Article
Multidisciplinary Sciences
Karl C. Koenig, Harald Lahm, Martina Dressen, Stefanie A. Doppler, Stefan Eichhorn, Nicole Beck, Kathrin Kraehschuetz, Sophia Doll, Stefan Holdenrieder, Adnan Kastrati, Ruediger Lange, Markus Krane
Summary: ACAN in plasma samples shows significantly higher levels in ATAAD patients compared to patients with other cardiovascular conditions or healthy volunteers. It may serve as a reliable potential biomarker for detecting ATAAD with high sensitivity and specificity.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Hong Liu, Ying-yuan Zhang, Xiao-hang Ding, Si-chong Qian, Ming-yu Sun, Al-Wajih Hamzah, Ya-nan Gao, Yong-feng Shao, Hai-yang Li, Kai Wang, Bu-qing Ni, Hong-jia Zhang
Summary: This study evaluated the impact of proximal vs extensive repair on mortality in patients with acute type A aortic dissection and examined how patient characteristics influence this impact. The results showed that extensive repair had a higher operative mortality compared to proximal repair, indicating a higher risk. The choice of surgery should be based on individualized risk prediction and treatment effectiveness.
ANNALS OF THORACIC SURGERY
(2023)
Article
Multidisciplinary Sciences
Yudai Tamura, Yuichi Tamura, Motoko Kametani, Yoshiaki Minami, Tomoko Nakayama, Daisuke Takagi, Takashi Unoki, Megumi Yamamuro, Akio Kawamura, Tomohiro Sakamoto, Tadashi Sawamura
Summary: This study revealed a significant association between the presence of hypoxemia in patients with type-B AAS and longer ICU and hospital stays. Male sex, obesity, patent false lumen, and high D-dimer levels were found to be independently associated with hypoxemia in patients with type-B AAS.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Yu-Ting Cheng, Kuang-Tso Lee, Chih-Hsiang Chang, Victor Chien-Chia Wu, Yi-Shin Chan, Dong-Yi Chen, Pao-Hsien Chu, An-Hsun Chou, Kuo-Sheng Liu, Shao-Wei Chen
Summary: This study evaluated the effectiveness of dexmedetomidine in patients who received surgery for type A aortic dissection. The results showed that post-operative dexmedetomidine infusion significantly reduced the risk of severe acute kidney injury and newly-onset dialysis in these patients.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Zhiwei Tang, Yongfeng Shao
Summary: This study aims to investigate whether postoperative thrombocytopenia following open aortic surgery with a median sternotomy can predict morbidity and mortality. The results indicate a significant association between postoperative thrombocytopenia and early-term mortality and acute renal injury.
ANNALS OF MEDICINE
(2023)
Article
Surgery
Xuelian Chen, Jiaojiao Zhou, Miao Fang, Jia Yang, Xin Wang, Siwen Wang, Lichuan Yang
Summary: This study aimed to evaluate the predictive value of peak procalcitonin, interleukin-6, and C-reactive protein levels on adverse renal outcomes and mortality in patients undergoing surgery for AAAD. The results showed that peak procalcitonin was associated with adverse renal outcomes, while peak interleukin-6 was associated with 30-day mortality.
FRONTIERS IN SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Kevin R. An, Charles de Mestral, Derrick Y. Tam, Feng Qiu, Maral Ouzounian, Thomas F. Lindsay, Harindra C. Wijeysundera, Jennifer C-Y Chung
Summary: This study found poor adherence to guideline-directed imaging surveillance following ATAAD repair, while long-term mortality and reinterventions rates remained high. Further research is needed to determine if guidelines should be modified.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Thierry Carrel, Thoralf M. Sundt, Yskert von Kodolitsch, Martin Czerny
Summary: Despite advancements in the prevention, diagnosis, and treatment of acute aortic dissection, it remains a complex cardiovascular event with high mortality and morbidity rates. Recent research has improved our understanding of the disease's pathophysiology and led to reevaluations of existing classifications. There is a shift towards a unified naming system based on morphology and function. The location and extent of the initial tear, as well as the affected aortic segments, determine the appropriate management approach - emergency surgery, endovascular intervention, or medical treatment. Ongoing scientific evidence continues to shape the management and follow-up of acute aortic dissection, the most severe form of acute aortic syndrome.
Article
Cardiac & Cardiovascular Systems
Manabu Yamasaki, Hideaki Yoshino, Takashi Kunihara, Koichi Akutsu, Tomoki Shimokawa, Hitoshi Ogino, Mitsuhiro Kawata, Toshiyuki Takahashi, Michio Usui, Kazuhiro Watanabe, Hiroshi Masuhara, Takeshi Yamamoto, Ken Nagao, Morimasa Takayama
Summary: This study found that male sex, use of percutaneous circulatory assist devices, shock, cardiac and cerebral ischemia are independent preoperative risk factors for early mortality after acute type A aortic dissection repair, while cardiac tamponade, cerebral and mesenteric ischemia are independent postoperative risk factors.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Lihua Zhang, Guangda He, Xiqian Huo, Aoxi Tian, Runqing Ji, Boxuan Pu, Yue Peng
Summary: Long-term cumulative hsCRP levels are associated with worse outcomes in patients hospitalized for acute heart failure, and repeated hsCRP measurements can help identify patients at high risk of death.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Kevin M. Harris, Christoph A. Nienaber, Mark D. Peterson, Elise M. Woznicki, Alan C. Braverman, Santi Trimarchi, Truls Myrmel, Reed Pyeritz, Stuart Hutchison, Craig Strauss, Marek P. Ehrlich, Thomas G. Gleason, Amit Korach, Daniel G. Montgomery, Eric M. Isselbacher, Kim A. Eagle
Summary: This study examined the early mortality rates for patients with TAAAD in the contemporary era and found that the mortality rate for the medical group was 0.5% per hour (23.7% at 48 hours), while for the surgical group, 48-hour mortality decreased to 4.4%.
Article
Endocrinology & Metabolism
Shi-Pan Wang, Yuan Xue, Hai-Yang Li, Wen-Jian Jiang, Hong-Jia Zhang
Summary: This study indicated that preoperative high-TSH subclinical hypothyroidism is an independent predictor of postoperative mortality in ATAAD patients undergoing aortic surgery. Patients with preoperative high-TSH subclinical hypothyroidism were associated with longer hospitalization stays, as well as higher 30-day and postoperative mortality rates.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Klaus Kallenbach, Christopher Buesch, Bartosz Rylski, Daniel-Sebastian Dohle, Tobias Krueger, Thomas Holubec, Jens Brickwedel, Jochen Poeling, Thilo Noack, Christian Hagl, Philipp Jawny, Andreas Boening, Khaled Chalabi, Matthias Karck, Rawa Arif
Summary: This study aimed to interpret the strategies of aortic root surgery in German AADA patients. The results showed that supracommissural replacement was the preferred surgical method for elderly and compromised patients. Extended root preservation techniques may be used for selected patients, even in combination with extended aortic arch surgery, with promising early outcomes.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Ashraf A. Sabe, Edward D. Percy, Tsuyoshi Kaneko, Ryan P. Plichta, G. Chad Hughes
Summary: ATAAD patients with factors including frailty, age, previous cardiac surgery, and novel anticoagulant medication use, are at increased risk for repair. Understanding of malperfusion syndromes has expanded significantly, with recommendations for surgical delay. Triage approaches have been influenced by resource limitations due to the ongoing COVID-19 pandemic.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Vincenzo Vento, Sebastien Multon, Ramzi Ramadan, Philippe Deleuze, Dominique Fabre, Julien Guihaire, Stephan Haulon
Summary: Ascending aorta wrapping is associated with favorable early outcomes and a low rate of aortic events during follow-up. This therapeutic option should be considered for patients considered too fragile for standard surgical repair.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Mohammed Fawzi Abosamak, Brandon M. Henry, Mahmoud Fawzi Aly, Carl. J. Lavie, Fabian Sanchis-Gomar
ACADEMIC RADIOLOGY
(2021)
Article
Medical Laboratory Technology
Brandon Michael Henry, Stefanie W. Benoit, Jens Vikse, Brandon A. Berger, Christina Pulvino, Jonathan Hoehn, James Rose, Maria Helena Santos de Oliveira, Giuseppe Lippi, Justin L. Benoit
Summary: This study found that IL-10 and IL-10/lymphocyte count levels were significantly higher in severe COVID-19 cases, as well as in those with severe AKI and new positive bacterial cultures. IL-10 and IL-10/lymphocyte count were independent predictors of COVID-19 severity.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Critical Care Medicine
David Cooper, Ravi Thiagarajan, Brandon Michael Henry, Jonathan W. Byrnes, Andrew Misfeldt, Jason Frischer, Eileen King, Zhiqian Gao, Peter Rycus, Bradley S. Marino
Summary: This study found that the outcomes of multiple runs of ECMO remain poor. Survival decreases with each additional run. Patients requiring additional runs for pulmonary indications should be considered prime candidates. Renal complications on the first run significantly increase the risk of mortality on subsequent runs.
JOURNAL OF INTENSIVE CARE MEDICINE
(2022)
Letter
Pharmacology & Pharmacy
Giuseppe Lippi, Brandon M. Henry, Fabian Sanchis-Gomar
EUROPEAN JOURNAL OF HOSPITAL PHARMACY
(2022)
Article
Hematology
Emmanuel J. Favaloro, Leonardo Pasalic, Brandon Henry, Giuseppe Lippi
Summary: The article introduces the role and detection methods of the metalloproteinase ADAMTS13 in clinical conditions such as thrombotic thrombocytopenic purpura, as well as discusses the limitations and potential utility of rapid ADAMTS13 testing methods.
AMERICAN JOURNAL OF HEMATOLOGY
(2021)
Letter
Peripheral Vascular Disease
Brandon Michael Henry, Maria Helena Santos de Oliveira, Isaac Cheruiyot, Justin L. Benoit, David S. Cooper, Giuseppe Lippi, Timothy D. Le Cras, Stefanie W. Benoit
Article
Pathology
Brandon Michael Henry, Isaac Cheruiyot, Stefanie W. Benoit, Fabian Sanchis-Gomar, Giuseppe Lippi, Justin Benoit
Summary: Necrosis seems to be the main driver of hospitalization in COVID-19 patients, while apoptosis and necrosis appear to drive ICU admission. Elevated levels of CK-18 are independent predictors of severe disease, and could be useful for risk stratification of COVID-19 patients and assessment of therapeutic efficacy in early-phase clinical trials.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Wonshill Koh, Megan Rodts, Ashley Nebbia, Jaclyn Sawyer, Brandon Henry, David S. Cooper
Summary: Patients with cyanotic heart disease are at an increased risk of thrombosis. Aspirin has been the main prophylactic anticoagulation method, but there is prevalent aspirin resistance, especially in neonates. This study found that low birth weight is associated with a higher incidence of aspirin resistance, and inadequate initial dosing is the primary reason for resistance. While there was no significant difference in thrombotic events between resistance and non-resistance groups, the presence of both thrombotic events and aspirin resistance was associated with significantly higher in-hospital mortality.
CARDIOLOGY IN THE YOUNG
(2022)
Letter
Medical Laboratory Technology
Giuseppe Lippi, Brandon M. Henry, Emmanuel J. Favaloro
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Letter
Medicine, General & Internal
Giuseppe Lippi, Brandon M. Henry, Fabian Sanchis-Gomar, Camilla Mattiuzzi
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Letter
Infectious Diseases
Camilla Mattiuzzi, Brandon M. Henry, Giuseppe Lippi
JOURNAL OF INFECTION
(2022)
Article
Cardiac & Cardiovascular Systems
Brandon Michael Henry, Alexis L. Benscoter, Maria Helena Santos de Oliveira, Jens Vikse, Tanya Perry, David S. Cooper
Summary: Extracorporeal Membrane Oxygenation (ECMO) has a reasonable survival rate in children with primary immunodeficiencies (PID) who require respiratory support. The type of immunodeficiency and the decade of support do not affect survival rates. The presence of a pre-ECMO infection or infection during the ECMO run does not impact survival rates. Cardiac, pulmonary, and neurological complications are independently associated with increased mortality.
Article
Hematology
Emmanuel J. Favaloro, Brandon Michael Henry, Giuseppe Lippi
Summary: Antiphospholipid antibodies (aPL) reflect a potential prothrombotic risk in several autoimmune conditions, especially antiphospholipid syndrome (APS). While various aPL have been found in COVID-19 patients, most identified solid-phase aPL have low titers and cannot be well-linked to the thrombotic aspects of COVID-19. High-titer or multiple aPL positivity is rare in COVID-19 presentations, suggesting a limited presence of APS in COVID-19 patients.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2022)
Article
Hematology
Emmanuel J. Favaloro, Brandon Michael Henry, Giuseppe Lippi
Summary: The presence of lupus anticoagulant (LA) in COVID-19 patients is potentially related to the severity of infection, but the relationship between LA and COVID-19-associated coagulopathy needs to be further investigated. Many confounders, such as anticoagulant therapy and elevated CRP levels, may affect the identification of LA. Larger and better studies are needed to clarify the role of LA in COVID-19 pathology.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2022)
Article
Medicine, General & Internal
Giuseppe Lippi, Riccardo Nocini, Camilla Mattiuzzi, Brandon Michael Henry
Summary: The current strategy of mass screening body temperature has several drawbacks, such as a high rate of asymptomatic infections, difficulty in defining normal body temperature, and device inaccuracy.
