Review
Health Care Sciences & Services
Giuseppe Davide Albano, Francesco Amico, Giuseppe Cocimano, Aldo Liberto, Francesca Maglietta, Massimiliano Esposito, Giuseppe Li Rosi, Nunzio Di Nunno, Monica Salerno, Angelo Montana
Summary: AASs are widely used molecules that enhance muscle growth and athletic performance, but also come with systemic side effects, particularly impacting the cardiovascular and reproductive systems. Preventive measures such as improving healthcare worker knowledge, standardized diagnostic tests, and educational interventions are essential to mitigate the negative effects of AAS abuse.
Article
Chemistry, Analytical
Yihao Zhang, Xiaopei Wu, Wei Wang, Jianglian Huo, Jiaoyang Luo, Youxuan Xu, Jianghai Lu
Summary: In recent years, synthetic androgenic steroids (AASs) have been frequently found as undeclared ingredients in dietary supplements. This study developed a method for simultaneous detection of 93 steroids and successfully analyzed over 300 dietary supplements, detecting one positive sample. The method provides a high throughput approach for screening and monitoring supplement ingredients and potential harm.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Review
Cardiac & Cardiovascular Systems
Kahtan Fadah, Gokul Gopi, Ajay Lingireddy, Vanessa Blumer, Tracy Dewald, Robert J. Mentz
Summary: Synthetic steroids have a negative impact on the heart, leading to cardiomyopathy and heart failure. While some treatments exist, further research is needed to understand the long-term effects and potential therapies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Medicine, General & Internal
Sanjay Sivalokanathan, Lukasz A. Malek, Aneil Malhotra
Summary: The use of performance-enhancing drugs in sports is controversial, with caffeine being the most commonly used drug and anabolic steroids being prohibited. While these drugs can enhance athletic performance, they may also have adverse effects on the cardiovascular system.
Review
Gastroenterology & Hepatology
Ana Petrovic, Sonja Vukadin, Renata Sikora, Kristina Bojanic, Robert Smolic, Davor Plavec, George Y. Wu, Martina Smolic
Summary: Anabolic androgenic steroids have therapeutic benefits but are commonly misused and have detrimental effects on various organs, particularly the liver. This article reviews the latest knowledge on the adverse effects of anabolic androgenic steroids on the liver and their mechanisms.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Endocrinology & Metabolism
Peter Bond, Diederik L. Smit, Willem de Ronde
Summary: This review provides a comprehensive overview of the working mechanism and potential side effects of anabolic-androgenic steroids (AAS). It discusses the absorption and transportation of AAS in the body and highlights the importance of understanding treatment options and self-medication practices for AAS users.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Analytical
Patrizia Leogrande, Francesco Botre, Xavier de la Torre, Daniel Jardines, Maria Kristina Parr, Federico Marini
Summary: Predictive models have been developed to early identify novel anabolic androgenic steroids and obtain information on their molecular structure, using a combination of gas-chromatographic and mass spectrometric characteristic parameters. The chemometric methods applied allowed for the classification and clustering of steroids, providing a spectral and structural characterization for each subclass. Through mass spectrometric data analysis, class-specific common fragments and spectral trends were identified, enabling the detection of novel designer anabolic steroids.
Article
Biochemistry & Molecular Biology
Buu N. Tran, Richard Okoniewski, Barbara C. Spink, David M. LeMaster, Kenneth M. Aldous, David C. Spink
Summary: From 2012 to 2013, 16 New York residents experienced adverse health effects after consuming B-50 vitamin and multimineral supplements from the same supplier. Chemical analysis revealed the presence of androgenic steroids and a related substance, which were associated with the reported symptoms, including hospitalization and severe virilization in a child. These findings highlight the need for stricter oversight of the nutritional supplement industry.
Article
Hematology
Johannes Jakobsen Sidelmann, Jorgen Brodersen Gram, Jon J. Rasmussen, Caroline Kistorp
Summary: Abuse of anabolic-androgenic steroids (AAS) is associated with reduced fibrin clot lysis, likely due to increased plasma concentrations of fibrinogen, FXIII, and plasmin inhibitor, rather than alterations in fibrin structure. This suggests a potential link between AAS abuse and increased thrombotic disease risk.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2021)
Article
Cardiac & Cardiovascular Systems
Antonello D'Andrea, Juri Radmilovic, Vincenzo Russo, Simona Sperlongano, Andreina Carbone, Marco Di Maio, Federica Ilardi, Lucia Riegler, Michele D'Alto, Francesco Giallauria, Eduardo Bossone, Eugenio Picano
Summary: In athletes abusing steroids, speckle tracking echocardiography analysis revealed impaired right ventricular systolic deformation, closely associated with reduced functional capacity during physical effort, and more pulmonary congestion during exercise.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Behavioral Sciences
Marie Lindvik Jorstad, Morgan Scarth, Svenn Torgersen, Harrison Graham Pope, Astrid Bjornebekk
Summary: This study found that personality disorders and clinical psychiatric syndromes are common among users of anabolic-androgenic steroids. The study identified four distinct psychopathology subgroups among AAS users, highlighting the importance of considering individual psychiatric profiles when providing treatment to this population.
BRAIN AND BEHAVIOR
(2023)
Article
Rehabilitation
Ameen Mosleh Almohammadi, Anas Mohammed Edriss, Turki Talal Enani
Summary: The study found that a minority of resistance-trained individuals in the western cities of Saudi Arabia frequently misuse anabolic-androgenic steroids, while most individuals lack knowledge about these products. The main reason for using hormones and supplements is to increase muscle mass.
BMC SPORTS SCIENCE MEDICINE AND REHABILITATION
(2021)
Article
Hematology
Johannes Jakobsen Sidelmann, Jorgen Brodersen Gram, Yaseelan Palarasah, Jon Jarlov Rasmussen, Caroline Kistorp
Summary: Current AAS abuse reduces the kallikrein-generating capacity of CAS by increasing the concentration of C1inh and reducing the concentration of prekallikrein. These changes may contribute to the anti-inflammatory effect of testosterone.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Chemistry, Analytical
Han Wang, Peng Wang, Xiaoya Zhao, Cheng Ye, Xiyue Zheng, Wei Cao
Summary: The study successfully identified and determined the concentration of 17 anabolic androgenic steroids in dietary supplements and external drugs using polyaniline-coated magnetic nanoparticles combined with magnetic solid-phase extraction and high-performance liquid chromatography-tandem mass spectrometry. The method had limits of detection ranging from 0.001-0.02 μg/L, with relative standard deviations of 5.52-11.6% and enrichment factors of 20.0-24.8. Dehydroepiandrosterone was detected in a commercially available external drug.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Substance Abuse
Lisa E. Hauger, Ingrid A. Havnes, Marie L. Jorstad, Astrid Bjornebekk
Summary: The study confirms a link between the use of anabolic androgenic steroids (AAS) and aggression and violence in a weightlifting population, especially among AAS dependent users. Antisocial personality traits may be an important mediator in this association.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Review
Pharmacology & Pharmacy
Motahareh Mahi-Birjand, Sajad Yaghoubi, Meghdad Abdollahpour-Alitappeh, Zahra Keshtkaran, Nader Bagheri, Aliyar Pirouzi, Mehrdad Khatami, Koushan Sineh Sepehr, Payam Peymani, Man Karimzadeh
EXPERT OPINION ON DRUG SAFETY
(2020)
Article
Transplantation
Iman Karimzadeh, Mahtab Jafari, Dorna Davani-Davari, Mani Ramzi
Summary: The study revealed that cyclosporine nephrotoxicity is a common adverse effect in hematopoietic stem cell transplant patients, mostly occurring within the first two weeks of treatment. Urine KIM-1 kidney injury molecule measurement did not show overall superiority and did not improve accuracy over serum or urine creatinine measurements in predicting or detecting cyclosporine nephrotoxicity.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2021)
Article
Infectious Diseases
Amirreza Roostaei Firozabad, Zohreh Akhoundi Meybodi, Seyed Ruhollah Mousavinasab, Adeleh Sahebnasagh, Mohsen Gholinataj Jelodar, Iman Karimzadeh, Solomon Habtemariam, Fatemeh Saghafi
Summary: This study suggests that Levamisole may improve most clinical statuses of patients with COVID-19, particularly in terms of cough and dyspnea. However, the clinical importance of this finding remains uncertain.
BMC INFECTIOUS DISEASES
(2021)
Article
Urology & Nephrology
Seyed Ruhollah Mousavinasab, Zohreh Akhoundi-Meybodi, Laleh Mahmoudi, Iman Karimzadeh
Summary: This clinical trial demonstrated that oral administration of 400 mg pentoxifylline three times a day in combination with gentamicin was effective in preventing nephrotoxicity and well tolerated in patients with different infectious diseases.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2021)
Article
Gastroenterology & Hepatology
Zahra Goudarzi, Abdollah Poursamad, Iman Karimzadeh, Nahid Jallaly, Khosro Keshavarz, Seyed Moayed Alavian
Summary: The study evaluated the cost-effectiveness of three medication regimens for HCV genotype 1 patients in Iran. Results indicated that VEL/SOF regimen was the most cost-effective strategy, followed by LDV/SOF and DCV/SOF.
Article
Immunology
Iman Karimzadeh, Samira Hossaini Alhashemi, Seyedeh Shima Ghetmiri, Afsaneh Vazin
Summary: This study investigated the clinical and economic benefits of an antimicrobial stewardship program on 5 costly antimicrobial drugs in a large referral teaching hospital. The study found that the active contribution of infectious diseases specialists in the program significantly reduced the total cost and defined daily dose of high-cost antimicrobial medications, while improving clinical outcomes.
INFECTIOUS DISEASES IN CLINICAL PRACTICE
(2022)
Article
Critical Care Medicine
Mahtabalsadat Mirjalili, Farid Zand, Iman Karimzadeh, Mansoor Masjedi, Golnar Sabetian, Ehsan Mirzaei, Afsaneh Vazin
Summary: This study compared the efficacy of extended infusion and intermittent infusion of ampicillin/sulbactam in the treatment of sepsis and septic shock patients in the ICU. The results showed that the extended group had significantly higher clinical cure rates, while there were no significant differences in ICU and hospital length of stay. Additionally, the ICU and hospital mortality rates were significantly lower in the extended infusion group.
JOURNAL OF CRITICAL CARE
(2023)
Review
Health Care Sciences & Services
Zahra Goudarzi, Mohsen Ghafari Darab, Afsaneh Vazin, Amirreza Hayatbakhsh, Iman Karimzadeh, Mojtaba Jafari, Khosro Keshavarz, Afshin Borhani-Haghighi
Summary: This study reviewed and systematically analyzed the cost-utility studies results of warfarin compared with other NOAC drugs in atrial fibrillation patients. The findings showed that NOAC drugs have acceptable cost-effectiveness in developed and developing countries, with apixaban having the lowest incremental cost-effectiveness ratio and the highest cost-effectiveness.
VALUE IN HEALTH REGIONAL ISSUES
(2023)
Review
Pharmacology & Pharmacy
Parisa Ghasemiyeh, Negar Mortazavi, Iman Karimzadeh, Afsaneh Vazin, Laleh Mahmoudi, Ebrahim Moghimi-Sarani, Ashkan MohammadSadeghi, Mina Shahisavandi, Ali Kheradmand, Soliman Mohammadi-Samani
Summary: Management of COVID-19 in patients with predisposing psychiatric disorders is challenging due to potential drug-drug interactions and exacerbation of their conditions. COVID-19 itself may also lead to unexpected psychiatric and neuropsychiatric complications in these patients. The most common type of major drug-drug interactions identified in this study is pharmacokinetics, with hydroxychloroquine/chloroquine and lopinavir/ritonavir being the most implicated anti-COVID-19 agents.
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Ashkan MohammadSadeghi, Iman Karimzadeh, Kamran Bagheri Lankarani, Morteza Banakar
MEDICAL HYPOTHESES
(2020)
Article
Chemistry, Medicinal
Parisa Ghasemiyeh, Afsaneh Vazin, Farid Zand, Amir Azadi, Iman Karimzadeh, Soliman Mohammadi-Samani
RESEARCH IN PHARMACEUTICAL SCIENCES
(2020)
Article
Chemistry, Medicinal
Iman Karimzadeh, Asma Sepehr-Sobhani, Mohammad Khoshnoud, Mohammad Sagheb, Reza Vejdani, Atefeh Jalali, Motahareh Mahi-Birjand
RESEARCH IN PHARMACEUTICAL SCIENCES
(2020)
Article
Transplantation
O. Moradi, I Karimzadeh, D. Davani-Davari, M. Shafiekhani, M. M. Sagheb, G. A. Raees-Jalali
INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE
(2020)
Article
Pharmacology & Pharmacy
Motahareh Mahi-Birjand, Imam Karimzadeh, Asghar Zarban, Meghdad Abdollahpour-Alitappeh, Seyed Alireza Saadatjoo, Masood Ziaee
PHARMACEUTICAL SCIENCES
(2020)
Article
Urology & Nephrology
Afsaneh Vazin, Maryam Malek, Iman Karimzadeh
JOURNAL OF RENAL INJURY PREVENTION
(2020)