Journal
TRENDS IN FOOD SCIENCE & TECHNOLOGY
Volume 88, Issue -, Pages 46-56Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tifs.2019.02.003
Keywords
beta-Cell dysfunction; Insulin resistance; Sesquiterpenoids; Type 2 diabetes; Key enzyme
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Funding
- National Natural Science Foundation of China (NSFC) [31701520, 31801459]
- China Postdoctoral Science Foundation [2018M642551]
- Funds for Distinguished Young Scientists at Fujian agriculture and forestry university of China [kxjq17012]
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Background: Treatment of type 2 diabetes mellitus (T2DM) through dietary terpenoids is receiving a promising interest and sesquiterpenoids' importance for food and pharmaceutical industries is mainly based on the existed scientific works. Scope and approach: Sesquiterpenoids might contribute to prevent or delay T2DM by inhibiting key enzymes relevant for hyperglycemia, modulating beta-cells function, targeting insulin signaling route, etc. Sesquiterpenoids also have been demonstrated to stimulate glucose uptake by enhancing glucose transport, repressing glucose production, or improving lipid metabolism. Key findings and conclusions: In this review, we summarized the latest developments of sesquiterpenoids in the treatment of type 2 diabetes as well as sesquiterpenoids-rich herbs against key enzymes relevant to hyperglycemia, and discussed their underlying molecular mechanisms of anti-diabetic potential. We also suggested a better evaluation of the pharmacological profile of sesquiterpenoids and their derivate with a clear-cut choice of possible human pathologies.
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