Article
Nanoscience & Nanotechnology
Eun Hye Koh, Won-Chul Lee, Yeong-Jin Choi, Joung-Il Moon, Jinah Jang, Sung-Gyu Park, Jaebum Choo, Dong-Ho Kim, Ho Sang Jung
Summary: A wearable SERS sensor has been developed for molecular sweat sensing, with the capability of measuring Raman signals without detachment from the skin. Through a multi-layer design, the sensor can absorb sweat, protect the skin, enhance signal, and has great potential for drug detection applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Xiaoming Su, Xinyu Liu, Yangcenzi Xie, Mingyang Chen, Hong Zhong, Ming Li
Summary: The widespread abuse of fentanyl has become a major global public health concern, leading to a drastic increase in overdose deaths. A recently developed freestanding surface-enhanced Raman spectroscopy (SERS) biosensor, called the FrEnSERS biosensor, has shown excellent capability in identifying and quantifying trace amounts of fentanyl in biofluids. This biosensor, composed of a reduced graphene oxide membrane decorated with hydrophobic Au nanostars, combines high SERS enhancement and analyte enrichment to achieve remarkable SERS performance. It has demonstrated sensitive and quantitative detection of fentanyl in serum and urine, with a wide dynamic range and low limits of detection. The FrEnSERS biosensor is a promising tool for forensic analysis and clinical diagnosis, providing a sensitive, cost-effective, and reliable method for rapid quantitative analysis of fentanyl in biofluids.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Brinton King Eldridge, Saghar Gomrok, James W. Barr, Elise Anne Chaffin, Lauren Fielding, Christian Sachs, Katie Stickels, Paiton Williams, Yongmei Wang
Summary: Gap-enhanced Raman tags are a new type of optical probe that utilize the strong electric field inside the gap between two plasmonic metals to enhance the surface-enhanced Raman scattering response. Our study investigated Au@SiO22@Au nanoparticles with varying shell and gap thicknesses and found that the near-field enhancement spectra inside the gap were stronger than on the outer surface of the nanoparticle. We also discovered that a thin shell combined with a thin gap produced the greatest near-field enhancement.
Article
Engineering, Electrical & Electronic
Baini Li, Tianran Wang, Weiguo Bai, Qingqing Su, Xuezhong Wu, Peitao Dong
Summary: A label-free detection scheme based on surface-enhanced Raman Scattering (SERS) was proposed for ultra-sensitive on-site rapid detection of anthrax protective antigens (PA). The detection limit of PA in human serum albumin (HSA) solution was found to be 100 μg/mL, lower than the PA concentration in human serum after anthrax infection. Principal Component Analysis (PCA) method was used to classify the SERS data of PA, HSA, and the mixture into three completely separated areas. The entire testing process only takes about eight minutes, faster than traditional technologies like Enzyme-linked Immunosorbent Assay (ELISA).
IEEE SENSORS JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Ting Zhang, Xubin Quan, Naisi Cao, Zhaoying Zhang, Yang Li
Summary: This study developed a label-free DNA detection method based on SERS, using the Au@AgNPs core-shell structure as the enhancement substrate. The method showed improved sensitivity and reproducibility of DNA SERS signals, allowing for the detection and qualification of specific DNA structures without structure destruction.
Article
Spectroscopy
Xinpeng Lv, Zhe Zhang, Yue Zhao, Xiaomeng Sun, Heng Jiang, Shuwen Zhang, Xianqi Sun, Xiaohong Qiu, Yang Li
Summary: This study develops a suitable virus detection hotspot using surface-enhanced Raman scattering (SERS) by reducing sodium borohydride and aggregating silver nanoparticles. Monkeypox virus and human papillomavirus fingerprints were successfully obtained and identified in serum and artificial vaginal discharge, respectively, using the principal component analysis method. The method has a low detection limit of 100 copies/mL, good reproducibility, and signal-to-noise ratio, and can solve the SERS signal interference problem in complex biological samples, showing potential for clinical application.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Ruipeng Chen, Yunfeng Sun, Bingyang Huo, Zefeng Mao, Xiaojuan Wang, Shiyu Li, Ran Lu, Shuang Li, Jun Liang, Zhixian Gao
Summary: A universal surface-enhanced Raman scattering (SERS) aptasensor was developed for the detection of Zearalenone (ZEN) with a linear detection range from 0.005 to 500 ng mL(-1) and a detection limit of 0.001 ng mL(-1). The sensor showed excellent performance for analytical applications with real-world samples.
ANALYTICA CHIMICA ACTA
(2021)
Article
Biophysics
Hongki Kim, Ba Thong Trinh, Kyung Ho Kim, Jeong Moon, Hyunju Kang, Kwanghyeon Jo, Rashida Akter, Jinyoung Jeong, Eun-Kyung Lim, Juyeon Jung, Ho-Suk Choi, Hyun Gyu Park, Oh Seok Kwon, Ilsun Yoon, Taejoon Kang
Summary: A metal-organic framework-coated SERS paper platform was developed for the detection of putrescine and cadaverine, with functionalized paper allowing quantitative detection of the molecules and demonstration of detection ability for volatile amines in spoiled food samples.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biophysics
Maryam Arabi, Abbas Ostovan, Zhiyang Zhang, Yunqing Wang, Rongchao Mei, Longwen Fu, Xiaoyan Wang, Jiping Ma, Lingxin Chen
Summary: A capillary sensor was developed for ultrasensitive and universal detection of protein biomarkers using an inner SERS substrate layer and an outer imprinted layer. The imprinted cavities selectively captured target proteins and allowed passage of Raman indicator to access the SERS substrate, leading to specific and reproducible detection of trypsin enzyme in biological samples without sample preparation. The platform offers a facile, fast, and general route for sensitive SERS detection of Raman inactive biomacromolecules.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Physical
Vo Thi Nhat Linh, Sang-Gu Yim, ChaeWon Mun, Jun-Yeong Yang, Seunghun Lee, Yeon Woo Yoo, Dong Kyung Sung, Yong-Ill Lee, Dong-Ho Kim, Sung-Gyu Park, Seung Yun Yang, Ho Sang Jung
Summary: A bioinspired nanoflower structure was fabricated on microneedle to serve as a surface-enhanced Raman scattering (SERS) sensor for intradermal sensing applications. The sensor was capable of detecting methylene blue down to a concentration of 50 nM and 1 nM in a skin phantom model.
APPLIED SURFACE SCIENCE
(2021)
Article
Chemistry, Analytical
Yuan Zhang, De-Sheng Zhan, Xiao-Ying Xu, Zhe Zhang, Mahmoud Elsayed Hafez, Yue He, Yang Li, Da-Wei Li
Summary: This study developed a SERS platform for detecting DNA methylation by modifying silver nanoparticles with zirconium ions. The use of zirconium ions enabled the opening of folded DNA molecules, allowing for the identification of subtle differences between normal and methylated DNA with single base-level sensitivity.
Article
Chemistry, Multidisciplinary
Shi Xuan Leong, Charlynn Sher Lin Koh, Howard Yi Fan Sim, Yih Hong Lee, Xuemei Han, Gia Chuong Phan-Quang, Xing Yi Ling
Summary: The study successfully achieves direct, label-free SERS sensing of biologically important enantiomers by synergizing asymmetric nanoporous gold (NPG) nanoparticles with electrochemical-SERS. This strategy is versatile and can be readily extended to detect various enantiomers, and allows for multiplex quantification of enantiomeric ratios with excellent predictive performance. The research offers a paradigm shift in achieving label-free chiral SERS sensing of various enantiomers.
Article
Chemistry, Analytical
Zhe Zhang, Shen Jiang, Xiaotong Wang, Tuo Dong, Yunpeng Wang, Dan Li, Xin Gao, Zhangyi Qu, Yang Li
Summary: This study presents a novel enhanced substrate for label-free detection of respiratory viruses using surface-enhanced Raman Scattering. The method involves the use of sodium borohydride to reduce silver ions, eliminating the disorganized peak signal of traditional reducing agents. The study successfully obtained the fingerprints and concentration-dependent curves of various respiratory viruses, including SARS-CoV-2, and identified them in serum and saliva within two minutes using linear discriminant diagnostic analysis. This enhanced substrate is therefore highly valuable for the global response to the COVID-19 pandemic.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Review
Chemistry, Physical
Liping Xie, Hedele Zeng, Jiaxin Zhu, Zelin Zhang, Hong-bin Sun, Wen Xia, Yanan Du
Summary: This review presents the latest advances in flexible surface-enhanced Raman scattering (SERS) sensors. The focus is on engineering plasmonic substrates to improve the performance of flexible SERS devices. Strategies for constructing flexible SERS sensors for point-of-care detection are discussed in depth. Advanced algorithms for assisting SERS data processing are also presented, along with the promising applications of flexible SERS sensors in various fields.
Article
Chemistry, Analytical
Xin Liu, Alei Dang, Tiehu Li, Yiting Sun, Weibin Deng, Tung-Chun Lee, Yong Yang, Amir Zada, Boning Wang, Yuhui Liu, Shaoheng Wu, Tingkai Zhao
Summary: This article introduces a surface-enhanced Raman scattering (SERS) sensor that achieves reliable and sensitive large-scale rapid screening of target analytes. The sensor demonstrates ultralow limit of detection, outstanding sensitivity, and high stability. It also allows for the multiplexed detection of pesticide residues and the recognition of target molecules in a wide range of fields.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Yuwei Liu, Xiaona Cui, Yong-Ill Lee, Hong-Guo Liu
Summary: This study systematically investigated the self-assembly behavior of polystyrene-block-poly(2-vinylpyridine) at the liquid/liquid interface. Different primary morphologies of aggregates were obtained depending on the molecular structure of the block copolymers and the amount of chloroauric acid. The findings provide valuable insights into the self-assembly behavior of block copolymers at interfaces and offer a facile approach for fabricating functional structures.
Article
Biochemistry & Molecular Biology
Iris Baffour Ansah, Soo Hyun Lee, ChaeWon Mun, Dong-Ho Kim, Sung-Gyu Park
Summary: This study presents a SERS platform with interior hotspots by developing an Ag-Au bimetallic nanocomposite. The platform exhibits enhanced plasmonic activity through the formation of interior hotspots during the galvanic replacement reaction. The platform demonstrates excellent detection performance for hazardous materials, making it a promising method for practical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biophysics
Iris Baffour Ansah, Soo Hyun Lee, Jun-Yeong Yang, ChaeWon Mun, Sunghoon Jung, Ho Sang Jung, Min -Young Lee, Taejoon Kang, Seunghun Lee, Dong-Ho Kim, Sung-Gyu Park
Summary: Nanoscale plasmonic hotspots are critical for enhancing molecular Raman signals, enabling sensitive analysis of biomedical molecules. However, label-free SERS diagnoses remain challenging due to random adsorption and size mismatch. In this study, interior hotspots templated with protein@Au core-shell nanostructures were proposed for effective SERS diagnosis. The targets embedded in the hotspots showed highly linear quantitative sensitivity with a low limit of detection. The feasibility of detecting targets in bodily fluids was demonstrated using the proposed templates. These interior hotspots provide a promising solution for early and on-site SERS diagnoses of infectious diseases.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Environmental
Soo Hyun Lee, Iris Baffour Ansah, Won-Chul Lee, Jun-Yeong Yang, ChaeWon Mun, Hyowon Jang, Sunjoo Kim, Sunghoon Jung, Ho Sang Jung, Taejoon Kang, Seunghun Lee, Dong-Ho Kim, Sung-Gyu Park
Summary: This study demonstrates the irreversible active engineering of three-dimensional (3D) interior organo-hotspots via electrochemical deposition, enabling the highly specific and sensitive detection of low-concentration viral lysates. The proposed platform shows great potential for point-of-care diagnoses of infectious diseases in clinical environments.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Hock Beng Lee, Rishabh Sahani, Vasanthan Devaraj, Neetesh Kumar, Barkha Tyagi, Jin-Woo Oh, Jae-Wook Kang
Summary: This study introduces the CsI-PbI2:DMSO complex as a phase stabilizer and defect passivator to improve the crystallization, energy band alignment, and optoelectronic properties of FAPbI(3) perovskite, and to inhibit the α → δ phase transition. Additive engineering can enhance the performance, stability, and reproducibility of FAPbI(3)-based solar cells.
ADVANCED MATERIALS INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Hajun Dang, Younju Joung, Chaehyeon Jeong, Chang Su Jeon, Sung Hyun Pyun, Sung-Gyu Park, Jaebum Choo
Summary: With the recent advancements in high-sensitivity optical detection technologies, researchers have conducted studies to accurately detect biomarkers with low concentrations such as tau-381 protein, a biomarker for Alzheimer's disease. A plasmonic Au nanopopcorn substrate fabricated via thermal evaporation was used in this study to achieve high sensitivity and reproducibility in detecting tau-381. The results showed a limit of detection value below the clinical cutoff value.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2023)
Article
Biotechnology & Applied Microbiology
Salah M. Tawfik, Atef S. Kobisy, Emad A. Badr, Ahmed H. Elged, Yong-Ill Lee
Summary: Microbial corrosion caused by microorganisms in the petroleum industry is a significant problem that can have severe environmental and economic consequences. Therefore, the development of innovative nonionic porous antimicrobial materials with diverse hydrophobic conjugated motifs is highly desirable.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2023)
Article
Chemistry, Multidisciplinary
Lip Ket Chin, Jun-Yeong Yang, Benjamin Chousterman, Sunghoon Jung, Do-Geun Kim, Dong-Ho Kim, Seunghun Lee, Cesar M. Castro, Ralph Weissleder, Sung-Gyu Park, Hyungsoon Im
Summary: In this study, an ultrasensitive multiplexed plasmonic sensing technology was developed for rapid quantification of multiple biomarkers in point-of-care settings, which could improve the diagnosis and management of sepsis. The technology integrated chemifluorescence signal enhancement with plasmon-enhanced fluorescence detection, allowing for rapid analysis of cytokine biomarkers with high sensitivity. A plasmonic sensing chip based on nanoparticle-spiked gold nanodimple structures was also developed for direct detection of cytokines in clinical plasma samples.
Article
Chemistry, Multidisciplinary
Seong Yeol Kim, Ramar Thangam, Nayeon Kang, Hyunsik Hong, Chowon Kim, Sungkyu Lee, Subin Son, Hyun-Jeong Lee, Kyong-Ryol Tag, Sunhong Min, Daun Jeong, Jangsun Hwang, Kanghyeon Kim, Dahee Kim, Yuri Kim, Jinmyoung Joo, Bong Hoon Kim, Yangzhi Zhu, Sung-Gyu Park, Hyun-Cheol Song, Wujin Sun, Jae-Pyoung Ahn, Woo Young Jang, Ramasamy Paulmurugan, Hong-Kyu Kim, Jong Seung Kim, Heemin Kang
Summary: In this study, the linking molecule-mediated conjugation of 1D magnetic nanocylinders (MNCs) to material surfaces pre-decorated with gold nanospheres (GNSs) was performed to establish a non-bridging state for RGD-coated MNCs (RGD-MNCs) over RGD-coated GNSs (RGD-GNSs). The use of magnetic field-mediated compression of the linking molecules enabled bridging between RGD-MNCs and RGD-GNSs. The optimized proportion of RGD-MNCs to RGD-GNSs allowed for effective remote stimulation of integrin binding and modulation of macrophages for immunomodulatory responses.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Instruments & Instrumentation
Vo Thi Nhat Linh, Muhammad Shalahuddin Al Ja'farawy, Eun Hye Koh, Min-Young Lee, Sung-Gyu Park, Dong-Ho Kim, Ho Sang Jung
Summary: The discovery of surface-enhanced Raman scattering (SERS) over the past 45 years has presented significant potential for ultrasensitive sensing applications. Recent advancements in flexible SERS sensors have enabled practical on-site sensing and diagnostic applications. This review summarizes the latest developments in flexible SERS substrates for on-site sensing and diagnosis over the past 4 years, highlighting different sampling methods and substrate materials, as well as discussing future challenges and perspectives.
APPLIED SPECTROSCOPY REVIEWS
(2023)
Article
Biophysics
Vo Thi Nhat Linh, Jungho Mun, Yeseul Kim, In Woong Han, Hongyoon Kim, Sung-Gyu Park, Samjin Choi, Dong-Ho Kim, Junsuk Rho, Ho Sang Jung
Summary: This article introduces a label-free surface-enhanced Raman scattering sensor based on a three-dimensional plasmonic coral nanoarchitecture. It has the potential to differentiate patients from the normal group with high sensitivity and specificity. This technology can be used for urinary cancer diagnosis and various human biofluid sensing systems as a future point-of-care testing platform.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biophysics
Iris Baffour Ansah, Matthew Leming, Soo Hyun Lee, Jun-Yeong Yang, ChaeWon Mun, Kyungseob Noh, Timothy An, Seunghun Lee, Dong-Ho Kim, Meehyein Kim, Hyungsoon Im, Sung-Gyu Park
Summary: Seasonal outbreaks of respiratory viral infections are a global concern, and timely and accurate responses are needed due to similar symptoms and subclinical infections. Reliable diagnostic assays are crucial for early infection diagnosis. In this study, a method using surface-enhanced Raman spectroscopy (SERS) and machine learning (ML) analysis was developed to specifically identify different viruses. The method showed high accuracy in identifying eight virus species and demonstrated feasibility for on-site multiplex detection.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Thanh Mien Nguyen, Cheol Woong Choi, Ji-Eun Lee, Damun Heo, Ye-Won Lee, Sun-Hwa Gu, Eun Jeong Choi, Jong-Min Lee, Vasanthan Devaraj, Jin-Woo Oh
Summary: This study reports on the influence of the M13 bacteriophage thin film layer on optical nanostructures and its control over optical and geometrical properties. A standard and dynamic model based on 3D FDTD simulations was designed to explain and predict the optical properties under different conditions. The importance of the dynamic model was demonstrated in humidity-based experiments, where it accurately predicted changes in plasmonic properties. It is believed that this work will provide fundamental insights into the geometrical and optical properties of nanostructures involving the M13 bacteriophage.
Article
Multidisciplinary Sciences
Bingyan Liu, Shirong Liu, Vasanthan Devaraj, Yuxiang Yin, Yueqi Zhang, Jingui Ai, Yaochen Han, Jicheng Feng
Summary: The researchers demonstrate a fast 3D nanoprinting technique for manufacturing nanostructured arrays of multiple materials and geometries over millimeter-scale areas by manipulating electric and flow fields. This technique has exciting prospects in the fields of nanophotonics and nanoelectronics.
NATURE COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Phommachith Sonexai, Minh Van Nguyen, Bui The Huy, Yong -Ill Lee
Summary: The detection of harmful chemicals in the environment and for food safety is important, but traditional techniques are expensive and time-consuming. Surface-enhanced Raman spectroscopy (SERS) offers a powerful alternative for detecting low concentrations of chemical compounds and biomolecules. This study presents a reproducible method for producing Ag nanoparticles that can be used to create highly sensitive SERS substrates. The developed SERS substrate exhibits exceptional analytical performance and has the potential to be a valuable analytical tool for monitoring environmental contaminants.
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
(2023)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)