Article
Biochemistry & Molecular Biology
Eunjeong Kang, Yufei Li, Bora Kim, Ki Young Huh, Miyeun Han, Jung-Hyuck Ahn, Hye Youn Sung, Yong Seek Park, Seung Eun Lee, Sangjun Lee, Sue K. Park, Joo-Youn Cho, Kook-Hwan Oh
Summary: In this study, metabolomics was used to discover novel biomarkers for predicting the risk of deterioration in patients with different causes of chronic kidney disease (CKD). The models constructed with selected metabolites and clinical parameters showed better ability to predict CKD progression compared to clinical parameters only.
Article
Public, Environmental & Occupational Health
Tianqi Li, Andrei Ihanus, Pauli Ohukainen, Marjo-Riitta Jarvelin, Mika Kahonen, Johannes Kettunen, Olli T. Raitakari, Terho Lehtimaki, Ville-Petteri Makinen, Tuulia Tynkkynen, Mika Ala-Korpela
Summary: Urinary metabolomics has the potential to assess kidney function and its metabolic corollaries. With the addition of metabolites and automated quantification, this study presents associations between metabolites and clinical measures, providing insights in renal-cardiometabolic system and supporting its application in epidemiology.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Nutrition & Dietetics
Hyunju Kim, Bing Yu, Xin Li, Kari E. Wong, Eric Boerwinkle, Sara B. Seidelmann, Andrew S. Levey, Eugene P. Rhee, Josef Coresh, Casey M. Rebholz
Summary: Through untargeted metabolomics, this study identified metabolites associated with plant-based diets and predicted the occurrence of chronic kidney disease. These metabolites highlight the pathways through which plant-based diets are related to chronic kidney disease.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Pharmacology & Pharmacy
Melanie Tepus, Elisa Tonoli, Elisabetta A. M. Verderio
Summary: Chronic kidney disease (CKD) is a global health issue affecting up to 16% of the population worldwide. If left untreated, it can progress to end-stage kidney disease (ESKD), requiring dialysis or transplantation. Kidney fibrosis, the unsuccessful wound-healing of kidney tissue, is the end point of CKD. Urinary extracellular vesicles (uEVs), which carry low-abundant proteins and large molecules, are a potential source of rare CKD biomarkers. This review discusses the diagnostic and prognostic value of uEVs biomarkers and their potential application in experimental antifibrotic therapeutics.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ashish Verma, Anand Vaidya, Sonu Subudhi, Sushrut S. Waikar
Summary: The study found that higher serum aldosterone levels are independently associated with an increased risk for kidney disease progression in individuals with chronic kidney disease, regardless of concomitant diabetes. This suggests a potential role for mineralocorticoid receptor antagonists in delaying CKD progression even in those without diabetes.
EUROPEAN HEART JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Alice Barinotti, Massimo Radin, Irene Cecchi, Silvia Grazietta Foddai, Elena Rubini, Dario Roccatello, Savino Sciascia
Summary: Chronic kidney disease is a widely prevalent pathological condition with a significant impact on patients' quality of life. Renal fibrosis, the main biological mechanism underlying CKD, poses challenges for therapeutic strategies. Kidney biopsy is currently the best tool for assessing renal fibrosis, but non-invasive biomarkers are needed. Systematic review of serological markers associated with renal fibrosis in CKD patients over the past five years showed scattered evidence, highlighting the complexity of the fibrotic process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mihaela-Roxana Glavan, Carmen Socaciu, Andreea Iulia Socaciu, Florica Gadalean, Octavian M. Cretu, Adrian Vlad, Danina M. Muntean, Flaviu Bob, Oana Milas, Anca Suteanu, Dragos Catalin Jianu, Maria Stefan, Lavinia Balint, Silvia Ienciu, Ligia Petrica
Summary: Chronic kidney disease (CKD) is a progressive disease with increased mortality and morbidity. Metabolomics is a valuable tool for studying CKD pathogenesis and identifying biomarkers for early diagnosis. This study assessed the metabolomic profiling of serum and urine samples from CKD patients and identified potential indicators of early CKD. The findings suggest that specific molecules in the serum and urine can correlate with CKD progression and may have an impact on both glomerular and tubular structures.
Review
Biochemistry & Molecular Biology
Natalia Chebotareva, Anatoliy Vinogradov, Valerie McDonnell, Natalia V. Zakharova, Maria I. Indeykina, Sergey Moiseev, Evgeny N. Nikolaev, Alexey S. Kononikhin
Summary: CKD is a non-specific kidney disease that causes gradual decline in kidney function, posing significant risks for death and other complications. Protein/peptide biomarkers can be used for early non-invasive diagnosis and may provide new approaches for targeted therapy. Mass spectrometry approaches offer valuable insights into understanding CKD progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Pedro Caetano Pinto, Cindy Roennau, Martin Burchardt, Ingmar Wolff
Summary: Kidney cancer and chronic kidney disease have different clinical management strategies, but share closely related cellular and molecular mechanisms, both involving the kidney's response to hypoxia. Fibrosis is a common factor in deteriorating renal function in both conditions.
Review
Biochemistry & Molecular Biology
Catarina Marreiros, Carla Viegas, Dina Simes
Summary: Chronic kidney disease (CKD) patients are at higher risk of developing early cardiovascular disease (CVD), with vascular calcification (VC) being a strong predictor of CVD risk. Diagnosis of VC in CKD population is challenging due to its complexity, but imaging biomarkers and circulating biomarkers play important roles in detection and monitoring, providing valuable insights for management of CVD risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Jing Zhang, Tobias Fuhrer, Hongping Ye, Brian Kwan, Daniel Montemayor, Jana Tumova, Manjula Darshi, Farsad Afshinnia, Julia J. Scialla, Amanda Anderson, Anna C. Porter, Jonathan J. Taliercio, Hernan Rincon-Choles, Panduranga Rao, Dawei Xie, Harold Feldman, Uwe Sauer, Kumar Sharma, Loki Natarajan
Summary: By analyzing urine samples using metabolomics, we identified several metabolites associated with the progression of diabetic kidney disease. These findings have the potential to inform risk stratification and treatment strategies for patients with diabetic kidney disease.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Review
Pharmacology & Pharmacy
Zhonghong Yan, Guanran Wang, Xingyang Shi
Summary: Chronic kidney disease (CKD) poses a serious public health concern globally, with issues including inaccurate diagnosis, dependency on biopsies, and multifactorial prognosis challenges in clinical treatment and management. Developing effective biomarkers is crucial for improving CKD prognosis and clinical management.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xian He, Ming-Xi Zhou, Cheng Cheng, Shan-Shan Li, Yuan Gao, Zhi-Tao Ma, Xin-Hua Song, Zhao-Fang Bai, Zheng-Sheng Zou, Xiao-He Xiao, Jia-Bo Wang, Ya-Wen Lu
Summary: Metabolomic analysis identified characteristic metabolites associated with fibrosis in chronic drug-induced liver injury, with disturbance of lipid metabolites being highlighted as the primary factor in fibrosis development. The metabolomic fingerprints have potential clinical diagnostic and prognostic significance.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Analytical
Jie Tang, Kai Xiong, Tong Zhang, Han Han
Summary: Chronic liver disease is a challenging condition to diagnose accurately, but metabolomics provides a powerful tool for understanding its pathogenesis and improving clinical diagnosis and treatment.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Ana Marta Gomes, Daniela Lopes, Clara Almeida, Sofia Santos, Jorge Malheiro, Irina Lousa, Alberto Caldas Afonso, Idalina Beirao
Summary: Alport syndrome is the second most common cause of inherited chronic kidney disease, caused by genetic variants on COL4A3, COL4A4 and COL4A5 genes. The disruption of the glomerular basement membrane structure leads to kidney damage and loss of renal function. Next-generation sequencing can accurately diagnose Alport syndrome, and early diagnosis is crucial for preventing disease progression. Besides conventional biomarkers, new biomarkers such as urinary Podocin, Vascular Endothelial Growth Factor A, and urinary Epidermal Growth Factor can be used for early detection of renal damage and prediction of disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Caroline Ivanne Le Roy, Alexander Kurilshikov, Emily R. Leeming, Alessia Visconti, Ruth C. E. Bowyer, Cristina Menni, Mario Fachi, Hana Koutnikova, Patrick Veiga, Alexandra Zhernakova, Mureil Derrien, Tim D. Spector
Summary: Yoghurt consumption is associated with reduced visceral fat mass and changes in the gut microbiome including transient increase of yoghurt-contained species (i.e. S. thermophilus and B. lactis).
Article
Nutrition & Dietetics
Panayiotis Louca, Ana Nogal, Olatz Mompeo, Paraskevi Christofidou, Rachel Gibson, Tim D. Spector, Sarah E. Berry, Ana M. Valdes, Massimo Mangino, Cristina Menni
Summary: The study found that BMI fully mediates the association between the DASH diet and hypertension, explaining 39.1% of the variance. A panel of six common metabolites predicting both the DASH diet and BMI with opposing effects was identified in the research.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Article
Biochemistry & Molecular Biology
Pirro G. Hysi, Massimo Mangino, Paraskevi Christofidou, Mario Falchi, Edward D. Karoly, Robert P. Mohney, Ana M. Valdes, Tim D. Spector, Cristina Menni
Summary: This study conducted a genome-wide association study on the levels of circulating metabolites in European subjects, identifying 202 unique genomic regions associated with 478 different metabolites. The replication study confirmed the robustness of these associations and discovered 74 novel genomic regions not previously associated with any metabolites.
Correction
Microbiology
Caroline Ivanne Le Roy, Alexander Kurilshikov, Emily R. Leeming, Alessia Visconti, Ruth C. E. Bowyer, Cristina Menni, Mario Fachi, Hana Koutnikova, Patrick Veiga, Alexandra Zhernakova, Muriel Derrien, Tim D. Spector
Article
Medicine, General & Internal
Cristina Menni, Ana M. Valdes, Lorenzo Polidori, Michela Antonelli, Satya Penamakuri, Ana Nogal, Panayiotis Louca, Anna May, Jane C. Figueiredo, Christina Hu, Erika Molteni, Liane Canas, Marc F. Osterdahl, Marc Modat, Carole H. Sudre, Ben Fox, Alexander Hammers, Jonathan Wolf, Joan Capdevila, Andrew T. Chan, Sean P. David, Claire J. Steves, Sebastien Ourselin, Tim D. Spector
Summary: This study investigated the differences in symptom prevalence, risk of hospital admission, and symptom duration between omicron and delta variants of the SARS-CoV-2 virus. The study found that loss of smell was less common in omicron infections, sore throat was more common, and the rate of hospital admission was lower.
Correction
Multidisciplinary Sciences
Long H. Nguyen, Amit D. Joshi, David A. Drew, Jordi Merino, Wenjie Ma, Chun-Han Lo, Sohee Kwon, Kai Wang, Mark S. Graham, Lorenzo Polidori, Cristina Menni, Carole H. Sudre, Adjoa Anyane-Yeboa, Christina M. Astley, Erica T. Warner, Christina Y. Hu, Somesh Selvachandran, Richard Davies, Denis Nash, Paul W. Franks, Jonathan Wolf, Sebastien Ourselin, Claire J. Steves, Tim D. Spector, Andrew T. Chan
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Helena Deris, Domagoj Kifer, Ana Cindric, Tea Petrovic, Ana Cvetko, Irena Trbojevic-Akmacic, Ivana Kolcic, Ozren Polasek, Louise Newson, Tim Spector, Cristina Menni, Gordan Lauc
Summary: Gonadal hormones affect the glycosylation of IgG, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause.
Article
Biochemistry & Molecular Biology
Panayiotis Louca, Ana Nogal, Aurelie Moskal, Neil J. Goulding, Martin J. Shipley, Taryn Alkis, Joni Lindbohm, Jie Hu, Domagoj Kifer, Ni Wang, Bo Chawes, Kathryn M. Rexrode, Yoav Ben-Shlomo, Mika Kivimaki, Rachel A. Murphy, Bing Yu, Marc J. Gunter, Karsten Suhre, Deborah A. Lawlor, Massimo Mangino, Cristina Menni
Summary: This study identified multiple metabolites associated with hypertension, with lipid and organic acids being predominant, and discovered 5 novel metabolites. Pathway analysis suggested important roles of amino acids, serine/glycine, and bile acids in hypertension regulation.
Article
Nutrition & Dietetics
Panayiotis Louca, Sarah E. Berry, Kate Bermingham, Paul W. Franks, Jonathan Wolf, Tim D. Spector, Ana M. Valdes, Phil Chowienczyk, Cristina Menni
Summary: Compared to normotensive controls, hypertensive individuals have higher postprandial insulin, triglycerides, and markers of inflammation, partially mediated by visceral fat mass. Reduction of visceral fat mass should be a key focus of health interventions in hypertension.
Article
Nutrition & Dietetics
Olatz Mompeo, Maxim B. Freidin, Rachel Gibson, Pirro G. Hysi, Paraskevi Christofidou, Eran Segal, Ana M. Valdes, Tim D. Spector, Cristina Menni, Massimo Mangino
Summary: Diet is a modifiable risk factor for chronic diseases and mental health disorders, and its effects are partially controlled by genetics. In this study, a genome-wide association study (GWA) was conducted to identify genetic variants associated with the DASH diet. The study found significant genetic correlations between DASH and educational traits, as well as enrichment of genes involved in appetite regulation.
Article
Nutrition & Dietetics
Yong Li, Yifan Xu, Caroline Le Roy, Jiaying Hu, Claire J. Steves, Jordana T. T. Bell, Tim D. D. Spector, Rachel Gibson, Cristina Menni, Ana Rodriguez-Mateos
Summary: This study found significant associations between phenolic acid metabolites, gut microbiome, and cardiovascular disease risk. Certain beverages and foods, especially coffee, tea, red wine, and berries, are rich in phenolic acids and negatively correlated with cardiovascular disease risk. The gut microbiome, particularly the genus 5-7N15, partially mediates the negative association between urinary (poly)phenols and cardiovascular risk.
Article
Nutrition & Dietetics
Kate M. Bermingham, Mohsen Mazidi, Paul W. Franks, Tyler Maher, Ana M. Valdes, Inbar Linenberg, Jonathan Wolf, George Hadjigeorgiou, Tim D. Spector, Cristina Menni, Jose M. Ordovas, Sarah E. Berry, Wendy L. Hall
Summary: This study characterized the variability and correlations of postprandial metabolite changes in a large cohort. The majority of metabolites showed significant changes after a meal, particularly in very large lipoprotein particles and ketone bodies. Strong correlations were observed between fasting and postprandial metabolites, although some metabolites showed weak correlations.
Article
Cardiac & Cardiovascular Systems
Ana Nogal, Taryn Alkis, Yura Lee, Domagoj Kifer, Jie Hu, Rachel A. Murphy, Zhe Huang, Rui Wang-Sattler, Gabi Kastenmueler, Birgit Linkohr, Clara Barrios, Marta Crespo, Christian Gieger, Annette Peters, Jackie Price, Kathryn M. Rexrode, Bing Yu, Cristina Menni
Summary: In this study, metabolomic profiling was used to identify 10 novel metabolites associated with myocardial infarction (MI). Metabolite profiles might help identify high-risk individuals before the onset of disease, and further research is needed to understand the mechanisms and pathways involved.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ashley van der Spek, Isobel D. Stewart, Brigitte Kuehnel, Maik Pietzner, Tahani Alshehri, Friederike Gauss, Pirro G. Hysi, Siamak MahmoudianDehkordi, Almut Heinken, Annemarie I. Luik, Karl-Heinz Ladwig, Gabi Kastenmueller, Cristina Menni, Johannes Hertel, M. Arfan Ikram, Renee de Mutsert, Karsten Suhre, Christian Gieger, Konstantin Strauch, Henry Voelzke, Thomas Meitinger, Massimo Mangino, Antonia Flaquer, Melanie Waldenberger, Annette Peters, Ines Thiele, Rima Kaddurah-Daouk, Boadie W. Dunlop, Frits R. Rosendaal, Nicholas J. Wareham, Tim D. Spector, Sonja Kunze, Hans Joergen Grabe, Dennis O. Mook-Kanamori, Claudia Langenberg, Cornelia M. van Duijn, Najaf Amin
Summary: The study identified 8 metabolites associated with depression through metabolome-wide association analysis. These metabolites are either directly derived from food or products of host and gut microbial metabolism of food-derived products. The findings highlight the potential of diet interventions in preventing depression.
MOLECULAR PSYCHIATRY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Anna Ramisch, Julia S. El-Sayed Moustafa, Diogo Ribeiro, Gwenael Leday, Yunlong Jiao, George Nicholson, Michael Stevens, Moustafa Abdalla, Cristina Menni, Ana Vinuela, Chris Holmes, Timothy D. Spector, Mark I. McCarthy, Sylvia Richardson, Olivier Delaneau, Emmanouil D. Dermitzakis
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
