Article
Nanoscience & Nanotechnology
Guang Ren, Patrick Tae Joon Hwang, Reid Millican, Juhee Shin, Brigitta C. Brott, Thomas van Groen, Craig M. Powell, Sushant Bhatnagar, Martin E. Young, Ho-Wook Jun, Jeong-A Kim
Summary: This study demonstrates the effects of using PANO gel to inject exogenous NO on high-fat diet-induced obesity, insulin resistance, and cognitive functions. The use of PANO gel reduces body weight gain, improves glucose tolerance, decreases insulin and leptin levels, and enhances insulin signaling. Additionally, the PANO gel reduces inflammation, increases lipolysis, decreases serum lipids and liver triglycerides, stimulates the development of brown and beige fat tissues, increases cerebral blood flow, and improves learning and memory abilities.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Natasha de Alwis, Natalie K. Binder, Yeukai T. M. Mangwiro, Sally Beard, Natasha Pritchard, Elif Kadife, Bianca R. Fato, Emerson Keenan, Fiona C. Brownfoot, Tu'uhevaha J. Kaitu'u-Lino, Natalie J. Hannan
Summary: Esomeprazole, a proton pump inhibitor, shows potential therapeutic effects in the treatment of pregnancy-induced hypertension, and may work via the nitric oxide pathway. Further research is needed to fully understand its mechanism of action.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rocio Salsoso, Alfonso Mate, Fernando Toledo, Carmen M. Vazquez, Luis Sobrevia
Summary: Late-onset preeclampsia is associated with altered endothelial function in the fetoplacental vasculature, causing an imbalance in the L-arginine/NO signaling pathway and reducing umbilical vein dilation to insulin, which requires A(2B)AR activation in HUVECs.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Endocrinology & Metabolism
Vanessa Rodrigues Vilela, Nolwenn Samson, Renato Nachbar, Lia Rossi Perazza, Gabriel Lachance, Volatiana Rokatoarivelo, Carolina Centano-Baez, Patricia Zancan, Mauro Solo-Penna, Kerstin Bellmann, Vincenzo Di Marzo, Mathieu Laplante, Andre Marette
Summary: This study demonstrates the crucial role of adipocyte NOS2 in the development of obesity-linked insulin resistance and dyslipidemia, partly through NO-dependent inhibition of BAT mitochondrial bioenergetics.
MOLECULAR METABOLISM
(2022)
Article
Endocrinology & Metabolism
Tianxue Zhao, Qian Li, Qianyun Mao, Kaida Mu, Chen Wang
Summary: The study found that nNOS inhibits the insulin signaling pathway by activating p38MAPK, promoting the development of hepatic insulin resistance.
JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Patricia Principe, George T. Mukosera, Nikia Gray-Hutto, Ashra Tugung, Ciprian P. Gheorghe, Arlin B. Blood
Summary: This study examined the effects of nitric oxide (NO) on placental cells and tissue, and found that NO significantly increased the levels of iron nitrosyl compounds (FeNO) in these samples. Furthermore, the expression levels of iron regulatory genes were significantly altered in response to NO exposure. These findings suggest a potential role for NO in regulating iron homeostasis in the placenta.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Cher-Rin Chong, Saifei Liu, Hasan Imam, Tamila Heresztyn, Benedetta C. Sallustio, Yuliy Y. Chirkov, John D. Horowitz
Summary: Perhexiline (Px) can inhibit platelet aggregation and improve insulin sensitivity in patients with Type 2 diabetes (T2D) and cardiovascular disease. However, approximately 30% of Px-treated patients with T2D lack the NO-sensitizing effect and show increased insulin resistance.
Article
Nutrition & Dietetics
Caitlyn Nguyen-Ngo, Anthony V. Perkins, Martha Lappas
Summary: Gestational diabetes mellitus (GDM) and maternal obesity have long-term detrimental impacts on the health of both mother and offspring. Increased inflammation and oxidative stress play key roles in the pathophysiology of these metabolic conditions. This study found that selenium supplementation may prevent inflammation and oxidative stress associated with GDM and maternal obesity.
Article
Biochemistry & Molecular Biology
Bianca Maria Rotoli, Rossana Visigalli, Francesca Ferrari, Marianna Ranieri, Grazia Tamma, Valeria Dall'Asta, Amelia Barilli
Summary: This study evaluated the effects of desmopressin on human pulmonary microvascular endothelial cells and found that it had no cytotoxic effect on the endothelium, but significantly stimulated the production of nitric oxide.
Article
Pharmacology & Pharmacy
Samantha L. Saunders, Dana S. Hutchinson, Fiona C. Britton, Lu Liu, Irit Markus, Shaun L. Sandow, Timothy V. Murphy
Summary: The study demonstrated the presence of all three beta-adrenoceptor subtypes in the endothelium of rat cremaster muscle artery, with beta(3)-adrenoceptor mediated vasodilation only evident after blockade of beta(1/2)-adrenoceptors. Constitutive beta(1/2)-adrenoceptor activity inhibits beta(3)-adrenoceptor function in the endothelium of skeletal muscle resistance arteries.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Physiology
Ezequiel J. Hid, Juana Mosele, Paula D. Prince, Cesar G. Fraga, Monica Galleano
Summary: This review summarizes experimental evidence on the beneficial effects of (-)-epicatechin (EC) attenuating major cardiometabolic risk factors, including dyslipidemias, obesity, hyperglycemia, and hypertension. The assessment of EC metabolism highlights the importance of both host metabolism-derived conjugated-EC metabolites and microbiota-derived species. EC appears to have significant effects on regulating oxidant production, nitric oxide production, and energy homeostasis in processes associated with cardiometabolic diseases.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Article
Food Science & Technology
Xiuwen Geng, Jiajun Ji, Yuanhua Liu, Xueyan Li, Yunan Chen, Lei Su, Lina Zhao
Summary: The anthocyanin cyanidin-3-O-glucoside (Cy3G) has the potential to prevent diabetes and its vascular complications by restoring impaired nitric oxide-mediated endothelial insulin transport and improving metabolic insulin resistance. This finding offers a novel explanation for the anti-diabetic effects of Cy3G.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Albino Carrizzo, Concetta Iside, Angela Nebbioso, Vincenzo Carafa, Antonio Damato, Sebastiano Sciarretta, Giacomo Frati, Flavio Di Nonno, Valentina Valenti, Michele Ciccarelli, Eleonora Venturini, Mariarosaria Scioli, Paola Di Pietro, Tommaso Bucci, Valentina Giudice, Marianna Storto, Bianca Serio, Annibale Alessandro Puca, Giuseppe Giugliano, Valentina Trimarco, Raffaele Izzo, Bruno Trimarco, Carmine Selleri, Lucia Altucci, Carmine Vecchione
Summary: In addition to well-known risk factors, cardiovascular events may also be associated with epigenetic and genetic alterations. This study found that the MTHFR C677T gene variant is related to increased cardiovascular risk. Interestingly, even with normal homocysteine levels, heterozygous carriers of this gene variant have an augmented risk of cardiovascular accidents, suggesting the presence of additional deregulated processes. The study suggests that targeting SIRT1 activation could be a new therapeutic strategy to control cardiovascular risk in MTHFR carriers.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Katie E. Cohen, Boran Katunaric, Mary E. Schulz, Gopika SenthilKumar, Micaela S. Young, James E. Mace, Julie K. Freed
Summary: This study found that chronic administration of exogenous adiponectin can restore nitric oxide as the mediator of flow-induced dilation in arterioles from patients with coronary artery disease. The Adiponectin Receptor 1 (AdipoR1) plays a critical role in adiponectin-induced NO signaling during shear. Additionally, osmotin, a plant-derived protein, showed similar effects to adiponectin.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Peter J. Little, Christopher D. Askew, Suowen Xu, Danielle Kamato
Summary: The endothelium is a single-cell monolayer that lines the entire vasculature, playing roles in barrier function, anticoagulation, vascular aging, endocrine secretion, and inflammation suppression. It produces important factors like nitric oxide and endothelin, with continued research on endothelial dysfunction leading to potential novel cardiovascular therapies.
Review
Biochemistry & Molecular Biology
Paola Valero, Gonzalo Fuentes, Marcelo Cornejo, Sofia Vega, Adriana Grismaldo, Fabian Pardo, Gerardo Garcia-Rivas, Jan-Luuk Hillebrands, Marijke M. Faas, Paola Casanello, Eline M. van der Beek, Harry van Goor, Luis Sobrevia
Summary: Balanced communication between the mother, placenta, and foetus is crucial for a successful pregnancy, and diseases or environmental toxins may negatively impact the foetus' development and growth.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Article
Cell Biology
Tamara Marin, Andres E. Dulcey, Fabian Campos, Catalina de la Fuente, Mariana Acuna, Juan Castro, Claudio Pinto, Maria Jose Yanez, Cristian Cortez, David W. McGrath, Pablo J. Saez, Kirill Gorshkov, Wei Zheng, Noel Southall, Maria Carmo-Fonseca, Juan Marugan, Alejandra R. Alvarez, Silvana Zanlungo
Summary: Niemann-Pick type A (NPA) disease is a fatal lysosomal neurodegenerative disorder. Recent studies have shown that c-Abl tyrosine kinase activity plays a role in neuronal damage and death in NPA disease. There is potential for the use of c-Abl inhibitors in the clinical treatment of NPA patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Letter
Nutrition & Dietetics
Francisco Mardones, Pedro Rosso, Alvaro Erazo, Marcelo Farias
REVISTA CHILENA DE NUTRICION
(2022)
Article
Obstetrics & Gynecology
Jose Galaz, Roberto Romero, Marcia Arenas-Hernandez, Marcelo Farias-Jofre, Kenichiro Motomura, Zhenjie Liu, Naoki Kawahara, Catherine Demery-Poulos, Tzu Ning Liu, Justin Padron, Bogdan Panaitescu, Nardhy Gomez-Lopez
Summary: Clarithromycin prevents preterm birth and improves neonatal survival in a mouse model of sterile intra-amniotic inflammation, demonstrating its potential as a therapeutic intervention for women with this condition.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Immunology
Catherine Demery-Poulos, Roberto Romero, Yi Xu, Marcia Arenas-Hernandez, Derek Miller, Li Tao, Jose Galaz, Marcelo Farias-Jofre, Gaurav Bhatti, Valeria Garcia-Flores, Megan Seyerle, Adi L. Tarca, Nardhy Gomez-Lopez
Summary: Problem pregnancy is associated with changes in circulating innate immune cells as well as adaptive immune components like T cells and B cells. T cells and B cells in pregnant women exhibit distinct responses and activations compared to non-pregnant women. These findings contribute to the understanding of immune changes during pregnancy and their role in preventing adverse perinatal outcomes.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jorge Carvajal, Paola Casanello, Alberto Toso, Marcelo Farias, Karina Carrasco-Negue, Kenny Araujo, Paola Valero, Javiera Fuenzalida, Caterina Solari, Luis Sobrevia
Summary: The SARS-CoV-2 infection causes COVID-19 disease, which leads to acute respiratory distress syndrome, bilateral pneumonia, and organ failure. The effects of maternal SARS-CoV-2 infection on pregnant women, fetuses, and neonates are still controversial, and it is important to determine the presence of viral and non-viral vertical transmission. SARS-CoV-2 infection alters the function of asymptomatic and symptomatic pregnant women, the fetoplacental unit, and the neonate, and various pregnancy-related diseases, including COVID-19, can affect the fetoplacental function and result in long-term health consequences.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Obstetrics & Gynecology
Wen Tong, Esha Ganguly, Roberto Villalobos-Labra, Anita Quon, Floor Spaans, Dino A. A. Giussani, Sandra T. T. Davidge
Summary: Gestational hypoxia is associated with fetal growth restriction and perinatal morbidity and mortality. This study found that chronic hypoxia promotes sexually dimorphic activation of the unfolded protein response (UPR) in the placenta, with increased GRP78 expression in male placentae and increased ATF6 activation in female placentae. Additionally, gestational hypoxia reduced fetal weight only in males and ATF6 activation correlated with an increase in the fetal crown-rump-length/body weight ratio only in females.
REPRODUCTIVE SCIENCES
(2023)
Article
Health Care Sciences & Services
Delia Indira Chiarello, Fabian Pardo, Jessica Moya, Maricela Pino, Andrea Rodriguez, Maria Eugenia Araneda, Ayleen Bertini, Jaime Gutierrez
Summary: This study aims to evaluate the effectiveness of an mHealth intervention in reducing excessive weight gain in pregnant women attending family health care centers. The study design follows a classic randomized clinical trial, and the findings will contribute to the design and implementation of personalized prevention strategies for gestational obesity.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Obstetrics & Gynecology
Lorena Suarez-Idueta, Judith Yargawa, Hannah Blencowe, Ellen Bradley, Yemisrach B. Okwaraji, Veronica Pingray, Luz Gibbons, Adrienne Gordon, Kara Warrilow, Enny S. Paixao, Ila Rocha Falcao, Sarka Lisonkova, Qi Wen, Francisco Mardones, Raul Caulier-Cisterna, Petr Velebil, Jitka Jirova, Erzsebet Horvath-Puho, Henrik Toft Sorensen, Luule Sakkeus, Lili Abuladze, Mika Gissler, Mohammad Heidarzadeh, Maziar Moradi-Lakeh, Khalid A. Yunis, Ayah Al Bizri, Shamala D. Karalasingam, Ravichandran Jeganathan, Arturo Barranco, Lisa Broeders, Aimee E. van Dijk, Luis Huicho, Hugo Guillermo Quezada-Pinedo, Kim Nail Cajachagua-Torres, Fawziya Alyafei, Mai AlQubaisi, Geum Joon Cho, Ho Yeon Kim, Neda Razaz, Jonas Soederling, Lucy K. Smith, Jennifer Kurinczuk, Estelle Lowry, Neil Rowland, Rachael Wood, Kirsten Monteath, Isabel Pereyra, Gabriella Pravia, Eric O. Ohuma, Joy E. Lawn
Summary: This study aims to examine the prevalence of novel newborn types among 165 million live births in 23 countries from 2000 to 2021. The distribution of newborn types varies across countries, with the highest prevalence of small newborn types in West Asian countries and large newborn types in European countries.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Dominik Kylies, Marina Zimmermann, Fabian Haas, Maria Schwerk, Malte Kuehl, Michael Brehler, Jan Czogalla, Lola C. Hernandez, Leonie Konczalla, Yusuke Okabayashi, Julia Menzel, Ilka Edenhofer, Sam Mezher, Hande Aypek, Bernhard Dumoulin, Hui Wu, Smilla Hofmann, Oliver Kretz, Nicola Wanner, Nicola M. Tomas, Susanne Krasemann, Markus Glatzel, Christoph Kuppe, Rafael Kramann, Bella Banjanin, Rebekka K. Schneider, Christopher Urbschat, Petra Arck, Nicola Gagliani, Marc van Zandvoort, Thorsten Wiech, Florian Grahammer, Pablo J. Saez, Milagros N. Wong, Stefan Bonn, Tobias B. Huber, Victor G. Puelles
Summary: Expansion microscopy physically enlarges biological specimens to achieve nanoscale resolution, but its applicability is limited due to the requirement of laser-based systems. A computational method called super-resolution radial fluctuations (SRRF) has been developed as an alternative. In this study, we introduce a workflow called expansion-enhanced super-resolution radial fluctuations (ExSRRF), which provides a resolution of up to 25 nm using LED-based widefield microscopy. ExSRRF enables molecular profiling of subcellular structures in complex clinical and experimental specimens and shows potential application in identifying pathological features.
NATURE NANOTECHNOLOGY
(2023)
Article
Medical Laboratory Technology
Jose Galaz, Kenichiro Motomura, Roberto Romero, Zhenjie Liu, Valeria Garcia-Flores, Li Tao, Yi Xu, Bogdan Done, Marcia Arenas-Hernandez, Tomi Kanninen, Marcelo Farias-Jofre, Derek Miller, Adi L. Tarca, Nardhy Gomez-Lopez
Summary: Preterm birth is a major cause of neonatal morbidity and mortality worldwide. Sterile intra-amniotic inflammation, triggered by alarmins, is a common condition associated with preterm labor. The NLRP3 inflammasome has been implicated in this process, but its mechanisms are not fully understood. By studying Nlrp3-/- mice, researchers found that NLRP3 deficiency prevents preterm birth and neonatal mortality by inhibiting premature labor activation and reducing inflammation. Furthermore, both maternal and fetal Nlrp3 signaling contribute to alarmin-induced preterm birth. These findings highlight the importance of targeting NLRP3 signaling to prevent adverse perinatal outcomes.
TRANSLATIONAL RESEARCH
(2023)
Article
Obstetrics & Gynecology
Marcelo Farias-Jofre, Roberto Romero, Yi Xu, Dustyn Levenson, Li Tao, Tomi Kanninen, Jose Galaz, Marcia Arenas-Hernandez, Zhenjie Liu, Derek Miller, Gaurav Bhatti, Megan Seyerle, Adi L. L. Tarca, Nardhy Gomez-Lopez
Summary: Pregnancy alters monocyte responses to viral ligands, mainly through TLR8 and membrane-bound TLR3 signaling. These differences may help explain the increased susceptibility of pregnant women to adverse outcomes resulting from viral infections.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Peripheral Vascular Disease
Roberto Villalobos-Labra, Ricky Liu, Floor Spaans, Tamara Saez, Tamara Semeria Maitret, Anita Quon, Tatsuya Sawamura, Christy-Lynn M. Cooke, Sandra T. Davidge
Summary: The study demonstrates that LOX-1 mediates the endothelial dysfunction induced by preeclampsia-STBEVs. This finding expands on the mechanisms that may lead to adverse outcomes in preeclampsia and proposes LOX-1 as a potential target for future interventions.
Article
Multidisciplinary Sciences
Marcel S. Woo, Friederike Ufer, Jana K. Sonner, Anouar Belkacemi, Joseph Tintelnot, Pablo J. Saez, Paula F. Krieg, Christina Mayer, Lars Binkle-Ladisch, Jan Broder Engler, Simone Bauer, Nina Kursawe, Vanessa Vieira, Stefanie Mannebach, Marc Freichel, Veit Flockerzi, Pablo Vargas, Manuel A. Friese
Summary: The study identifies CACNB3 as a master regulator of ATP-dependent migDC migration, which plays a crucial role in regulating tissue-specific immune responses during injury and inflammation.
Article
Multidisciplinary Sciences
Tiago Dias Domingues, Joao Malato, Anna D. Grabowska, Ji-Sook Lee, Jose Ameijeiras-Alonso, Przemyslaw Biecek, Luis Graca, Helena Mourin, Carmen Scheibenbogen, Francisco Westermeier, Luis Nacul, Jacqueline M. Cliff, Eliana Lacerda, Nuno Sepulveda
Summary: In this study, the researchers re-analyzed data from ME/CFS and MS patients and found that IgG antibody data is more informative in explaining the symptoms of MS patients than ME/CFS patients. However, the clinical implications of these findings in ME/CFS patients remain to be determined due to the fluctuating nature of their symptoms.