
FRONTIERS IN GENETICS
(2021)
Article
Environmental Sciences
Laura Rojas, Martin Haulena, Colleen Reichmuth, Bjoern Busse, L. Aurora Ramos-Garduno, Oscar Rico-Chavez, Ursula Siebert, Maria Morell
Summary: This study provides the first morphometric descriptions of the sensory cells of the inner ear in harbor seals, highlighting specific morphological features and their variations along the cochlear spiral. The findings offer a baseline for further research on the morphology and morphometry of the organ of Corti in harbor seals and allow for comparisons between normal and pathological features.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Clinical Neurology
Enrique R. Perez, Olena Bracho, Liliana Ein, Mikhaylo Szczupak, Paula V. Monje, Cristina Fernandez-Valle, Abdulaziz Alshaiji, Michael Ivan, Jacques Morcos, Xue-Zhong Liu, Michael Hoffer, Adrien Eshraghi, Simon Angeli, Fred Telischi, Christine T. Dinh
OTOLOGY & NEUROTOLOGY
(2018)
Article
Clinical Neurology
Carey D. Balaban, Alex Kiderman, Mikhaylo Szczupak, Robin C. Ashmore, Michael E. Hoffer
FRONTIERS IN NEUROLOGY
(2018)
Review
Neurosciences
Thanos Tzounopoulos, Carey Balaban, Lori Zitelli, Catherine Palmer
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
(2019)
Article
Clinical Neurology
Carey D. Balaban, Robert D. Black, Stephen D. Silberstein
Editorial Material
Otorhinolaryngology
Mikhaylo Szczupak, Gary D. Josephson
ENT-EAR NOSE & THROAT JOURNAL
(2019)
Article
Clinical Neurology
P. Ashley Wackym, Carey D. Balaban, Pengfei Zhang, David A. Siker, Jasdeep S. Hundal
FRONTIERS IN NEUROLOGY
(2019)
Article
Clinical Neurology
Carey D. Balaban, Mikhaylo Szczupak, Alexander Kiderman, Bonnie E. Levin, Michael E. Hoffer
FRONTIERS IN NEUROLOGY
(2020)
Article
Neurosciences
Andrew A. McCall, Derek M. Miller, Carey D. Balaban
Summary: The study demonstrates that vestibular nucleus neurons in conscious cats respond well to combined vestibular and hindlimb proprioceptive stimulation, fitting a simple additive model. This suggests that neurons in this region play a key role in adjusting vestibulospinal outflow in response to limb state.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Takaki Inui, Michael Hoffer, Carey D. Balaban
Summary: This study examines regional changes in immunoreactive MMP2 in the rat brain after blast overpressure exposure, showing differences in MMP2 expression in different brain regions, suggesting that local MMP2 responses may serve as biomarkers for locally regulated responses to brain injury.
Review
Otorhinolaryngology
Jennifer Coto, Carmen L. Alvarez, Ivette Cejas, Brett M. Colbert, Bonnie E. Levin, Joshua Huppert, Tatjana Rundek, Carey Balaban, Susan H. Blanton, David J. Lee, David Loewenstein, Michael Hoffer, Xue Zhong Liu
Summary: The study emphasizes the importance of examining the individual contributions of factors such as balance, vision, and cognition in age-related vestibular loss. While the relationship between the vestibular and visual systems has been well studied, little is known about the association of the peripheral vestibular system with neurodegenerative disorders. Emerging research suggests that the vestibular system can be a key factor in examining brain function beyond balance, into areas such as cognition and psychological functioning.
JOURNAL OF OTOLOGY
(2021)
Article
Otorhinolaryngology
Michael E. Hoffer, Bonnie E. Levin, Hillary Snapp, James Buskirk, Carey Balaban
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2019)
Meeting Abstract
Clinical Neurology
Alex Kiderman, Carey Balaban, Mikhaylo Szczupak, Hillary Snapp, Michael Hoffer
Meeting Abstract
Critical Care Medicine
Michael E. Hoffer, Bonnie Levin, Hillary Snapp, James K. Buskirk, Carey Balaban
JOURNAL OF NEUROTRAUMA
(2018)