Article
Endocrinology & Metabolism
Filippo Luca Gurgoglione, Dario Pitocco, Rocco A. Montone, Riccardo Rinaldi, Riccardo C. Bonadonna, Giulia Magnani, Camilla Calvieri, Emilia Solinas, Alessandro Rizzi, Linda Tartaglione, Andrea Flex, Luca Viti, Carlo Trani, Diego Ardissino, Filippo Crea, Giampaolo Niccoli
Summary: The study aimed to investigate the influence of diabetic microvascular complications (DMC) on coronary collateral (CC) vessel development in patients with coronary chronic total occlusion (CTO). Results showed that patients with DMC had a higher prevalence of CC and high-grade CC compared with those without DMC. Furthermore, there was a positive association between the number of DMC in each patient and the prevalence of high-grade CC.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Afnan Mansour, Mira Mousa, Dima Abdelmannan, Guan Tay, Ahmed Hassoun, Habiba Alsafar
Summary: This study conducted an Exome-Wide Association Study (EWAS) on Emirati individuals with type 2 diabetes mellitus (T2DM) to identify susceptibility loci associated with T2DM-related complications. The results showed associations between various genes and each complication category. The study also highlighted the limitations of the current genotyping arrays in representing diverse populations, emphasizing the need for better representation in future studies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Chuanyan Wu, Yan Borne, Rui Gao, Maykel Lopez Rodriguez, William C. Roell, Jonathan M. Wilson, Ajit Regmi, Cheng Luan, Dina Mansour Aly, Andreas Peter, Juergen Machann, Harald Staiger, Andreas Fritsche, Andreas L. Birkenfeld, Rongya Tao, Robert Wagner, Mickael Canouil, Mun-Gwan Hong, Jochen M. Schwenk, Emma Ahlqvist, Minna U. Kaikkonen, Peter Nilsson, Angela C. Shore, Faisel Khan, Andrea Natali, Olle Melander, Marju Orho-Melander, Jan Nilsson, Hans-Ulrich Haering, Erik Renstrom, Claes B. Wollheim, Gunnar Engstrom, Jianping Weng, Ewan R. Pearson, Paul W. Franks, Morris F. White, Kevin L. Duffin, Allan Arthur Vaag, Markku Laakso, Norbert Stefan, Leif Groop, Yang De Marinis
Summary: The study shows that elevated plasma follistatin levels are associated with an increased risk of T2D and adipose tissue insulin resistance, suggesting a potential role of follistatin in the development of T2D and related metabolic disorders.
NATURE COMMUNICATIONS
(2021)
Review
Multidisciplinary Sciences
Qiaoyu Hou, Rongjing Song, Xuecheng Zhao, Changqing Yang, Yufei Feng
Summary: This study provides evidence of differences in circulating irisin levels between type 2 diabetes mellitus (T2DM) patients with and without chronic complications. The results indicate that T2DM patients with chronic complications have lower circulating irisin levels, which further decrease with the aggravation of complications.
Article
Biochemistry & Molecular Biology
Mohammad Reza Tabandeh, Amal Sattar Taha, Hanaa Addai Ali, Mohammad Razijalali, Narges Mohammadtaghvaei
Summary: This study investigated the alterations of circulating adipocytokines in patients with type 2 diabetes mellitus (T2DM) coinciding with clinical and subclinical thyroid dysfunctions. The results showed that T2DM patients with clinical thyroid dysfunctions had higher levels of circulating adipocytokines and inflammatory factors compared to those with subclinical thyroid dysfunctions or without thyroid dysfunctions. These findings suggest that clinical thyroid dysfunction in T2DM patients is associated with elevated levels of circulating adipocytokines and inflammatory factors.
Review
Endocrinology & Metabolism
Xinyang Guo, Yiqiao Xing, Wei Jin
Summary: Diabetic microangiopathy is a common and severe problem in diabetics, and it includes diabetic retinopathy, nephropathy, neuropathy, and cardiomyopathy. Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), is significantly elevated in patients with type 2 diabetes and microvascular complications. ADMA promotes the occurrence and progression of microvascular complications in type 2 diabetes through influencing endothelial cell function, oxidative stress damage, inflammation, and fibrosis. This review paper explores the association between ADMA and microvascular complications of diabetes, and provides new insights and potential treatment options.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Yuanjue Wu, Ting Xiong, Xiao Tan, Liangkai Chen
Summary: This study aimed to evaluate the association of pre-frailty and frailty with diabetic microvascular complications (DMC) in patients with type 2 diabetes (T2D). The results showed that both pre-frailty and frailty were associated with an increased risk of DMC in T2D patients.
Article
Nutrition & Dietetics
Camelia Oana Iatcu, Aimee Steen, Mihai Covasa
Summary: The gut microbiota plays a crucial role in the development of obesity, metabolic syndrome, and type 2 diabetes. Modulating the gut microbiota through probiotics, prebiotics, synbiotics, and fecal microbial transplantation shows potential in treating diabetes and its complications. The severity of gut microbiota dysbiosis is associated with disease severity, and restoration of the gut microbiota through probiotic administration can improve symptoms and disease progression.
Article
Cardiac & Cardiovascular Systems
Rocco A. Montone, Dario Pitocco, Filippo Luca Gurgoglione, Riccardo Rinaldi, Marco Giuseppe Del Buono, Massimiliano Camilli, Alessandro Rizzi, Linda Tartaglione, Gaetano Emanuele Rizzo, Mauro Di Leo, Andrea Flex, Michele Russo, Giovanna Liuzzo, Giulia Magnani, Riccardo C. Bonadonna, Diego Ardissino, Filippo Crea, Giampaolo Niccoli
Summary: This study aimed to investigate the impact of diabetic microvascular complications (DMC) on the features of coronary plaques. The results showed that the presence of DMC could identify a distinct diabetic population with more severe coronary artery disease (CAD), but a more stable pattern of coronary plaques.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Medicine, General & Internal
David M. Nathan, GRADE Study Res Grp, John M. Lachin, Ionut Bebu, Henry B. Burch, John B. Buse, Andrea L. Cherrington, Stephen P. Fortmann, Jennifer B. Green, Steven E. Kahn, M. Sue Kirkman, Heidi Krause-Steinrauf, Mary E. Larkin, Lawrence S. Phillips, Rodica Pop-Busui, Michael Steffes, Margaret Tiktin, Mark Tripputi, Deborah J. Wexle, Naji Younes
Summary: There were no material differences among the four commonly used glucose-lowering medications when added to metformin in terms of microvascular complications and death in participants with type 2 diabetes, but possible differences were indicated in the incidence of any cardiovascular disease.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Fu-Rong Li, Daniel Nyarko Hukportie, Jing Yang, Huan-Huan Yang, Guo-Chong Chen, Xian-Bo Wu
Summary: This study aimed to examine the association between microvascular disease (MVD) and risk of heart failure (HF) among individuals with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM). The results showed that a heavier burden of MVD was associated with an increased risk of HF, especially in individuals with T1DM.
Article
Immunology
Bing Zhao, Miaomiao Zhang, Jing Xie, Tingwang Jiang, Jie Li, Zaixing Yang
Summary: This study found that circulating MIP-5 levels are increased in patients with type 2 diabetes mellitus and are closely associated with the risk of diabetic kidney disease and renal decline. Therefore, circulating MIP-5 may be a novel potential biomarker for type 2 diabetes mellitus and diabetic kidney disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Naba Al-Sari, Svetlana Kutuzova, Tommi Suvitaival, Peter Henriksen, Flemming Pociot, Peter Rossing, Douglas McCloskey, Cristina Legido-Quigley
Summary: Using blood small molecule profiling and machine learning, the risk of developing complications, such as kidney disease and retinopathy, in diabetes patients can be predicted. This precision diagnostic approach has the potential to be implemented in clinical settings to screen patients early and prevent complications.
Article
Cardiac & Cardiovascular Systems
Arno R. Bourgonje, Margery A. Connelly, Harry van Goor, Peter R. van Dijk, Robin P. F. Dullaart
Summary: This study found that the total lipoprotein particle concentrations of both LDL and HDL are positively associated with an increased risk of developing microvascular complications in patients with established T2D. The protective role of HDL on the development of microvascular complications may be lost in established T2D.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Peripheral Vascular Disease
Claudia R. L. Cardoso, Nathalie C. Leite, Gil F. Salles
Summary: This study aimed to evaluate the prognostic value of on-treatment mean cumulative ambulatory blood pressures in individuals with type 2 diabetes. Results showed that this blood pressure parameter had a stronger association with cardiovascular events and mortality compared to baseline blood pressures in patients with type 2 diabetes.
Article
Dermatology
Theodosios Bisdas, Nikolaos Patelis, Georgia Argyrakopoulou, Dimitrios Tsiachris, Aristotelis Kurtis, Panagiotis Gargalianos-Kakoliris, Christodoulos Stefanadis
Summary: The complexity of critical limb ischemia (CLI) requires a dedicated multidisciplinary team for treatment. This study aimed to assess the effectiveness of referring CLI patients scheduled for major amputation elsewhere to a dedicated CLI center. The analysis showed that patients in severe stages of CLI who received a second opinion from a dedicated multidisciplinary team had high limb salvage and survival rates after major amputation.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Review
Pharmacology & Pharmacy
Hassan Yousefi, Ladan Mashouri, Samuel C. Okpechi, Nikhilesh Alahari, Suresh K. Alahari
Summary: The outbreak of the novel coronavirus has caused a major global public health concern, with over 31 million cases confirmed and efforts being made to repurpose existing cancer drugs to treat COVID-19. These drugs target the viral replication cycle and immune response, offering a potential novel approach to combat the virus.
BIOCHEMICAL PHARMACOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Georgios Zakynthinos, Gerasimos Siasos, Evangelos Oikonomou, Maria Gazouli, Konstantinos Mourouzis, Marina Zaromitidou, Vasiliki Tsigkou, Evanthia Bletsa, Panagiota Stampouloglou, Stamatis Tsouroulas, Georgios Marinos, Konstantinos Vlasis, Manolis Vavuranakis, Christodoulos Stefanadis, Dimitris Tousoulis
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Erika Rimondi, Annalisa Marcuzzi, Fabio Casciano, Gianluca Tornese, Agnese Pellati, Barbara Toffoli, Paola Secchiero, Elisabetta Melloni
Summary: This study demonstrates that vitamin D deficiency may contribute to the formation and instability of atheromatous plaques in mice, suggesting a potential role for vitamin D in preventing or delaying atheromatous disease in cardiovascular disorders. Further research is needed to fully understand the impact of vitamin D in cardiovascular diseases.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Cardiac & Cardiovascular Systems
Dimitris Tsiachris, Ioannis Doundoulakis, Eirini Pagkalidou, Athanasios Kordalis, Spyridon Deftereos, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: Our network meta-analysis identified the most effective antiarrhythmics for pharmacologic cardioversion over different time settings, with intravenous vernakalant and flecainide showing the highest conversion rate within 4 hours. Flecainide, especially when compared to propafenone, demonstrated superiority for conversion rates within 12 hours, while amiodarone exhibited efficacy within 24 hours, particularly if ranolazine was added.
CARDIOVASCULAR DRUGS AND THERAPY
(2021)
Article
Gastroenterology & Hepatology
Corey J. Ketchem, Craig C. Reed, Zoe Stefanadis, Evan S. Dellon
Summary: The study evaluated the efficacy of a compounded fluticasone suspension for treating eosinophilic esophagitis, showing significant improvements in symptoms and endoscopic findings, with over a third of patients achieving histologic response.
DISEASES OF THE ESOPHAGUS
(2021)
Letter
Cardiac & Cardiovascular Systems
Dimitrios A. Vrachatis, George V. Giannopoulos, Sotiria G. Giotaki, Konstantinos Raisakis, Charalampos Kossyvakis, Konstantinos E. Iliodromitis, Bernhard Reimers, Dimitrios Tousoulis, Michael Cleman, Christodoulos Stefanadis, Alexandra Lansky, Spyridon G. Deftereos
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Dimitris Tsiachris, Ioannis Doundoulakis, Panagiotis Tsioufis, Eirini Pagkalidou, Christos-Konstantinos Antoniou, Stefanos M. Zafeiropoulos, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This systematic review compares the effectiveness and safety of class Ic agents for cardioversion of paroxysmal AF and finds that intravenous flecainide is the most effective option. Class Ic agents appear to be safe for pharmacologic cardioversion of AF regardless of the presence of SHD.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Economics
Jay Pil Choi, Christodoulos Stefanadis
Summary: This article examines tippy network markets that allow price discrimination and finds that under certain conditions, network competition may lead to a unique subgame-perfect equilibrium where the winner's identity is fully determined by its product features. The concept of the dominant value margin is introduced as a metric for the effectiveness of divide-and-conquer strategies. However, the outcome of a market where suppliers with larger dominant value margins can sell to all customers does not necessarily result in social efficiency.
INTERNATIONAL ECONOMIC REVIEW
(2022)
Letter
Cardiac & Cardiovascular Systems
Christodoulos Stefanadis, Christina Chrysohoou, Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Panagiota Manolakou, Gerasimos Siasos, Konstantinos Tsioufis, George Panagiotakopoulos, Theoklis Zaoutis, Demosthenes Panagiotakos
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Grigorios Chatzantonis, Christos-Konstantinos Antoniou, Haris Lalos, Gregory C. Bogdanis, Pantelis Nikolaou, Anastasios Spanos, Stefanos Karagiannis, Costas Tsiou, Ali Yilmaz, Christodoulos Stefanadis
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Dimitris Tsiachris, Ioannis Doundoulakis, Christos-Konstantinos Antoniou, Eirini Pagkalidou, Stefanos Zafeiropoulos, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study conducted a systematic review and meta-analysis to evaluate the effectiveness and safety of a time to isolation (TTI)-based strategy of cryoballoon ablation (CBA) in the treatment of atrial fibrillation. The results suggest that an individualized CBA dosing strategy based on TTI and extended duration of CBA can reduce recurrence post-AF ablation and decrease procedure time and incidence of phrenic nerve palsy.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Athanasios Kordalis, Dimitrios Konstantinou, Konstantinos Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study compared the clinical outcomes of a three-dimensional electroanatomical mapping (3D-EAM)-based strategy targeting slow pathway (SP) elimination with the conventional fluoroscopic approach in atrioventricular node reentrant tachycardia (AVNRT) ablation. The results showed that 3D-EAM improved procedural parameters, reduced fluoroscopy time and dose, and increased SP elimination frequency. Follow-up results demonstrated lower recurrence rates and redo procedure rates in the 3D-EAM-based group.
JOURNAL OF ARRHYTHMIA
(2022)
Article
Endocrinology & Metabolism
Ping Gu, Kai Ding, Lei Lu, Yu Zhang, Wei Wang, Qingyu Guo, Yannian Liao, Bingjie Yang, Tiantian Wang, Changsheng Zhou, Bin Lu, Alice P. S. Kong, Alfred S. Cheng, Hannah Xiaoyan Hui, Jiaqing Shao
Summary: This study investigated the expressions of major brown adipose markers in white adipose tissue (WAT) of different ages and their associations with metabolic parameters and key adipokines. The findings suggest that UCP1 and PRDM16 have differential clinical correlations with metabolic features in human WAT in an age-dependent manner. UCP1 and PRDM16 may participate in the pathogenesis of ageing-related metabolic diseases with distinct mechanisms.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Demetrios Sougiannis, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Christodoulos Stefanadis, Konstantinos Tsioufis
Summary: Nowadays, cryoballoon (CB) has become an established alternative to radio frequency (RF) ablation for pulmonary vein isolation (PVI), with the ability to isolate PVs in a single application. In a study on over 1000 consecutive patients, our center optimized the CB PVI procedure. It is expected that future guidelines will recommend CB as the first-line PVI for patients with paroxysmal AF and a class I indication. In a long-term follow-up of the EARLY-AF trial, CB showed a lower incidence of persistent atrial fibrillation compared to anti-arrhythmic drugs.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)