Review
Medicine, General & Internal
Estera Boeriu, Alexandra Borda, Dan Dumitru Vulcanescu, Vlad Sarbu, Smaranda Teodora Arghirescu, Ovidiu Ciorica, Felix Bratosin, Iosif Marincu, Florin George Horhat
Summary: Infectious diseases are a significant concern for pediatric cancer patients, particularly those experiencing fever and neutropenia. This review analyzes the latest literature on therapeutic strategies and efficacy for pediatric patients with febrile neutropenia. It highlights the importance of prompt administration of empiric broad-spectrum antibiotics and the need for improved identification of underlying causes.
Review
Pharmacology & Pharmacy
Vera Battini, Alessandra Mari, Michele Gringeri, Francesca Casini, Francesco Bergamaschi, Giulia Mosini, Greta Guarnieri, Marco Pozzi, Maria Nobile, Gianvincenzo Zuccotti, Emilio Clementi, Sonia Radice, Valentina Fabiano, Carla Carnovale
Summary: This study aimed to characterize pediatric cases of antibiotic-associated neutropenia and explore the temporal association between different antibiotics and the occurrence of this adverse event. The results showed that the time to onset of neutropenia varied among different antibiotics, highlighting the importance of clinicians' awareness and timely discontinuation of antibiotics.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Amy McCarthy, Katharine Balfour, Iman El Sayed, Richard Edmondson, Yee-Loi Louise Wan
Summary: There is no consensus on optimal treatment for advanced endometrial cancer, with neoadjuvant therapies like chemotherapy and radiotherapy being used to improve surgical outcomes. This review aims to assess whether neoadjuvant therapy improves health outcomes compared to upfront surgery in advanced endometrial cancer patients. Data will be collected and analyzed using PRISMA guidelines, with findings disseminated through peer-reviewed publications and practice guidelines updates.
Review
Medicine, General & Internal
Shufei Yu, Shuyang Zhang, Haiyan Xu, Guangjian Yang, Fei Xu, Liang Yang, Duo Chen, Guangyu An, Yan Wang
Summary: This meta-analysis investigates the efficacy of immune checkpoint inhibitors (ICIs) compared to chemotherapy in lung cancer patients with liver or brain metastases. The results show that ICIs are more effective than chemotherapy in these patients, with less benefit observed in patients with liver metastases and greater benefit observed in patients with brain metastases, specifically in non-small cell lung cancer patients.
Review
Medicine, General & Internal
Xin-Yu Zhang, Quan Wang, Ke-Lu Yang, Dang Wei, Xiao-Nan Liu
Summary: Childhood cancer survivors are at high risk of cardiovascular diseases due to anticancer therapy-induced cardiotoxicity. However, there is sparse evidence on the prevention of anticancer therapy-induced cardiovascular disease. This systematic review aims to summarize the current prevention strategies for anticancer therapy-induced cardiotoxicity in childhood cancer survivors.
Review
Emergency Medicine
Christian D. Pulcini, Skyler Lentz, Richard A. Saladino, Richard Bounds, Ramsey Herrington, Marian G. Michaels, Scott H. Maurer
Summary: This review evaluates the management of pediatric patients with cancer and neutropenic fever, emphasizing the importance of timely evaluation and treatment for these patients. Hospital admission for parenteral antibiotics and monitoring is required for high-risk and most low-risk children with fever and neutropenia. Oral antibiotic therapy may be considered for certain low-risk patients in specific pediatric centers.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Review
Oncology
Kazuhiro Ishikawa, Tetsuhiro Masaki, Fujimi Kawai, Erika Ota, Nobuyoshi Mori
Summary: It is uncertain whether early discontinuation of antibiotics is safe and effective in patients with hematologic malignancy and febrile neutropenia. Short-term treatment showed no significant differences in clinical outcomes compared to long-term treatment.
Review
Medicine, General & Internal
Ye Zhao, Haiming Feng, Jinhui Tian, Bin Li, Cheng Wang, Long Ge, Jian kai Wang, Kehu Yang, Qin Yu
Summary: This systematic review aims to evaluate the clinical efficacy of different combinations of CCRTs and consolidation therapies. Traditional meta-analysis and network meta-analysis methods will be used to analyze the data. The primary endpoints include overall survival and progression-free survival, while secondary outcomes include tumor response and health-related quality of life. The results of this study will be published in a peer-reviewed journal.
Review
Medicine, General & Internal
Mariza Branco-Silva, Izildinha Maesta, Kevin Elias, Ross Stuart Berkowitz, Joelcio Francisco Abbade, Neil S. Horowitz
Summary: This study aims to investigate whether consolidation chemotherapy is necessary for all patients with postmolar low-risk GTN after human chorionic gonadotropin normalization with first-line single-agent chemotherapy. The study will include both randomized and non-randomized studies, excluding those that do not report relapse rates or whether consolidation chemotherapy was delivered. The primary outcome is the rate of recurrence/relapse.
Article
Pediatrics
Mathilde Delebarre, Fanny Gonzales, Helene Behal, Aude Tiphaine, Helene Sudour-Bonnange, Anne Lutun, Samuel Abbou, Sophie Pertuisel, Sandrine Thouvenin-Doulet, Isabelle Pellier, Ludovic Mansuy, Christophe Piguet, Catherine Paillard, Laurence Blanc, Estelle Thebaud, Dominique Plantaz, Pascale Blouin, Pascale Schneider, Cecile Guillaumat, Pauline Simon, Carine Domenech, Helene Pacquement, Marion Le Meignen, Claire Pluchart, Cecile Verite, Genevieve Plat, Alain Martinot, Alain Duhamel, Francois Dubos
Summary: The study aimed to build and validate a new CDR (DISCERN-FN) to predict the risk of severe infection in children with febrile neutropenia. Significant variables included cancer type, age, high-risk chemotherapy, fever level, C-reactive protein concentration, leucocyte and platelet counts, and procalcitonin. The CDR demonstrated high sensitivity and negative likelihood ratio in both the derivation and validation sets.
LANCET CHILD & ADOLESCENT HEALTH
(2022)
Article
Multidisciplinary Sciences
Muayad Alali, Anoop Mayampurath, Yangyang Dai, Allison H. Bartlett
Summary: The study aimed to develop a model for predicting blood stream infection (BSI) and transfer to intensive care (TIC) in pediatric cancer patients with febrile neutropenia (FN) using random forest model, which demonstrated higher accuracy.
SCIENTIFIC REPORTS
(2022)
Review
Pharmacology & Pharmacy
Julian M. Holz, Alon Chevtchenko, Aleksandra Aitullina
Summary: Acute neutropenia induced by antibiotics is a rare side effect, typically occurring after 21 days of treatment and taking about 6 days to recover. Vancomycin and ceftaroline are the two most commonly described antibiotics, and the use of granulocyte colony-stimulating growth factors (CSFs) can shorten the duration of neutropenia and improve patient outcomes.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Qiancheng Hu, Wenli Kang, Qiuji Wu, Xin Wang, Qingfeng Wang, Ting Luo
Summary: This study aims to compare different maintenance strategies for patients with advanced ovarian cancer, analyzing their impact on progression-free survival, overall survival, toxicities, quality-adjusted life years, and cost-effectiveness. The results will be disseminated through international conferences and peer-reviewed manuscripts.
Article
Oncology
Mohammad Al Qadire, Cherry Ann C. Ballad, Ma'en Aljezawi, Omar Al Omari, Fawwaz Alaloul, Ahmad Musa, Sulaiman Al Sabei, Atika Khalaf
Summary: This study assesses nurses' knowledge of chemotherapy-induced neutropenia (CIN) and identifies factors associated with their level of knowledge. The results show that nurses have a moderate level of knowledge about CIN and its management. Those with post-graduate degrees, oncology education, and more oncology experience are more likely to have a higher level of knowledge. Further education and training are needed to improve nurses' understanding of CIN.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Rehabilitation
Aida Herranz-Gomez, Ferran Cuenca-Martinez, Luis Suso-Marti, Clovis Varangot-Reille, Miriam Prades-Monfort, Joaquin Calatayud, Jose Casana
Summary: This study assessed and compared the effectiveness of different exercise modalities in reducing cancer-related fatigue (CRF) in patients with cancer undergoing chemotherapy. The study also compared the exercise intensities for selected exercise types. The results showed that adding low-to moderate-intensity aerobic and/or resistance exercise can improve CRF in patients with cancer undergoing chemotherapy, compared to usual care or usual care with flexibility training.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Pediatrics
Gerard Cathal Millen, Roland Arnold, Jean-Baptiste Cazier, Helen Curley, Richard Feltbower, Ashley Gamble, Adam Glaser, Richard G. Grundy, Laura Kirton, Lennard Y. W. Lee, Martin G. McCabe, Claire Palles, Bob Phillips, Charles A. Stiller, Csilla Varnai, Pamela Kearns
Summary: Children with haematological malignancies are at no greater risk of severe SARS-CoV-2 infection than those with non-haematological malignancies.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Pediatrics
Hadeel Hassan, Sally Kinsey, Bob Phillips
Summary: This study aimed to evaluate the feasibility of using probiotics to reduce or prevent mucositis and infection in children with cancer, and found that recruitment needs to be improved before undertaking a sufficiently powered RCT.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Pediatrics
Melody Grace Redman, Katherine Harris, Bob S. Phillips
Summary: The study reviewed the safety and efficacy of low-level laser therapy for oral mucositis in pediatric cancer patients. The results suggest that LLLT may help reduce the severity of oral mucositis and oral pain, but further randomized controlled trials are needed to confirm these findings. The lack of blinding in some studies introduced a risk of bias, indicating a need for more robust research to determine the true effectiveness of LLLT for treating oral mucositis in children with cancer.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Letter
Pediatrics
Bob Phillips
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Editorial Material
Pediatrics
Bob Phillips
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Multidisciplinary Sciences
Christa Koenig, Claudia E. Kuehni, Nicole Bodmer, Philipp K. A. Agyeman, Marc Ansari, Jochen Roessler, Nicolas X. von der Weid, Roland A. Ammann
Summary: The time to antibiotics (TTA) was not associated with poor clinical outcomes in pediatric patients with fever in neutropenia (FN) without severe disease. However, in patients with severe disease, a longer TTA was trended towards more safety relevant events (SRE).
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Thomas John Jackson, Rachel Napper, Gabrielle M. Haeusler, Barry Pizer, Jessica Bate, Richard G. Grundy, Sujith Samarasinghe, Paola Angelini, Ashley Ball-Gamble, Bob Phillips, Jessica Elizabeth Morgan
Summary: This study aimed to evaluate a new protocol of risk stratification and early discharge for children with febrile neutropenia (FN). The results showed that the use of the Australian-UK-Swiss (AUS) rule and homecare criteria allowed for safe early outpatient management of children with FN.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Editorial Material
Pediatrics
Bob Phillips
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Review
Oncology
Michael V. Ortiz, Christa Koenig, Amy E. Armstrong, Jesper Brok, Beatriz de Camargo, Annelies M. C. Mavinkurve-Groothuis, Thelma B. Velasquez Herrera, Rajkumar Venkatramani, Andrew D. Woods, Jeffrey S. Dome, Filippo Spreafico
Summary: Outcomes for the majority of Wilms tumor patients are excellent, but there are still subgroups with a lower survival rate. This review discusses the historical and current approach to the classification and treatment of high-risk Wilms tumors, including specific criteria for high-risk patients. Inadequate conventional therapies highlight the urgency for advancements in laboratory and early-phase clinical investigations to identify effective agents.
PEDIATRIC BLOOD & CANCER
(2023)
Review
Oncology
Robert S. Phillips, Bas Vaarwerk, Jessica E. Morgan
Summary: Evidence-based medicine uses healthcare professional experience, research evidence, and patient preferences to inform clinical decision-making. In the field of rhabdomyosarcoma, collaborative groups like EpSSG have played a crucial role in developing evidence to support this process. This review explores key research developments in areas such as patient and public involvement, decision-making research, core outcome sets, evidence synthesis, and supporting research in rhabdomyosarcoma.
Review
Oncology
Michael V. Ortiz, Christa Koenig, Amy E. Armstrong, Jesper Brok, Beatriz de Camargo, Annelies M. C. Mavinkurve-Groothuis, Thelma B. Velasquez Herrera, Rajkumar Venkatramani, Andrew D. Woods, Jeffrey S. Dome, Filippo Spreafico
Summary: Outcomes for most Wilms tumor patients are positive, but there are subgroups with a survival rate of around 50% or lower. This article discusses the historical and current approach to the classification and treatment of high-risk Wilms tumors, including those with specific histology, relapsed patients, and those in socioeconomic disadvantaged areas. As conventional therapies are insufficient, further investigation is needed to identify active agents.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Multidisciplinary Sciences
Ruth Walker, Bob Phillips, Sofia Dias
Summary: Recruiting children for randomized clinical trials poses challenges, resulting in less certainty about the safety and effectiveness of treatments compared to adults. However, it is possible to use adult evidence to better understand the effectiveness of treatments in children, and there are various statistical methods available for conducting these analyses.
Article
Oncology
Constanza M. Vargas, Gabrielle A. Haeusler, Monica E. Slavin, Franz Babl, Francoise Mechinaud, Robert Phillips, Karin Thursky, Richard De Abreu Lourenco, Australian PICNICC Study Grp
Summary: The study examined the costs of in-hospital and outpatient care for febrile neutropenia (FN) in children with cancer. The results showed that FN events classified as high-risk had significantly higher costs compared to low-risk events. It was found that in-hospital admission and length of stay were the main drivers of FN costs.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Multidisciplinary Sciences
Marina Santschi, Roland A. Ammann, Philipp K. A. Agyeman, Marc Ansari, Nicole Bodmer, Eva Brack, Christa Koenig
Summary: This study aimed to develop new clinical decision rules (CDRs) for predicting low and high risk children with fever in neutropenia (FN), and externally validate existing CDRs. The results showed that the developed CDRs can effectively predict three different outcomes of infection severity. Additionally, six out of eleven published CDRs were found to have some reproducibility.
Article
Health Care Sciences & Services
Andre Bedendo, Sebastian Hinde, Bryony Beresford, Andrew Papworth, Bob Phillips, Chakrapani Vasudevan, Emma McLorie, Gabriella Walker, George Peat, Helen Weatherly, Richard Feltbower, Catherine Hewitt, Andrew Haynes, Fliss Murtagh, Jane Noyes, Julia Hackett, Richard Hain, Sam Oddie, Gayathri Subramanian, Lorna Fraser
Summary: The objective of this study is to gather information on the professional team members, services provided, funding sources and population served for all consultant-led specialised paediatric palliative care teams in the UK. The findings show that only six services meet the minimum criteria defined by NICE. Most services provide symptom management, specialist nursing care, end-of-life planning and care, and support for discharges and transfers. Additionally, charity funding plays a significant role in funding the services.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2023)