Article
Medicine, General & Internal
Roemer B. Brandt, Leopoldine A. Wilbrink, Ilse F. de Coo, Joost Haan, Wim M. Mulleners, Frank J. P. M. Huygen, Erik W. van Zwet, Michel D. Ferrari, Rolf Fronczek
Summary: ONS is a safe, well-tolerated and long-term effective treatment for medically intractable chronic cluster headache.
Article
Clinical Neurology
Ida Stisen Fogh-Andersen, Jens Christian Hedemann Sorensen, Rigmor Hojland Jensen, Anne Lene Knudsen, Kaare Meier
Summary: This study reports the results of occipital nerve stimulation in 15 patients with chronic cluster headache. The results showed that occipital nerve stimulation significantly reduced the frequency and intensity of headache attacks, leading to clinically important improvement in patients' headache condition.
Article
Clinical Neurology
Aurelie Leplus, Denys Fontaine, Anne Donnet, Jean Regis, Christian Lucas, Nadia Buisset, Serge Blond, Sylvie Raoul, Evelyne Guegan-Massardier, Stephane Derrey, Bechir Jarraya, Bich Dang-Vu, Frederic Bourdain, Dominique Valade, Caroline Roos, Christelle Creach, Stephan Chabardes, Pierric Giraud, Jimmy Voirin, Jocelyne Bloch, Sophie Colnat-Coulbois, Francois Caire, Philippe Rigoard, Laurie Tran, Coralie Cruzel, Michel Lanteri-Minet
Summary: This study evaluated the long-term efficacy of occipital nerve stimulation (ONS) in treating refractory chronic cluster headache (rCCH) and found that ONS can significantly reduce attack frequency, improve quality of life, and emotional impacts in patients. In responders, ONS led to a major reduction of functional and emotional headache-related impacts and a dramatic improvement of quality of life.
Review
Clinical Neurology
Adam G. Evans, Abigail N. Horrar, Maryo M. Ibrahim, Brady L. Burns, Christopher L. Kalmar, Patrick E. Assi, Krista N. Brooks-Horrar, Tigran Kesayan, Salam Al Kassis
Summary: The study found that transcutaneous nerve stimulators showed significant reductions in both headache frequency and severity, effectively reducing the number of headache days and pain scores.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Stewart J. Tepper, Brian Grosberg, Oved Daniel, Deena E. Kuruvilla, Gabriel Vainstein, Lisa Deutsch, Roni Sharon
Summary: This study evaluated the efficacy and safety of concurrent non-invasive stimulation of occipital and trigeminal nerves in the acute treatment of migraine. The results showed that this treatment method provided fast and durable relief from migraine pain and associated symptoms, and was well-tolerated.
Article
Neurosciences
Javier Diaz-de-Teran, Javier A. Membrilla, Jose Paz-Solis, Inigo de Lorenzo, Javier Roa, Manuel Lara-Lara, Alfonso Gil-Martinez, Exuperio Diez-Tejedor
Summary: The study suggests that occipital nerve stimulation (ONS) could be an interesting option for selected drug-resistant chronic cluster headache (drCCH) patients in the long term, as it can significantly reduce the frequency and intensity of headache attacks, improve overall perceived improvement, and decrease oral medication intake with minimal adverse events.
Article
Clinical Neurology
Ida Stisen Fogh-Andersen, Jens Christian Hedemann Sorensen, Anja Sofie Petersen, Rigmor Hojland Jensen, Kaare Meier
Summary: This study aims to evaluate the efficacy of burst ONS in treating CCH and gather more information by comparing it to tonic stimulation and placebo. Additionally, the study attempts to use transcutaneous electrical nerve stimulation (TENS) as a preoperative screening tool to predict the outcomes of ONS treatment.
Review
Clinical Neurology
Catherine Veilleux, Devon Khousakoun, Churl-Su Kwon, Farnaz Amoozegar, Fady Girgis
Summary: Occipital nerve stimulation (ONS) may be an effective surgical treatment for approximately two thirds of patients with medically refractory trigeminal autonomic cephalalgias (TACs).
Article
Medicine, Research & Experimental
Julie Bulsei, Aurelie Leplus, Anne Donnet, Jean Regis, Christian Lucas, Nadia Buisset, Sylvie Raoul, Evelyne Guegan-Massardier, Stephane Derrey, Bechir Jarraya, Dominique Valade, Caroline Roos, Christelle Creach, Stephan Chabardes, Pierric Giraud, Jimmy Voirin, Sophie Colnat-Coulbois, Francois Caire, Philippe Rigoard, Eric Fontas, Michel Lanteri-Minet, Denys Fontaine
Summary: The ONS strategy was found to be more costly than the conventional strategy in the short term, but with a gain of 0.07 QALY. However, the extrapolated one-year results showed a lower total cost for the ONS strategy, a gain of 0.28 QALY, and a significant cost-effectiveness ratio. Additionally, indirect costs were slightly lower over the three-month period.
Article
Clinical Neurology
Juan Angel Aibar-Duran, Maria Jesus Alvarez Holzapfel, Rodrigo Rodriguez Rodriguez, Robert Belvis Nieto, Carles Roig Arnall, Joan Molet Teixido
Summary: In this study, occipital nerve stimulation (ONS) and deep brain stimulation (DBS) showed significant efficacy in treating patients with refractory cluster headache. However, ONS may have a trend towards loss of efficacy in long-term follow-up, while DBS appears to provide a more stable clinical response over time with an acceptable rate of surgical complications.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Oved Daniel, Stewart J. Tepper, Lisa Deutsch, Roni Sharon
Summary: This study evaluated the efficacy, safety, and tolerability of a novel external combined occipital and trigeminal neurostimulation device as a self-administered home treatment for migraine. The results showed that the device was significantly more effective in reducing pain intensity, increasing pain-free ratings, and improving pain relief compared to the sham device.
Review
Engineering, Biomedical
Oved Daniel, Roni Sharon, Stewart J. Tepper
Summary: The Relivion (R) system offers a noninvasive, customizable PNS solution for migraine treatment, with potential applications for remote disease management and a promising role in the treatment of depression. Through digital monitoring, cloud-based technology, and artificial intelligence, it may become a preferred treatment option for managing neurological and psychiatric disorders in the future.
EXPERT REVIEW OF MEDICAL DEVICES
(2021)
Article
Clinical Neurology
Philippe Magown, Werner J. Becker, Zelma H. T. Kiss
Summary: The study found that occipital nerve regional stimulation (ONS) significantly improved long-term pain symptoms, reduced the number of headache days, and improved patients' quality of life.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2021)
Review
Medicine, General & Internal
Federico Castillo-Alvarez, Ignacio Hernando de la Barcena, Maria Eugenia Marzo-Sola
Summary: Peripheral nerve blocks, particularly greater occipital nerve block, have been widely used as a safe and effective treatment for various types of headaches. A systematic review of 13 studies found that greater occipital nerve block is effective in relieving migraine, cluster headache, cervicogenic headache, and post-dural puncture headache. However, further studies are needed to determine its long-term efficacy, optimal dosage, and potential differences between different anesthetics, as well as the role of corticosteroid use.
Review
Medicine, General & Internal
David Fernandez-Hernando, Cristian Justribo Manion, Juan A. Pareja, Francisco J. Garcia-Esteo, Juan A. Mesa-Jimenez
Summary: This study conducted a systematic review on the effectiveness of non-invasive neuromodulation of the vagus nerve in patients with cluster headaches. The results showed that neuromodulation had some positive effects on relieving the frequency and intensity of cluster headaches. However, the limited quantity and heterogeneity of available studies prevented a meta-analysis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Simon Little, Alex Pogosyan, Spencer Neal, Baltazar Zavala, Ludvic Zrinzo, Marwan Hariz, Thomas Foltynie, Patricia Limousin, Keyoumars Ashkan, James FitzGerald, Alexander L. Green, Tipu Z. Aziz, Peter Brown
ANNALS OF NEUROLOGY
(2013)
Article
Engineering, Biomedical
James J. FitzGerald, Stephanie P. Lacour, Stephen B. McMahon, James W. Fawcett
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2008)
Article
Engineering, Biomedical
James J. FitzGerald, Stephanie P. Lacour, Stephen B. McMahon, James W. Fawcett
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2009)
Article
Engineering, Biomedical
Stephanie P. Lacour, James J. Fitzgerald, Natalia Lago, Edward Tarte, Stephen McMahon, James Fawcett
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2009)
Article
Engineering, Biomedical
James J. FitzGerald, Natalia Lago, Samia Benmerah, Jordi Serra, Christopher P. Watling, Ruth E. Cameron, Edward Tarte, Stephanie P. Lacour, Stephen B. McMahon, James W. Fawcett
JOURNAL OF NEURAL ENGINEERING
(2012)
Article
Biochemical Research Methods
C. P. Watling, N. Lago, S. Benmerah, J. J. FitzGerald, E. Tarte, S. McMahon, S. P. Lacour, R. E. Cameron
JOURNAL OF NEUROSCIENCE METHODS
(2010)
Review
Computer Science, Interdisciplinary Applications
Stephanie P. Lacour, Samia Benmerah, Edward Tarte, James FitzGerald, Jordi Serra, Stephen McMahon, James Fawcett, Oliver Graudejus, Zhe Yu, Barclay Morrison
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2010)
Article
Multidisciplinary Sciences
Chrystalina A. Antoniades, Philip Buttery, James J. FitzGerald, Roger A. Barker, Roger H. S. Carpenter, Colin Watts
Article
Engineering, Electrical & Electronic
Stephanie P. Lacour, Raghied Atta, James J. FitzGerald, Mark Blamire, Edward Tarte, James Fawcett
SENSORS AND ACTUATORS A-PHYSICAL
(2008)
Article
Medicine, Research & Experimental
Sean Martin, George Hadjipavlou, Rodrigo Garcia Ortega, Liz Moir, Tamara Edwards, Stana Bojanic, Alexander L. Green, James J. FitzGerald
Review
Medicine, Research & Experimental
Ashley L. B. Raghu, Tariq Parker, Tipu Z. Aziz, Alexander L. Green, George Hadjipavlou, Rustam Rea, James J. FitzGerald
Summary: Neuromodulation is an effective treatment option for painful diabetic neuropathy (PDN) patients who do not respond to traditional pharmacotherapy. Research has shown that surgical pain management options, such as tonic spinal cord stimulation (t-SCS), offer lasting and safe solutions for PDN patients, with other emerging treatments like high-frequency SCS and DRGS also showing promising results. Ongoing randomized controlled trials are being conducted to further evaluate the efficacy of different neuromodulation techniques.
Article
Medicine, Research & Experimental
Tariq Parker, Yongzhi Huang, Ashley L. B. Raghu, James FitzGerald, Tipu Z. Aziz, Alexander L. Green
Summary: This study used MEG to investigate potential biomarkers of pain and pain relief, finding increased low-frequency power spectral activity in chronic pain patients in the absence of stimulation and a shift toward higher frequency power spectrum activity in response to therapeutic DRGS. The results support the use of neuroimaging in the search for potential biomarkers of pain.
Article
Medicine, Research & Experimental
Krishnan Chakravarthy, James FitzGerald, Andrew Will, Karen Trutnau, Robert Corey, David Dinsmoor, Leonid Litvak
Summary: Spinal cord stimulation (SCS) is a treatment for chronic neuropathic pain, and evoked compound action potential (ECAP) sensing has enhanced SCS. The study characterizes sensitivity of ECAP growth curve slope (S) to neural response and stimulation artifact for spinal ECAP estimation methods. Results show that SA reduction schemes using HP and AM methods outperform others in preserving neural signals and reducing artifact misclassification.
Editorial Material
Clinical Neurology
James Manfield, Sheena Thomas, Charalambos Antoniades, Alexander L. Green, James J. Fitzgerald