Journal
REACTIVE & FUNCTIONAL POLYMERS
Volume 140, Issue -, Pages 103-110Publisher
ELSEVIER
DOI: 10.1016/j.reactfunctpolym.2019.04.013
Keywords
POSS; Click chemistry; Drug delivery; Antibacterial activity
Funding
- National Natural Science Foundation of China (NSFC) [21604093, 81071454, 51803188]
- Beijing Novel Program [Z181100006218059]
- Beijing Natural Science Foundation [7184249]
- China Postdoctoral Science Foundation [2018M642783]
- Henan Postdoctoral Science Foundation [001801001]
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Here we demonstrate a general approach to crafting a myriad of soluble octa-functionalized POSS derivatives by manipulating the sequential click reactions. After flexible modification with bio-functional groups, these uniform POSSs possess good biocompatibility, remarkable anticancer therapeutic effect and outstanding antibacterial activity in aqueous solutions. Notably, this 'one-pot' approach provides a simple strategy to produce customized POSS macromolecules, which may afford a novel platform for clear elucidation of more complex mechanisms and precise fabrication of high-performance biomaterials in various applications.
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