Septin 9 isoforms promote tumorigenesis in mammary epithelial cells by increasing migration and ECM degradation through metalloproteinase secretion at focal adhesions

Matrix Metalloproteinase Inhibitors in Cancer Therapy: Turning Past Failures Into Future Successes

(2018) Arthur Winer et al.   MOLECULAR CANCER THERAPEUTICS

Pyk2 and FAK differentially regulate invadopodia formation and function in breast cancer cells

(2017) Alessandro Genna et al.   JOURNAL OF CELL BIOLOGY

Tumor Cell Invadopodia: Invasive Protrusions that Orchestrate Metastasis

(2017) Robert J. Eddy et al.   TRENDS IN CELL BIOLOGY

A Comparative Study of Serum Exosome Isolation Using Differential Ultracentrifugation and Three Commercial Reagents

(2017) Inas Helwa et al.   PLoS One

Septin 9_i2 is downregulated in tumors, impairs cancer cell migration and alters subnuclear actin filaments

(2017) P. Verdier-Pinard et al.   Scientific Reports

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Septin 9 interacts with kinesin KIF17 and interferes with the mechanism of NMDA receptor cargo binding and transport

(2016) Xiaobo Bai et al.   MOLECULAR BIOLOGY OF THE CELL

Inhibition of Breast Cancer Metastasis by Presurgical Treatment with an Oral Matrix Metalloproteinase Inhibitor: A Preclinical Proof-of-Principle Study

(2016) A. Winer et al.   MOLECULAR CANCER THERAPEUTICS

Septin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by HCV

(2016) Abdellah Akil et al.   Nature Communications

MenaINV dysregulates cortactin phosphorylation to promote invadopodium maturation

(2016) Maxwell D. Weidmann et al.   Scientific Reports

GOplot: an R package for visually combining expression data with functional analysis: Fig. 1.

(2015) Wencke Walter et al.   BIOINFORMATICS

Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

(2015) Giovanni Ciriello et al.   CELL

Profilin1 regulates invadopodium maturation in human breast cancer cells

(2015) A. Valenzuela-Iglesias et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Septin Dynamics Are Essential for Exocytosis

(2015) Elmira Tokhtaeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Septin 9 Exhibits Polymorphic Binding to F-Actin and Inhibits Myosin and Cofilin Activity

(2015) Clayton Smith et al.   JOURNAL OF MOLECULAR BIOLOGY

The Reactome pathway Knowledgebase

(2015) Antonio Fabregat et al.   NUCLEIC ACIDS RESEARCH

An Innovative Method for Exosome Quantification and Size Measurement

(2015) Arash Mehdiani et al.   Jove-Journal of Visualized Experiments

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Matrix Metalloproteinase-3 (MMP-3) Is an Endogenous Activator of the MMP-9 Secreted by Placental Leukocytes: Implication in Human Labor

(2015) Arturo Flores-Pliego et al.   PLoS One

Off-Target Effects of the Septin Drug Forchlorfenuron on Nonplant Eukaryotes

(2014) Lydia R. Heasley et al.   EUKARYOTIC CELL

Septins promote stress fiber–mediated maturation of focal adhesions and renal epithelial motility

(2014) Lee Dolat et al.   JOURNAL OF CELL BIOLOGY

CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover

(2014) Samantha J. Stehbens et al.   NATURE CELL BIOLOGY

A sphingolipid-dependent diffusion barrier confines ER stress to the yeast mother cell

(2014) Lori Clay et al.   eLife

Septin 9 amplification and isoform-specific expression in peritumoral and tumor breast tissue

(2013) Diana Connolly et al.   BIOLOGICAL CHEMISTRY

SEPT9_i1 is required for the association between HIF-1α and importin-α to promote efficient nuclear translocation

(2013) Maya Golan et al.   CELL CYCLE

Tks5 and SHIP2 Regulate Invadopodium Maturation, but Not Initiation, in Breast Carcinoma Cells

(2013) Ved P. Sharma et al.   CURRENT BIOLOGY

Extracellular matrix proteins regulate epithelial–mesenchymal transition in mammary epithelial cells

(2013) Qike K. Chen et al.   DIFFERENTIATION

Novel septin 9 repeat motifs altered in neuralgic amyotrophy bind and bundle microtubules

(2013) Xiaobo Bai et al.   JOURNAL OF CELL BIOLOGY

Rab40b regulates trafficking of MMP2 and MMP9 during invadopodia formation and invasion of breast cancer cells

(2013) A. Jacob et al.   JOURNAL OF CELL SCIENCE

β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation

(2013) Brian T. Beaty et al.   MOLECULAR BIOLOGY OF THE CELL

PITPs as targets for selectively interfering with phosphoinositide signaling in cells

(2013) Aaron H Nile et al.   Nature Chemical Biology

Autocrine HBEGF expression promotes breast cancer intravasation, metastasis and macrophage-independent invasion in vivo

(2013) Z N Zhou et al.   ONCOGENE

Forchlorfenuron Disrupts SEPT9_i1 Filaments and Inhibits HIF-1

(2013) Dikla Vardi-Oknin et al.   PLoS One

RSeQC: quality control of RNA-seq experiments

(2012) Liguo Wang et al.   BIOINFORMATICS

Septin-Driven Coordination of Actin and Microtubule Remodeling Regulates the Collateral Branching of Axons

(2012) Jianli Hu et al.   CURRENT BIOLOGY

Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK–p130Cas complex

(2012) Yu Wang et al.   JOURNAL OF CELL BIOLOGY

Comparison of protein, microRNA, and mRNA yields using different methods of urinary exosome isolation for the discovery of kidney disease biomarkers

(2012) M. Lucrecia Alvarez et al.   KIDNEY INTERNATIONAL

Mammalian SEPT9 isoforms direct microtubule-dependent arrangements of septin core heteromers

(2012) Mikael E. Sellin et al.   MOLECULAR BIOLOGY OF THE CELL

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Septins: the fourth component of the cytoskeleton

(2012) Serge Mostowy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Network Analysis of the Focal Adhesion to Invadopodia Transition Identifies a PI3K-PKC  Invasive Signaling Axis

(2012) D. Hoshino et al.   Science Signaling

Epithelial-Mesenchymal Transition: General Principles and Pathological Relevance with Special Emphasis on the Role of Matrix Metalloproteinases

(2012) P. Nistico et al.   Cold Spring Harbor Perspectives in Biology

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Expression of the SEPT9_i4 isoform confers resistance to microtubule-interacting drugs

(2012) Alex D. Chacko et al.   CELLULAR ONCOLOGY

MLL-SEPTIN gene fusions in hematological malignancies

(2011) Nuno Cerveira et al.   BIOLOGICAL CHEMISTRY

Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway

(2011) Marco A. O. Magalhaes et al.   JOURNAL OF CELL BIOLOGY

Uroplakins in the Lower Urinary Tract

(2011) Gilho Lee   International Neurourology Journal

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Targeted Knockdown of SEPT9_v1 Inhibits Tumor Growth and Angiogenesis of Human Prostate Cancer Cells Concomitant with Disruption of Hypoxia-Inducible Factor-1 Pathway

(2010) Sharon Amir et al.   MOLECULAR CANCER RESEARCH

Critical Evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the Measurement of Nanoparticles and Protein Aggregates

(2010) Vasco Filipe et al.   PHARMACEUTICAL RESEARCH

Mammary Gland Reprogramming: Metalloproteinases Couple Form with Function

(2010) R. Khokha et al.   Cold Spring Harbor Perspectives in Biology

SEPT9_v1 Up-regulates Hypoxia-inducible Factor 1 by Preventing Its RACK1-mediated Degradation

(2009) Sharon Amir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion

(2009) Keefe T. Chan et al.   JOURNAL OF CELL BIOLOGY

Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia

(2009) R. Poincloux et al.   JOURNAL OF CELL SCIENCE

Uroplakins in urothelial biology, function, and disease

(2009) Xue-Ru Wu et al.   KIDNEY INTERNATIONAL

Matrix metalloproteinase expression and outcome in patients with breast cancer: analysis of a published database

(2008) P. M. McGowan et al.   ANNALS OF ONCOLOGY

Up-regulation of SEPT9_v1 stabilizes c-Jun-N-Terminal kinase and contributes to its pro-proliferative activity in mammary epithelial cells

(2008) Maria E. Gonzalez et al.   CELLULAR SIGNALLING

Structural insights shed light onto septin assemblies and function

(2008) Yves Barral et al.   CURRENT OPINION IN CELL BIOLOGY

A new role for cortactin in invadopodia: Regulation of protease secretion

(2008) E CLARK et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Epithelial polarity requires septin coupling of vesicle transport to polyglutamylated microtubules

(2008) Elias T. Spiliotis et al.   JOURNAL OF CELL BIOLOGY

Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-κB and Brg-1

(2008) K-Y Tai et al.   ONCOGENE