Article
Oncology
Carrie Anne Minnaar, Innocent Maposa, Jeffrey Allan Kotzen, Ans Baeyens
Summary: This study investigated the effects of adding modulated electro-hyperthermia (mEHT) to chemoradiotherapy for the management of locally advanced cervical cancer in resource-constrained settings. The results showed that mEHT significantly improved disease-free survival rates at two and three years, as well as quality of life, and also resulted in cost savings. The effect was most significant in patients with Stage III disease and those with distant nodal metastases.
Article
Oncology
Ruby Mcharo, Tessa Lennemann, John France, Liseth Torres, Merce Gari, Wilbert Mbuya, Wolfram Mwalongo, Anifrid Mahenge, Asli Bauer, Jonathan Mnkai, Laura Glasmeyer, Mona Judick, Matilda Paul, Nicolas Schroeder, Bareke Msomba, Magreth Sembo, Nhamo Chiwerengo, Michael Hoelscher, Otto Geisenberger, Ralph J. Lelle, Elmar Saathoff, Leonard Maboko, Mkunde Chachage, Arne Kroidl, Christof Geldmacher
Summary: In sub-Saharan Africa, women living with HIV are at increased risk for developing cervical cancer. Factors such as age, HIV status, and CD4 T cell counts are independent risk factors for HPV infections, predominantly caused by HR-HPV types. Specific attention should be paid to HPV16, 18, and 45 during cervical cancer prevention programs for HIV+ women from this region.
FRONTIERS IN ONCOLOGY
(2021)
Article
Virology
Ongeziwe Taku, Zizipho Z. A. Mbulawa, Keletso Phohlo, Mirta Garcia-Jardon, Charles B. Businge, Anna-Lise Williamson
Summary: South African women in the Eastern Cape province have a high prevalence of HPV infection in CIN, especially in HIV-positive individuals. The study found a higher rate of multiple HPV types in HIV-positive women and identified common HPV genotypes in CIN2 and CIN3 cases. The nonavalent HPV vaccine could offer some benefits in preventing CIN2 and CIN3 in both HIV-negative and HIV-positive women, although complete protection may not be guaranteed.
Review
Oncology
Attila Marcell Szasz, Elisabeth Estefania Arrojo Alvarez, Giammaria Fiorentini, Magdolna Herold, Zoltan Herold, Donatella Sarti, Magdolna Dank
Summary: In this meta-analysis, the effects of modulated electro-hyperthermia (mEHT) and Tumor Treating Fields (TTF) in the treatment of glioblastoma were investigated. The results showed that both mEHT and TTF can improve patient survival rates, with the most benefit observed in newly diagnosed cases.
Article
Oncology
Yohan Lee, Sunghyun Kim, Hyejung Cha, Jae Hun Han, Hyun Joon Choi, Eun Go, Sei Hwan You
Summary: This study demonstrates the feasibility and potential therapeutic effects of using 13.56 MHz modulated electro-hyperthermia (mEHT) boost in neoadjuvant treatment for rectal cancer. It also suggests that mEHT could be a useful tool in combination treatment with radiotherapy due to its low thermotoxicity and improved treatment compliance.
Article
Multidisciplinary Sciences
Oppah Kuguyo, Racheal S. Dube Mandishora, Nicholas Ekow Thomford, Rudo Makunike-Mutasa, Charles F. B. Nhachi, Alice Matimba, Collet Dandara
Summary: This study compared the frequency, multiplicity, and consanguinity of HR-HPVs in HIV-negative and HIV-positive Zimbabwean women with cervical cancer. The results showed that HIV status does not influence the HR-HPV status in cervical cancer patients. The most prevalent genotypes were HPV16, HPV35, and HPV18 in HR-HPV positive samples.
Article
Medicine, General & Internal
Tafadzwa Dhokotera, Julia Bohlius, Matthias Egger, Adrian Spoerri, Jabulani Ronnie Ncayiyana, Gita Naidu, Victor Olago, Marcel Zwahlen, Elvira Singh, Mazvita Muchengeti
Summary: This study aimed to determine the spectrum of cancers in adolescents and young adults living with and without HIV in South Africa. The results showed that young people living with HIV were more likely to have certain types of cancers compared to those without HIV.
Article
Pediatrics
Candice W. Ramsammy, Lisa Galvin, Celeste Joyce, Given Leshabane, Janice Buckley, Kennedy Otwombe, Afaaf Liberty, Avy Violari
Summary: This study describes the responses of children during a longitudinal disclosure study conducted in South Africa. The findings show that children who received full disclosure had mixed responses, with many experiencing strong negative emotions. However, through reassurance and subsequent counseling sessions, some children showed emotional improvement. The study also observed improvements in the communication and relationship between caregivers and children. Nevertheless, some children were avoidant of the topic of HIV.
FRONTIERS IN PEDIATRICS
(2022)
Article
Oncology
Tamas Vancsik, Domokos Mathe, Ildiko Horvath, Anett Anna Varallyaly, Anett Benedek, Ralf Bergmann, Tibor Krenacs, Zoltan Benyo, Andrea Balogh
Summary: mEHT as a monotherapy for melanoma xenograft tumors induces irreversible heat and cell stress, leading to caspase-dependent apoptosis driven by p53. mEHT can facilitate the intratumoral attraction of distantly injected NK cells, contributed by upregulation of CXCL11 and MMP2, resulting in additive tumor destruction and growth inhibition. Therefore, mEHT may serve as a promising partner for immunotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biophysics
Sara I. Abdelsalam, Jorge X. Velasco-Hernandez, A. Z. Zaher
Summary: This study investigates the electro-magneto-biomechanics of sperm swimming through the cervical canal in the female reproductive system. By applying an external magnetic field, the transport of sperm can be controlled, and the results show that an increase in the electric field reduces the propulsive velocity, which is an important feature for controlling sperm transport.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)
Article
Medicine, General & Internal
Sun Young Lee, Dong Hyun Lee, Dong-Hyu Cho
Summary: In this observational retrospective study, it was found that the addition of modulated electrohyperthermia (mEHT) to concurrent chemoradiotherapy (CCRT) improved the therapeutic response in locally advanced cervical cancer (LACC) patients with lymph node metastasis. The complete remission rate and no-evidence-of-disease rate were significantly higher in LACC cases treated with CCRT + mEHT compared to CCRT alone. Disease-free survival also increased in the CCRT + mEHT group with lymph node metastasis.
Article
Medicine, General & Internal
Andris M. Evans, Mikhail Salnikov, Steven F. Gameiro, Saman Maleki Vareki, Joe S. Mymryk
Summary: HPV-negative cervical cancers have distinct disease phenotypes and immune characteristics compared to HPV-positive cervical cancers. They also exhibit a higher expression of potential neoantigens.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Sunghyun Kim, Jun Hyeok Lee, Jihye Cha, Sei Hwan You
Summary: Analysis of clinical data from 120 patients with locally advanced rectal cancer revealed that Purpose Modulated electro-hyperthermia (mEHT) combined with neoadjuvant therapy may enhance tumor response, reduce radiation doses, improve tumor regression, decrease gastrointestinal toxicity, and increase 2-year disease-free survival rate.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Article
Biochemistry & Molecular Biology
Matilde Sanchez-Conde, Claudio Alba, Irma Castro, Fernando Dronda, Margarita Ramirez, Rebeca Arroyo, Santiago Moreno, Juan Miguel Rodriguez, Fatima Branas
Summary: Comparing the fecal bacteriome of people with HIV and non-HIV controls, it was found that the composition of the bacteriome in people with HIV is different, and there may be a link between depression and gut dysbiosis in the HIV population.
Article
Medical Laboratory Technology
Hafsa Aziz, Areej A. Sattar, Humera Mahmood, Shazia Fatima, Mona Khurshid, Mohammad Faheem
Summary: The prevalence of HPV was higher in HIV-positive females (36.9%) compared to HIV-negative females (4.4%). High-risk HPV types, such as HPV18, HPV16, HPV58, HPV45, HPV68, and HPV33, were identified and were found to be associated with low-grade squamous intraepithelial lesions. Risk factors such as age, educational status, and contraceptive use were found to be correlated with HPV infection.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Article
Oncology
Carrie Anne Minnaar, Jeffrey Allan Kotzen, Olusegun Akinwale Ayeni, Mboyo-Di-Tamba Vangu, Ans Baeyens
FRONTIERS IN ONCOLOGY
(2020)
Article
Health Care Sciences & Services
Simon Sioen, Karlien Cloet, Anne Vral, Ans Baeyens
JOURNAL OF PERSONALIZED MEDICINE
(2020)
Article
Biology
Elien Beyls, Ans Baeyens, Anne Vral
Summary: This study successfully applied the MN assay on cryopreserved whole blood samples, demonstrating its reliability for radiosensitivity testing. Repeated analysis showed that MN values in cryopreserved blood samples remain stable for up to one year of storage. Radiosensitive patients were successfully identified using the MN assay on cryopreserved samples.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Dineo Mpanya, Akinwale Ayeni, Stuart More, Bawinile Hadebe, Mike Sathekge, Nqoba Tsabedze
Summary: Current guidelines recommend timely revascularisation for acute coronary syndromes, but many patients in LMIC or remote areas in HIC do not have immediate access to this treatment, resulting in delayed intervention and potentially worse outcomes.
CLINICAL AND TRANSLATIONAL IMAGING
(2022)
Article
Multidisciplinary Sciences
Monique Engelbrecht, Roya Ndimba, Maryna de Kock, Xanthene Miles, Shankari Nair, Randall Fisher, Peter du Plessis, Julie Bolcaen, Matthys Hendrik Botha, Elbie Zwanepoel, Simon Sioen, Ans Baeyens, Jaime Nieto-Camero, Evan de Kock, Charlot Vandevoorde
Summary: The study showed that HSPCs exhibit higher DNA damage induction after neutron irradiation, leading to increased apoptosis rate and levels of cytogenetic damage, which contribute to a higher risk of leukemogenesis.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Carrie Anne Minnaar, Innocent Maposa, Jeffrey Allan Kotzen, Ans Baeyens
Summary: This study investigated the effects of adding modulated electro-hyperthermia (mEHT) to chemoradiotherapy for the management of locally advanced cervical cancer in resource-constrained settings. The results showed that mEHT significantly improved disease-free survival rates at two and three years, as well as quality of life, and also resulted in cost savings. The effect was most significant in patients with Stage III disease and those with distant nodal metastases.
Article
Multidisciplinary Sciences
Evi Duthoo, Anne Vral, Ans Baeyens
Summary: In this study, the proliferative characteristics of human T lymphocytes in response to PHA stimulation were characterized using flow cytometric assays. The cell cycle kinetics and the impact of irradiation on proliferation were also investigated, providing valuable information on T lymphocyte proliferation characteristics.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Elena Catanzaro, Eleonora Turrini, Tessa Kerre, Simon Sioen, Ans Baeyens, Alessandra Guerrini, Mohamed Lamin Abdi Bellau, Gianni Sacchetti, Guglielmo Paganetto, Dmitri V. Krysko, Carmela Fimognari
Summary: This study investigates the potential of the monoterpene compound perillaldehyde to induce ferroptosis in leukemia cells. Perillaldehyde induces lipid peroxidation, decreases the expression of a specific protein, and reduces intracellular glutathione. Additionally, it stimulates the secretion of ATP.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
David Endesfelder, Ulrike Kulka, Martin Bucher, Ulrich Giesen, Guy Garty, Christina Beinke, Matthias Port, Gaetan Gruel, Eric Gregoire, Georgia Terzoudi, Sotiria Triantopoulou, Elizabeth A. Ainsbury, Jayne Moquet, Mingzhu Sun, Maria Jesus Prieto, Mercedes Moreno Domene, Joan-Francesc Barquinero, Monica Pujol-Canadell, Anne Vral, Ans Baeyens, Andrzej Wojcik, Ursula Oestreicher
Summary: Biological dosimetry is an important tool in supporting clinical decision-making during a radiological or nuclear event. This study evaluated the effectiveness of dicentric chromosome scoring using manual and semi-automatic methods in detecting unknown doses and the influence of neutron spectra differences. Results showed that the neutron energy spectrum had a strong impact on the dicentric counts.
CYTOGENETIC AND GENOME RESEARCH
(2023)
Article
Biology
D. Endesfelder, U. Oestreicher, M. Bucher, C. Beinke, C. Siebenwirth, E. Ainsbury, J. Moquet, G. Gruel, E. Gregoire, J. S. Martinez, A. Vral, A. Baeyens, M. Valente, A. Montoro, G. Terzoudi, S. Triantopoulou, A. Pantelias, O. Monteiro Gil, M. J. Prieto, M. M. Domene, D. Zafiropoulos, J. F. Barquinero, M. Pujol-Canadell, K. Lumniczky, R. Hargitai, E. Kis, A. Testa, C. Patrono, S. Sommer, R. Hristova, N. Kostova, M. Atanasova, O. Sevriukova, I. Dominguez, N. Pastor, I. Guclu, J. Pajic, L. Sabatier, P. Brochard, A. Tichy, M. Milanova, F. Finot, C. Cuceu Petrenci, R. C. Wilkins, L. A. Beaton-Green, K. M. Seong, Y. Lee, Y. H. Lee, A. S. Balajee, N. Maznyk, T. Sypko, N. D. Pham, T. M. Tran, T. Miura, Y. Suto, M. Akiyamam, N. Tsuyama, Y. Abe, V. S. T. Goh, C. E. L. Chua, M. Abend, M. Port
Summary: Biological and physical retrospective dosimetry assays are important tools in large-scale radiation accidents to categorize individuals and aid clinical decision making. Quality-controlled inter-laboratory comparisons are regularly performed to optimize international networking and emergency readiness. The participation of laboratories from around the world allows for international comparison of results.
RADIATION RESEARCH
(2023)
Article
Biology
M. Port, J-F. Barquinero, D. Endesfelder, J. Moquet, U. Oestreicher, G. Terzoudi, F. Trompier, A. Vral, Y. Abe, L. Ainsbury, L. Alkebsi, S. A. Amundson, C. Badie, A. Baeyens, A. S. Balajee, K. Balazs, S. Barnard, C. Bassinet, L. A. Beaton-Green, C. Beinke, L. Bobyk, P. Brochard, K. Brzoska, M. Bucher, B. Ciesielski, C. Cuceu, M. Discher, M. C. D. Oca, I. Dominguez, S. Doucha-Senf, A. Dumitrescu, P. N. Duy, F. Finot, G. Garty, S. A. Ghandhi, E. Gregoire, V. S. T. Goh, I. Guclu, L. Hadjiiska, R. Hargitai, R. Hristova, K. Ishii, E. Kis, M. Juniewicz, R. Kriehuber, J. Lacombe, Y. Lee, M. Lopez Riego, K. Lumniczky, T. T. Mai, N. Maltar-Strmecki, M. Marrale, J. S. Martinez, A. Marciniak, N. Maznyk, S. W. S. McKeever, P. K. Meher, M. Milanova, T. Miura, O. Monteiro Gil, A. Montoro, M. Moreno Domene, A. Mrozik, R. Nakayama, G. O'Brien, D. Oskamp, P. Ostheim, J. Pajic, N. Pastor, C. Patrono, M. Pujol-Canadell, M. J. Prieto Rodriguez, M. Repin, A. Romanyukha, U. Roessler, L. Sabatier, A. Sakai, H. Scherthan, S. Schuele, K. M. Seong, O. Sevriukova, S. Sholom, S. Sommer, Y. Suto, T. Sypko, T. Szatmari, M. Takahashi-Sugai, K. Takebayashi, A. Testa, I. Testard, A. Tichy, S. Triantopoulou, N. Tsuyama, M. Unverricht-Yeboah, M. Valente, O. Van Hoey, R. C. Wilkins, A. Wojcik, M. Wojewodzka, Lee Younghyun, D. Zafiropoulos, M. Abend
Summary: Tools for radiation exposure reconstruction are necessary for medical management of radiation victims. Various biological and physical dosimetry assays can be used to estimate the dose of ionizing radiation absorbed by a person.
RADIATION RESEARCH
(2023)
Article
Biology
A. Vral, D. Endesfelder, J. Balazs, C. Beinke, C. Cuceu Petrenci, F. Finot, G. Garty, L. Hadjiiska, R. Hristova, I. Ivanova, Y. Lee, K. Lumniczky, M. Milanova, O. Monteiro Gil, U. Oestreicher, J. Pajic, C. Patrono, N. D. Pham, G. Perletti, K. M. Seong, S. Sommer, T. Szatmari, A. Testa, A. Tichy, T. M. Tran, R. Wilkins, M. Port, M. Abend, A. Baeyens
Summary: The RENEB inter-laboratory comparison exercise in 2021 aimed to simulate a large-scale radiation accident involving a network of biodosimetry labs. This article reports the results obtained with the cytokinesis-block micronucleus assay.
RADIATION RESEARCH
(2023)
Article
Biology
Simon Sioen, Louise D'Hondt, Fien Van Houte, Robin Demuynck, Klaus Bacher, Carlos De Wagter, Anne Vral, Barbara Vanderstraeten, Dmitri V. Krysko, Ans Baeyens
Summary: This study compared the DNA damage response in peripheral blood lymphocytes exposed to X-rays with varying beam quality, mean photon energy, and dose rate. The results showed that different beam qualities and mean photon energies of X-rays had varying effects on chromosomal damage and DNA double-stranded breaks, while cell death induction was similar. Additional copper filtration reduced chromosomal damage and double-stranded breaks, but dose rate variation did not have a significant effect on cell response.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Simon Sioen, Oniecha Vanhove, Barbara Vanderstraeten, Carlos De Wagter, Monique Engelbrecht, Charlot Vandevoorde, Evan De Kock, Marc-Jan Van Goethem, Anne Vral, Ans Baeyens
Summary: Proton therapy and photon irradiation were investigated for their effects on DNA damage and repair in hematopoietic stem and progenitor cells (HSPCs). The study found that there were no significant differences in the induction and repair of DNA damage between proton therapy and X-ray irradiation. However, proton irradiation caused more severe chromosomal damage in HSPCs compared to X-rays, indicating possible changes in biological response.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Carrie Anne Minnaar, Jeffrey Allan Kotzen, Thanushree Naidoo, Mariza Tunmer, Vinay Sharma, Mboyo-Di-Tamba Vangu, Ans Baeyens
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2020)