Journal
ORGANIC LETTERS
Volume 21, Issue 16, Pages 6378-6382Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.9b02283
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Funding
- Scientific Independence of Young Researchers (SIR) [RBSI142AMA]
- University of Campania Luigi Vanvitelli
- Progetti di Rilevante Interesse Nazionale (PRIN) [2015FCHJ8E_003]
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We investigated the ultrasonication-mediated effects on the Fmoc-based solid-phase peptide synthesis (SPPS). Our study culminated with the development of an ultrasound-assisted strategy (US-SPPS) that allowed for the synthesis of different biologically active peptides (up to 44-mer), with a remarkable savings of material and reaction time. Noteworthy, ultrasonic irradiation did not exacerbate the main side reactions and improved the synthesis of peptides endowed with difficult sequences, placing the US-SPPS among the current high-efficient peptide synthetic strategies.
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