Correction
Computer Science, Theory & Methods
Lu Yang, Gongping Yang, Xiaoming Xi, Kun Su, Qing Chen, Yilong Yin
Summary: The institution information of Lu Yang and Xiaoming Xi in the second paragraph of the footnote on the first page of [1] is inaccurate and should be corrected to School of Computer Science and Technology, Shandong University of Finance and Economics.
IEEE TRANSACTIONS ON INFORMATION FORENSICS AND SECURITY
(2021)
Article
Multidisciplinary Sciences
Tirtha K. Das, Jared Gatto, Rupa Mirmira, Ethan Hourizadeh, Dalia Kaufman, Bruce D. Gelb, Ross Cagan
Summary: RASopathies are a family of diseases caused by missense variants in the RAS/MAPK pathway, with diverse phenotypic effects on various systems. Drosophila transgenic lines expressing different RASopathy isoforms show similarities and differences compared to their human counterparts, with varying therapeutic responses to different classes of drugs.
Article
Pharmacology & Pharmacy
Jiahe Tan, Rui Song, Siyue Luo, Wenqiao Fu, Yinrui Ma, Lian Zheng, Zhaohui He
Summary: This study conducts a systematic review and meta-analysis on the application of lapatinib in patients with HER2/EGFR-positive breast cancer and finds that the combination of lapatinib with chemotherapy can significantly improve the survival rate and quality of life of patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Immunology
Yani Berckmans, Jolien Ceusters, Ann Vankerckhoven, Roxanne Wouters, Matteo Riva, An Coosemans
Summary: Immune checkpoint inhibitors have revolutionized cancer therapy, but their success is limited to specific indications and cancer types. The combination treatment of immune checkpoint inhibitors and chemotherapy has gained attention to overcome this limitation. However, many clinical trials testing these combinations have had limited success, possibly due to inadequate selection of preclinical models and a lack of scientific rationale.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell & Tissue Engineering
Chenchen Li, Haiyun Qin, Liuwang Zeng, Zhiping Hu, Chunli Chen
Summary: This study systematically evaluated the effect size of stem cell therapy in animal models of intracerebral hemorrhage (ICH) by pooling and analyzing data from newly published studies. The results showed that stem cell therapy had remarkable benefits on both functional and structural outcomes in animal models of ICH, with a very large effect size.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Oncology
Roberta Coletti, Andrea Pugliese, Andrea Lunardi, Orazio Caffo, Luca Marchetti
Summary: This mathematical study investigates the clinical relevance of ipilimumab for the treatment of castration-resistant prostate cancer patients. The results suggest that high-dose short-term administration of ipilimumab may be more effective, and combining ipilimumab with sipuleucel-T can improve tumor control.
Review
Oncology
Priyanka Sahu, Chantal Donovan, Keshav Raj Paudel, Sophie Pickles, Vrushali Chimankar, Richard Y. Kim, Jay C. Horvart, Kamal Dua, Antonio Ieni, Francesco Nucera, Helle Bielefeldt-Ohmann, Sarah Mazilli, Gaetano Caramori, J. Guy Lyons, Philip M. Hansbro
Summary: This review discusses the pathogenesis, diagnosis, and current treatment strategies for lung squamous cell carcinoma (LSCC), as well as the existing animal models for studying LSCC. LSCC is a common subtype of non-small-cell lung carcinoma (NSCLC) with low survival rates. Understanding the risk factors, genetic and epigenetic alterations, and miRNA biomarkers associated with LSCC can contribute to the development of new diagnostic and therapeutic targets.
FRONTIERS IN ONCOLOGY
(2023)
Review
Plant Sciences
Xiao-Le Wang, Ya-Ting Wang, Zhen-Yu Guo, Ning-Ning Zhang, Yuan-Yuan Wang, Die Hu, Zhen-Zhen Wang, Yi Zhang
Summary: This study systematically reviewed and meta-analyzed the effectiveness of paeoniflorin in relieving depressive-like behaviors in animal models. The results showed that paeoniflorin significantly improved depressive-like symptoms in animals, suggesting its potential as a therapy for depression in the future.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Correction
Social Sciences, Interdisciplinary
Esben Strodl, Madhavan Mani, Srishyama Vempaty, Sibnath Deb
Summary: After the publication, Dr. Deb acknowledged that he had mistakenly left out two authors, Dr. Mani and Dr. Vempaty.
APPLIED RESEARCH IN QUALITY OF LIFE
(2021)
Review
Medicine, General & Internal
Hengben Zhai, Jinming Zhang, Dabao Shang, Chuanwu Zhu, Xiaogang Xiang
Summary: Acute-on-chronic liver failure (ACLF) is a severe syndrome characterized by acute liver dysfunction following an acute insult on the basis of chronic liver diseases, often accompanied by bacterial infection and multi-organ failure. Lack of suitable animal models has hindered the progress of basic research on ACLF.
FRONTIERS IN MEDICINE
(2023)
Article
Mathematical & Computational Biology
Renata Eirini Tsirpitzi, Frank Miller
Summary: Dose-finding studies aim to determine a suitable dose for future drug development based on both efficacy and safety, using a balance between efficacy and safety provided by the clinical utility index concept to maximize patient utility. Optimal designs are determined based on drug's expected therapeutic index, influencing the number of doses, doses themselves, and their weights in the design. A sequential design is proposed to address parameter dependency complications and illustrated in a simulation study.
BIOMETRICAL JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Traian Constantin, Mihai Pavalean, Stefana Bucur, Maria Magdalena Constantin, Alin Codrut Nicolescu, Irina Pacu, Victor Madan
Summary: Bladder cancer animal models can be categorized as either autochthonous or non-autochthonous, with the non-autochthonous models further classified into syngeneic and xenograft models. These models have different characteristics and applications based on the type of tumor implantation.
Correction
Computer Science, Information Systems
Master Prince, Suliman A. Alsuhibany, Nahid A. Siddiqi
Summary: The affiliation of the first two authors in the above article [1] did not mention the name of the college.
Review
Cell Biology
Liuwang Zeng, Yuwei Zhu, Xiangyu Hu, Haiyun Qin, Jiayu Tang, Zhiping Hu, Chunli Chen
Summary: Melatonin shows promising effects in improving outcomes in animal models of intracerebral hemorrhage, with positive impacts on neurobehavioral outcomes and cerebral edema reduction. However, the interpretation of results should consider the limitations in experimental design and methodological quality of the studies included in the meta-analysis.
Review
Infectious Diseases
Christopher G. Bunick, Jonette Keri, S. Ken Tanaka, Nika Furey, Giovanni Damiani, Jodi L. Johnson, Ayman Grada
Summary: Sarecycline, a narrow-spectrum third-generation tetracycline-class antibiotic approved by the FDA for treating moderate-to-severe acne, exhibits activity against Gram-positive bacteria, particularly Staphylococcus aureus, with reduced efficacy against Gram-negative bacteria like Escherichia coli. Its unique C7 moiety interacts with bacterial ribosomes to block translation and prevent resistance, showing promising results in in vivo studies of infection and inflammation.
Article
Multidisciplinary Sciences
Freek de Haan, Oladimeji Akeem Bolarinwa, Rosemonde Guissou, Fatoumata Tou, Paulina Tindana, Wouter P. C. Boon, Ellen H. M. Moors, Phaik Yeong Cheah, Mehul Dhorda, Arjen M. Dondorp, Jean Bosco Ouedraogo, Olugbenga A. Mokuolu, Chanaki Amaratunga
Summary: The market readiness for Triple artemisinin-based combination therapies (TACTs) in Nigeria and Burkina Faso depends on support from the WHO and international funders, as well as the ability to integrate TACTs into existing regulatory and distribution systems. Challenges are expected in the private sector due to patient demand and profit motives. Further studies are needed to inform decision makers about the implications of transitioning to TACTs in African countries.
Article
Environmental Sciences
Freek de Haan, Ellen H. M. Moors, Arjen M. Dondorp, Wouter P. C. Boon
Summary: This article focuses on market formation in the global health transition caused by drug-resistant malaria, investigating the formation of Artemisinin-based Combination Therapies (ACT) markets in the Greater Mekong Subregion. It highlights the roles of public institutes, academia, and partnerships in early innovation system development and how transnational organizations created a supportive global landscape for ACT development. The study shows how these advancements led to the establishment of public-sector and private-sector ACT markets in the region at global, national, and local scales.
ENVIRONMENTAL INNOVATION AND SOCIETAL TRANSITIONS
(2021)
Article
Management
Taneli Vaskelainen, Karla Munzel, Wouter Boon, Koen Frenken
Summary: This article examines the strategies and order of entry for established B2B lease companies to enter the B2C private leasing and carsharing markets. The study reveals that companies' knowledge of opportunities, position in the value chain, and resources significantly impact their ability to be pioneers, early followers, or late entrants. The findings also show that manufacturing incumbent companies are not actively exploiting opportunities in private leasing, while leasing companies are developing capabilities for private leasing on their own and partnering with others for carsharing services.
INNOVATION-ORGANIZATION & MANAGEMENT
(2022)
Review
Gerontology
Dirk R. M. Lukkien, Henk Herman Nap, Hendrik P. Buimer, Alexander Peine, Wouter P. C. Boon, Johannes C. F. Ket, Mirella M. N. Minkman, Ellen H. M. Moors
Summary: This scoping review investigates the design and implementation of responsible AI innovation in long-term care for older adults. The study found that while there are measures and recommendations addressing responsible AI innovation, there is limited empirical evidence on how it is addressed in context. The study recommends expanding empirical research and developing specific flexible guidance frameworks for responsible AI innovation.
Article
Information Science & Library Science
Wilke van Beest, Wouter P. C. Boon, Daan Andriessen, Harald Pol, Gerrita van der Veen, Ellen H. M. Moors
Summary: This study examines the evaluation of research pathways for self-management health innovations from discovery to implementation in practice-based research settings. The development of a Research Pathway Model enables researchers to monitor the incremental work required for successful innovation implementation. The exploration of solutions in real-life environments appears to be crucial for the successful adoption of self-management health innovations.
RESEARCH EVALUATION
(2022)
Article
Public, Environmental & Occupational Health
Freek de Haan, Wouter P. C. Boon, Chanaki Amaratunga, Arjen M. Dondorp
Summary: This study provides a structured overview of malaria experts' perceptions on the major advantages, disadvantages, and implementation challenges for introducing Triple Artemisinin-based Combination Therapies (TACTs) as first-line treatment for uncomplicated falciparum malaria in Southeast Asia. The findings can benefit strategic decision making in the battle against drug-resistant malaria.
Article
Environmental Sciences
Wouter P. C. Boon, Jakob Edler, Douglas K. R. Robinson
Summary: This paper develops a framework for characterizing and analyzing new market formation processes, using three case studies to demonstrate its effectiveness. The framework can help diagnose issues in market formation and identify entry points for policy intervention.
ENVIRONMENTAL INNOVATION AND SOCIETAL TRANSITIONS
(2022)
Article
Genetics & Heredity
Conor M. W. Douglas, Fernando Aith, Wouter Boon, Marina de Neiva Borba, Liliana Doganova, Shir Grunebaum, Rob Hagendijk, Larry Lynd, Alexandre Mallard, Faisal Ali Mohamed, Ellen Moors, Claudio Cordovil Oliveira, Florence Paterson, Vanessa Scanga, Julino Soares, Vololona Raberharisoa, Tineke Kleinhout-Vliek
Summary: Rare diseases pose challenges that cannot be addressed by traditional pharmaceutical innovation. We need to rethink innovation and provide more alternative pathways, such as social pharmaceutical innovation. As an interdisciplinary research team, we aim to contribute to the development of social pharmaceutical innovation and provide comparative and evaluative value to these initiatives.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Editorial Material
Environmental Sciences
Wouter Boon, Thomas Magnusson, Sampsa Hyysalo
Summary: This special issue aims to unpack the notion of markets and market formation in sustainability transitions and propose relevant topics for future studies on markets.
ENVIRONMENTAL INNOVATION AND SOCIETAL TRANSITIONS
(2022)
Review
Psychiatry
Guilherme S. Ferreira, Francis M. Dijkstra, Desiree H. Veening-Griffioen, Wouter P. C. Boon, Huub Schellekens, Ellen H. M. Moors, Peter J. K. van Meer, Frederik E. Stuurman, Joop M. A. van Gerven
Summary: The primary aim of this study was to determine the translatability of preclinical to early clinical dose ranges for CNS active drugs. Investigator's Brochures (IBs) were examined to assess reporting quality. The quality of IBs was assessed based on the animal model rationale, completeness of PK results, and internal validity of preclinical evidence. The IB-derisk tool was used to generate data overviews. Overall, the reporting quality in IBs was found to be poor, with about a third of studies not exploring the entire concentration-effect curve. C-max was the most accurate predictor of single-dose tolerability ranges, while HED and AUC were the best predictors of pharmacologically active ranges. The study suggests that preclinical data with the IB-derisk tool can reasonably predict tolerable and pharmacologically active doses in healthy volunteers, and improving reporting standards in IBs can enhance the translatability of preclinical studies.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Environmental Sciences
Marjolein J. Hoogstraaten, Koen Frenken, Taneli Vaskelainen, Wouter P. C. Boon
Summary: This study examines categories and strategies of categorization in the shift towards sustainable diets. The research focuses on the emergence of meat substitutes and views the meat substitute category as a hybrid one that targets vegetarian/vegan diets while replacing meat. The category is characterized by its negative definition, explicitly indicating the product it is intended to substitute. The ambiguous nature of this category poses challenges for producers in terms of innovation. The study investigates the strategies employed by nine Dutch meat substitute producers, revealing that most of them prioritize meat resemblance in their innovation strategies, conforming to the dominant practices of meat production and consumption. However, the study also demonstrates that the hybrid and negatively defined nature of the meat substitute category creates opportunities for more radical innovations that can potentially transform the entire regime in the long run.
ENVIRONMENTAL INNOVATION AND SOCIETAL TRANSITIONS
(2023)
Article
Pathology
Audrey M. M. Hermans, Marc Maliepaard, Wouter P. C. Boon, Anna M. G. Pasmooij
Summary: The study investigated the current use of companion diagnostics (CDx) in hospital practice in the Netherlands, focusing on factors influencing the choice between in-house or commercial CDx. Factors such as costs, convenience, complexity of application, and compatibility with existing workflows were found to play key roles. Concerns were raised about potential increased costs, administrative work, and decreased quality with the introduction of the In Vitro Diagnostics Regulation 2017/746 (IVDR).
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2022)
Review
Public, Environmental & Occupational Health
Wilke van Beest, Wouter P. C. Boon, Daan Andriessen, Ellen H. M. Moors, Gerrita van der Veen, Harald Pol
Summary: This study examines the factors contributing to the successful implementation of self-management health innovations. Through a literature review and multiple case studies, nine factors were identified as important for implementation success. While some projects achieved successful implementation, not all factors were present in each case.
JOURNAL OF PUBLIC HEALTH-HEIDELBERG
(2022)
Article
Political Science
Albert Meijer, Wouter Boon
Summary: This article provides a theoretical understanding of the potential contribution of digital platforms to the co-creation of public value, proposing basic configurations and hybrid configurations. It identifies three basic configurations and illustrates them with examples from digital platforms worldwide. The configurational understanding of digital platforms provides the basis for a systematic analysis of these rapidly growing practices in countries around the world.
POLICY AND POLITICS
(2021)
Article
Medicine, Research & Experimental
Desiree H. Veening-Griffioen, Guilherme S. Ferreira, Wouter P. C. Boon, Christine C. Gispen-de Wied, Huub Schellekens, Ellen H. M. Moors, Peter J. K. van Meer
Summary: The study found that the current selection of a specific animal model is more based on tradition rather than its potential predictive value for clinical outcome. In the future, there should be a more systematic and transparent approach to selecting animal models in order to reduce the likelihood of poorly translatable research outcomes.
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION
(2021)
