Article
Radiology, Nuclear Medicine & Medical Imaging
Kouta Hirotaki, Shunsuke Moriya, Hidenobu Tachibana, Takeji Sakae
Summary: The study proposes a system for detecting anatomical changes using 2D x-ray images. The system shows good agreement with cone-beam computed tomography (CBCT) images and exhibits high sensitivity and specificity in detecting anatomical changes. It can be applied to daily online adaptive proton beam therapy and triggered adaptive radiotherapy.
Article
Oncology
Janita E. Van Timmeren, Madalyne Chamberlain, Marta Bogowicz, Stefanie Ehrbar, Riccardo Dal Bello, Helena Garcia Schuler, Jerome Krayenbuehl, Lotte Wilke, Nicolaus Andratschke, Matthias Guckenberger, Stephanie Tanadini-Lang, Panagiotis Balermpas
Summary: During radiotherapy for head and neck cancer patients, minimizing radiation dose to major salivary glands is crucial to reduce toxicity risks. Weekly MRI-guided adaptations can help mitigate volume changes and positional shifts of salivary glands, optimizing treatment outcomes. This study demonstrated significant changes in salivary gland volumes and positions with MR-guided radiotherapy, highlighting the importance of future clinical evaluation for toxicity optimization and benefits.
Article
Engineering, Biomedical
Erik van der Bijl, Peter Remeijer, Jan-Jakob Sonke, Uulke A. van der Heide, Tomas Janssen
Summary: This study introduces a method to update treatment margins based on patient treatment history and explores the potential benefits of adaptive margins. The results show that using adaptive margins can reduce margins in most patients without compromising those with greater than average target motion.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Oncology
Olga Hamming-Vrieze, Simon van Kranen, Iris Walraven, Arash Navran, Abrahim Al-Mamgani, Margot Tesselaar, Michiel van den Brekel, Jan-Jakob Sonke
Summary: Delivered radiation dose in head-and-neck cancer patients may differ from intended dose, with large dose deteriorations in a minority of patients, particularly when smaller margins are used. Factors associated with dose deterioration include higher baseline weight/BMI, weight gain early in treatment, and smaller PTV margins. Clinical prediction based on patient characteristics or CBCT is challenging, indicating the need for dosimetric selection tools to identify patients in need of adaptive radiotherapy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Henning Schmitz, Moritz Rabe, Guillaume Janssens, Simon Rit, Katia Parodi, Claus Belka, Florian Kamp, Guillaume Landry, Christopher Kurz
Summary: This study evaluated the potential of using scatter-corrected 4D cone beam CTs (4DCBCT(cor)) for dose calculations in intensity-modulated proton therapy (IMPT). The results showed that 4DCBCT(cor) had better quality compared to 4DCBCT. However, there were significant deviations and smaller gamma pass rates between dose calculations on 4DvCT and 4DCT, indicating substantial anatomical changes during treatment for some patients.
Article
Oncology
Stefania Russo, Rosalinda Ricotti, Silvia Molinelli, Filippo Patti, Amelia Barcellini, Edoardo Mastella, Andrea Pella, Chiara Paganelli, Giulia Marvaso, Matteo Pepa, Stefania Comi, Mattia Zaffaroni, Barbara Avuzzi, Tommaso Giandini, Emanuele Pignoli, Riccardo Valdagni, Guido Baroni, Federica Cattani, Mario Ciocca, Barbara Alicja Jereczek-Fossa, Ester Orlandi, Roberto Orecchia, Barbara Vischioni
Summary: Rectum and bladder volumes are crucial in prostate cancer radiotherapy, and their variations can affect dose distribution. By analyzing synthetic CT images and DVH metrics, the impact of bladder and rectum volume changes on dose distribution can be assessed. The study found that dose distributions were reproducible in terms of both target coverage and organ at risk sparing.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yves C. P. Willems, Femke Vaassen, Catharina M. L. Zegers, Alida A. Postma, Jaap Jaspers, Alejandra Mendez Romero, Mirko Unipan, Ans Swinnen, Monique Anten, Onno Teernstra, Inge Compter, Wouter van Elmpt, Danielle B. P. Eekers
Summary: The study found significant changes in the resection cavity (RC) during radiotherapy in brain tumor patients, suggesting the consideration of an additional margin to avoid insufficient target coverage. Future research on local recurrence patterns is recommended.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Review
Oncology
Adham Hijab, Boris Tocco, Ian Hanson, Hanneke Meijer, Christina Junker Nyborg, Anders Smedegaard Bertelsen, Robert Jan Smeenk, Gillian Smith, Jeff Michalski, Brian C. Baumann, Shaista Hafeez
Summary: Radiotherapy plays a significant role in both curative and palliative treatment of bladder cancer, but faces technical challenges such as poor tumor visualization and bladder size variability. Magnetic resonance imaging (MRI) is favored for tumor visualization and staging, and the integration of MRI scanning with linear accelerator in MR-Linac systems allows for real-time plan adaptation during treatment, potentially improving outcomes for bladder cancer patients. However, robust evidence is needed to determine if MR-guided radiotherapy translates into better patient outcomes before widespread clinical implementation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Ran Gu, Jingyang Zhang, Guotai Wang, Wenhui Lei, Tao Song, Xiaofan Zhang, Kang Li, Shaoting Zhang
Summary: We propose a contrastive semi-supervised learning method for cross-anatomy domain adaptation, which improves the performance of the target domain model by leveraging annotated images of similar structures from a source domain. We use domain-specific batch normalization to normalize feature maps and introduce a cross-domain contrastive learning strategy to extract domain invariant features. Extensive experiments demonstrate that our method solves the challenging cross-anatomy domain shift problem and achieves accurate segmentation of coronary arteries in X-ray images and cardiac MR images given only a small number of annotations in the target domain.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Article
Oncology
Valeria Faccenda, Denis Panizza, Martina Camilla Daniotti, Roberto Pellegrini, Sara Trivellato, Paolo Caricato, Raffaella Lucchini, Elena De Ponti, Stefano Arcangeli
Summary: With an increasing acceptance in the radiation oncology community, stereotactic body radiation therapy (SBRT) has become a common option for localized prostate cancer. This study investigated the dosimetric impact of both intrafraction prostate motion and interfraction anatomical changes in dose-escalated SBRT. The results showed that the implemented motion management strategy, along with other treatment optimization strategies, ensured no significant degradation of dose metrics in delivered treatments.
Article
Oncology
Ditte Sloth Moller, Christina Maria Lutz, Azza Ahmed Khalil, Markus Alber, Marianne Ingerslev Holt, Maria Kandi, Hjordis Hjalting Schmidt, Marie Tvilum, Ane Appelt, Marianne Marquard Knap, Lone Hoffmann
Summary: This study investigated the clinical benefits of tumor match and adaptive radiotherapy for non-small cell lung cancer patients. The results showed that tumor match and adaptive radiotherapy significantly reduced the incidence of radiation pneumonitis and improved progression-free and overall survival.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Oncology
Christoph Poettgen, Christian Hoffmann, Thomas Gauler, Maja Guberina, Nika Guberina, Toke Ringbaek, Alina Santiago Garcia, Ulrich Krafft, Boris Hadaschik, Aymane Khouya, Martin Stuschke
Summary: This study analyzes the impact of intra-fraction deformations on the dose distribution of bladder cancer radiotherapy. The results show that intra-fraction deformations lead to a decrease in the equivalent uniform dose (EUDCTV). However, even with this decrease, the dose fractions series can still maintain a high EUDCTV according to dose accumulation and cold spot correlation methods.
Article
Oncology
Eline D. Hessen, Sebastian Makocki, Uulke A. van der Heide, Bas Jasperse, Lotte J. Lutkenhaus, Emmy Lamers, Eugene Damen, Esther G. C. Troost, Gerben R. Borst
Summary: The study demonstrated that anatomical changes during radiotherapy in glioblastoma patients may affect dose coverage, but only a small number of patients experienced potentially clinically relevant underdosage as a result.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Rasmus Lubeck Christiansen, Lars Dysager, Christian Ronn Hansen, Henrik Robenhagen Jensen, Tine Schytte, Christina Junker Nyborg, Anders Smedegaard Bertelsen, Soren Nielsen Agergaard, Faisal Mahmood, Steinbjorn Hansen, Olfred Hansen, Carsten Brink, Uffe Bernchou
Summary: This study investigated the potential benefits of MR-guided online adapted radiotherapy (MRgART) compared to standard radiotherapy for high-risk prostate cancer. The results showed that MRgART resulted in lower doses to critical organs and reduced the risks of urine incontinence, urine voiding pain, and acute gastrointestinal toxicity in comparison to standard radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2022)
Review
Oncology
Daniela Thorwarth, Daniel A. Low
Summary: MR-guided cancer treatment technology has the potential to revolutionize the field of radiotherapy, but still faces technical challenges such as magnetic field strength tradeoffs, limitations of purely MR-based RT workflows, and the potential of real-time 3D MR imaging for real-time RT.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Uros Stankovic, Lennert S. Ploeger, Jan-Jakob Sonke
Summary: Tube current modulation (TCM) has the potential to improve CBCT image quality, but its effectiveness depends on the amount of detected x-ray scatter.
Article
Engineering, Biomedical
Benjamin K. F. Lau, Tess Reynolds, Andrew Wallis, Sandie Smith, Armia George, Paul J. Keall, Jan-Jakob Sonke, Shalini K. Vinod, Owen Dillon, Ricky T. O'Brien
Summary: Adaptive 4DCBCT has been developed to reduce imaging dose and scan time, and this study investigated reconstruction algorithms for optimal image quality. Real patient data from the first 10 adaptive 4DCBCT patients were used to assess imaging dose reduction and scan time improvement compared to conventional 4DCBCT. Reconstruction algorithms FDK, MKB, MCFDK, and MCMKB were evaluated based on SSIM, SNR, CNR, TIS-D, and TIS-T metrics, showing significant image quality improvements with adaptive 4DCBCT acquisitions.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
V. Mohan, N. M. Bruin, M. E. T. Tesselaar, J. P. de Boer, E. Vegt, J. J. M. A. Hendrikx, A. Al-Mamgani, J. B. van de Kamer, J. -J. Sonke, W. V. Vogel
Summary: The study aimed to investigate whether the antimuscarinic drug glycopyrronium bromide (GPB) could reduce the accumulation of radiotracers in the salivary glands. Results showed that GPB did not significantly affect the uptake of PSMA ligands or radioiodine in the salivary glands.
Article
Oncology
Jean-Pierre Bissonnette, Alexander Sun, Inga S. Grills, Muayad F. Almahariq, Geoffrey Geiger, Wouter Vogel, Jan-Jakob Sonke, Sarah Everitt, Michael Mac Manus
Summary: This study showed that the disease progression rate in NSCLC patients is associated with the interval between PET/CT scans and RT planning, with higher stage migration rates observed in patients with more severe initial nodal involvement and adenocarcinoma.
Article
Oncology
Anna C. Nuijens, Arlene L. Oei, Bregje van Oorschot, Jorrit Visser, Rob M. van Os, Perry D. Moerland, Nicolaas A. P. Franken, Coen R. N. Rasch, Lukas J. A. Stalpers
Summary: This study investigated the contribution of genetic predisposition and dose-volume factors to late radiation toxicity in cancer patients treated with highly conformal radiation therapy. The results suggest that impaired DNA double-strand break repair is the critical determining factor of late radiation toxicity.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
A. Clough, J. Sanders, K. Banfill, C. Faivre-Finn, G. Price, C. L. Eccles, M. C. Aznar, M. Van Herk
Summary: Thoracic CT plays a crucial role in the early diagnosis of COVID-19 patients. The study shows that COVID-19 infection can be detected on CBCT, providing assistance in patient management and staff protection.
Article
Engineering, Biomedical
Benjamin K. F. Lau, Tess Reynolds, Paul J. Keall, Jan-Jakob Sonke, Shalini K. Vinod, Owen Dillon, Ricky T. O'Brien
Summary: This study investigates the dose and time limits of adaptive 4DCBCT acquisitions compared with current conventional 4DCBCT acquisition. The results show that adaptive-acquisition with lower imaging dose and faster scan time can achieve equivalent or improved image quality compared to conventional-acquisition.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lukas Schroder, Uros Stankovic, Simon Rit, Jan-Jakob Sonke
Summary: Improvement of image quality in cone beam computed tomography scans can be achieved through dual energy imaging and iterative reconstruction, particularly in image quality phantoms.
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS
(2022)
Article
Engineering, Biomedical
Erik van der Bijl, Peter Remeijer, Jan-Jakob Sonke, Uulke A. van der Heide, Tomas Janssen
Summary: This study introduces a method to update treatment margins based on patient treatment history and explores the potential benefits of adaptive margins. The results show that using adaptive margins can reduce margins in most patients without compromising those with greater than average target motion.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Engineering, Biomedical
Carlos Huesa-Berral, Celia Juan-Cruz, Simon van Kranen, Maddalena Rossi, Jose Belderbos, Juan Diego Azcona, Javier Burguete, Jan-Jakob Sonke
Summary: This study evaluates and validates the dosimetric effect of respiratory motion and inter-fraction variations in SBRT using 4D-CT and daily 4D-CBCT dose accumulation scenarios. The results show that both 4D-Acc and 3D-Acc have an impact on the dose, especially in the tumor and organs at risk region. The effectiveness of CT-CBCT deformable image registration techniques is also validated.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Martijn H. van der Ree, Edith M. T. Dieleman, Jorrit Visser, R. Nils Planken, S. Matthijs Boekholdt, Rianne H. A. de Bruin-Bon, Coen R. N. Rasch, Wiert F. Hoeksema, Rianne M. A. J. de Jong, Michiel J. B. Kemme, Jippe C. Balt, Arthur A. M. Wilde, Brian Balgobind, Pieter G. Postema
Summary: This study aims to evaluate the efficacy and safety of Stereotactic Arrhythmia Radiotherapy (STAR). It found that STAR can reduce the number of treated ventricular tachycardia episodes by more than 50% in 67% of patients with therapy-refractory VT. No decrease in cardiac and pulmonary function or treatment-related serious adverse events were observed during follow-up.
Article
Oncology
Miet Vandemaele, Marianne Aznar, Pierre Blanchard, Josep M. Borras, Michelle Leech, Ajay Aggarwal, Yolande Lievens
Summary: In order to address the evaluation issue of radiotherapy innovations, the HERO project of ESTRO has initiated the development of a radiotherapy-specific value-based framework. A systematic literature search revealed no widely accepted definition or classification system for radiotherapy innovations. However, the unique properties of radiotherapy interventions can be used to categorize innovations in radiation oncology, but clear terminology denoting radiotherapy-specific characteristics is still needed.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
Buket Kinaci-Tas, Tanja Alderliesten, Frank D. Verbraak, Coen R. N. Rasch
Summary: Retinopathy and optic neuropathy are common and severe ocular complications in patients undergoing radiation therapy for brain, head, and neck cancer. However, there is limited knowledge about the prevalence and dose-response relationship of these complications. Further research is needed to improve the precision of radiation therapy.
Article
Oncology
S. Gaito, N. G. Burnet, M. C. Aznar, G. Marvaso, B. A. Jereczek-Fossa, A. Crellin, D. Indelicato, S. Pan, R. Colaco, R. Rieu, E. Smith, G. Whitfield
Summary: This systematic review examines the use of proton beam therapy (PBT) in the management of recurrent central nervous system (CNS) and base of skull (BoS) tumors. The findings suggest that PBT can provide good local control with acceptable toxicity rates in the reirradiation setting. However, there are several factors to consider that may increase the risk of toxicities in CNS or BoS tumor recurrences, highlighting the importance of patient selection.
Editorial Material
Cardiac & Cardiovascular Systems
Marianne Aznar, Anju Nohria
EUROPEAN HEART JOURNAL
(2023)
