Review
Chemistry, Physical
Arezoo Sodagar Taleghani, Ali Taghvaie Nakhjiri, Mohammad Javad Khakzad, Seyed Mahdi Rezayat, Pedram Ebrahimnejad, Amir Heydarinasab, Azim Akbarzadeh, Azam Marjani
Summary: In recent decades, significant progress has been made in cancer treatment, but finding more effective therapies is crucial. The application of drug delivery nanovehicles, particularly mesoporous silica nanoparticles (MSNPs), shows promise in reducing side effects. MSNPs possess excellent characteristics that make them suitable for targeted and stimuli responsive drug delivery in cancer treatment.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Pharmacology & Pharmacy
Bhagavathi Sundaram Sivamaruthi, Subramanian Thangaleela, Periyanaina Kesika, Natarajan Suganthy, Chaiyavat Chaiyasut
Summary: Complete recovery from infection, sepsis, injury, or trauma requires a vigorous inflammatory response. Nanoparticles have become an efficient medical tool for diagnosing, preventing, and treating diseases due to their unique interactions with biological molecules. Mesoporous silica nanoparticles (MSNs) play a significant role in nano therapy and have several advantages such as easy synthesis, loading, and biocompatibility. MSNs can be used as theranostics in immune-modulatory nano systems to diagnose and treat inflammatory diseases.
Review
Pharmacology & Pharmacy
Alba Garcia-Fernandez, Felix Sancenon, Ramon Martinez-Manez
Summary: Respiratory diseases have become a major clinical concern worldwide and nanomedicine shows promise in overcoming the limitations of current lung therapies by enhancing drug bioavailability and reducing side effects. However, more efforts are needed to achieve effective pulmonary drug delivery despite the different approaches that have been developed.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Shuwen Dong, Zhenhan Feng, Runpu Ma, Tianyu Zhang, Jinhong Jiang, Yibo Li, Yumo Zhang, Silu Li, Xiao Liu, Xiangsheng Liu, Huan Meng
Summary: We developed tailor-designed mesoporous silica nanoparticles (MSNPs) for delivering mRNA by electrostatically binding it to the MSNP surface after premixing it with a cationic polymer. We investigated the roles of size, porosity, surface topology, and aspect ratio of MSNPs on mRNA delivery. The optimized carrier achieved efficient cellular uptake and intracellular escape while delivering luciferase mRNA in mice, and enabled tissue-specific mRNA expression without toxicity.
Review
Chemistry, Physical
Saman Sargazi, Ushna Laraib, Mahmood Barani, Abbas Rahdar, Iqra Fatima, Muhammad Bilal, Sadanad Pandey, Rakesh K. Sharma, George Z. Kyzas
Summary: The shape of nanoparticles is crucial for drug delivery efficiency. Rod-shaped mesoporous silica nanoparticles (RMSNs) have shown advantages over spherical MSNs in targeted drug delivery. RMSNs have desirable properties such as biocompatibility, low toxicity, large surface area, and stability, making them a perfect nanostructure. They have been utilized in various applications including bioimaging, cancer treatment, and drug/gene delivery.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Review
Biotechnology & Applied Microbiology
Ranjith Kumar Kankala, Ya-Hui Han, Hong-Ying Xia, Shi-Bin Wang, Ai-Zheng Chen
Summary: Mesoporous silica nanoparticles (MSNs) have great potential in biomedical applications, but traditional MSNs have limitations such as reduced drug encapsulation efficacy and poor degradability. Hierarchically-engineered MSNs have been developed by tuning the pore sizes, modifying the surfaces, and engineering the siliceous networks. These engineered MSNs have complex structures and can be applied in drug delivery, bioimaging, tissue engineering, and other fields.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Multidisciplinary Sciences
Josephine Oluwagbemisola Tella, Joseph Adeyemi Adekoya, Kolawole Oluseyi Ajanaku
Summary: Conventional drug delivery systems face challenges in treating tuberculosis due to lengthy and costly treatment regimens, patient non-compliance, and drug resistance. However, novel drug delivery carrier systems like mesoporous silica nanoparticles show promise in addressing these challenges with their biocompatibility and unique physico-chemical properties.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Krismala Djayanti, Pooja Maharjan, Kwan Hyung Cho, Sehoon Jeong, Man Su Kim, Meong Cheol Shin, Kyoung Ah Min
Summary: With advances in nanotechnology, mesoporous silica nanoparticles (MSNs) have been extensively studied as potential nanocarriers for drug delivery. This review introduces the physicochemical properties and synthesis procedures of MSNs as well as their biomedical applications and clinical trials. MSNs offer advantages such as nanoscale size, high surface area, and porous structures for efficient delivery of high drug-loading content. However, there are still considerations, such as optimizing physicochemical properties and dosage regimens, and addressing biosafety and toxicity issues, for the clinical use of MSNs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Eleen Dayana Mohamed Isa, Haslina Ahmad, Mohd Basyaruddin Abdul Rahman, Martin R. Gill
Summary: Mesoporous silica nanoparticles (MSNs) as drug delivery agents show great potential in cancer treatment by enhancing efficacy and reducing side effects. Through the development of smart DDAs and the capability to efficiently trap cargo molecules, MSNs have a bright future in both the diagnosis and treatment of cancer.
Article
Chemistry, Multidisciplinary
Pradip Das, Silvia Pujals, Lamiaa M. A. Ali, Magali Gary-Bobo, Lorenzo Albertazzi, Jean-Olivier Durand
Summary: In this study, the degradation of biodegradable periodic mesoporous organosilica nanoparticles (nanoPMOs) triggered by glutathione and the multivalency of antibody-conjugated nanoPMOs were quantified using direct stochastic optical reconstruction microscopy (dSTORM). The impact of these properties on cancer cell targeting, drug loading and release capability, and anticancer activity were also investigated. The higher spatial resolution of dSTORM imaging enabled the characterization of structural properties of fluorescent and biodegradable nanoPMOs. The quantification of nanoPMOs' biodegradation using dSTORM imaging demonstrated their excellent structure-dependent degradation behavior at a higher glutathione concentration. The surface functionality of anti-M6PR antibody-conjugated nanoPMOs, as quantified by dSTORM imaging, played a key role in prostate cancer cell labeling and the higher biodegradability and cancer cell-targeting properties of nanorods conjugated with oriented antibody effectively delivered the anticancer drug doxorubicin to cancer cells, exhibiting potent anticancer effects.
Article
Chemistry, Multidisciplinary
Amal Alfawaz, Khalid Alzahrani, Abdurahman Niazy, Hamdan Alghamadi, Rhodanne Lambarte, Abeer Beagan, Latifah Alfhaid, Khalid Alotaibi, Abdullah Alswieleh
Summary: A platform technology based on inorganic/organic nanoparticles for carrying drugs could be of enormous potential benefit in treating cancer. In this study, a new nanoplatform based on mesoporous silica nanoparticles (MSNs) conjugated with poly(2-(diethylamino) ethyl methacrylate) (PDEAEMA) brushes was reported as a candidate for stimuli-responsive intracellular drug delivery system.
APPLIED SCIENCES-BASEL
(2022)
Article
Nanoscience & Nanotechnology
Haoyuan Yin, Hongdan Lu, Yaokun Xiong, Lu Ye, Chuanhui Teng, Xiang Cao, Shengnan Li, Shanbo Sun, Wentao Liu, Wei Lv, Hongliang Xin
Summary: The smart nanocarrier mP-NPs-DNase/PTX can degrade NETs structure by releasing DNase I at tumor tissue, mediate tumor cell uptake through exposed cell penetrating peptide, and exert cytotoxic effect by releasing PTX. It shows potential as a NET-regulated nanocarrier for inhibiting malignant tumor growth and metastasis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Polymer Science
Khalid M. Alotaibi, Abdurrahman A. Almethen, Abeer M. Beagan, Latifah H. Alfhaid, Maqusood Ahamed, Ahmed M. El-Toni, Abdullah M. Alswieleh
Summary: A new pH-responsive nanosystem based on mesoporous silica nanoparticles (MSNs) was developed for cancer therapy, featuring a gatekeeper PDEAEMA and further modification to encapsulate the anti-cancer drug doxorubicin (DOX). The fabricated nanoplatform exhibited significant drug release and cytotoxicity in acidic media, suggesting its potential as a nanocarrier for anti-cancer drugs.
Review
Pharmacology & Pharmacy
Ahmed Abu-Dief, Mosa Alsehli, Abdullah Al-Enizi, Ayman Nafady
Summary: Nanotechnology provides the means to design and fabricate delivery vehicles capable of overcoming physiologically imposed obstacles and undesirable side effects of systemic drug delivery. Mesoporous Silica Nanoparticles (MSNPs) have sparked interest in nanomedicine research community due to their stability and versatility in drug delivery systems. This review article emphasizes the design, synthesis, and influencing factors of MSNPs, as well as their fate in the body and potential applications when combined with other functional materials.
CURRENT DRUG DELIVERY
(2022)
Article
Pharmacology & Pharmacy
Jie Zhuang, Yiming Yu, Rui Lu
Summary: Due to abuse of antibiotics, antibiotic resistance has become a global health threat. Many existing antibiotics have lost their effectiveness against drug-resistant bacteria, and the discovery of new antibiotics is becoming increasingly difficult. It is necessary to develop new strategies to combat antibiotic resistance. Nano-drug delivery systems, particularly mesoporous silica nano-particles (MSNs), have been extensively investigated as carriers of antibiotics. MSNs improve the delivery of antibiotics by reducing size, modifying surface, and regulating shapes. Furthermore, MSNs hybridized with metal ions or nanoparticles enhance the antibacterial effect by controlling the release of metal ions or increasing active oxygen species. Metal-capped MSNs can also load antibiotics to exert a synergistic antibacterial effect. This paper reviews the current application of various nanomaterials as antibacterial agents, with a focus on MSNs and approaches for improving their antibacterial effect.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Engineering, Biomedical
Hui Huang, Zeyu Wang, Liang Chen, Hong Yu, Yu Chen
Summary: Catalytic therapy has shown promise in enhancing therapeutic efficacy and reducing side effects by converting less toxic or nontoxic endogenous substances into highly toxic reactive species to induce cell death. This review summarizes the recent advances in the development and use of catalytic biomaterials and nanomedicines in various biomedical applications. The study focuses on the use of endogenous activators and exogenous stimuli to improve treatment efficacy, and discusses the biosafety and biocompatibility of these materials. The challenges and future opportunities for catalytic biomaterials and nanomedicines are also highlighted.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Meiqi Chang, Zeyu Wang, Caihong Dong, Ruirui Zhou, Liang Chen, Hui Huang, Wei Feng, Ziliang Wang, Yin Wang, Yu Chen
Summary: This study developed an ultrasound-enhanced enzyme dynamic therapy to induce pyroptosis in breast cancer cells and achieve efficient treatment by increasing the rate of reactive oxygen species (ROS) generation. The perovskite nanocrystals used in this therapy possess multiple enzyme-like activities and can counteract apoptosis resistance through cascade reactions. Ultrasound stimulation promotes ROS production and facilitates the pyroptosis process through a specific signaling pathway. In vitro and in vivo experiments confirm the superiority of this method in anti-tumor treatment.
ADVANCED MATERIALS
(2023)
Review
Materials Science, Biomaterials
Dongmiao Cao, Liang Chen, Ziwen Zhang, Yu Luo, Linjing Zhao, Chunping Yuan, Jie Lu, Xijian Liu, Jingchao Li
Summary: This article summarizes the application of degradable nanomaterials in cancer imaging and treatment. It presents four mechanisms of tumor microenvironment-responsive degradation and briefly summarizes external stimulation degradation. The applications of nanomaterials in bioimaging are outlined, and typical examples of biodegradable nanomaterials in various cancer therapies are focused.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Shanshan Zhang, Shujun Xia, Liang Chen, Yu Chen, Jianqiao Zhou
Summary: In this study, COF nanobowls were synthesized and utilized as activatable nanosensitizers with tumor-specific sonodynamic activity. The high crystallinity of the COF nanobowls enables efficient loading of the sonosensitizer and the in situ growth of manganese oxide inhibits non-specific damage to normal tissues. When reacting with tumor-overexpressed glutathione, the gatekeeper manganese oxide is decomposed to restore the ROS generation capability, leading to increased intracellular ROS stress and enhanced sonodynamic efficacy.
Article
Chemistry, Multidisciplinary
Yuyi Liu, Liang Chen, Zhiyang Chen, Minchao Liu, Xilei Li, Yufang Kou, MengMeng Hou, Huiren Wang, Xiaomin Li, Bo Tian, Jian Dong
Summary: In this study, a Janus nanoplatform (Janus-CPS) was developed for the simultaneous early diagnosis and effective treatment of rheumatoid arthritis (RA). The Janus nanostructure with increased reactive oxygen species scavenging capability and the loading of micheliolide in the mesopores showed promising results in vitro cellular experiments and in vivo collagen-induced arthritis (CIA) model. Additionally, the Janus-CPS exhibited desirable effectiveness in detecting early-stage RA lesions using near-infrared imaging.
Article
Chemistry, Multidisciplinary
Xiaojun Zhou, Yuhan Qian, Liang Chen, Tao Li, Xin Sun, Xiaojun Ma, Jinwu Wang, Chuanglong He
Summary: The study demonstrates the construction of a dual-factor delivery scaffold, which combines short nanofibers and a 3D printed scaffold, for guiding vascularized bone regeneration. The scaffold exhibits an adjustable porous structure and strong compressive strength. The sequential release of the loaded factors promotes angiogenesis and osteogenesis, accelerating tissue ingrowth and vascularized bone regeneration. This study provides a promising strategy for constructing a bone microenvironment-matched biomimetic scaffold for bone regeneration.
Article
Chemistry, Multidisciplinary
Xinyue Cao, Ying Wang, Xinran Song, Wanqing Lou, Xiaoyan Li, Weiping Lu, Kai Chen, Liang Chen, Yu Chen, Bingcang Huang
Summary: Sonodynamic therapy has the potential to revolutionize biomedicine with its non-invasiveness, deep tissue penetration, and controllability. However, the lack of suitable nanosonosensitizers with reactive oxygen species generation ability is a significant obstacle for its wider application. This study designs a bismuth-based nanosonosensitizer (Bi-HJ) that combines tumor therapy with metabolic regulation, photothermal therapy, and computed tomography imaging. The results demonstrate the effectiveness of Bi-HJ in achieving enhanced tumor therapy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yanqiu Duan, Yang Yu, Peilai Liu, Yao Gao, Xinyue Dai, Liang Zhang, Liang Chen, Yu Chen
Summary: The development of covalent organic framework (COF) sonosensitizers with intrinsic sonodynamic effects is highly desirable. In this study, a COF-based sonosensitizer (TPE-NN) is synthesized using reticular chemistry-based synthesis from two inert monomers. The sonodynamic activity of TPE-NN is enhanced by embedding copper (Cu)-coordinated sites, and ultrasound (US) irradiation augments the chemodynamic efficacy of TPE-NN-Cu. This study demonstrates the potential of COF-based sonosensitizers for nanodynamic therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Engineering, Biomedical
Lingqing Zong, Yang Yu, Junhao Wang, Peilai Liu, Wei Feng, Xinyue Dai, Liang Chen, Cindy Gunawan, Sung Lai Jimmy Yun, Rose Amal, Soshan Cheong, Zi Gu, Yu Chen
Summary: In this study, researchers propose a strategy to develop an oxygen-vacancy-rich MoOx nanonetwork on fluorine-free Mo2C MXene, which can generate reactive oxygen species under ultrasound irradiation and effectively kill bacteria without damaging normal tissues.
Article
Engineering, Biomedical
Wei Yang, Jianwei Cao, Hui Cheng, Liang Chen, Meihua Yu, Yu Chen, Xingang Cui
Summary: The approved use of two mRNA vaccines (BNT162b2 and mRNA-1273) worldwide in late 2020 has demonstrated the success of mRNA therapeutics and lipid nanoformulation technology in protecting against coronaviruses during the COVID-19 pandemic. This innovative approach with nanoformulations and mRNA therapeutics is believed to hold promise in targeted cancer immunotherapy.
BIOACTIVE MATERIALS
(2023)
Article
Microbiology
Shana Chen, Quan Fu, Mandlaa Mandlaa, Qingchun Wang, De Sheng, Saijilahu Saijilahu, Tana Tana, Dezhi Yang
Summary: Brucellosis is rapidly spreading in Inner Mongolia, China, and investigating its genetics may provide insights into bacterial host adaptation mechanisms. This study reports the genome sequence of Brucella melitensis strain BM6144 isolated from a human patient.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Article
Chemistry, Multidisciplinary
Ziyi Lu, Shan Du, Jiaxun Li, Min Zhang, Huali Nie, Xiaojun Zhou, Fulun Li, Xinwei Wei, Jinqiang Wang, Fuyao Liu, Chuanglong He, Guang Yang, Zhen Gu
Summary: A simple method using the Langmuir-Blodgett (LB) technique is developed to deposit antibacterial nanoparticles of various shapes, sizes, and compositions onto microneedles (MNs), which solves the concern of skin infections caused by MNs during long-term transdermal drug delivery. This technique offers advantages over conventional dip coating techniques, providing controlled coating layers, uniform and high coverage, and a straightforward fabrication process. The antibacterial MNs demonstrate superior bacterial elimination in vitro and in vivo without compromising payload capacity, drug release, or mechanical strength. It is believed that this functional nanoparticle coating technique expands the capabilities of MNs in long-term transdermal drug delivery.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Zhiyang Chen, Liang Chen, Yiqun Ma, Yuyi Liu, Qianyi Zhang, Hao Qin, Yu Chen, Bo Tian, Jian Dong
Summary: A nanosystem is designed and fabricated for synergistic sonodynamic-immunometabolic therapy of spinal-metastasized tumors by integrating oxygen-deficient molybdenum oxide (ODM) nanosonosensitizers and R7 peptides. The nanosystem combines sonodynamic therapy with tumor metabolic regulation, achieving concurrent immune activation and immunosuppressive tumor microenvironment remodeling.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Ziyi Lu, Shan Du, Jiaxun Li, Min Zhang, Huali Nie, Xiaojun Zhou, Fulun Li, Xinwei Wei, Jinqiang Wang, Fuyao Liu, Chuanglong He, Guang Yang, Zhen Gu
Summary: The Langmuir-Blodgett technique is used to deposit antibacterial nanoparticles onto microneedles, providing a fast-acting and long-lasting antibacterial effect without sacrificing their payload capacity, drug release, or mechanical strength.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Ai Yang, Yue Wang, Qian Feng, Kanwal Fatima, Qianqian Zhang, Xiaojun Zhou, Chuanglong He
Summary: This study fabricated a multifunctional scaffold based on a hard-and-soft integration strategy, which can simultaneously promote osteogenesis and allow for non-invasive monitoring of in vivo bone regeneration. The scaffold significantly enhances bone formation through controlled release of simvastatin (SV) and enables visualization of scaffold degradation using alkaline phosphatase-responsive near-infrared II fluorescence imaging and magnetic resonance imaging.
ADVANCED HEALTHCARE MATERIALS
(2023)
