Article
Environmental Sciences
Fang Jiao, Yongfang Ma, Tiantian Hu, Kun Qiao, Yao Jiang, Wei Zhu, Quan Jin, Wenjun Gui
Summary: This study exposed zebrafish to low doses of azocyclotin and found that it induced developmental and reproductive endocrine-disrupting effects on both F0 generation and offspring (F1 and F2), resulting in decreased physiological and reproductive parameters, as well as alterations in gene expression and DNA methylation.
Article
Environmental Sciences
Dongmin Yu, Dawei Zhu, Xufeng Wang, Ben Li, Jinghang Li, Peng Lu, Yumeng Ji, Xiaowei Wang
Summary: Maternal environmental sanitation during pregnancy plays a crucial role in fetal development. Exposure to DEHP is associated with potential risks to fetal heart development. The study investigated the molecular mechanisms of DEHP-induced cardiotoxicity in fetal mice.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Sadaf Dabeer, Sheikh Raisuddin
Summary: This study examined the intergenerational effect of parental exposure to an environmentally relevant dose of BPA on the hepatic health outcome of their offspring in a metabolically challenged population. The results showed that BPA exposure led to increased birth weight and rapid weight gain in the offspring, along with changes in liver function enzymes, histological changes in the liver tissue, and the onset of non-alcoholic fatty liver disease (NAFLD).
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Weirong Si, Mengjie Zhao, Huimin Che, Zaiwei Wu, Yuchun Xiao, Xinxin Xie, Jiayao Duan, Tong Shen, Dexiang Xu, Sujuan Zhao
Summary: This study investigates the intergenerational inheritance of MC-LR-induced thyroid toxicity in zebrafish and rat thyroid cells. Maternal exposure to MC-LR disrupts the hypothalamic-pituitary-thyroid axis and decreases thyroid hormone production in F0 generation. It also interferes with thyroid hormone homeostasis and development in the F1 offspring.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Xiangliang Tang, Dian Li, Tianxin Zhao, Shibo Zhu, Xiaofeng Gao, Rui Zhou, Fuming Deng, Wen Fu, Wei Jia, Guochang Liu
Summary: DEHP, an environmental endocrine disruptor, may cause serious consequences such as cryptorchidism. This study found that DEHP exposure resulted in abnormal expression of CFTR and its downstream signals in both undescended and descended testis, suggesting that CFTR abnormal expression may contribute to abnormal male reproductive function.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Michele Santoni, Roberto Frau, Marco Pistis
Summary: Several epidemiological studies suggest a link between maternal infections during pregnancy and neurodevelopmental disorders in the offspring. Animal models have provided further insights into the pathophysiological mechanisms behind this association. Transgenerational effects of maternal immune activation on the dopamine system were explored in this study, revealing a negative impact on neurodevelopmental trajectories across generations.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Ana Lopez Sanchez, David Pascual-Pardo, Leonardo Furci, Michael R. Roberts, Jurriaan Ton
Summary: Pathogen-mediated transgenerational induced resistance provides benefits in matched environments but comes with ecological costs that become apparent in mismatched environments.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Debbie Montjean, Anne-Sophie Neyroud, Marina G. Yefimova, Moncef Benkhalifa, Rosalie Cabry, Celia Ravel
Summary: EDCs can influence gene expression through epigenetic alterations, leading to transgenerational inheritance of traits. Mechanisms such as DNA methylation, acetylation, histone modification, RNA-mediated effects, and extracellular vesicle effects have been implicated. While limited effects on sperm epigenetics have been described, there has been growing interest in this issue in recent years.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Ying Zhang, Jingjing Li, Wei Shi, Lu Lu, Qian Zhou, Hu Zhang, Ran Liu, Yuepu Pu, Lihong Yin
Summary: With the increased production and use of plastic products, global plastic pollution has become a serious issue. The plasticizer DEHP, commonly used in plastic production, raises concerns for human health, particularly regarding damage to the reproductive system. The role of DEHP in promoting reproductive aging and its underlying mechanisms are still not well-studied, making it significant to explore. In this study, Caenorhabditis elegans (C. elegans) was used as a model organism to investigate the mechanisms of DEHP-induced female reproductive senescence. The results showed that DEHP reduced offspring numbers and gonad area, leading to shortened reproductive and lifespan, as well as abnormal somatic gonad structures, oxidative stress, and autophagy. Additionally, the effects of DEHP were shown to be passed down to offspring not directly exposed to DEHP.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Marie Usal, Sylvie Veyrenc, Marie Darracq--Ghitalla-Ciock, Christophe Regnault, Sophie Sroda, Jean-Baptiste Fini, Cecile Canlet, Marie Tremblay-Franco, Muriel Raveton, Stephane Reynaud
Summary: This study demonstrates that exposure to endocrine disruptor benzo[a]pyrene can induce delayed metamorphosis, fatty liver, and disrupted metabolism in F2 offspring of Xenopus tropicalis, ultimately leading to population collapse. These findings suggest a potential transgenerational impact of endocrine disruptors on metabolism in amphibians, supporting the link between environmental endocrine disruptors and metabolic diseases in humans.
ENVIRONMENTAL POLLUTION
(2021)
Article
Marine & Freshwater Biology
Tianyu Wang, Shanshan Wu, Jianjie Chen, Lijuan Li, Jinling Cao
Summary: This study investigated the alleviating effects of sesamin on thyroid endocrine disruption caused by fluoride in zebrafish. Sesamin significantly improved growth performance and reduced mortality rate in adults, while also improving hatching rate and body length and alleviating spinal curvature and cyst formation in embryos and larvae. It also alleviated damage to thyroid tissues, reduced oxidative stress, improved thyroid hormone imbalance, and reversed the expression of endocrine-related genes.
AQUATIC TOXICOLOGY
(2023)
Review
Endocrinology & Metabolism
Nicole Mohajer, Erika M. Joloya, Jeongbin Seo, Toshi Shioda, Bruce Blumberg
Summary: Obesity and metabolic disorders are global pandemics, potentially linked to exposure to endocrine disrupting chemicals known as obesogens. Transgenerational inheritance of phenotypic traits and diseases, such as obesity, may be mediated by epigenetic mechanisms, highlighting the complexity of inherited susceptibility to environmental exposures.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Raquel Chamorro-Garcia, Nathalie Poupin, Marie Tremblay-Franco, Cecile Canlet, Riann Egusquiza, Roselyne Gautier, Isabelle Jouanin, Bassem M. Shoucri, Bruce Blumberg, Daniel Zalko
Summary: Metabolomics confirmed transgenerational obesogenic effects of environmentally relevant doses of TBT in male mice, while also showing impaired liver biotransformation capacity in females. This study demonstrates the transgenerational effects of EDC exposure and highlights the potential use of metabolomic fingerprints in identifying individuals susceptible to adverse health effects from ancestral exposure to obesogens.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Food Science & Technology
Wang Zhang, Peng Xu, Jing-ya Li
Summary: The widespread usage of plastic products has led to serious health problems caused by exposure to plasticizers. This study focused on the potential mechanism of liver insulin resistance induced by DEHP and found that it affects the TXNIP in the liver, damaging the insulin signaling pathway. Reversing the insulin resistance caused by DEHP through the inhibition of TXNIP may be an effective treatment.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Shah Tauseef Bashir, Karen Chiu, Eileen Zheng, Angel Martinez, Justin Chiu, Kishori Raj, Sandra Stasiak, Nastasia Zhen Ee Lai, Rachel B. Arcanjo, Jodi A. Flaws, Romana A. Nowak
Summary: DEHP exposure has differential effects on the ileum and colon, altering colonic morphology and the intestinal immune microenvironment.
Article
Pharmacology & Pharmacy
Alexis Alvear-Jimenez, Irene Zabala Gutierrez, Yingli Shen, Gonzalo Villaverde, Laura Lozano-Chamizo, Pablo Guardia, Miguel Tinoco, Beatriz Garcia-Pinel, Jose Prados, Consolacion Melguizo, Manuel Lopez-Romero, Daniel Jaque, Marco Filice, Rafael Contreras-Caceres
Summary: In this study, a biocompatible hybrid nanosystem for drug delivery purposes was fabricated using the electrospraying technique, combining Ag2S nanoparticles and superparamagnetic iron oxide nanoparticles (SPION). The hybrid nanosystems showed good photoluminescent properties and relatively long decay times. Encapsulation and release capabilities were demonstrated using a model chemotherapeutic drug, and in vitro cytotoxicity assays showed promising results against tumor cell lines.
Article
Biochemistry & Molecular Biology
Beat Moeckli, Vaihere Delaune, Julien Prados, Matthieu Tihy, Andrea Peloso, Graziano Oldani, Thomas Delmi, Florence Slits, Quentin Gex, Laura Rubbia-Brandt, Nicolas Goossens, Stephanie Lacotte, Christian Toso
Summary: The global obesity epidemic particularly affects women of reproductive age. Offspring of obese mothers have an increased risk of liver disease, but the molecular mechanisms involved remain unknown. Through genomic analysis of mice, researchers found that pathways related to metabolism, the immune system, clotting cascade, and cell cycle were consistently dysregulated in the offspring of obese mothers.
Article
Biochemical Research Methods
Javier Bajo-Morales, Daniel Castillo-Secilla, Luis Javier Herrera, Octavio Caba, Jose Carlos Prados, Ignacio Rojas
Summary: A new intelligent pipeline was implemented to develop a specific gene signature that can detect the severity of patients suffering from COVID-19. The pipeline integrates RNA-Seq data from different databases using an artificial intelligence algorithm. CD93, RPS24, PSCA, and CD300E were identified as COVID-19 severity gene signatures, and a multi-class classifier was optimized to classify patients with an accuracy of 97.5%.
CURRENT BIOINFORMATICS
(2023)
Review
Chemistry, Medicinal
Cristina Luque, Ana Cepero, Gloria Perazzoli, Cristina Mesas, Francisco Quinonero, Laura Cabeza, Jose Prados, Consolacion Melguizo
Summary: Colorectal cancer (CRC) is a major cause of cancer-related deaths globally, and new treatment strategies are needed due to the side effects of current treatments. Fungi have gained attention as a potential source of antitumor compounds due to their antimicrobial and antioxidant properties. A systematic review of the literature found that extracts and compounds from Ascomycota fungi showed promising antitumor activity against CRC cells. The study identified the most studied order of fungi, the most commonly used extraction method, and highlighted specific compounds with high cytotoxic activity. The review also focused on the mechanisms through which fungi extracts and compounds inhibit CRC cell proliferation and migration, suggesting their potential for developing new therapies.
Article
Cell Biology
Yasmine Neirijnck, Pauline Sararols, Francoise Kuhne, Chloe Mayere, Lahiru Chamara Weerasinghe Arachchige, Violaine Regard, Serge Nef, Andreas Schedl
Summary: This study provides a comprehensive single-cell transcriptomic atlas of early mouse adrenogonadal development, revealing the differentiation process and molecular mechanisms. It is found that the fate of adrenal and gonadal has diverged prior to Nr5a1 expression and involves differential expression of genes related to Wnt signaling and Hox patterning. This study provides important insights into the ontogenesis of adrenal and gonadal and will be a valuable resource for further research.
Article
Andrology
Fanny Zufferey, Elina Buitrago, Rita Rahban, Alfred Senn, Eric Stettler, Serge Rudaz, Serge Nef, Nicolas Donze, Aurelien Thomas, Michel F. Rossier
Summary: This study assessed the impact of cannabis consumption on semen parameters, reproductive hormones, and endocannabinoid levels in young Swiss men. The results showed higher levels of anandamide, androgens, estradiol, and sex hormone binding globulin in chronic, recent, and cannabidiol-positive cannabis users. Gonadotropin levels were not significantly different, while prolactin and albumin concentrations were lower in cannabis users. Moreover, cannabis users had a more basic semen pH and a higher percentage of spermatozoa with progressive motility, which may be influenced by sexual abstinence rather than cannabis use.
Review
Chemistry, Multidisciplinary
Francisco Quinonero, Cristina Mesas, Mercedes Pena, Laura Cabeza, Gloria Perazzoli, Consolacion Melguizo, Raul Ortiz, Jose Prados
Summary: Colorectal cancer is a major cause of illness and death, and drug resistance is a leading cause of treatment failure. Bioactive compounds derived from vegetables are being studied as a new approach to improve antitumor treatment and reduce drug resistance. In vitro and in vivo studies have shown that these compounds, such as polyphenols, flavonoids, and terpenes, can enhance therapeutic efficacy by reducing resistance. This review summarizes the current knowledge on the antitumor and chemo-sensitizing properties of vegetable-derived biomolecules and their potential in improving colorectal cancer treatment.
APPLIED SCIENCES-BASEL
(2023)
Review
Oncology
Maria Angeles Chico, Cristina Mesas, Kevin Doello, Francisco Quinonero, Gloria Perazzoli, Raul Ortiz, Jose Prados, Consolacion Melguizo
Summary: Sarcomas are a diverse group of neoplasms with a high incidence rate in childhood cancers. Cancer stem cells (CSCs) play a role in recurrence, metastasis, and drug resistance, making the search for diagnostic and prognostic biomarkers crucial. This systematic review analyzed the expression of CSC biomarkers in in vitro cell lines and patient tumor samples, revealing significant heterogeneity in markers and isolation techniques. ALDH was identified as a common marker in various types of sarcomas. The identification of CSC markers in sarcomas may aid in personalized medicine development and improve treatment outcomes.
Editorial Material
Surgery
Kevin Doello, Cristina Mesas, Francisco Quinonero, Gloria Perazzoli, Jose Prados
ANZ JOURNAL OF SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Mercedes Pena, Cristina Mesas, Gloria Perazzoli, Rosario Martinez, Jesus M. Porres, Kevin Doello, Jose Prados, Consolacion Melguizo, Laura Cabeza
Summary: Anemonia sulcata has potential as a source of marine natural products with antioxidant and antitumor activity. A bioguided chromatographic fractionation assay revealed that the 20% and 40% fractions had antioxidant and antiproliferative activities in colon cancer cells, respectively. Further characterization and isolation of the bioactive compounds are required.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Francisco Quinonero, Belen Parra-Torrejon, Gloria B. Ramirez-Rodriguez, Victor Garces, Jose M. Delgado-Lopez, Cristina Jimenez-Luna, Gloria Perazzoli, Jose Prados, Raul Ortiz
Summary: This study functionalized calcium phosphate-based nanoparticles with Olaparib and ascorbic acid to enhance their individual effects in treating pancreatic cancer. The resulting dual nanosystem showed a gradual release of Olaparib and ascorbic acid, demonstrating a better cytotoxic effect and apoptosis-mediated cytotoxic effect in human pancreatic ductal adenocarcinoma cell line. In vivo studies further confirmed the therapeutic benefits of the nanoparticle system in terms of tumor volume reduction and survival improvement.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Cristina Mesas, Francisco Quinonero, Francisco Revueltas, Laura Cabeza, Gloria Perazzoli, Consolacion Melguizo, Jose Prados
Summary: The encapsulation of natural extracts in nanoparticles has shown significant cytotoxic activity against colon neoplastic cells, while causing no toxicity to healthy cells. Further research is needed to determine the biocompatibility and potential therapeutic applications of these nanodrugs.
APPLIED SCIENCES-BASEL
(2023)
Review
Pharmacology & Pharmacy
Lidia Gago, Francisco Quinonero, Gloria Perazzoli, Consolacion Melguizo, Jose Prados, Raul Ortiz, Laura Cabeza
Summary: The incidence of gastrointestinal cancers has been increasing in recent years, leading to challenges in current treatments. A promising strategy is to use magnetic nanoparticles for hyperthermia therapy, generating heat in tumor regions using an external magnetic field. This systematic review analyzed 40 articles published in the last decade, showing that iron oxide is the preferred material for magnetism generation and colorectal cancer is the most studied gastrointestinal cancer. Combination therapies using nanoparticles loaded with chemotherapeutic drugs and magnetic hyperthermia demonstrated excellent antitumor effects. Hyperthermia treatments mediated by magnetic nanoparticles appear to be an effective approach for gastrointestinal cancers.
Review
Biochemistry & Molecular Biology
Gloria Perazzoli, Olga M. Garcia-Valdeavero, Mercedes Pena, Jose Prados, Consolacion Melguizo, Cristina Jimenez-Luna
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with low survival rates. Surgical resection is the only curative option, but most patients are not eligible due to late diagnosis. Metabolomics has shown promise in identifying biomarkers for early PDAC detection. This review summarizes recent studies on metabolites for early PDAC diagnosis and highlights amino acid and lipid metabolic pathways as potential biomarkers.
Article
Engineering, Marine
Gloria Perazzoli, Carolina de los Reyes, Cristina Pinedo-Rivilla, Rosa Duran-Patron, Josefina Aleu, Laura Cabeza, Consolacion Melguizo, Jose Prados
Summary: Marine microorganisms, especially fungi, are able to produce bioactive compounds with therapeutic properties. This study found that fractions derived from marine fungi showed potent antitumor activity and antioxidative capacity, highlighting their potential as effective and selective agents for the treatment of colorectal cancer.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2023)
