Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 44, Issue 10, Pages 885-896Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2019.05.004
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Funding
- National Natural Science Foundation of China [81873373, 81574058, 81473760, 81774429]
- Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning [JZ2016010]
- Shanghai Talent Development Fund [201610]
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Transgelin-2 has been regarded as an actin-binding protein that induces actin gelation and regulates actin cytoskeleton. However, transgelin-2 has recently been shown to relax the myosin cytoskeleton of the airway smooth muscle cells by acting as a receptor for extracellular metallothionein-2. From a clinical perspective, these results support transgelin-2 as a promising therapeutic target for diseases such as cancer and asthma. The inhibition of transgelin-2 prevents actin gelation and thereby cancer cell proliferation, invasion, and metastasis. Conversely, the activation of transgelin-2 with specific agonists relaxes airway smooth muscles and reduces pulmonary resistance in asthma. Here, we review new studies on the biochemical properties of transgelin-2 and discuss their clinical implications for the treatment of immune, oncogenic, and respiratory disorders.
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