Article
Biochemistry & Molecular Biology
Zhao Yang, Jichao Zhang, Yuexin Zhu, Congcong Zhang, Guang Li, Shuo Liu, Jie Du, Yingchun Han, Bin You
Summary: Calcific aortic valve disease (CAVD) is an aging related disease characterized by inflammation and fibrocalcific remodeling. IL-17A-IL-17RA signaling is activated in calcified valves and may promote valve inflammation, fibrosis, and calcification by inducing endothelial activation and inflammation. Targeting IL-17A-IL-17RA signaling may be a potential therapeutic strategy for CAVD.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Wen-Qing Feng, Yu-Chen Zhang, Zhuo-Qing Xu, Su-Yue Yu, Jian-ting Huo, Abudumaimaitijiang Tuersun, Min-Hua Zheng, Jing-Kun Zhao, Ya-Ping Zong, Ai-Guo Lu
Summary: This study explores the role of IL-17A in colorectal cancer by evaluating its expression in patients and investigating its effects on cancer cells. The findings suggest that IL-17A can induce mitochondrial dysfunction and pyroptosis, promote intracellular ROS accumulation, and stimulate the secretion of inflammatory factors. Additionally, IL-17A can recruit CD8 + T cells to infiltrate tumors.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Immunology
Hai-Bo Tan, Yan-Qiu Zheng, Yu-Pei Zhuang
Summary: IL-17A plays a role in DKD that is not only negative; it can alleviate inflammation and fibrosis caused by DKD by regulating autophagy or macrophage phenotype, and contradictory expression of IL-17A has been observed in human DKD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Mervat E. Asker, Asmaa A. Abdelmeged, Mohamed A. Shaheen, Rana G. Eissa
Summary: This study aimed to examine the pulmonary protective potential of Secu in SUN-induced pulmonary fibrosis. Results revealed that IL-17A participates in the development and progression of pulmonary fibrosis, suggesting that components of IL-17A signaling pathway represent potential therapeutic targets for fibro-proliferative lung disease protection and treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Pulavendran Sivasami, Cody Elkins, Pamela P. Diaz-Saldana, Kyndal Goss, Amy Peng, Michael Hamersky IV, Jennifer Bae, Miaoer Xu, Brian P. Pollack, Edwin M. Horwitz, Christopher D. Scharer, Lindsey Seldin, Chaoran Li
Summary: Obesity disrupts the regulatory mechanisms that control skin inflammation in psoriasis. PPARy+ skin Treg cells have a unique transcriptional program and function to suppress psoriatic inflammation. Diet-induced obesity reduces the number of PPARy+ skin Treg cells, resulting in a loss of control over inflammation mediated by IL-17A+ y8 T cells.
Article
Biochemistry & Molecular Biology
Ana Asenjo-Bueno, Elena Alcalde-Estevez, Mariam El Assar, Gemma Olmos, Patricia Plaza, Patricia Sosa, Patricia Martinez-Miguel, Maria Piedad Ruiz-Torres, Susana Lopez-Ongil
Summary: Aging impairs vascular function, potentially due to hyperphosphatemia-induced oxidative stress. Old mice showed an imbalance in oxidant/antioxidant levels in their aortas, but a low-phosphate diet improved vascular function and restored the balance.
Review
Immunology
Daria M. Kartasheva-Ebertz, Stanislas Pol, Sylvie Lagaye
Summary: Liver fibrosis progression is guided by type 3 inflammation, influenced by factors like vitamin A, genetics, and active metabolites, while the interaction between IL-17A, IL-22, and vitamin A-active metabolites remains underexplored.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Nutrition & Dietetics
Agata Stanek, Klaudia Brozyna-Tkaczyk, Wojciech Myslinski
Summary: PVAT plays a significant role in regulating vascular tone, thermoregulation, and VSMC proliferation. Obesity-induced dysfunction can be improved by physical activity and diet interventions.
Article
Cell Biology
Huijuan Xiao, Liang Peng, Dingyuan Jiang, Yuan Liu, Lili Zhu, Zhen Li, Jing Geng, Bingbing Xie, Xiaoxi Huang, Jing Wang, Huaping Dai, Chen Wang
Summary: IL-17A promotes apoptosis of alveolar epithelial cells and pulmonary fibrosis in IPF by disrupting mitochondrial dynamics and inhibiting PINK1-mediated mitophagy.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sumie Hiramatsu-Asano, Tomoyuki Mukai, Takahiko Akagi, Haruhito A. Uchida, Shunichi Fujita, Kazuhisa Nakano, Yoshitaka Morita
Summary: IL-17A significantly promoted vascular calcification in ex vivo cultured aortas, suggesting its involvement in the increased risk of cardiovascular events in IL-17A-mediated inflammatory diseases.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Microbiology
Bock-Gie Jung, Buka Samten, Kristin Dean, Richard J. Wallace, Barbara A. Brown-Elliott, Torry Tucker, Steven Idell, Julie Philley, Ramakrishna Vankayalapati
Summary: This study established an NTM mouse model and found that early IL-17A production promotes organized pulmonary M. intracellulare infection, partly through MMP-3 production.
Review
Cell Biology
Amer Ahmed, Aasia Bibi, Massimo Valoti, Fabio Fusi
Summary: Perivascular adipose tissue (PVAT) is an important regulator of vascular tone, endothelium function, and cardiovascular disease. Under physiological conditions, PVAT releases various vasoactive substances to exert an anticontractile effect. However, under certain pathophysiological conditions, PVAT can have pro-contractile effects by altering the production of vasoactive factors. Understanding the precise role of PVAT is essential for developing PVAT-targeted therapies.
Article
Neurosciences
Miguel A. Gama Sosa, Rita De Gasperi, Dylan Pryor, Georgina S. Perez Garcia, Gissel M. Perez, Rania Abutarboush, Usmah Kawoos, Seth Hogg, Benjamin Ache, William G. Janssen, Allison Sowa, Timothy Tetreault, David G. Cook, Susan J. Tappan, Sam Gandy, Patrick R. Hof, Stephen T. Ahlers, Gregory A. Elder
Summary: The study found that chronic vascular degenerative changes induced by explosions may affect cerebral blood circulation and neuroinflammation, contributing to the progression of blast-induced post-traumatic outcomes. Specifically, abnormalities in blood vessels and neuronal degeneration may be key targets for potential therapies for blast-induced brain injury.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Marcelo Queiroz, Adriana Leandro, Lara Azul, Artur Figueirinha, Raquel Seica, Cristina M. Sena
Summary: Luteolin was found to improve endothelial function, vascular oxidative stress, and perivascular adipose tissue in type 2 diabetes mellitus rats, showing therapeutic potential for vascular complications associated with type 2 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Xu Hong, Yi Zhou, Zhiyuan Zhu, Yuting Li, Zuo Li, Yuheng Zhang, Xinxin Hu, Fuhai Zhu, Yong Wang, Mingliang Fang, Yichao Huang, Tong Shen
Summary: This study demonstrates a significant association between BPA exposure and risk of obesity, as well as elevated levels of IL-17A in human adipose tissue. Animal experiments further confirm that BPA exposure exacerbates weight gain, insulin resistance, and inflammation in adipose tissue. Genetically modified mice with altered IL-17A gene show reversed inflammatory response and improved insulin sensitivity. Mediation analysis in humans suggests that IL-17A plays a mediating role in the association between BPA exposure and obesity risk.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Natalie Arnold, Iris M. Hermanns, Andreas Schulz, Omar Hahad, Volker H. Schmitt, Marina Panova-Noeva, Juergen H. Prochaska, Harald Binder, Norbert Pfeiffer, Manfred Beutel, Karl J. Lackner, Thomas Muenzel, Philipp S. Wild
Summary: This study investigates the predictive ability of direct plasma renin and aldosterone concentrations as well as their ratio (aldosterone-to-renin, ARR) for incident hypertension in the general population. The study finds that ARR has a stronger predictive value for incident hypertension than renin or aldosterone alone, especially in obese subjects.
CARDIOVASCULAR RESEARCH
(2023)
Article
Psychology, Clinical
Danieelle Otten, Mareike Ernst, Antonia M. Werner, Ana N. Tibubos, Iris Reiner, Elmar Braehler, Joerg Wiltink, Matthias Michal, Markus Nagler, Philipp S. Wild, Thomas Muenzel, Jochem Koenig, Karl J. Lackner, Norbert Peiffer, Manfred E. Beutel
Summary: This study aimed to predict the occurrence of chronic diseases based on baseline depressive symptoms and to examine the sex-dependent effects. The results showed that baseline depressive symptoms predicted cardiovascular disease, chronic obstructive lung disease, diabetes, and migraine in both men and women, but not cancer. Additional adjustments for metabolic and lifestyle risk factors increased the risk of chronic obstructive lung disease and migraine for each point of depressive symptoms. There were trends suggesting a relevance of depressive symptoms for cardiovascular disease in men and for diabetes in women.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Thomas Muenzel, Omar Hahad, Andreas Daiber, Philip J. Landrigan
Summary: Healthy soil is essential for human health as it supports the growth of crops, provides food, and sustains populations. However, soil pollution poses a great threat to human health, reducing soil's ability to yield food and resulting in contamination and disease. It also causes water pollution and contributes to air, water, and soil pollution, leading to millions of deaths each year.
CARDIOVASCULAR RESEARCH
(2023)
Article
Ophthalmology
Achim Fiess, Michael S. Urschitz, Markus Nagler, Stefan Nickels, Susanne Marx-Gross, Thomas Muenzel, Philipp S. Wild, Manfred E. Beutel, Karl J. Lackner, Norbert Pfeiffer, Alexander K. Schuster
Summary: This study aimed to analyze the long-term effect of low birth weight on corneal aberrations in adulthood. The results indicated that low birth weight is associated with increased spherical aberration, which may affect optical image quality and visual function.
JOURNAL OF OPTOMETRY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Thomas Muenzel, Tommaso Gori
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Michael Molitor, Maria T. Bayo-Jimenez, Omar Hahad, Claudius Witzler, Stefanie Finger, Venkata S. Garlapati, Sanela Rajlic, Tanja Knopp, Tabea K. Bieler, Melania Aluia, Johannes Wild, Jeremy Lagrange, Recha Blessing, Steffen Rapp, Andreas Schulz, Hartmut Kleinert, Susanne Karbach, Sebastian Steven, Wolfram Ruf, Philipp Wild, Andreas Daiber, Thomas Muenzel, Philip Wenzel
Summary: The study found that aircraft noise may have a significant impact on the development and deterioration of ischaemic heart disease. Exposure to noise before myocardial infarction (MI) can induce cardiovascular dysfunction and inflammation, leading to worsened cardiac function and increased inflammation in the vascular and cardiac tissues. The findings suggest that reducing environmental noise exposure may improve the clinical outcomes of patients with MI.
CARDIOVASCULAR RESEARCH
(2023)
Editorial Material
Medicine, General & Internal
John F. Keaney, Thomas Muenzel
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Recha Blessing, Ioannis Drosos, Thomas Muenzel, Philip Wenzel, Tommaso Gori, Zisis Dimitriadis
Summary: This study aimed to evaluate the changes in right atrial function after revascularization of right coronary artery chronic total occlusion (CTO). Transthoracic echocardiography with strain imaging was used to assess right atrial function in 55 patients undergoing CTO recanalization. The results showed that successful revascularization improved right atrial function.
BMC CARDIOVASCULAR DISORDERS
(2023)
Review
Cell Biology
Sanela Rajlic, Hendrik Treede, Thomas Muenzel, Andreas Daiber, Georg Daniel Duerr
Summary: Previous studies have shown that oxidative stress plays an important role in the development of cardiovascular disease (CVD) in diabetic patients with high blood sugar. CVD is still the leading cause of premature death in the western world. Therefore, it is crucial to recognize diabetes mellitus-associated oxidative stress and subsequent inflammation as early as possible to initiate appropriate treatment before the occurrence of cardiovascular complications such as hypertension or coronary artery disease (CAD). This review provides an overview of methods for quantifying reactive oxygen and nitrogen species (RONS) production, which originate from different cellular mechanisms in separate cellular compartments, in order to facilitate early detection and effective treatment of these patients and their cardiovascular sequelae.
Article
Virology
Volker H. Schmitt, Lukas Hobohm, Ingo Sagoschen, Visvakanth Sivanathan, Omar Hahad, Christine Espinola-Klein, Thomas Muenzel, Karsten Keller
Summary: A study in Germany found that diabetes mellitus (DM) has a significant impact on the clinical outcome of patients with COVID-19 infection. Compared to non-diabetic patients, COVID-19 patients with DM are more likely to develop pneumonia, acute respiratory distress syndrome, require intensive care, and have a higher mortality rate.
Article
Cardiac & Cardiovascular Systems
Omar Hahad, Donya A. Gilan, Julian Chalabi, Sadeer Al-Kindi, Alexander K. Schuster, Felix Wicke, Matthias Buettner, Oliver Tuescher, Karl J. Lackner, Peter R. Galle, Stavros Konstantinides, Andreas Daiber, Philipp S. Wild, Thomas Muenzel
Summary: This study aims to investigate the association between social disadvantage and cardiovascular burden and mortality. The findings suggest that low socioeconomic status is associated with increased risk of cardiovascular disease and mortality, with education and occupation being stronger predictors compared to household net income.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sebastian Goebel, Arthur Wingerter, Juergen H. Prochaska, Andreas Schulz, Marie A. Neu, Nicole Henninger, Claudia Spix, Manfred Beutel, Karl Lackner, Thomas Muenzel, Carolyn S. Lam, Hiltrud Merzenich, Joerg Faber, Philipp S. Wild
Summary: The CVSS study found that the prevalence of different stages of heart failure in childhood cancer survivors is higher than the general population, but varies significantly based on tumor history. Systolic dysfunction is primarily associated with tumor entities, while diastolic dysfunction is associated with a higher burden of cardiovascular risk factors in childhood cancer survivors.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Christoph Kowalewski, Peter Schnuerer, Sabrina Kopp, Johannes Windschmitt, Mehmet Oezkur, Marc Kriege, Thomas Muenzel, Joachim Kaes, Ingo Sagoschen, Johannes Wild
Summary: In cases of near-fatal asthma, the combination of ECMO therapy and isoflurane application via an anesthetic-conserving device can be a successful treatment option. This case report highlights the successful decannulation and extubation of an adult patient after 13 days of ventilator support and multiple therapeutic approaches.
CLINICAL CASE REPORTS
(2023)
Article
Medicine, Research & Experimental
Venkata Garlapati, Michael Molitor, Thomas Michna, Gregory S. Harms, Stefanie Finger, Rebecca Jung, Jeremy Lagrange, Panagiotis Efentakis, Johannes Wild, Maike Knorr, Susanne Karbach, Sabine Wild, Ksenija Vujacic-Mirski, Thomas Muenzel, Andreas Daiber, Moritz Brandt, Tommaso Gori, Hendrik Milting, Stefan Tenzer, Wolfram Ruf, Philip Wenzel
Summary: Despite advances in MI interventions, adverse cardiac remodeling and fibrosis leading to IHF remain a major cause of death. A profibrotic coagulation signaling pathway involving MAPK could be targeted for improved cardiac function post-MI. Targeted interventions with trametinib in this pathway show promising results in a murine model.
JOURNAL OF CLINICAL INVESTIGATION
(2023)