Article
Emergency Medicine
Bryan W. Greenfield, Briauna M. Lowery, Hannah E. Starke, Lesby Mayorquin, Chelsea Stanford, Elizabeth A. Camp, Andrea T. Cruz
Summary: This study found that young infants with respiratory viral infections were less likely to have serious bacterial infections compared to infants without viral infections.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Pediatrics
Son H. McLaren, Andrea T. Cruz, Kenneth Yen, Matthew J. Lipshaw, Kelly R. Bergmann, Rakesh D. Mistry, Colleen K. Gutman, Fahd A. Ahmad, Christopher M. Pruitt, Graham C. Thompson, Matthew D. Steimle, Xian Zhao, Abigail M. Schuh, Amy D. Thompson, Holly R. Hanson, Stacey L. Ulrich, James A. Meltzer, Jennifer Dunnick, Suzanne M. Schmidt, Lise E. Nigrovic, Muhammad Waseem, Roberto Velasco, Samina Ali, Danielle L. Cullen, Borja Gomez, Ron L. Kaplan, Kajal Khanna, Jonathan Strutt, Paul L. Aronson, Ankita Taneja, David C. Sheridan, Carol C. Chen, Amanda L. Bogie, Aijin Wang, Peter S. Dayan
Summary: The study aimed to determine the prevalence of invasive bacterial infections and adverse events in afebrile infants with acute otitis media. The findings showed a low prevalence of IBIs and adverse events in these infants, suggesting that outpatient management without diagnostic testing may be reasonable.
Article
Pediatrics
Yuval Barak-Corren, Yoav Elizur, Shira Yuval, Amalia Burstyn, Noy Deri, Shepard Schwartz, Orli Megged, Ori Toker
Summary: This study aimed to determine the rate of serious bacterial infections (SBI) in young ex-premature infants with fever and develop a risk-stratification algorithm. The study found that well-appearing ex-preterm infants had a significant risk for invasive bacterial infection (IBI) until the adjusted age of 28 days and for urinary tract infection (UTI) until the adjusted age of 60 days. Further studies are needed to evaluate the approach to fever in this unique population.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Anne-Sophie Romain, Romain Guedj, Anais Chosidow, Nicolas Mediamolle, Aurelie Schnuriger, Sophie Vimont, Charlene Ferrandiz, Nicolas Robin, Marie-Helene Odievre, Emmanuel Grimprel, Mathie Lorrot
Summary: This study investigated the performance of procalcitonin (PCT) assay between 12 and 36 hours after onset of fever (PCT H12-H36) in predicting invasive bacterial infection (IBI) in febrile neonates. The results showed that PCT H12-H36 had high sensitivity and specificity in identifying IBI and could potentially help in stopping early antibiotic treatment in febrile neonates.
FRONTIERS IN PEDIATRICS
(2022)
Article
Pediatrics
Prashant Mahajan, John M. VanBuren, Leah Tzimenatos, Andrea T. Cruz, Melissa Vitale, Elizabeth C. Powell, Aaron N. Leetch, Michelle L. Pickett, Anne Brayer, Lise E. Nigrovic, Peter S. Dayan, Shireen M. Atabaki, Richard M. Ruddy, Alexander J. Rogers, Richard Greenberg, Elizabeth R. Alpern, Michael G. Tunik, Mary Saunders, Jared Muenzer, Deborah A. Levine, John D. Hoyle Jr, Kathleen Grisanti Lillis, Rajender Gattu, Ellen F. Crain, Dominic Borgialli, Bema Bonsu, Stephen Blumberg, Jennifer Anders, Genie Roosevelt, Lorin R. Browne, Daniel M. Cohen, James G. Linakis, David M. Jaffe, Jonathan E. Bennett, David Schnadower, Grace Park, Rakesh D. Mistry, Eric W. Glissmeyer, Allison Cator, Amanda Bogie, Kimberly S. Quayle, Angela Ellison, Fran Balamuth, Rachel Richards, Octavio Ramilo, Nathan Kuppermann
Summary: This study examined the prevalence of bacteremia and bacterial meningitis in febrile infants with positive urinalysis results. The results showed no difference in the prevalence of bacterial meningitis between infants with positive and negative urinalysis results aged 29-60 days. Additionally, low-risk blood thresholds can effectively predict the absence of bacteremia and/or bacterial meningitis in low-risk infants.
Article
Pediatrics
Jefferson Antonio Buendia, Diana Guerrero Patino
Summary: This study evaluates the cost-effectiveness of PCT, CRP, and Rochester scale in detecting febrile infants without focus. The results show that PCT is the most cost-effective strategy.
Article
Medicine, General & Internal
Ali Gungor, Aytac Goktug, Raziye Merve Yaradilmis, Muhammed Mustafa Guneylioglu, Betul Ozturk, Ilknur Bodur, Can Demir Karacan, Nilden Tuygun
Summary: This study found that high CRP and SII values can predict urinary tract infections without bacteremia in infants with fever without a source. The advantage of SII is that it can be easily calculated using blood test results without extra cost or blood collection.
POSTGRADUATE MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Yahiya Y. Syed
Summary: Cefiderocol is a cephalosporin with activity against carbapenem-resistant bacteria and nonfermenters, using the bacteria's iron uptake system to disrupt the cell wall and kill the bacteria. It has shown good effectiveness and safety in clinical trials for various serious bacterial infections, providing a useful addition to treatment options for adults with limited choices.
Article
Pediatrics
Paul L. Aronson, Ellen Kerns, Brittany Jennings, Sloane Magee, Marie E. Wang, Corrie E. McDaniel
Summary: During the COVID-19 pandemic, the prevalence of urinary tract infection (UTI) and invasive bacterial infection (IBI) in febrile infants decreased. Moreover, for every 5% increase in COVID-19 prevalence in the month of presentation, the odds of an infant having UTI and bacteremia decreased.
Article
Pediatrics
Tan Shi Rui Victoria, Ong Gene Yong-Kwang, Lee Khai Pin, Ganapathy Sashikumar, Chong Shu-Ling
Summary: A higher temperature at triage is associated with a higher risk of serious bacterial infections (SBIs) among febrile infants ≤ 90 days old. However, other risk factors must be considered in conjunction with height of temperature to identify SBIs in these infants.
Article
Public, Environmental & Occupational Health
Runqiang Liang, Ziyu Chen, Shumei Yang, Jie Yang, Zhu Wang, Xin Lin, Fang Xu
Summary: This study aimed to develop a model to diagnose serious bacterial infections (SBI) in ICU neonates based on routine blood parameters. The model showed a good performance with an AUC of 0.812 in diagnosing SBI for ICU neonates.
EPIDEMIOLOGY AND INFECTION
(2023)
Article
Medicine, General & Internal
Mohamad Hadhud, Itai Gross, Noa Hurvitz, Lea Ohana Sarna Cahan, Zivanit Ergaz, Giora Weiser, Noa Ofek Shlomai, Smadar Eventov Friedman, Saar Hashavya
Summary: Adjusting the chronological age of preterm infants according to their gestational age is a widely accepted practice, but its validation in assessing infection in these infants is lacking. Correcting for chronological age is especially critical in infants with a chronological age above 3 months, but a corrected age below 3 months due to differences in assessment protocols. This study assessed the difference in incidence of serious bacterial infection (SBI) according to chronological and corrected age in preterm infants.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Emergency Medicine
Sweeti Bhakta Jain, Tucker Anderson, Daniel Mikhail, Ritu Banerjee, Donald H. Arnold
Summary: This retrospective observational study examined well-appearing neonates with incidental hypothermia detected during a routine visit. The study found that these infants had a low risk of serious infection and may not require a full sepsis evaluation.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Critical Care Medicine
Anne M. Drewry, Nicholas M. Mohr, Enyo A. Ablordeppey, Catherine M. Dalton, Rebecca J. Doctor, Brian M. Fuller, Marin H. Kollef, Richard S. Hotchkiss
Summary: This study aimed to test the hypothesis that forced-air warming improves immune function in critically ill afebrile sepsis patients compared to standard temperature management. The results showed no difference in immune function between the two groups, but the group receiving forced-air warming had lower 28-day mortality and more hospital-free days, indicating the importance of forced-air warming in the treatment of critically ill afebrile sepsis.
CRITICAL CARE MEDICINE
(2022)
Review
Geriatrics & Gerontology
Thomas Struyf, Hanne A. Boon, Alma C. van de Pol, Jos Tournoy, Alexander Schuermans, Theo J. M. Verheij, Jan Y. Verbakel, Ann Van den Bruel
Summary: This study aimed to summarize the evidence on the accuracy of clinical features and blood tests for diagnosing serious infections in older patients presenting to ambulatory care. Results showed that combining clinical features with blood tests can provide useful information for infection diagnosis, but there is a limited number of studies in this area.
Article
Immunology
Taylor Eddens, Daniel J. Kaplan, Alyce J. M. Anderson, Andrew J. Nowalk, Brian T. Campfield
CLINICAL INFECTIOUS DISEASES
(2019)
Article
Infectious Diseases
Santiago M. C. Lopez, Brian T. Campfield, Andrew J. Nowalk
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2019)
Article
Pediatrics
Vikram Kalathur Raghu, Andrew J. Nowalk, Arvind I. Srinath
CLINICAL PEDIATRICS
(2019)
Article
Pediatrics
Nader Shaikh, Judith M. Martin, Alejandro Hoberman, Megan Skae, Linette Milkovich, Andrew Nowalk, Christi McElheny, Robert W. Hickey, Diana Kearney, Massoud Majd, Eglal Shalaby-Rana, George Tseng, John F. Alcorn, Jay Kolls, Marcia Kurs-Lasky, Zhiguang Huo, William Horne, Greg Lockhart, Hans Pohl, Timothy R. Shope
JOURNAL OF PEDIATRICS
(2019)
Article
Infectious Diseases
Anna C. Sick-Samuels, Katherine E. Goodman, Glenn Rapsinski, Elizabeth Colantouni, Aaron M. Milstone, Andrew J. Nowalk, Pranita D. Tamma
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2020)
Article
Emergency Medicine
Sriram Ramgopal, Lorne W. Walker, Melissa A. Vitale, Andrew J. Nowalk
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2019)
Article
Pediatrics
Sriram Ramgopal, Lorne W. Walker, Andrew J. Nowalk, Andrea T. Cruz, Melissa A. Vitale
ARCHIVES OF DISEASE IN CHILDHOOD
(2019)
Article
Immunology
Lorne W. Walker, Lindsay Montoya, Sopio Chochua, Bernard Beall, Michael Green
OPEN FORUM INFECTIOUS DISEASES
(2019)
Article
Cardiac & Cardiovascular Systems
Cheyenne M. Beach, Stephen A. Hart, Andrew Nowalk, Brian Feingold, Kristen Kurland, Gaurav Arora
PEDIATRIC CARDIOLOGY
(2020)
Article
Computer Science, Information Systems
Lorne W. Walker, Andrew J. Nowalk, Shyam Visweswaran
Summary: This study utilized machine learning to predict outcomes of salvage of infected central venous catheters in pediatric CLABSI, showing that the infection recurrence model outperformed the CVC removal model. The research illustrated the variability of predictors over time.
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2021)
Article
Immunology
Lorne W. Walker, Shyam Visweswaran, Andrew J. Nowalk
Summary: This study investigated central line-associated bloodstream infections (CLABSI) treated with antimicrobial lock therapy (ALT) at a pediatric hospital from 2004 to 2018. The results showed that 85% of CLABSI initially cleared, but 20% experienced recurrence. Skin and bowel bacteria played different roles in the infections. The findings provide guidance for selecting CLABSI for optimal ALT use.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)