Article
Engineering, Environmental
Han Peng, Huichen Li, Xi Zhang, Jiezhang Tang, Yongping Liang, Lipeng Qiao, Yun Zhu, Mengmeng Hou, Siming Wei, Zhaoxiang Zhang, Chaohua Liu, Xinmao Li, Baoyan Liang, Baoqiang Song, Baolin Guo, Jie Zhang
Summary: In this study, a multi-functional hydrogel with 3D-exosome-sustained release features was developed to improve diabetic wound healing. It exhibited tissue-adhesive, self-healing, antibacterial, anti-inflammatory, and antioxidant properties. The hydrogel promoted angiogenesis and collagen deposition, accelerated the recovery of diabetic wounds, and achieved rapid hemostasis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Hongchi Chen, Bohao Yin, Bin Hu, Baokun Zhang, Jingwen Liu, Yingzhe Jing, Zhiyuan Fan, Yuchen Tian, Xiaojuan Wei, Wei Zhang
Summary: The study focused on the fabrication of acellular fish skin (AFS) from black carp skin, evaluating its physical and mechanical properties and its impact on wound healing. AFS showed high porous structure, hydrophilicity, water absorption and permeability, along with high tensile strength and stitch tear resistance, indicating great potential in clinical applications. In vitro and in vivo tests confirmed the viability of L929 cells cultured in AFS extracts, as well as its promotion of angiogenesis, collagen synthesis, anti-inflammation, and acceleration in wound healing.
BIOMEDICAL MATERIALS
(2021)
Article
Plant Sciences
Pengdong Xie, Yangyang Yang, William Oyom, Tingting Su, Yingbo Tang, Yi Wang, Yongcai Li, Dov Prusky, Yang Bi
Summary: Chitooligosaccharide (COS), a product of chitosan degradation, was found to accelerate wound healing in potato tubers. It activated enzymes involved in phenylpropanoid metabolism and promoted the synthesis of phenolic acids, lignin monomers, and other compounds. COS also increased antioxidant activity and helped in the deposition of suberin polyphenols and lignin at wounds, resulting in reduced weight loss and inhibited lesion expansion in infected tubers.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Cell & Tissue Engineering
Yi Yi, Min Wu, Xiaomei Zhou, Mingchen Xiong, Yufang Tan, Honghao Yu, Zeming Liu, Yiping Wu, Qi Zhang
Summary: The study demonstrated that AA2G-treated BMSCs showed enhanced proliferation, angiogenesis and collagen formation abilities. In animal models, the group treated with AA2G exhibited faster wound healing and higher vascularization in the new wound. Moreover, AA2G treatment may enhance the biological functionality of BMSCs through various pathways.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Zhixiao Lin, Congying Zhao, Zhanjun Lei, Yuheng Zhang, Rong Huang, Bin Lin, Yuchen Dong, Hao Zhang, Jinqing Li, Xueyong Li
Summary: In this study, we developed a PCL+CA micro/nanofiber scaffold to maintain the stemness of EpSCs and inhibit their differentiation by activating YAP-mediated inhibition of the Notch signaling pathway. The proteomic analysis revealed significant differential expression of proteins in EpSCs cultured on the scaffold. Moreover, undifferentiated EpSCs transplanted with the scaffold promoted wound healing through the activation of the Notch signaling pathway in rat models.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Chemistry, Multidisciplinary
Tingting Cui, Jiafei Yu, Cai-Feng Wang, Su Chen, Qing Li, Kun Guo, Renkun Qing, Gefei Wang, Jianan Ren
Summary: This work presents a microfluidic assembly technique to fabricate micro-gel ensembles that can precisely tune the pH value of wound surface and accelerate wound healing. By regulating the wound pH, the physiological processes are greatly facilitated, resulting in much accelerated healing of chronic wounds.
Article
Environmental Sciences
Yuxiang Dai, Tianfu Yu, Chen Yu, Tianyu Lu, Lu Zhou, Chuandong Cheng, Hongbin Ni
Summary: ISG15 is upregulated in glioma tissues and positively correlated with stemness markers. It interacts with Oct4 protein, induces its ISGylation, and enhances its stability, thereby regulating glioma cell stemness.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hyunsik Choi, Bolam Kim, Sang Hoon Jeong, Tae Yeon Kim, Dong-Pyo Kim, You-Kwan Oh, Sei Kwang Hahn
Summary: A microalgae-based biohybrid microrobot has been developed to accelerate diabetic wound healing. The microrobot autonomously moves and generates oxygen to alleviate the hypoxic condition while efficiently modulating immune responses. The experimental results showed that the wounds treated with microrobots healed completely in a shorter time with reduced inflammatory cytokines and increased angiogenesis.
Article
Engineering, Environmental
Fei Gao, Xiaowei Ma, Fukai Wang, Fei Zhou, Jing Ye, Donglei Yang, Min Li, Pengfei Wang
Summary: Multidrug-resistant bacteria-infected refractory wounds present a significant challenge to public health, necessitating the urgent development of wound dressing materials with effective antibacterial and anti-inflammatory properties. In this study, a multifunctional DNA hydrogel was created as an efficient wound dressing material using programmable DNA self-assembly. The hydrogel formed at the wound site within seconds through precise base-pairing between sticky ends. The incorporation of cytosine (C)-silver ion (Ag+)-C bridges improved the mechanical properties of the hydrogel, allowing for sustained release and enhanced broad-spectrum antibacterial effects. Additionally, the hydrogel carried a fractalkine aptamer that recruited M2 macrophages, leading to a premature transition from inflammation to the proliferative process. In vivo experiments demonstrated that the dual-functionalized DNA hydrogel dressing accelerated skin tissue regeneration and wound closure in a methicillin-resistant staphylococcus aureus (MRSA) infected rat model. Overall, this simple and injectable DNA hydrogel dressing holds great clinical potential for accelerated wound healing.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Zunzhen Ming, Lin Han, Meiyu Bao, Huanhuan Zhu, Sujing Qiang, Shaobo Xue, Weiwei Liu
Summary: A bio-bacterial hydrogel scaffold has been reported to accelerate the healing of infected wounds by using beneficial bacteria that secrete antibacterial substances. The hydrogel protects bacteria from immune system attack and prevents them from escaping, promoting wound closure and tissue regeneration. This work may offer new avenues for the clinical application of living bacteria in managing infected wounds.
Article
Biophysics
Yanwei Li, Tangfeng Wu, Guozheng Zhang, Ai Fang, Yurong Li, Susu Wang, Hui Yan, Peisheng Liang, Jialin Lian, Yeshun Zhang
Summary: In this study, a novel bioactive dressing based on native nondestructive sericin was developed. The dressing was directly secreted by silkworms through regulating their spinning behaviors. It possessed natural structures and bioactivities, as well as a porous fibrous network structure with high air permeability. Furthermore, the dressing showed pH-responsive degradability, softness, super absorbency, and high mechanical strength. It also supported cell viability, proliferation, and migration, and significantly accelerated the healing process in a mouse full-thickness skin wound model. These findings suggest that the sericin wound dressing has promising application and commercial value in wound repair.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Biochemistry & Molecular Biology
Ge Xie, Xiao Wang, Min Mo, Lianbin Zhang, Jintao Zhu
Summary: Photothermal hydrogels, as an important platform for photothermal therapies, have shown promising prospects in the field of infected wound treatments. This review summarizes the progress, challenges, and prospects of photothermal hydrogels in promoting infected wound healing.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Li Mei, Dongjie Zhang, Huarong Shao, Yuanping Hao, Ting Zhang, Weiping Zheng, Yanjing Ji, Peixue Ling, Yun Lu, Qihui Zhou
Summary: Superbacteria-induced skin wound infections are significant health challenges. Probiotic therapy combined with biomimicking hydrogels shows great potential in treating infections and promoting wound repair.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Biochemistry & Molecular Biology
Yukang Liu, Chaofei Li, Zhangbin Feng, Biao Han, Deng-Guang Yu, Ke Wang
Summary: This article briefly reviews the pathogenesis and commonly used dressings of chronic diabetic wounds, and emphasizes on the advantages of electrospun nanofibers in the treatment of diabetic wounds. It also summarizes the reports of different types of nanofiber dressings on diabetic wounds. The article highlights the method of using multi-drug combination therapy in diabetic wounds, providing new ideas for the effective treatment of diabetic wounds.
Article
Chemistry, Multidisciplinary
Xiangchun Meng, Xiao Xiao, Sera Jeon, Dabin Kim, Byung-Joon Park, Young-Jun Kim, Najaf Rubab, SeongMin Kim, Sang-Woo Kim
Summary: A bioadhesive triboelectric nanogenerator (BA-TENG) is designed for instant wound sealing and accelerated wound healing. It is fabricated with biocompatible materials and integrates a flexible TENG as the top layer and bioadhesive as the bottom layer. The BA-TENG can produce stable electricity supply and strong sealing capability, and when driven by ultrasound, it can significantly accelerate wound healing. The E-field generated by BA-TENG promotes cell migration and proliferation.
ADVANCED MATERIALS
(2023)
