Article
Nutrition & Dietetics
Naotake Funamizu, Kyosei Sogabe, Mikiya Shine, Masahiko Honjo, Akimasa Sakamoto, Yusuke Nishi, Takashi Matsui, Mio Uraoka, Tomoyuki Nagaoka, Miku Iwata, Chihiro Ito, Kei Tamura, Katsunori Sakamoto, Kohei Ogawa, Yasutsugu Takada
Summary: C-reactive protein-to-albumin ratio (CAR) can be used as a risk factor to predict postoperative pancreatic fistula (POPF) in patients with pancreatic cancer following distal pancreatectomy (DP).
Article
Surgery
Stefano Andrianello, Elisa Bannone, Giovanni Marchegiani, Giuseppe Malleo, Salvatore Paiella, Alessandro Esposito, Roberto Salvia, Claudio Bassi
Summary: It was found that postoperative acute pancreatitis is a common event after distal pancreatectomy and it is closely associated with postoperative pancreatic fistula. Factors influencing postoperative acute pancreatitis include neoadjuvant therapy, age, duct size, pancreatic thickness, resection level, and histology type. Postoperative acute pancreatitis may increase the risk of further complications for patients.
Article
Surgery
Naoki Ikenaga, Takao Ohtsuka, Kohei Nakata, Yusuke Watanabe, Yasuhisa Mori, Masafumi Nakamura
Summary: The study found a high incidence of postoperative acute pancreatitis after pancreatoduodenectomy and distal pancreatectomy, with different impacts on patients. Patients with clinically relevant postoperative acute pancreatitis were more likely to develop severe complications.
Article
Surgery
Giovanni Guarneri, Giorgia Guazzarotti, Nicolo Pecorelli, Diego Palumbo, Marco Palucci, Lorenzo Provinciali, Chiara Limongi, Stefano Crippa, Stefano Partelli, Francesco De Cobelli, Massimo Falconi
Summary: This study analyzed clinically relevant postoperative pancreatic fistula (CR-POPF) cases related to distal pancreatectomy and identified factors associated with the need for invasive procedures. The results showed that the occurrence rate of CR-POPF within 90 days after surgery was 40.1%, with 25.2% of patients experiencing symptomatic fluid collections related to fistula. Increased body mass index and intraoperative blood loss were associated with fluid collections, while CT scan parameters were associated with the need for invasive procedures.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Gastroenterology & Hepatology
Artem Boyev, Laura R. Prakash, Yi-Ju Chiang, Christopher P. Childers, Anish J. Jain, Timothy E. Newhook, Morgan L. Bruno, Elsa M. Arvide, Whitney L. Dewhurst, Michael P. Kim, Naruhiko Ikoma, Jeffrey E. Lee, Rebecca A. Snyder, Matthew H. G. Katz, Ching-Wei D. Tzeng, Jessica E. Maxwell
Summary: This study found an association between postoperative opioid use and the occurrence of clinically relevant postoperative pancreatic fistula (CR-POPF) after distal pancreatectomy. Decreasing perioperative opioid use through enhanced postoperative management may be an effective approach to reduce the rates of CR-POPF.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Gastroenterology & Hepatology
Ibrahim Nassour, Samer AlMasri, Jacob C. Hodges, Steven J. Hughes, Amer Zureikat, Alessandro Paniccia
Summary: This study emphasizes the importance of Delta DFA in predicting CR-POPF following distal pancreatectomy and provides a calculator to facilitate prediction and postoperative drain management.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Surgery
Jun Suh Lee, Yoo-Seok Yoon, Ho-Seong Han, Jai Young Cho, Hae-Won Lee, Boram Lee, Yeongsoo Jo, MeeYoung Kang, Eunhye Lee, Yeshong Park
Summary: This study investigated the impact of drain fluid amylase (DFA) level, drain position, and fluid collection on postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP). The results showed that the incidence of POPF was similar between the high and low DFA groups, but drain malposition increased the risk of POPF. Male sex, high body mass index, transfusion, and drain malposition were identified as risk factors for POPF.
WORLD JOURNAL OF SURGERY
(2023)
Article
Surgery
Masahiro Fukada, Katsutoshi Murase, Toshiya Higashi, Itaru Yasufuku, Yuta Sato, Jesse Yu Tajima, Shigeru Kiyama, Yoshihiro Tanaka, Naoki Okumura, Takao Takahashi, Nobuhisa Matsuhashi
Summary: This study aimed to identify the most reliable indicator related to postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP). The study found that the drain and serum amylase concentration ratio (DSACR) on postoperative day 3 (POD3) is the most accurate indicator for predicting POPF.
Article
Surgery
Pongsatorn Tangtawee, Somkit Mingphruedhi, Narongsak Rungsakulkij, Wikran Suragul, Watoo Vassanasiri, Paramin Muangkaew
Summary: This study compared surgical complications and the incidence of clinically relevant postoperative pancreatic fistula (CR-POPF) between distal pancreatectomy (DP) with extended organ resection and standard DP. The results showed that patients in the extended DP group had greater blood loss, higher incidence of major complications, and longer hospital stay compared to the DP group. However, there were no differences in the incidence of CR-POPF, readmission rate, or the need for postoperative intervention drainage between the two groups.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Surgery
Lihan Qian, Binwei Hu, Jiancheng Wang, Xiongxiong Lu, Xiaxing Deng, Weimin Chai, Zhiwei Xu, Weishen Wang, Baiyong Shen
Summary: This study investigated the impact of remnant pancreas and other perioperative factors on postoperative pancreatic fistula (POPF) occurring after robot-assisted distal pancreatectomy (RDP) for nonmalignant pancreatic neoplasms. The results showed that a transection plan involving the tail of the pancreas and spleen preservation independently increased the incidence of POPF. The length of the remnant pancreas was also found to be a risk factor for POPF.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Chenchen He, Yibing Zhang, Longfei Li, Mingda Zhao, Chunhui Wang, Yufu Tang
Summary: This study aimed to identify the risk factors for clinically relevant postoperative pancreatic fistula (CR-POPF) following distal pancreatectomy (DP) and develop a nomogram model for predicting CR-POPF. A total of 115 patients who underwent DP at the General Hospital of Northern Theater Command between January 2005 and December 2020 were retrospectively analyzed. Multivariable logistic regression analysis identified BMI, preoperative albumin level, pancreatic thickness, and pancreatic texture as independent risk factors for CR-POPF. A nomogram incorporating these risk factors showed better predictive value compared to each risk factor alone. Decision curve and clinical impact curve analyses confirmed the clinical utility of the nomogram.
Article
Surgery
J. Wennerblom, Z. Ateeb, C. Jonsson, B. Bjornsson, B. Tingstedt, C. Williamsson, P. Sandstrom, C. Ansorge, J. Blomberg, M. Del Chiaro
Summary: The use of biodegradable reinforcement at the transection line of the pancreas did not reduce postoperative pancreatic fistula compared to regular stapler transection in distal pancreatectomy. Additionally, there was no significant difference in postoperative complications and duration of hospital stay between the two groups.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Surgery
Taoyuan Yin, Jingxiong Yuan, Yi Wu, Shizhen Li, Min Wang, Ruizhi He, Renyi Qin
Summary: This study retrospectively evaluated the efficacy and safety of retroperitonealization of the pancreatic stump in distal pancreatectomy. The results showed that retroperitonealization can reduce the incidence of postoperative pancreatic fistula and shorten the time until drainage removal. Non-retroperitonealization and intra-abdominal infection were identified as independent risk factors for postoperative pancreatic fistula.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Gastroenterology & Hepatology
Katsunori Sakamoto, Kohei Ogawa, Kei Tamura, Miku Iwata, Takashi Matsui, Yusuke Nishi, Tomoyuki Nagaoka, Naotake Funamizu, Akihiro Takai, Yasutsugu Takada
Summary: This study identified high CRP levels and high DFA output on postoperative day 3 as independent predictors of clinically relevant POPF after distal pancreatectomy. Postoperative CRP values and DFA output may help guide postoperative management for patients undergoing this procedure.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Yosuke Mukai, Kei Asukai, Hirofumi Akita, Masahiko Kubo, Shinichiro Hasegawa, Hiroshi Wada, Hiroshi Miyata, Masayuki Ohue, Masato Sakon, Hidenori Takahashi
Summary: Combining postoperative fluid collection and drain amylase levels can provide a more precise assessment of the intra-abdominal status related to postoperative pancreatic fistula. C-reactive protein levels can also be used as a risk factor for clinically relevant postoperative pancreatic fistula after distal pancreatectomy.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Oncology
Zhefu Zhao, Nathalie Bauer, Ewa Aleksandrowicz, Libo Yin, Jury Gladkich, Wolfgang Gross, Joerg Kaiser, Thilo Hackert, Oliver Strobel, Ingrid Herr
INTERNATIONAL JOURNAL OF CANCER
(2018)
Article
Oncology
Daniele Campa, Martina Matarazzi, William Greenhalf, Maarten Bijlsma, Kai-Uwe Saum, Claudio Pasquali, Hanneke van Laarhoven, Andrea Szentesi, Francesca Federici, Pavel Vodicka, Niccola Funel, Raffaele Pezzilli, H. Bas Bueno-de-Mesquita, Ludmila Vodickova, Daniela Basso, Ofure Obazee, Thilo Hackert, Pavel Soucek, Katarina Cuk, Joerg Kaiser, Cosimo Sperti, Martin Lovecek, Gabriele Capurso, Beatrice Mohelnikova-Duchonova, Kay-Tee Khaw, Anna-Katharina Koenig, Juozas Kupcinskas, Rudolf Kaaks, Franco Bambi, Livia Archibugi, Andrea Mambrini, Giulia Martina Cavestro, Stefano Landi, Peter Hegyi, Jakob R. Izbicki, Domenica Gioffreda, Carlo Federico Zambon, Francesca Tavano, Renata Talar-Wojnarowska, Krzysztof Jamroziak, Timothy J. Key, Gianfranco Delle Fave, Oliver Strobel, Laimas Jonaitis, Angelo Andriulli, Rita T. Lawlor, Felice Pirozzi, Verena Katzke, Chiara Valsuani, Yogesh K. Vashist, Hermann Brenner, Federico Canzian
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Oncology
O. Obazee, L. Archibugi, A. Andriulli, P. Soucek, E. Malecka-Panas, A. Ivanauskas, T. Johnson, M. Gazouli, T. Pausch, R. T. Lawlor, G. M. Cavestro, A. C. Milanetto, M. Di Leo, C. Pasquali, P. Hegyi, A. Szentesi, C. E. Radu, C. Gheorghe, G. E. Theodoropoulos, F. Bergmann, H. Brenner, L. Vodickova, V. Katzke, D. Campa, O. Strobel, J. Kaiser, R. Pezzilli, F. Federici, B. Mohelnikova-Duchonova, U. Boggi, R. Lemstrova, J. S. Johansen, S. E. Bojesen, I. Chen, B. V. Jensen, G. Capurso, V. Pazienza, C. Dervenis, C. Sperti, A. Mambrini, T. Hackert, R. Kaaks, D. Basso, R. Talar-Wojnarowska, E. Maiello, J. R. Izbicki, K. Cuk, K. U. Saum, M. Cantore, J. Kupcinskas, O. Palmieri, G. Delle Fave, S. Landi, R. Salvia, P. Fogar, Y. K. Vashist, A. Scarpa, P. Vodicka, C. Tjaden, E. Iskierka-Jazdzewska, F. Canzian
INTERNATIONAL JOURNAL OF CANCER
(2019)
Review
Surgery
S. Schimmack, J. Kaiser, P. Probst, E. Kalkum, M. K. Diener, O. Strobel
BRITISH JOURNAL OF SURGERY
(2020)
Article
Surgery
Oliver Strobel, Philipp Lorenz, Ulf Hinz, Matthias Gaida, Anna-Katharina Koenig, Thomas Hank, Willem Niesen, Joerg Kaiser, Mohammed Al-Saeedi, Frank Bergmann, Christoph Springfeld, Christoph Berchtold, Markus K. Diener, Martin Schneider, Arianeb Mehrabi, Beat P. Mueller-Stich, Thilo Hackert, Dirk Jaeger, Markus W. Buechler
Summary: This study investigated the actual five-year survival rate of pancreatic ductal adenocarcinoma (PDAC) with a strategy of upfront surgery and adjuvant therapy. The results showed that the actual five-year survival rate for PDAC patients who underwent upfront surgery and adjuvant therapy was 18.8%. Tumor grading, number of positive lymph nodes, intraductal papillary mucinous neoplasia, and vascular resections were found to be independent factors associated with the five-year survival rate.
Article
Oncology
Philipp Mayer, Yixin Jiang, Tristan A. Kuder, Frank Bergmann, Ekaterina Khristenko, Verena Steinle, Joerg Kaiser, Thilo Hackert, Hans-Ulrich Kauczor, Miriam Klauss, Matthias M. Gaida
Article
Gastroenterology & Hepatology
Shigenori Ei, Andre L. Mihaljevic, Yakup Kulu, Joerg Kaiser, Ulf Hinz, Markus W. Buechler, Thilo Hackert
Summary: This study found that compared with open surgery, minimally invasive enucleation can reduce blood loss, lead to earlier discharge for patients, without increasing the risk of major complications. Therefore, minimally invasive enucleation should be considered as a feasible option for benign pancreatic tumors.
Article
Oncology
Joerg Kaiser, Ulf Hinz, Philipp Mayer, Thomas Hank, Willem Niesen, Thilo Hackert, Matthias M. Gaida, Markus W. Buechler, Oliver Strobel
Summary: Adenosquamous carcinoma of the pancreas (ASCP) is a more aggressive subtype of pancreatic adenocarcinoma compared to pancreatic ductal adenocarcinoma (PDAC), with poorer differentiation and higher rates of lymph node metastases. Despite a shorter median survival, 5-year survival rates after surgical resection of about 18% can be expected in ASCP, supporting resection as part of a multimodal therapy as the treatment of choice in this rare cancer.
Article
Surgery
Thomas Hank, Ulf Hinz, Thomas Reiner, Giuseppe Malleo, Anna-Katharina Koenig, Laura Maggino, Giovanni Marchegiani, Joerg Kaiser, Salvatore Paiella, Alessandra Binco, Roberto Salvia, Thilo Hackert, Claudio Bassi, Markus W. Buechler, Oliver Strobel
Summary: This study developed and validated a prognostic score for pancreatic cancer based on pretreatment parameters. The score, called HELPP-score, was able to stratify survival independently of resection status and pathological tumor stage.
Article
Surgery
Christine Tjaden, Marta Sandini, Andre L. Mihaljevic, Jorg Kaiser, Ekaterina Khristenko, Philipp Mayer, Ulf Hinz, Matthias M. Gaida, Christoph Berchtold, Markus K. Diener, Martin Schneider, Arianeb Mehrabi, Beat P. Mueller-Stich, Oliver Strobel, Thilo Hackert, Markus W. Buechler
Summary: This study analyzed the surgical management of IPMNs in a single referral center, showing that the too early group had a higher rate of parenchyma-sparing resections, while the too late group had higher morbidity and mortality. Until accurate guidelines are established, caution should be applied in implementing a watch-and-wait policy for IPMNs, especially those with a main-duct component.
Article
Oncology
Anna-Katharina Koenig, Helene Gros, Ulf Hinz, Thomas Hank, Joerg Kaiser, Thilo Hackert, Frank Bergmann, Markus W. Buechler, Oliver Strobel
Summary: The 8th edition of the TNM staging system for pancreatic cancer needs improvement, and integrating tumor grading into the system can further optimize prognostic stratification.
Article
Oncology
Joerg Kaiser, Cornelius Scheifele, Ulf Hinz, Carl-Stephan Leonhardt, Thomas Hank, Anna-Katharina Koenig, Christine Tjaden, Thilo Hackert, Frank Bergmann, Markus W. Buechler, Oliver Strobel
Summary: The prognostic factors, validity of the AJCC/UICC staging system, and role of adjuvant chemotherapy remain unclear for IPMN-associated carcinoma. This study analyzed the clinical and treatment data of patients with IPMN-associated carcinoma undergoing resection and found that tumor stage, histologic subtype, grading, and Ca 19-9 levels influenced the survival of patients.
Article
Oncology
Klaus Felix, Kazufumi Honda, Kengo Nagashima, Ayumi Kashiro, Keiko Takeuchi, Takashi Kobayashi, Sascha Hinterkopf, Matthias M. Gaida, Hien Dang, Niall Brindl, Joerg Kaiser, Markus W. Buechler, Oliver Strobel
Summary: This study found that serum apoA2-i has potential clinical value in risk stratification of IPMN and associated cancer. It showed higher accuracy and sensitivity in diagnosing IPMN-associated cancer compared to the routine biomarker CA 19-9. Further validation in larger and independent international cohort studies is needed for clinical application.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Review
Surgery
M. Heckler, L. Brieger, U. Heger, T. Pausch, C. Tjaden, J. Kaiser, M. Tanaka, T. Hackert, C. W. Michalski