Article
Surgery
Richard Wagner, Paula Lieckfeldt, Hadeesha Piyadasa, Moritz Markel, Jan Riedel, Camelia Stefanovici, Nicole Peukert, Daywin Patel, Gabrielle Derraugh, Suyin A. Lum Min, Jan-Hendrik Gosemann, Jan Deprest, Christopher D. Pascoe, Wai Hei Tse, Martin Lacher, Neeloffer Mookherjee, Richard Keijzer
Summary: The pathogenesis of lung hypoplasia in congenital diaphragmatic hernia (CDH) remains unclear. Proteomic analysis revealed significant differences in inflammatory response proteins between CDH lungs and non-CDH control lungs. Tenascin C was decreased while STAT3 was significantly increased in CDH lungs. Inhibition of STAT3 partially rescued the hypoplastic lung phenotype in CDH. These findings indicate the involvement of downstream inflammatory processes in the abnormal lung development of CDH.
Article
Pediatrics
June-Young Koh, Euiseok Jung, Hyun Woo Goo, Seong-Chul Kim, Dae Yeon Kim, Jung-Man Namgoong, Byong Sop Lee, Ki-Soo Kim, Ellen Ai-Rhan Kim
Summary: The study focused on evaluating the long-term pulmonary development in children with repaired CDH and found that 25% of the children had abnormal pulmonary function, with 87% showing restrictive patterns. Smaller head and abdominal circumferences at birth were significantly associated with worse pulmonary function.
Review
Biochemistry & Molecular Biology
Flaminia Pugnaloni, Irma Capolupo, Neil Patel, Paola Giliberti, Andrea Dotta, Pietro Bagolan, Florian Kipfmueller
Summary: This review highlights the importance of miRNAs in CDH-related PH and summarizes the findings from animal and human CDH studies. The focus on epigenetic modulators of CDH-PH offers potential for developing innovative diagnostic tools and treatment approaches, and enhances researchers' understanding of CDH pathophysiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Alecsander F. Bressan, Victoria Oliveira Maia, Beatriz de Souza Rodrigues, Giuliana Bertozi, Sabrina S. Batah, Alexandre T. Fabro, Gloria Pelizzo, Ugo Maria Pierucci, Rita C. Tostes, Lourenco Sbragia, Fernando S. Carneiro
Summary: Congenital diaphragmatic hernia (CDH) can cause abnormalities in the pulmonary arteries of both the contralateral and ipsilateral sides of the diaphragm. Nitric oxide (NO) is commonly used to treat CDH but may not always be effective. This study investigated the different responses of the left and right pulmonary arteries to a NO donor in a rabbit model of left CDH. The results showed that newborns with CDH had increased vasorelaxant responses to the NO donor compared to the control group, possibly due to increased cGMP mobilization.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Pediatrics
Moritz Markel, Wai Hei Tse, Nolan DeLeon, Daywin Patel, Shana Kahnamouizadeh, Martin Lacher, Richard Wagner, Richard Keijzer
Summary: The absence of miR-200b results in abnormal lung development, with dysregulation of Tenascin C potentially contributing to lung hypoplasia in miR-200b(-/-) mice.
PEDIATRIC SURGERY INTERNATIONAL
(2022)
Letter
Pediatrics
Huiyong Hu, Xiaoping Jing, Xiuhua Duan, Leiping Zhou, Yunfeng Xu
Summary: A fetus was diagnosed with a right diaphragmatic hernia during a late second trimester prenatal ultrasound. A green channel with multi department dynamic monitoring was implemented, and at 40 + 4 weeks, the infant underwent successful hernia repair under general anesthesia. Post-operation, the infant's vital signs were stable and their condition remained good during follow-up.
PEDIATRIC PULMONOLOGY
(2023)
Article
Medicine, General & Internal
Felix Rafael De Bie, Christopher Gates Halline, Travis Kotzur, Kevin Hayes, Christopher Copeland Rouse, Jonathan Chang, Abby Christine Larson, Sameer Ahmad Khan, Ashley Spina, Samantha Tilden, Francesca Maria Russo, Holly Lee Hedrick, Jan Deprest, Emily Anne Partridge
Summary: In a nitrofen rat model, prenatal administration of treprostinil significantly reduces pulmonary arteriole muscularization. These results suggest that prophylactic treatment may be a potential approach for managing CDH-related PH.
Article
Anatomy & Morphology
Mar Janna Dahl, Anna Lavizzari, Jonathan W. Davis, Peter B. Noble, Raffaele Dellaca, J. Jane Pillow
Summary: The extent of lung hypoplasia affects the outcomes of infants with congenital diaphragmatic hernia. Current treatments aim to balance the need for increased gas exchange surface area with the restoration of pulmonary epithelial cells and consideration of long-term effects of prematurity. Sufficient lung development in utero requires intra-thoracic space, appropriate composition of fetal lung fluid, regular fetal breathing movements, adequate gas exchange area, and surfactant production.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2022)
Article
Medicine, General & Internal
Ricards Kaulins, Laura Ramona Rozite, Mara Pilmane, Aigars Petersons
Summary: Congenital diaphragm hernia (CDH) is a congenital disease that occurs during prenatal development with significant morbidity and mortality rates. This study evaluated the expression of various growth factors and markers in CDH pathological tissues, revealing multiple morphopathogenetic pathways at play in CDH pathogenesis.
Article
Pediatrics
R. Gregorio-Hernandez, C. Ramos-Navarro, S. Vigil-Vazquez, E. Rodriguez-Corrales, A. Perez-Perez, M. Arriaga-Redondo, M. Sanchez-Luna
Summary: Lung ultrasound is a valuable tool for assessing pulmonary aeration in neonates, including those with congenital diaphragmatic hernia (CDH). In this study, lung ultrasound examinations were performed on 8 CDH patients before and after surgical correction, and compared between two groups based on mechanical ventilation duration. Lung ultrasound showed potential for diagnosing postoperative complications without radiation exposure and offered quick and serial assessments. These findings highlight the importance of lung ultrasound as an effective alternative to conventional imaging methods in managing CDH.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Pediatrics
Arimatias Raitio, Adeline Salim, Paul D. Losty
Summary: This study suggests that newborns with a hernia sac in congenital diaphragmatic hernia (CDH) have significant survival benefits compared to those without a sac. This may be due to more favorable physiology, less severe pulmonary hypertension, and smaller anatomical defects requiring primary closure only in infants with a hernia sac.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Pediatrics
Aabha A. Anekar, Sumana Nanjundachar, Dhaneshgouda Desai, Jafferali Lakhani, Prakash M. Kabbur
Summary: This case report highlights a late-diagnosed congenital diaphragmatic hernia in an 8-year-old boy presenting with respiratory distress, chest pain, and non-bilious vomiting. Late-presenting CDH should be considered in pediatric patients with respiratory distress, chest pain, non-bilious vomiting, and radiological findings suggestive of tension pneumothorax.
FRONTIERS IN PEDIATRICS
(2021)
Review
Surgery
Xiao-Yue Han, Leigh Taryn Selesner, Marilyn W. Butler
Summary: Congenital diaphragmatic hernia (CDH) is a surgical disease primarily affecting newborn infants, requiring timely diagnosis and treatment. Management involves interventions such as endotracheal intubation, fluid resuscitation, and echocardiographic evaluation. After surgical repair, infants may experience various morbidities.
SURGICAL CLINICS OF NORTH AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Mayo Miura, Kenji Imai, Hiroyuki Tsuda, Rika Miki, Sho Tano, Yumiko Ito, Shima Hirako-Takamura, Yoshinori Moriyama, Takafumi Ushida, Yukako Iitani, Tomoko Nakano-Kobayashi, Shinya Toyokuni, Hiroaki Kajiyama, Tomomi Kotani
Summary: The study demonstrated that molecular hydrogen (H-2) as an antioxidant can improve respiratory function in CDH rat models by attenuating lung morphology and pulmonary artery thickening, enhancing alveolarization and pulmonary artery remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Daphne S. Mous, Marjon J. Buscop-van Kempen, Rene M. H. Wijnen, Dick Tibboel, Rory E. Morty, Robbert J. Rottier
Summary: Studies on the activation of TGF beta and BMP signaling pathways in CDH are limited and inconsistent. However, research on a nitrofen-CDH rat model suggests increased activation of TGF beta pathway and decreased activation of BMP pathway in pulmonary vasculature, which may contribute to the development of pulmonary hypertension in CDH.
FRONTIERS IN MEDICINE
(2021)
Review
Genetics & Heredity
Lennart Van der Veeken, Simen Vergote, Yada Kunpalin, Karl Kristensen, Jan Deprest, Matteo Bruschettini
Summary: In children with isolated congenital diaphragmatic hernia, 16% experience neurodevelopmental delay, primarily linked to motor issues with lesser impact on cognitive dysfunction and hearing problems. More research focusing on this population, especially those who underwent fetal surgery, is needed for accurate patient counseling.
PRENATAL DIAGNOSIS
(2022)
Article
Obstetrics & Gynecology
Ann-Sophie Page, Jan Y. Verbakel, Johan Verhaeghe, Yani P. Latul, Susanne Housmans, Jan Deprest
Summary: The study aimed to assess whether CO2 laser treatment is more effective than sham application in relieving symptoms in women with genitourinary syndrome of menopause (GSM). The results showed that the treatment response after 12 weeks of laser application was comparable to that of the sham applications, and no serious adverse events were reported.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Genetics & Heredity
Aymara Taillieu, Jan Deprest, Simen Vergote, Anne Debeer, Francesca Maria Russo, Beverley Power, Frank Meijer, Neeltje Crombag
Summary: This study aimed to identify patient-reported outcomes for parents with a prenatal diagnosis of isolated congenital diaphragmatic hernia (CDH). Thematic analysis of in-depth interviews identified 11 key outcomes throughout the CDH trajectory, including survival chances, maternal complications, and family impact. These outcomes provide important directions for clinicians to support parents and their family in making challenging healthcare decisions.
PRENATAL DIAGNOSIS
(2023)
Article
Genetics & Heredity
Yada Kunpalin, Simen Vergote, Luc Joyeux, Onur Telli, Anna L. David, Michael Belfort, Paolo De Coppi, Jan Deprest
Summary: A study on commercially available patches used in fetal rabbit models for spina bifida repair found that covering the spinal cord with Duragen or Durepair and closing the skin preserves motor neuron density and reduces the inflammatory response.
PRENATAL DIAGNOSIS
(2023)
Article
Engineering, Biomedical
Sophia Bano, Francisco Vasconcelos, Anna L. David, Jan Deprest, Danail Stoyanov
Summary: Fetoscopic video mosaicking can create an expanded field-of-view image of the fetoscopic intraoperative environment to support surgeons during twin-to-twin transfusion syndrome treatment. However, existing methods relying on vessel presence have limitations. We propose a vessel-guided hybrid fetoscopic mosaicking framework that combines placental vessel-based registration and deep learning-based dense matching to improve overall performance. Experimental results demonstrate the robustness of the proposed framework over state-of-the-art methods, even in vessel-free and low-textured fetoscopic views.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING-IMAGING AND VISUALIZATION
(2023)
Article
Clinical Neurology
T. Deprest, L. Fidon, F. De Keyzer, M. Ebner, J. Deprest, P. Demaerel, L. De Catte, T. Vercauteren, S. Ourselin, S. Dymarkowski, M. Aertsen
Summary: This study tested an algorithm for segmenting abnormal fetal brains and found that it achieved good results in fetuses with severe brain abnormalities. However, it is necessary to include rare cases in the current dataset and quality control measures should be implemented to prevent occasional errors.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Obstetrics & Gynecology
Emily J. J. Horn-Oudshoorn, Francesca M. Russo, Jan A. Deprest, Florian Kipfmueller, Annegret Geipel, Thomas Schaible, Neysan Rafat, Anne-Gael Cordier, Alexandra Benachi, Nimrah Abbasi, Priscilla P. L. Chiu, Willem P. de Boode, Esther Sikkel, Nina C. J. Peters, Bettina E. Hansen, Irwin K. M. Reiss, Philip L. J. DeKoninck
Summary: This retrospective cohort study aimed to describe the outcomes of preterm born infants with congenital diaphragmatic hernia (CDH) and investigate the associations between prenatal imaging markers and survival. The results showed that prenatal imaging markers, including lung-to-head ratio, stomach position, and total fetal lung volume, were associated with postnatal survival in infants with CDH born at or before 32 weeks of gestation.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Acoustics
B. Packet, A. -s. Page, L. Cattani, J. Bosteels, J. Deprest, J. Richter
Summary: This systematic review investigates predictive factors for obstetric anal sphincter injury (OASI) occurrence at first vaginal delivery using ultrasound diagnosis. The study found that increasing gestational age at delivery, shorter antepartum perineal body length, labor augmentation, instrumental delivery, shoulder dystocia, episiotomy use, and shorter episiotomy length were associated with ultrasound-diagnosed OASI.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Emma Bauters, Ann-Sophie Page, Laura Cattani, Susanne Housmans, Frank Van der Aa, Andre D'Hoore, Jan Deprest
Summary: This study compared the outcomes of 39 patients who underwent redo laparoscopic sacrocolpopexy (LSCP) with 156 patients who had primary LSCP, and found that redo LSCP carries a higher risk of complications but has comparable efficacy to the primary procedure.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Article
Genetics & Heredity
Veronika Beck, Guy Froyen, Sebastiaan Deckx, Inga Sandaite, Thomas Deprest, Koen Plevoets, Jan A. Deprest
Summary: The duration of tracheal occlusion in rats with congenital diaphragmatic hernia can predict lung growth and airway development, while the timepoint of occlusion does not have a significant impact. Prolonged occlusion results in enhanced lung growth, increased cell proliferation, and more refined airway architecture.
PRENATAL DIAGNOSIS
(2023)
Article
Genetics & Heredity
Simen Vergote, Francesca Maria Russo, David Basurto, Jan Deprest, Neeltje Crombag
Summary: The survey shows that most maternal-fetal medicine specialists consider the risk-benefit ratio of FETO for severe LCDH and RCDH clear and often offer this treatment option. However, they are uncertain about the risks and benefits of FETO for moderate LCDH and severe RCDH, and therefore do not frequently offer this option. However, not offering FETO to parents is considered a psychological burden.
PRENATAL DIAGNOSIS
(2023)
Article
Cell Biology
Josep Mercader-Barcelo, Aina Martin-Medina, Joan Truyols-Vives, Gabriel Escarrer-Garau, Linda Elowsson, Ana Montes-Worboys, Carlos Rio-Bocos, Josep Muncunill-Farreny, Julio Velasco-Roca, Anna Cederberg, Mans Kadefors, Maria Molina-Molina, Gunilla Westergren-Thorsson, Ernest Sala-Llinas
Summary: Idiopathic pulmonary fibrosis (IPF) is characterized by abnormal repair response and uncontrolled turnover of extracellular matrix. Lung resident mesenchymal stem cells (LRMSC) are believed to play an important role in IPF, but their contribution is not fully understood. This study analyzed LRMSC isolated from IPF patients and control patients, and found that oxidative phosphorylation was dysregulated in IPF LRMSC. Additionally, mitochondrial dysfunction and impaired autophagy response were observed in IPF LRMSC, which might contribute to the development of IPF.
Article
Engineering, Biomedical
Viktor Voros, Jef De Smet, Mouloud Ourak, Vladimir Poliakov, Jan Deprest, Tom Kimpe, Emmanuel Vander Poorten
Summary: This study investigates the use and benefits of an autostereoscopic (3D) display in a simulated laparoscopic task, aiming to restore the sense of depth. Results show that 3D vision improves task completion time, total traveled distance, and error rate compared to 2D visualization.
INTERNATIONAL JOURNAL OF COMPUTER ASSISTED RADIOLOGY AND SURGERY
(2023)
Article
Obstetrics & Gynecology
Nada Mufti, Michael Aertsen, Dominic Thomson, Phillippe De Vloo, Philippe Demaerel, Jan Deprest, Andrew Melbourne, Anna L. David
Summary: This study investigated the use of fetal magnetic resonance imaging (MRI) for open spina bifida (OSB) patients eligible for fetal surgery. The results showed that there was timely access to supervised MRI, but the acquisition of important imaging parameters was not widespread. Specific guidance for fetal MRI for OSB is suggested.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Review
Genetics & Heredity
Yair J. Blumenfeld, Kunj R. Sheth, Eric Johnson, James K. Wall, Jan A. Deprest, Francesca M. Russo, Enrico Danzer
Summary: Fetal lower urinary tract obstruction (LUTO) is a severe malformation that can lead to high mortality and morbidity. Fetal vesico-amniotic shunts (VAS) have been used to bypass the obstruction, but currently available shunts have high dislodgement rates. We have developed a novel Vortex shunt that aims to improve deployment accuracy and reduce dislodgement risk.
PRENATAL DIAGNOSIS
(2023)
