Article
Biochemistry & Molecular Biology
Christian Giommi, Marta Lombo, Nina Montik, Michela Paolucci, Valentina Notarstefano, Giovanni Delli Carpini, Andrea Ciavattini, Antonio Ragusa, Francesca Maradonna, Elisabetta Giorgini, Oliana Carnevali
Summary: Gestational diabetes mellitus (GDM) and small-for-gestational-age (SGA) are metabolic-related diseases that can occur during pregnancy. This study investigated the changes in the placental chorionic villi (CVs) of GDM and SGA patients. The results showed higher levels of SOD-1 and CAT in GDM placentae, which may be related to the hyperglycemic environment. Lipid composition and structure of the placenta were altered in both pathologies, with SGA inducing lipid peroxidation and reducing collagen deposition in the CVs. The cannabinoid system does not seem to be involved in these two pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Hanna Ostling, Maria Lodefalk, Helena Backman, Robert Kruse
Summary: This study investigated the global expression of miRNAs and proteins in healthy term placentas and found important functions related to immune and inflammatory response, lipid metabolism, and neural development.
FRONTIERS IN MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Yi-jun Liu, Yan Xie, Ying-kuan Tian, Hui Liu, Cai-die He, Song-lin An, Wei Chen, Yuan-zhong Zhou, Xiao-ni Zhong
Summary: This study adds to the literature by measuring PBDEs exposure during pregnancy using placental samples, and provides evidence that prenatal exposure to PBDEs may be associated with the risk of SGA.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Obstetrics & Gynecology
Pinar Calis, Ayse Cakir Gundogdu, Ezgi Turgut, Cemile Merve Seymen, Atiye Seda Saglam, Deniz Karcaaltincaba, Gulnur Take Kaplanoglu
Summary: The aim of this study was to evaluate the differences in placental microvasculature and expression of anti-angiogenic factor PEDF and CD68 in early onset FGR, late onset FGR, SGA, and AGA pregnancies. The study found that the degeneration was highest in the early onset FGR group and SGA placentas showed worse degeneration compared to AGA placentas. The intensity of PEDF and CD68 was significant in the FGR and SGA groups compared to the AGA group. The mRNA level results were also parallel to the immunostaining results.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Endocrinology & Metabolism
Jose M. Murrieta-Coxca, Emanuel Barth, Paulina Fuentes-Zacarias, Ruby N. Gutierrez-Samudio, Tanja Groten, Alexandra Gellhaus, Angela Koeninger, Manja Marz, Udo R. Markert, Diana M. Morales-Prieto
Summary: Placenta accreta spectrum (PAS) is a group of pathological conditions characterized by abnormal attachment of the placenta to the uterus wall, and it is a major cause of maternal morbidity and mortality worldwide. In this study, altered miRNA expression, particularly in placenta-specific miRNA clusters, was identified in placenta accreta tissue compared to normal placental tissues. Dysregulated pathways associated with cell cycle regulation, inflammation, and invasion were also observed. The study provides miRNA:mRNA associations that could contribute to our understanding of PAS development.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jorge Lopez-Tello, Amanda N. Sferruzzi-Perri
Summary: Babies with small for gestational age (SGA), defined as birthweight below the 10th percentile, may have a higher risk of neurodevelopmental abnormalities compared to babies with normal birthweight. Previous research has focused on studying the transport function of the placenta, while the role of placental hormones in fetal growth regulation remains largely unexplored. Using a mouse model, this study found that SGA fetuses had lower placental efficiency and reduced hormone production, leading to decreased brain weight and expression of certain genes related to development and metabolism. These findings highlight the importance of placental endocrine dysfunction in fetal growth and brain development in SGA babies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Acoustics
R. L. Deter, W. Lee, P. Dicker, E. C. Tully, F. Cody, F. D. Malone, K. M. Flood
Summary: This study found that there are seven growth restriction patterns in small fetuses with delayed growth in the third trimester. 37% of fetuses without evidence of growth restriction had vascular abnormalities. The distribution and types of normal growth and growth restriction patterns in the AGA cohort were different compared to the SGA cohort.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Endocrinology & Metabolism
Yuqi Yang, Fang Guo, Yue Peng, Rong Chen, Wenbo Zhou, Huihui Wang, Jun OuYang, Bin Yu, Zhengfeng Xu
Summary: This study utilized single-cell RNA sequencing to analyze the comprehensive transcriptomic profile of human placenta in patients with gestational diabetes mellitus (GDM), identifying cellular function and intercellular interactions, which can help elucidate the molecular mechanisms of GDM.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Junshen He, Zhao Chen, Chunlin Chen, Ping Liu
Summary: Functional MRI can assess the differences in oxygenation and perfusion status between pregnancies complicated by FGR and SGA. The results showed that oxygenation status was significantly lower in pregnancies complicated by FGR compared to pregnancies complicated by SGA. However, diffusion and perfusion parameters were similar between the two groups.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Joseph Phillipos, Thao Vi Luong, Deborah Chang, Suresh Varadarajan, Paul Howat, Lauren Hodgson, Deb Colville, Judy Savige
Summary: The study compared the effects of gestational diabetes, pregnancy-associated hypertension, and small-for-gestational age babies on systemic small vessel calibre examined in the retina. Results showed that women with gestational diabetes, pregnancy-associated hypertension, or small-for-gestational age babies had reduced mean retinal arterial calibre, with the greatest reduction seen in pregnancy-associated hypertension and small-for-gestational age babies.
FRONTIERS IN MEDICINE
(2023)
Article
Cell Biology
Jingsi Chen, Lili Du, Feiyang Wang, Xuan Shao, Xiaoyi Wang, Wenzhe Yu, Shilei Bi, Dexiong Chen, Xingfei Pan, Shanshan Zeng, Lijun Huang, Yingyu Liang, Yulian Li, Rufang Chen, Fengwu Xue, Xiuying Li, Shouping Wang, Manli Zhuang, Mingxing Liu, Lin Lin, Hao Yan, Fang He, Lin Yu, Qingping Jiang, Zhongtang Xiong, Lizi Zhang, Bin Cao, Yan-Ling Wang, Dunjin Chen
Summary: This study reveals that SARS-CoV-2 infection during mid-gestation may result in placental insufficiency and immune activation, significantly impacting maternal and foetal health.
CELL PROLIFERATION
(2022)
Article
Developmental Biology
Yiwen Cui, Meredith Cruz, Anna Palatnik, Stephanie Olivier-Van Stichelen
Summary: Gestational diabetes mellitus (GDM) can be influenced by fetal sex, in addition to placental endocrine dysregulation. This study investigated the role of the O-GlcNAc pathway in mediating sex-specific placenta dysfunction in GDM. The expression of O-GlcNAc enzymes, specifically OGT, was found to be significantly reduced in male placentas from GDM mothers. In vitro studies further demonstrated the impact of OGT downregulation on hormonal production in trophoblast cells and primary syncytiotrophoblasts (SCTs) derived from male placentas.
Article
Medicine, General & Internal
Yoo-Mi Kim, Han-Hyuk Lim, Eunhee Kim, Geena Kim, Minji Kim, Hyejin So, Byoung Kook Lee, Yoowon Kwon, Jeesu Min, Young Seok Lee
Summary: This study aimed to investigate monogenic growth failure in patients with familial short stature (FSS) and idiopathic short stature (ISS), and analyze their response to growth hormone therapy. The results identified several genetic causes associated with short stature, and showed that growth hormone therapy can improve height in genetically confirmed patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Shuman Zhang, Lingna Zhou, Lin Zhang, Yu Wang, Huaiyan Wang
Summary: This study aims to examine the clinical application of genomic screening in newborns small for gestational age (SGA) for early discovery of neonatal diseases. A total of 93 full-term SGA newborns were assessed using tandem mass spectrometry (TMS) and Angel Care genomic screening (GS). The results showed that Angel Care GS detected cases of thyroid dyshormonogenesis 6 (TDH6) and identified variants associated with recessive childhood-onset disorders in 48.4% of the cases.
Article
Obstetrics & Gynecology
Hadas Ganer Herman, Alina Rechulski Keizman, Hadas Miremberg, Yossi Mizrachi, Tomer Dicker, Michal Levy, Letizia Schreiber, Michal Kovo
Summary: This study aimed to compare obstetric, perinatal, and placental histologic findings in small-for-gestational-age (SGA) neonates according to different growth charts. The results support the use of a local population-based growth chart for the diagnosis of fetal growth restriction.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Endocrinology & Metabolism
Maria Lodefalk, Carina Frykholm, Elisabeth Esbjorner, Osten Ljunggren
HORMONE RESEARCH IN PAEDIATRICS
(2016)
Letter
Endocrinology & Metabolism
Maria Lodefalk, Ola Nilsson
HORMONE RESEARCH IN PAEDIATRICS
(2017)
Article
Obstetrics & Gynecology
Marianne Allbrand, Jan Aman, Maria Lodefalk
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2018)
Article
Endocrinology & Metabolism
M. Lodefalk, J. Amant, P. Bang
Article
Endocrinology & Metabolism
M. Lodefalk, C. Carlsson-Skwirut, J. J. Holst, J. Aman, P. Bang
HORMONE RESEARCH IN PAEDIATRICS
(2010)
Article
Endocrinology & Metabolism
Maria Lodefalk, Jan Aman
PEDIATRIC DIABETES
(2010)
Article
Obstetrics & Gynecology
Marianne Allbrand, Jan Aman, Kerstin Nilsson, Yang Cao, Maria Lodefalk
JOURNAL OF PERINATAL MEDICINE
(2019)
Article
Endocrinology & Metabolism
Maria Rodanaki, Maria Lodefalk, Katharina Forssell, Carl-Goran Arvidsson, Maria Forssberg, Jan Aman
HORMONE RESEARCH IN PAEDIATRICS
(2019)
Article
Obstetrics & Gynecology
Maria Lodefalk, Marianne Allbrand, Scott Montgomery
Summary: The duration of the pushing phase of labor is inversely associated with the expression of genes in placenta from vaginal deliveries, specifically tumor necrosis factor, interleukin-6, insulin-like growth factor 1 and 2. Future research should consider these associations with labor duration, especially during the pushing phase.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Maria Rodanaki, Eva Rask, Maria Lodefalk
Summary: This study investigates the relationship between GnRH signaling and ghrelin levels, suggesting that the addition of a protease inhibitor to sampling tubes can help preserve ghrelin levels.
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Review
Cell Biology
Maria Lodefalk, Felix Chelslin, Johanna Patriksson Karlsson, Stefan R. Hansson
Summary: Placental dysfunction may increase the offspring's later-life disease risk. This systematic review aimed to examine the association between pathological placental changes and neuropsychological outcomes in children beyond the neonatal period. A total of 16 studies involving 15,862 participants were included in the review. While some studies reported an association between placental changes and outcomes, the evidence was limited and there was a risk of publication bias. The largest study found a small association between placental size and psychiatric symptoms in boys.
Article
Endocrinology & Metabolism
M. Lodefalk, J. Aman
Article
Pediatrics
M Svensson, I Engstrom, J Aman