Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs

Plasma kallikrein cleaves and inactivates apelin-17: Palmitoyl- and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents

(2019) Conrad Fischer et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cell-Specific Functions of ADAM17 Regulate the Progression of Thoracic Aortic AneurysmNovelty and Significance

(2018) Mengcheng Shen et al.   CIRCULATION RESEARCH

The exerkine apelin reverses age-associated sarcopenia

(2018) Claire Vinel et al.   NATURE MEDICINE

Apelin Is a Negative Regulator of Angiotensin II–Mediated Adverse Myocardial Remodeling and DysfunctionNovelty and Significance

(2017) Zhen-Zhou Zhang et al.   HYPERTENSION

Synthetic Modification within the “RPRL” Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation

(2017) Shaun M. K. McKinnie et al.   JOURNAL OF MEDICINAL CHEMISTRY

Roles of Angiotensin Peptides and Recombinant Human ACE2 in Heart Failure

(2017) Ratnadeep Basu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter

(2017) Alexander G. Bick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Metalloprotease Neprilysin Degrades and Inactivates Apelin Peptides

(2016) Shaun M. K. McKinnie et al.   CHEMBIOCHEM

Role of the ACE2/Angiotensin 1–7 Axis of the Renin–Angiotensin System in Heart Failure

(2016) Vaibhav B. Patel et al.   CIRCULATION RESEARCH

Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17Novelty and Significance

(2016) Wang Wang et al.   HYPERTENSION

Divergent Roles of Matrix Metalloproteinase 2 in Pathogenesis of Thoracic Aortic AneurysmSignificance

(2015) Mengcheng Shen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Genetic targeting of sprouting angiogenesis using Apln-CreER

(2015) Qiaozhen Liu et al.   Nature Communications

Angiotensin-Converting Enzyme 2 Is a Critical Determinant of Angiotensin II–Induced Loss of Vascular Smooth Muscle Cells and Adverse Vascular Remodeling

(2014) Vaibhav B. Patel et al.   HYPERTENSION

Gender-dependent aortic remodelling in patients with bicuspid aortic valve-associated thoracic aortic aneurysm

(2014) Jiwon Lee et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Abdominal Aortic Aneurysms

(2014) K. Craig Kent   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacokinetics and Pharmacodynamics of Recombinant Human Angiotensin-Converting Enzyme 2 in Healthy Human Subjects

(2013) Manuel Haschke et al.   CLINICAL PHARMACOKINETICS

The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis

(2013) Anne-Marie O'Carroll et al.   JOURNAL OF ENDOCRINOLOGY

Prevalence and Trends of the Abdominal Aortic Aneurysms Epidemic in General Population - A Meta-Analysis

(2013) Xi Li et al.   PLoS One

Loss of Apelin Exacerbates Myocardial Infarction Adverse Remodeling and Ischemia‐reperfusion Injury: Therapeutic Potential of Synthetic Apelin Analogues

(2013) Wang Wang et al.   Journal of the American Heart Association

Loss of Angiotensin-Converting Enzyme-2 Exacerbates Diabetic Cardiovascular Complications and Leads to Systolic and Vascular Dysfunction

(2012) Vaibhav B. Patel et al.   CIRCULATION RESEARCH

Loss ofTimp3Gene Leads to Abdominal Aortic Aneurysm Formation in Response to Angiotensin II

(2012) Ratnadeep Basu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

APJ acts as a dual receptor in cardiac hypertrophy

(2012) Maria Cecilia Scimia et al.   NATURE

Lessons on the pathogenesis of aneurysm from heritable conditions

(2011) Mark E. Lindsay et al.   NATURE

Angiotensin-Converting Enzyme 2 Suppresses Pathological Hypertrophy, Myocardial Fibrosis, and Cardiac Dysfunction

(2010) JiuChang Zhong et al.   CIRCULATION

Acute Cardiovascular Effects of Apelin in Humans

(2010) A.G. Japp et al.   CIRCULATION

International Union of Basic and Clinical Pharmacology. LXXIV. Apelin Receptor Nomenclature, Distribution, Pharmacology, and Function

(2010) S. L. Pitkin et al.   PHARMACOLOGICAL REVIEWS

ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice

(2009) Lisa A. Cassis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Medical Management of Small Abdominal Aortic Aneurysms

(2008) B. Timothy Baxter et al.   CIRCULATION