Review
Pharmacology & Pharmacy
Xie-Yuan Leng, Chang-Ning Liu, Shi-Chan Wang, Hao-Dong Peng, De-Guang Wang, Hai-Feng Pan
Summary: This study conducted a systematic review and meta-analysis to compare the effectiveness and safety between NSAIDs and opioids in the treatment of acute renal colic. The results showed no significant differences in various outcomes between these two treatment options, but patients treated with NSAIDs experienced fewer side effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Hye Jin Cho, Eunyoung Kang, Seonghoon Kim, D. ChangMo Yang, Joohan Nam, Eunji Jin, Jinhyu Lee, Wonyoung Choe
Summary: In this study, a water-stable Zr-based porphyrinic metal-organic framework (MOF), PCN-224, was used for the targeted adsorption of nonsteroidal anti-inflammatory drugs. The results showed high removal efficiencies for NPX and IBP, but lower efficiency for SMX. The strong interaction between the carboxylic acid functional groups in drugs and the open metal sites of PCN-224 was found to be responsible for the high adsorption capacity.
ACS APPLIED NANO MATERIALS
(2023)
Article
Surgery
Summary: This study aimed to investigate the relationship between early postoperative NSAID administration and postoperative AKI and anastomotic leak. The results showed that early use of NSAIDs in selected patients following major gastrointestinal surgery is safe.
Article
Chemistry, Medicinal
Zhaoping Pan, Yi Chen, Haiying Pang, Xiaoyun Wang, Yuehua Zhang, Xin Xie, Gu He
Summary: A novel class of thieno [2,3-d] pyrimidine derivatives containing resorcinol and morpholine fragments as Hsp90/mTOR dual inhibitors were designed, synthesized, and evaluated. The most potent compound 17o showed remarkable inhibitory activities on Hsp90, mTOR, and SW780 cancer cell, both in vitro and in vivo. Mechanism studies revealed that 17o suppressed cell proliferation through the over-activation of the PI3K/AKT/mTOR pathway regulated by mTOR inhibition and apoptosis regulated by the mitochondrial pathway.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Clinical Neurology
Jessica Ailani, Stephanie J. J. Nahas, Deborah I. I. Friedman, Todd Kunkel
Summary: NSAIDs are a common choice for treating acute migraine attacks, but their safety depends on dosage, duration, and mechanism of action. Prolonged exposure to any NSAID increases the risk and severity of adverse events. Celecoxib oral solution, a low-dose NSAID, provides acute migraine relief with fewer cardiovascular and gastrointestinal events compared to previous formulations.
Review
Cell Biology
Ajantha Sinniah, Samia Yazid, Rod J. Flower
Summary: Interest in inflammation and its treatment dates back to ancient times, with discoveries of glucocorticoids and endogenous anti-inflammatory proteins marking a new era of anti-inflammatory therapy. The pharmaceutical industry has made progress in seeking safer synthetic glucocorticoids for treatment.
Article
Microbiology
Anna Pawelczyk, Rafal Nowak, Monika Gazecka, Anna Jelinska, Lucjusz Zaprutko, Pawel Zmora
Summary: The study explores the potential of combining cannabidiol (CBD) and non-steroidal anti-inflammatory drugs (NSAIDs) as novel antiviral dual-target agents against SARS-CoV-2/COVID-19. Chemical modifications were made to CBD to enhance its activity against the virus. The results showed promising antiviral activity against SARS-CoV-1 and SARS-CoV-2, suggesting a potential therapeutic role for these compounds in treating emerging coronavirus infections.
Article
Biochemistry & Molecular Biology
Agnieszka Siemieniuk, Michal Ludynia, Malgorzata Rudnicka
Summary: The research found that tomatoes are more sensitive to NSAIDs, experiencing growth inhibition and other effects, while corn is less affected by these drugs. Plants showed activation of defense mechanisms in response to the oxidative stress triggered by NSAIDs treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Marta S. Krawczyk, Irena Majerz
Summary: This study explores the synthesis of complexes of fenamic, flufenamic, mefenamic, and tolfenamic acids with ethacridine lactate, and characterizes them using X-ray diffraction. The formation of hydrogen bonds and other weak interactions is analyzed using Quantum Theory of Atoms in Molecules and noncovalent interaction approaches. The presence of solvent molecules in crystals also contributes to the formation of interaction networks.
CRYSTAL GROWTH & DESIGN
(2022)
Review
Peripheral Vascular Disease
J. David Spence, Tilo Grosser, Garret A. FitzGerald
Summary: Recent studies have questioned the safety of using acetaminophen for pain relief and fever reduction in patients with cardiovascular disease and those taking anticoagulants. The studies suggest that acetaminophen, like most nonsteroidal anti-inflammatory drugs, can increase blood pressure and formulations containing sodium can increase cardiovascular risk. The influence of acetaminophen on coagulation through its effects on vitamin K metabolism is also discussed.
Review
Microbiology
Elena Tyumina, Maria Subbotina, Maxim Polygalov, Semyon Tyan, Irina Ivshina
Summary: Ketoprofen, a commonly used anti-inflammatory drug, has been identified as an environmental contaminant with ecotoxicological effects on various organisms. It is bioaccumulated and biomagnified in the food chain, posing a threat to ecosystems. Despite this, it is not currently considered a priority substance. This review provides a comprehensive summary of the global distribution of ketoprofen, its ecotoxicity, and available removal methods, focusing on the impact on microorganisms and potential biodegradation and phytoremediation approaches.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Zoltan S. Zadori, Kornel Kiraly, Mahmoud Al-Khrasani, Klara Gyires
Summary: The composition of intestinal microbiota can be affected by medications such as NSAIDs and opioids, leading to dysbiosis. The underlying mechanisms of dysbiosis caused by these drugs are not well understood, but mucosal inflammation, changes in motility and pH, and direct drug effect on bacterial growth are possible contributors. The microbiota signatures of NSAIDs and opioids overlap with certain diseases like SpA, RA, and neuropathic pain in T2D. Drug-induced dysbiosis may contribute to the persistence of these diseases and limit the therapeutic effect of these medications. Probiotic supplementation and fecal microbiota transplantation may have an impact on the therapeutic efficacy of NSAIDs and opioids in these diseases.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Oncology
Fan Yang, Rui Sun, Zeng Hou, Fang-Lin Zhang, Yi Xiao, Yun-Song Yang, Shao-Ying Yang, Yi-Fan Xie, Ying-Ying Liu, Cheng Luo, Guang-Yu Liu, Zhi-Min Shao, Da-Qiang Li
Summary: In this study, it is found that HSP90 N-terminal inhibitors can disrupt MORC2 homodimer formation and promote its lysosomal degradation, thereby reducing the stability of MORC2 in cancer cells. This provides a new possibility for the treatment of MORC2-overexpressing tumors.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Physical
Aldo Arturo Castaneda Ramirez, Elizabeth Rojas Garcia, Ricardo Lopez Medina, Jose L. Contreras Larios, Raul Suarez Parra, Ana Marisela Maubert Franco
Summary: The study proposed a novel material, FeBTC metal-organic framework (MOF) incorporated with magnetite, for solving water contamination issues with last generation pollutants. The material showed increased adsorption capacity by adding Fe3O4 nanoparticles, and interactions such as electrostatic interaction, H-bonding, and competitive adsorption played vital roles in drug adsorption. The study demonstrated how superficial modification with a low-surface-area MOF can achieve significant adsorption results in water pollutants.
Article
Pharmacology & Pharmacy
Carsten Skarke, Ronan Lordan, Kayla Barekat, Amruta Naik, Divij Mathew, Takuya Ohtani, Allison R. Greenplate, Gregory R. Grant, Nicholas F. Lahens, Sigrid Gouma, Elizabeth Troisi, Arjun Sengupta, Aalim M. Weljie, Wenzhao Meng, Eline T. Luning Prak, Kendall Lundgreen, Paul Bates, Hu Meng, Garret A. FitzGerald
Summary: In this small pilot study, it was found that the immune response elicited by the SARS-CoV-2 vaccine was not affected by concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs). The absence of significant immunomodulation signals suggests that NSAIDs do not impact vaccine efficacy. The gathered information may be useful for designing a larger clinical trial.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
