Article
Physiology
Eleanor J. Jones, Philip J. Atherton, Mathew Piasecki, Bethan E. Phillips
Summary: The question of this study is whether CEUS can be used as a repeatable method for measuring skeletal muscle microvascular blood flow at rest and during exercise. The main finding is that there is a strong agreement between CEUS measures across sessions, indicating its repeatability and potential for further longitudinal studies.
EXPERIMENTAL PHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Junzhen Zhan, Longhe Zhong, Juefei Wu
Summary: With growing evidence, the understanding of coronary syndromes has shifted from focusing on the link between stenosis of epicardial coronary artery and myocardial ischemia to the abnormalities at the level of coronary microcirculation. Coronary microvascular dysfunction (CMD) is an important cause of myocardial ischemia in patients with angina symptoms without obstructive coronary artery disease. CMD has also been found to be involved in other cardiovascular diseases. Myocardial contrast echocardiography (MCE) is a breakthrough non-invasive technique that can assess coronary microvasculature and provide new insights into the pathophysiological role of CMD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Zeng Zhang, Misun Hwang, Todd J. Kilbaugh, Anush Sridharan, Joseph Katz
Summary: The study developed contrast-enhanced ultrasound imaging and intravascular microbubble tracking in hydrocephalic pediatric porcine models to noninvasively assess intracranial pressure and detect cerebral ischemia.
NATURE COMMUNICATIONS
(2022)
Article
Computer Science, Interdisciplinary Applications
Peiran Chen, Ruud J. G. van Sloun, Simona Turco, Hessel Wijkstra, Domenico Filomena, Luciano Agati, Patrick Houthuizen, Massimo Mischi
Summary: A novel technique for LV blood velocity and relative-pressure field estimation from dynamic contrast-enhanced ultrasound at low frame rates was proposed and evaluated on CRT patients, showing significant impact on responders. This method enables effective visualization and quantification of LV blood flow patterns, potentially facilitating clinical adoption.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Roberto Cannella, Giulia Pilato, Mariasole Mazzola, Tommaso Vincenzo Bartolotta
Summary: Microvascular ultrasound (MVUS) is a new ultrasound technique that allows the detection of slow-velocity flow in small vessels without the need of contrast agent administration. Compared to conventional imaging techniques, MVUS provides higher capability to detect intralesional flow and has potential applications in hepatobiliary, genitourinary, and vascular pathologies. This article aims to provide a detailed review on the current evidences and applications of MVUS in abdominal imaging.
Article
Acoustics
Cuiwei Wang, Teng Zhang, Shuwen Sun, Xinhua Ye, Yali Wang, Minhong Pan, Haibin Shi
Summary: This study established CEUS and CEMR models for predicting microvascular invasion in hepatocellular carcinoma (HCC) and compared their predictive efficiency. The results showed that both models had similar predictive efficiencies, and CEUS was also an effective method for predicting microvascular invasion before surgery.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hualu Han, Zixuan Lin, Anja Soldan, Corinne Pettigrew, Joshua F. Betz, Kumiko Oishi, Yang Li, Peiying Liu, Marilyn Albert, Hanzhang Lu
Summary: The study aims to evaluate short-term longitudinal changes in global cerebral blood flow (CBF) in cognitively normal older adults and finds that the rate of CBF reduction is associated with increased white matter damage with age.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Grace M. Young, Digby Krastins, David Chang, Jeng Lam, Jing Quah, Tony Stanton, Fraser Russell, Kim Greaves, Yuri Kriel, Christopher D. Askew
Summary: The study found strong correlations and level of agreement between CEUS and NIRS-derived measures of post-occlusion skeletal muscle microvascular responsiveness in older adults. This suggests that NIRS can serve as a non-invasive, portable, and cost-effective method for assessing post-occlusion skeletal muscle microvascular responsiveness in older adults.
HEART LUNG AND CIRCULATION
(2021)
Article
Chemistry, Multidisciplinary
Gyounghwan Kim, Hyun-Sang Park, Paul Shin, Taeguk Eom, Jin-Hui Yoon, Yong Jeong, Wang-Yuhl Oh
Summary: Blood flow dynamics in microvascular networks play a critical role in tissue and organ health. Direct blood cell flow imaging (DBFI) is a new imaging technique that allows visualization of individual blood cell motions without using any contrast agents, with high time resolution. DBFI has the potential to analyze blood flow dynamics in various vessels and has been demonstrated in applications such as quantifying 3D vascular networks, analyzing heartbeat-induced blood flow, and studying neurovascular coupling.
Article
Acoustics
Xintong Li, Xue Han, Lei Li, Chang Su, Jianmin Sun, Chao Zhan, Di Feng, Wen Cheng
Summary: The aim of this study was to investigate the imaging features observed in pre-operative Sonazoid contrast-enhanced ultrasound (SZ-CEUS) and their correlations with the presence of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) patients. The results showed that the non-single nodular (non-SN) type in the post-vascular phase (PVP) was a significant independent risk factor for MVI in HCC. Therefore, SZ-CEUS can provide useful information for the diagnosis of MVI in HCC.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Oncology
Yafang Zhang, Qingyue Wei, Yini Huang, Zhao Yao, Cuiju Yan, Xuebin Zou, Jing Han, Qing Li, Rushuang Mao, Ying Liao, Lan Cao, Min Lin, Xiaoshuang Zhou, Xiaofeng Tang, Yixin Hu, Lingling Li, Yuanyuan Wang, Jinhua Yu, Jianhua Zhou
Summary: This study developed a deep convolutional neural network model based on contrast-enhanced ultrasound to predict microvascular invasion in hepatocellular carcinoma patients and thus predict prognosis. The CECL-DCNN model showed higher specificity and accuracy in predicting MVI compared to clinical models.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Di Zhang, Qi Wei, Ge-Ge Wu, Xian-Ya Zhang, Wen-Wu Lu, Wen-Zhi Lv, Jin-Tang Liao, Xin-Wu Cui, Xue-Jun Ni, Christoph F. Dietrich
Summary: This study developed a radiomics nomogram based on CEUS for preoperatively assessing MVI in HCC patients, showing superior predictive value compared to a clinical model. The model incorporating radiomics scores and clinical factors demonstrated good discrimination and calibration, suggesting the potential clinical usefulness of PVP and DP radiomics signatures as biomarkers for MVI prediction in HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Matthew R. Lowerison, Nathiya Chandra Sekaran, Wei Zhang, Zhijie Dong, Xi Chen, Daniel A. Llano, Pengfei Song
Summary: Aging-related cognitive decline is a health crisis, with no established mechanism identified. This study used super-resolution ultrasound localization microscopy to image the vasculature of aged mice and found decreased blood velocity, increased vascular tortuosity, and reduced blood volume in the cerebral cortex. These findings provide novel insights into subcortical microvascular dynamics in the aging brain.
SCIENTIFIC REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yanqin Guo, Xinghua Wang, Lu Wang, Xiaoli Wei, Yinling Duan, Xiaohuan Yang, Min Zhang, Bin Zhao
Summary: This study compared the consistency between superb microvascular imaging (SMI) and contrast-enhanced ultrasound (CEUS) for the detection of neovascularization in carotid plaques of different thicknesses and evaluated their diagnostic value. The results showed that SMI was able to detect neovascularization in carotid plaques and had good agreement with CEUS.
ACADEMIC RADIOLOGY
(2023)
Review
Urology & Nephrology
Li Yang, Yuan Tao, Zhang Weixin, Bao Meiling, Hang Jing
Summary: The study retrospectively investigated the ultrasound findings of five patients with primary testicular lymphoma, showing localized hypoechogenicity, increased blood flow in color Doppler ultrasound, hyper enhancement in contrast-enhanced ultrasound, and linear nonbranching pattern on microvascular ultrasound.