Article
Health Care Sciences & Services
Beliz Su Gundogdu, John Gaitanis, James B. Adams, Daniel A. Rossignol, Richard E. Frye
Summary: This study collected data on seizure characteristics, treatment effectiveness, and age differences in individuals with autism spectrum disorder (ASD) through an online survey. It found that seizure severity decreases with age and that specific medications and diets have different effectiveness depending on the age of seizure onset. These findings are important for improving personalized treatment for epilepsy in ASD.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Sebastiano Cicco, Marco D'Abbondanza, Marco Proietti, Vincenzo Zaccone, Chiara Pes, Federica Caradio, Massimo Mattioli, Salvatore Piano, Alberto Maria Marra, Alessandro Nobili, Pier Mannuccio Mannucci, Antonello Pietrangelo, Giorgio Sesti, Elena Buzzetti, Andrea Salzano, Antonio Cimellaro
Summary: This study investigated the determinants and outcomes of antihypertensive drug prescription in older hospitalized patients. The findings suggest that adherence to guideline-recommended antihypertensive treatment is associated with a lower risk of adverse clinical outcomes.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Pharmacology & Pharmacy
Soumiya Pal, Jenat Rahman, Shengyu Mu, Nancy J. Rusch, Amanda J. Stolarz
Summary: The lymphatic circulation is crucial for the transport of lymph fluid, but certain medications may disrupt lymph flow and contribute to the development of lymphedema. This review examines the potential mechanisms of drug-related lymphedema, with a focus on common medications used for cardiovascular diseases, metabolic disorders, and cancer. It also explores possible therapeutic options for lymphedema.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Ting Xu, Zhen-Hao Li, Ting Liu, Cai-Hong Jiang, Ya-Juan Zhang, Hui Li, Ying Jiang, Juan Zhao, Wen-Jing Guo, Jia-Yuan Guo, Lu Wang, Jia-Xuan Li, Jing Shen, Gao-Wa Jin, Ze-Wei Zhang, Quan-Fu Li
Summary: In recent years, more attention has been paid to the dynamic changes in skeletal muscles during antitumor drug therapy. These changes focus on the increasing or decreasing levels of skeletal muscles during or at the end of the entire treatment course.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Sofie H. Tolmeijer, Emmy Boerrigter, Takayuki Sumiyoshi, Edmond M. Kwan, Sarah W. S. Ng, Matti Annala, Grainne Donnellan, Cameron Herberts, Guillemette E. Benoist, Paul Hamberg, Diederik M. Somford, Inge M. van Oort, Jack A. Schalken, Niven Mehra, Nielka P. van Erp, Alexander W. Wyatt
Summary: This study aimed to investigate the relationship between changes in circulating tumor DNA (ctDNA) and clinical prognosis in patients with metastatic castration-resistant prostate cancer (mCRPC) during androgen receptor pathway inhibitor (ARPI) treatment. The results showed that a decrease in ctDNA fraction within 4 weeks was associated with longer duration of first-line ARPI treatment and improved survival, suggesting its potential to identify resistance early and guide treatment decisions.
CLINICAL CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Dantong Wang, Christian Rausch, Simon A. Buerger, Sebastian Tschuri, Maja Rothenberg-Thurley, Melanie Schulz, Jan Hasenauer, Frank Ziemann, Klaus H. Metzeler, Carsten Marr
Summary: By studying the kinetics of blast cells and ctDNA in AML patients, we found that ctDNA can be used for less invasive monitoring of AML disease, and a mathematical model can predict bone marrow blast content and relapse risk.
Article
Medicine, Research & Experimental
Yuwei Liu, Shuang Guo, Yue Sun, Caiyu Zhang, Jing Gan, Shangwei Ning, Junwei Wang
Summary: This study found that most core clock genes are up-regulated, while clock control genes are down-regulated, and copy number variation may affect aberrations of clock genes. Based on the Circadian rhythm score (CRS) model, patients can be classified into high and low groups, with significant differences in survival and immune cell infiltration. Patients with low CRS are more sensitive to chemotherapy and immunotherapy, and 10 compounds positively associated with CRS have the potential to modulate circadian rhythms.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Kefan Lin, Yingtong Zhou, Yanling Lin, Yuanyuan Feng, Yuting Chen, Longmei Cai
Summary: A predictive signature consisting of four senescence-related lncRNAs was developed, and patients were classified into high- and low-risk groups. GSEA showed different activation of immune-related pathways in two groups. Significant differences were found in tumor immune microenvironment, tumor burden mutation, immune checkpoint expression, and chemotherapeutic drug sensitivity between the two groups of patients. This study provides new insights for guiding personalized treatment in SKCM patients.
Article
Cell Biology
Haochen Yu, Yong Fu, Zhenrong Tang, Linshan Jiang, Chi Qu, Han Li, Zhaofu Tan, Dan Shu, Yang Peng, Shengchun Liu
Summary: Pyroptosis, a new form of programmed cell death, has been found to play a significant role in the progression and medication resistance of breast cancer. Through the integration of various bioinformatics and statistical methods, a predictive multigene signature, consisting of pyroptosis-related genes, was created and verified for its ability to predict patient prognosis and responses to treatment. Furthermore, a predictive model based on the gene signature and clinicopathological markers was developed to classify risk and assess individual patients.
Article
Cell Biology
Pan Wang, Jihong Ma, Wenjing Li, Qilong Wang, Yinan Xiao, Yuening Jiang, Xiaoyang Gu, Yu Wu, Suwei Dong, Hongyan Guo, Mo Li
Summary: Metabolomics analysis identifies a panel of seven metabolites that can be used for early detection of ovarian cancer. This study not only reveals metabolic features in uterine fluid of gynecological patients but also establishes a noninvasive approach for the early diagnosis of OC.
CELL REPORTS MEDICINE
(2023)
Article
Oncology
Phoebe Lyons, Dana Polini, Kate Russell-Ryan, A. James P. Clover
Summary: Electroporation is a method that uses electrical pulses to temporarily or permanently change the structure of cells. High-frequency electroporation with biphasic waves can permeabilize cell membranes without causing side effects, allowing treatment under local anesthesia.
Article
Chemistry, Multidisciplinary
Junyi Chen, Yadan Zhang, Yao Chai, Zhao Meng, Yahan Zhang, Longming Chen, Dongqin Quan, Yongan Wang, Qingbin Meng, Chunju Li
Summary: This study demonstrates the effectiveness of a supramolecular detoxification system in treating organophosphorus poisoning. The formation of compound complexes enhances the inhibition effect of ACh-induced hyperstimulation on ACh receptors, thereby alleviating cholinergic crisis symptoms.
Article
Public, Environmental & Occupational Health
Diana Corona-Mata, Antonio Rivero-Juarez, Angela Camacho, Laura Ruiz-Torres, Inmaculada Ruiz-Caceres, Bartolome de la Fuente Darder, David Caceres-Anillo, Maria de Guia Castro-Granados, Maria Lizaur-Barbudo, Maria Victoria Cabrera-Gisbert, Justa Redondo-Ecija, Ana Aparicio-Aparicio, Leticia Manchado-Lopez, Luciano Cobos, Ignacio Perez-Valero, Antonio Rivero
Summary: This study aimed to evaluate an intervention for the diagnosis and treatment of chronic hepatitis C and HIV in individuals with a history or current drug use. The results suggest that personalized intervention models can contribute to the control of hepatitis C infection in this population.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Immunology
Mirinda Ann Gormley, Matthew J. Akiyama, Lior Rennert, Kerry A. Howard, Brianna L. Norton, Irene Pericot-Valverde, Sam Muench, Moonseong Heo, Alain H. Litwin
Summary: The study examines the changes in health-related quality of life (HRQOL) throughout and after hepatitis C virus (HCV) treatment for people who inject drugs (PWID) achieving sustained virologic response (SVR).
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Chemistry, Analytical
Akanksha Jain, Tapas Das
Summary: The use of radiolabeled chemotherapeutics shows promising potential in cancer treatment by delivering lethal radiation dose to cancerous lesions with minimum chemotherapy drugs, thus overcoming a significant obstacle in chemotherapeutic interventions. Successful radiolabeling of certain chemotherapeutic drugs with suitable radionuclides has shown considerable promise in pre-clinical studies.
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
(2023)
Article
Surgery
Amir Keshvari, Reyhaneh Ettehadi, Sina Azadnajafabad, Mohammad Reza Keramati
Summary: This study presents the outcome of surgical treatment for patients with severe encapsulating peritoneal sclerosis (EPS) who did not respond to medical therapy. The study found that early surgical intervention is highly recommended when conservative treatments fail to resolve obstructive symptoms in EPS patients.
INDIAN JOURNAL OF SURGERY
(2023)
Review
Medicine, General & Internal
Mairead G. McNamara, John Bridgewater, Lipika Goyal, Timothy Jacobs, Anna D. Wagner, David Goldstein, Rachna Shroff, Markus Moehler, Maeve Lowery, Tanios Bekaii-Saab, Robin K. Kelley, Junji Furuse, Lorenza Rimassa, Chigusa Morizane, Angela Lamarca, Richard Hubner, Jennifer Knox, Juan Valle
Summary: Female representation as first and senior authors in later phase systemic oncological clinical trials in biliary tract cancer is low and has not changed significantly over time. The reasons behind this imbalance need to be better understood and addressed.
Article
Oncology
Rille Pihlak, Melissa Frizziero, Soo Yit Gustin Mak, Christina Nuttall, Angela Lamarca, Richard A. Hubner, Juan W. Valle, Mairead G. McNamara
Summary: This study investigated the expectations and priorities of patients with advanced pancreatic cancer and their clinicians, and found a mismatch between patient and physician views regarding treatment goals, priorities, and expected outcomes. Patients significantly overestimated the expected survival extension from chemotherapy and prioritized length of survival, while physicians believed that patients would prioritize the balance between side-effects and survival. Patients had higher hopes for treatment leading to life extension and experienced fear and worry about the future with poor symptom scores and quality of life.
Review
Immunology
Reem D. Mahmood, Kathryn Graham, Jack Gleeson, Richard A. Hubner, Juan W. Valle, Mairead G. McNamara
Summary: Novel therapies using PD-1 and PD-L1 monoclonal antibodies show potential in treating both early-stage and advanced biliary tract cancer (BTC). Multiple phase III clinical trials demonstrate significant overall survival benefits when PD-1/PD-L1 inhibitors are added to chemotherapy for first-line management of advanced BTC. Future research should focus on identifying biomarkers to optimize patient selection for these therapies.
Article
Multidisciplinary Sciences
Mohammad Reza Keramati, Seyed Mostafa Meshkati Yazd, Mostafa Omidi, Amir Keshvari, Sepehr Shahriarirad, Reza Shahriarirad, Seyed Mohsen Ahmadi-Tafti, Behnam Behboudi, Alireza Kazemeini, Leyla Sahebi, Mohammad Sadegh Fazeli
Summary: This study aimed to cross-culturally adapt the Persian version of the Quality of Life in patients with Anal Fistula questionnaire and evaluate its validity and reliability. The results showed that the Persian translation of the questionnaire was valid and reliable for the evaluation of the QoL of patients with anal fistula.
Article
Gastroenterology & Hepatology
M. S. Najafi, A. Kazemeini, S. M. Meshkati Yazd, M. Dashtkuhi, S. M. Ahmadi Tafti, B. Behboudi, M. S. Fazeli, A. Keshvari, M. R. Keramati
Summary: This study compared two surgical methods for treating chronic anal fissures, mucosal advancement flap anoplasty (MAFA) and cutaneous advancement flap anoplasty (CAFA). A randomized clinical trial was conducted involving patients with refractory fissures, and outcomes, pain reduction, and complications were compared. Both techniques significantly reduced anal pain, and there were no significant differences in recurrence, healing duration, postoperative pain, and bleeding between the two groups. Overall, the surgical procedures were effective with minimal complications and satisfactory results.
TECHNIQUES IN COLOPROCTOLOGY
(2023)
Review
Oncology
Simon Gray, Octave Letissier, Constance d'Abrigeon, Dinakshi Shah, Stephen Wardell, Olusola Faluyi, Angela Lamarca, Richard A. Hubner, Julien Edeline, Juan W. Valle, Mairead G. McNamara
Summary: Biliary tract cancer (BTC) has a poor prognosis and lacks standard third-line systemic therapy. This study evaluated 97 patients who received three lines of palliative systemic therapy for BTC and found a median survival of 6.4 months after starting third-line treatment. Patients with targeted molecular aberrations had significantly improved survival. This study provides a benchmark for future clinical trials in BTC.
Article
Oncology
Lindsay E. Carnie, Dinakshi Shah, Kate Vaughan, Zainul Abedin Kapacee, Lynne McCallum, Marc Abraham, Alison Backen, Mairead G. McNamara, Richard A. Hubner, Jorge Barriuso, Loraine Gillespie, Angela Lamarca, Juan W. Valle
Summary: In advanced pancreatic cancer, most patients experience pancreatic exocrine insufficiency (PEI), which can negatively affect their nutritional status, quality of life, and survival rates. This study aimed to identify a simple screening panel to identify patients who require timely intervention with pancreatic enzyme replacement therapy. The screening panel proposed is a practical tool that can be used in a clinical setting to identify patients at a higher risk of PEI and in need of immediate dietetic intervention.
Article
Medicine, General & Internal
Mairead G. McNamara, Jayne Swain, Zoe Craig, Rohini Sharma, Olusola Faluyi, Jonathan Wadsley, Carys Morgan, Lucy R. Wall, Ian Chau, Nick Reed, Debashis Sarker, Jane Margetts, Daniel Krell, Judith Cave, Sharmila Sothi, Alan Anthoney, Christopher Bell, Alkesh Patel, Jamie B. Oughton, David A. Cairns, Wasat Mansoor, Angela Lamarca, Richard A. Hubner, Juan W. Valle
Summary: This study compared the efficacy of liposomal irinotecan/5-FU/folinic acid and docetaxel in the treatment of PD-EP-NEC as second-line therapy. The results showed that liposomal irinotecan/5-FU/folinic acid achieved a 6-month progression-free survival rate of 29.6%, while docetaxel did not meet the primary endpoint. Liposomal irinotecan/5-FU/folinic acid demonstrated manageable toxicity and maintained quality of life.
Article
Oncology
Constance d'Abrigeon, Mairead G. Mcnamara, Samuel Le Sourd, Angela Lamarca, Astrid Lievre, Heloise Bourien, Alexandre Peinoit, Thomas Uguen, Richard A. Hubner, Juan W. Valle, Julien Edeline
Summary: This retrospective analysis of patients with advanced intrahepatic cholangiocarcinoma (iCC) found that cirrhosis was relatively common and was associated with increased chemotherapy-induced toxicity and shorter overall survival. The study highlights the importance of formal assessment and consideration of cirrhosis in the therapeutic management of iCC.
BRITISH JOURNAL OF CANCER
(2023)
Review
Oncology
Jamie M. J. Weaver, Richard A. Hubner, Juan W. Valle, Mairead G. Mcnamara
Summary: Extra-pulmonary poorly differentiated neuroendocrine carcinoma is a rare and poorly understood tumor type. While there is limited evidence for its treatment, recent research has helped clarify the first-line chemotherapy choices. However, the lack of data continues to be a challenge in the second-line setting. A personalized approach and emerging translational approaches focused on mouse models and genomic profiling may guide future trial designs.
Review
Oncology
Matthew D. D. Robinson, Mairead G. McNamara, Hamish W. W. Clouston, Paul A. A. Sutton, Richard A. A. Hubner, Juan W. W. Valle
Summary: As cancer treatment advances, the safety concerns related to surgical procedures in cancer patients receiving systemic anti-cancer therapy (SACT) become more complex. This review examines the available evidence on surgical complications in these patients, recommends risk mitigation strategies, and highlights important safety considerations for surgery during cancer treatment.
Article
Health Care Sciences & Services
Sarah Clelland, Christina L. Nuttall, Helen E. Stott, Joseph Cope, Natalie L. Barratt, Kelly Farrell, Manyi V. Eyong, Jack P. Gleeson, Angela Lamarca, Richard A. Hubner, Juan W. Valle, Mairead G. Mcnamara
Summary: This study analyzed the case-notes of newly diagnosed patients with advanced pancreatic cancer and found that approximately two-thirds of cases had documented prognosis discussions. However, there were missed opportunities for prognosis discussions. Nurse clinicians had the highest frequency of prognosis discussion and referral to community palliative care services. Greater attention to documentation of prognosis discussions is recommended.
Review
Oncology
Angela Lamarca, Lorena Ostios, Mairead G. Mcnamara, Carlos Garzon, Jack P. Gleeson, Julien Edeline, Ana Herrero, Richard A. Hubner, Victor Moreno, Juan W. Valle
Summary: Precision medicine has had a major impact on the management of advanced cholangiocarcinoma (CCA) patients, with molecular profiling providing new targets for treatment. However, there are still challenges such as lack of response and the development of drug resistance.
CANCER TREATMENT REVIEWS
(2023)
Review
Oncology
Victoria Foy, Mairead G. McNamara, Juan W. Valle, Angela Lamarca, Julien Edeline, Richard A. Hubner
Summary: This review explores the current evidence for immune checkpoint inhibition (ICI) in patients with advanced HCC and discusses future directions, including the need for predictive biomarkers, the impact of cirrhosis etiology on treatment response, and the safety of ICI in patients with impaired liver function.