Article
Medicine, General & Internal
Jinru Xue, Erna Jia, Na Ren, Hua Xin
Summary: Identification of independent prognostic miRNA signatures in esophageal cancer showed that higher expression levels of hsa-miR-186-5p and hsa-let-7d-5p were associated with poor prognosis in EADC and ESCC, respectively. Functional enrichment analysis revealed involvement of these miRNAs' target genes in various cancer-related pathways.
Article
Biochemistry & Molecular Biology
Yating Fu, Jiahui Chen, Xianhua Ma, Wenjun Chang, Xiongbao Zhang, Yu Liu, Hao Shen, Xuefei Hu, An-Jing Ren
Summary: In this study, we analyzed the expression of FKBP10 in tumor tissues and investigated its subcellular expression pattern and patient outcomes in CRC. The results showed that FKBP10 was significantly elevated and exhibited three different subcellular expression patterns. The FKBP10-D expression pattern was only found in tumor tissues and was associated with unfavorable disease-free survival in CRC patients. High expression levels of FKBP10-C predicted an unfavorable prognosis of recurrence of CRC, while FKBP10-D did not.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Yu-Jie Huang, Zhi-Fei Cao, Jie Wang, Jian Yang, Yi-Jun Wei, Yu-Chen Tang, Yin-Xiang Cheng, Jian Zhou, Zi-Xiang Zhang
Summary: The study found that MUC16 mutations may activate the DNA repair and p53 pathways as an anti-tumor agent, with the NPY1R gene significantly overexpressed in the mutation group and predicting a poorer prognosis. Further analysis suggested NPY1R as a potential drug target for gastric cancer. Additionally, immune cells in the mutation group exhibited higher anti-tumor effects, with higher tumor mutation burden and cancer stem cells index compared to the wild-type group.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Medicine, General & Internal
Shuoshan Wang, Xiansheng Yang, Chang Liu, Jinlun Hu, Mei Yan, Chan Ding, Yue Fu
Summary: This study systematically explored the core genes and crucial pathways in gastric cancer, providing insights into clinical management and individualized treatment.
Article
Biology
Sayed Haidar Abbas Raza, Ruimin Zhong, Shen Xing, Xiaoting Yu, Liang Chengcheng, Linsen Zan, Nicola M. Schreurs, Sameer D. Pant, Hongtao Lei
Summary: The purpose of this study was to identify potential RNA binding proteins associated with the survival of gastric adenocarcinoma and investigate their biological characteristics and signaling pathways. A total of 1495 RNA binding protein related genes were analyzed for differential expression, resulting in 296 differential RNA binding proteins. Cox regression analysis identified 20 prognosis-related RNA binding proteins, from which a new prognostic model was constructed. The model was validated using survival analysis, receiver operating characteristic curves, and prognosis analysis curves, and a prediction nomogram with good performance was developed.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Jianwen Hu, Yanpeng Yang, Yongchen Ma, Yingze Ning, Guowei Chen, Yucun Liu
Summary: Gastric cancer is a highly heterogeneous tumor with multiple molecular disturbances. Understanding the differences in tumor proliferation cycle phenotypes can lead to better classification and targeted treatment options based on specific transcriptome data. The study identified two subtypes with distinct clinical and biological characteristics through cluster analysis of gastric cancer transcriptome data, which showed different clinical outcomes and tumor mutation burden.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Yu-Jie Lu, Lian Lian, Xiao-Ming Shen, Ying Li, Sheng-Jun Ji, Wen-Jie Wang, Yi Yang, Ying Wang, Wei-Ming Duan
Summary: This study identified potential sternness-related targets in gastric cancer, established a prognostic model using eight sternness-related genes, and found that patients in the high-risk group had worse prognosis with distinct differences in signaling pathways compared to the low-risk group.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Oncology
Junhao Liu, Zexuan Liu, Yangying Zhou, Manting Zeng, Sanshui Pan, Huan Liu, Qiong Liu, Hong Zhu
Summary: Transcription factors (TFs) play a crucial role in cancer progression, with their influence on breast cancer still unknown. This study utilized comprehensive bioinformatics analysis to identify nine co-expression modules related to TFs and construct a risk model using four TFs to predict progression free interval (PFI) in breast cancer patients. The findings suggest that the TF-related signature can independently predict patient prognosis and provide insights into the potential biological mechanisms of TFs in breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Zhi-kun Ning, Hua-kai Tian, Jiang Liu, Ce-gui Hu, Zi-tao Liu, Hui Li, Zhen Zong
Summary: This study identified a novel signature of 6 RNA-binding protein gene pairs to predict the prognosis of gastric cancer patients, providing potential targets for clinical gene therapy.
Article
Genetics & Heredity
Yunjin Yao, Yongfeng Ding, Yuntong Bai, Quan Zhou, Hyun Lee, Xiawei Li, Lisong Teng
Summary: This study identified three miRNAs with high sensitivity and specificity in distinguishing gastric cancer cases from non-cancer controls, suggesting their potential as biomarkers for gastric cancer screening.
FRONTIERS IN GENETICS
(2021)
Article
Cell Biology
Jin Ouyang, Zhijian Hu, Jianlin Tong, Yong Yang, Juan Wang, Xi Chen, Ting Luo, Shiqun Yu, Xin Wang, Shaoxin Huang
Summary: This study identified eight prognosis-associated hub genes in lung cancer patients and created a prognostic risk score (PRS) with good predictive performance. The PRS showed superior survival prediction in different subgroups and when combined with clinical risk factors. A nomogram was established to quantitatively assess individual risk by integrating the PRS and clinical factors.
Article
Cell Biology
Mengyuan Liu, Heming Li, Huijing Zhang, Huan Zhou, Taiwei Jiao, Mingliang Feng, Fangjian Na, Mingjun Sun, Mingfang Zhao, Lei Xue, Lu Xu
Summary: By analyzing high-throughput sequencing datasets, this study identified RBMS1 as a potential promoter gene for gastric cancer metastasis, which activates the JAK2/STAT3 signaling pathway and IL-6 transcriptional activation, promoting cell migration and invasion.
CELL DEATH & DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Gang Chen, Mingwei Yu, Jianqiao Cao, Huishan Zhao, Yuanping Dai, Yizi Cong, Guangdong Qiao
Summary: This study identified 11 key genes as potential prognosis biomarkers for breast cancer through bioinformatics analysis, which are mainly related to cell cycle and cell proliferation, significantly influencing the prognosis of breast cancer patients.
Article
Multidisciplinary Sciences
Ting Gui, Chenhe Yao, Binghan Jia, Keng Shen
Summary: The study identified two hub genes, CDCA5 and ESPL1, potentially playing crucial roles in EOC progression, with their expression levels in EOC tissues correlated with patient survival rates. These findings provide valuable insights for the development of new therapeutic targets in EOC treatment.
Article
Genetics & Heredity
Quanxiao Li, Limin Jin, Meng Jin
Summary: A hypoxia gene signature was developed and validated for risk stratification and prognosis prediction of HCC patients. Patients in the high-risk group had worse overall survival outcomes than those in the low-risk group in multiple datasets.
FRONTIERS IN GENETICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
P. Lin, W. K. Liu, X. Li, D. Wan, H. Qin, Q. Li, G. Chen, Y. He, H. Yang
CLINICAL RADIOLOGY
(2020)
Article
Acoustics
Hui Qin, Yu-quan Wu, Peng Lin, Rui-zhi Gao, Xin Li, Xin-rong Wang, Gang Chen, Yun He, Hong Yang
Summary: Radiomic models based on B-mode ultrasound signatures were developed to determine the origin of primary tumors in metastatic liver disease. These models showed good performance with high AUC values in both training and testing sets, providing effective supplemental means for identifying the primary sites of hepatic metastatic lesions.
JOURNAL OF ULTRASOUND IN MEDICINE
(2021)
Article
Chemistry, Applied
Wang-Yang Ye, Jun-Zhi Wang, Gai-Gai Deng, Yi-Wu Dang, Hong-Wei Liu, Gang Chen
Summary: The study found that GL-1 has a good binding ability to estrogen receptor beta and exhibits estrogen-like effects, possibly related to the secretion of estrogen and expression of ER beta through binding to ERs.
NATURAL PRODUCT RESEARCH
(2021)
Article
Oncology
Liang Liang, Jin-hui Zhu, Gang Chen, Xin-gan Qin, Jun-qiang Chen
JOURNAL OF ONCOLOGY
(2020)
Article
Hematology
Ruolin Li, Gang Chen, Yiwu Dang, Rongquan He, Angui Liu, Jie Ma, Chengbin Wang
Summary: This study revealed that both mRNA and protein levels of ATIC are significantly upregulated in multiple myeloma, and the upregulation of ATIC may play a crucial role in the tumorigenesis and development of MM, potentially through the pathway of complement and coagulation cascades.
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2021)
Article
Oncology
Tongtong Wei, Jinjing Song, Kai Liang, Li Li, Xiaoxiang Mo, Zhiguang Huang, Gang Chen, Naiquan Mao, Jie Yang
Summary: In this study, NRK was found to be significantly elevated in LUAD-associated CAFs and may serve as a promising therapeutic target for cancer combination treatment. Modulation of ECM and glycolysis/gluconeogenesis pathways could be an efficient approach to alter CAFs functionality in LUAD.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Hui-Ping Lu, Xiu-Fang Du, Jian-Di Li, Su-Ning Huang, Rong-Quan He, Hua-Yu Wu, Ming-Fen Li, Wei-Zi Wu, Ji-Tian Chen, Wei-Jia Mo, Gang Chen
Summary: This study revealed that CDC45 and Cdc45 are overexpressed in HCC tissues and high CDC45 expression is associated with worse prognosis in HCC patients. Genetic alterations of CDC45 in HCC patients are correlated with poorer outcomes, and CDC45 may promote HCC by co-expressing with NUDT1, E2F1, CCNE2, MCM5, and CENPM.
MEDICAL SCIENCE MONITOR
(2021)
Article
Biotechnology & Applied Microbiology
Yu Sun, Gang Chen, Juan He, Zhi-Guang Huang, Sheng-Hua Li, Yuan-Ping Yang, Lu-Yang Zhong, Shu-Fan Ji, Ying Huang, Xin-Hua Chen, Mao-Lin He, Hao Wu
Summary: Study findings indicate that miRNA-222-3p is downregulated in MPCa with moderate diagnostic potential. Through target gene screening and functional enrichment analysis, it is suggested that miRNA-222-3p may play an important role in MPCa by negatively regulating SNAP91.
Article
Genetics & Heredity
Shang-Wei Chen, Hua-Fu Zhou, Han-Jie Zhang, Rong-Quan He, Zhi-Guang Huang, Yi-Wu Dang, Xia Yang, Jun Liu, Zong-Wang Fu, Jun-Xian Mo, Zhong-Qing Tang, Chang-Bo Li, Rong Li, Li-Hua Yang, Jie Ma, Lin-Jie Yang, Gang Chen
Summary: Esophageal squamous cell carcinoma (ESCC) is the major histological type of esophageal cancers. The transcription factor PTTG1 was found to be highly expressed in ESCC tissues and may interact with target genes through chemokines and cytokine signaling pathways, particularly SLC25A17 and ERH. This suggests that PTTG1 may play a crucial role in the formation of ESCC by regulating downstream target genes.
FRONTIERS IN GENETICS
(2021)
Review
Oncology
Dandan Xiong, Rongquan He, Yiwu Dang, Huayu Wu, Zhenbo Feng, Gang Chen
Summary: Hepatocellular carcinoma (HCC) is a leading cause of tumor-related deaths worldwide, with difficulty in early diagnosis and poor treatment outcomes. Circular RNA (circRNA) has been shown to play a significant role in the pathogenesis and treatment of HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Rong-Quan He, Jian-Di Li, Xiu-Fang Du, Yi-Wu Dang, Lin-Jie Yang, Zhi-Guang Huang, Li-Min Liu, Liu-Feng Liao, Hong Yang, Gang Chen
Summary: This study revealed that increased LPCAT1 expression correlated with poor prognosis in HCC patients and promoted HCC progression by enhancing cellular growth, migration, and metastasis. The cell cycle and chemical carcinogenesis were identified as the most enriched signaling pathways.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Yu Sun, Gang Chen, Juan He, Jing-Xiao Li, Xiang-Yu Gan, Shu-Fan Ji, Ying Huang, Xin-Hua Chen, Mao-Lin He, Zhi-Guang Huang
Summary: The study found that CELSR3 is highly expressed in metastatic prostate cancer and has the potential to distinguish between metastatic and localized prostate cancer. CELSR3 may play a key role in MPCa by affecting the focal adhesion pathway and being targeted by miRNA-221-3p.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2022)
Article
Oncology
Wang-Yang Ye, Hui-Ping Lu, Jian-Di Li, Gang Chen, Rong-Quan He, Hua-Yu Wu, Xian-Guo Zhou, Min-Hua Rong, Li-Hua Yang, Wei-Ying He, Qiu-Yu Pang, Shang-Ling Pan, Yu-Yan Pang, Yi-Wu Dang
Summary: The study confirmed the upregulation of E2F1 in hepatocellular carcinoma (HCC) patients, with elevated E2F1 level correlating with Asian race, tumor classification, neoplasm histologic grade, eastern cancer oncology group, and plasma AFP levels. E2F1 possessed moderate discriminatory capability in differentiating HCC patients from non-HCC controls. Furthermore, two putative targeted genes (CCNE1 and CCNA2) of E2F1 were identified for their potential roles in regulating cell cycle and promoting antiapoptotic activity in HCC patients.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2021)
Article
Medicine, General & Internal
Jing-Xiao Li, Jin-Shu Pang, Bin-Tong Yin, Gang Chen, Jun-Hong Chen, Jia-Yuan Luo, Xia Yang, Li-Ting Qin, Jiang-Hui Zeng, Peng Chen, Jia-Bo Chen, Deng Tang
Summary: The study found that ATF3 is downregulated in hepatoblastoma, possibly playing a significant role in disease occurrence by regulating mechanisms like ferroptosis.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Oncology
Shi-Shuo Wang, Gao-Qiang Zhai, Gang Chen, Zhi-Guang Huang, Yu Zhang, Li-Jie Zhang, Yi-Wu Dang, Sheng-Hua Li, Hai-Biao Yan
Summary: This study found that MTDH promotes the growth of bladder cancer cells through the pathway of cell division, providing new directions and biomarkers for future treatment.
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2023)