Article
Multidisciplinary Sciences
Douglas Feitosa Tome, Sadra Sadeh, Claudia Clopath
Summary: This study presents a biologically-plausible computational model that demonstrates the crucial role of hippocampal-thalamic-cortical activity in systems consolidation. The model provides testable predictions for experimental neuroscience and sheds new light on the mechanisms of memory engram reorganization and associated pathways.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Huiling Gao, Wei Zheng, Cheng Li, He Xu
Summary: Studies have shown that ApoE2 and ApoE3 can significantly attenuate H2O2-induced neuronal apoptosis, while ApoE4 has no neuroprotective effect and may even have a toxic effect. ApoE2 and ApoE3 regulate the Akt/FoxO3a/Bim signaling pathway in the presence of H2O2 to exert their effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Yiyun Ding, Hongxia Zhang, Zhaojun Liu, Qiuping Li, Yujiao Guo, Ye Chen, Yue Chang, Hongyan Cui
Summary: This study has shown that CPT1C can mitigate Aβ(25-35)-induced oxidative stress, apoptosis, and accumulation of AD marker proteins in hippocampal neurons, suggesting that CPT1C has beneficial effects in alleviating AD and is involved in PPARα activation.
Article
Neurosciences
Martina Brofiga, Marietta Pisano, Mariateresa Tedesco, Anna Boccaccio, Paolo Massobrio
Summary: The brain is a complex organ composed of billions of neurons. Its structure, which exhibits a modular topological organization, is influenced by network heterogeneity and the topological properties of the underlying connectivity. This study explores the functional and structural connections between interconnected subpopulations of cortical and hippocampal neurons, and their impact on the patterns of electrophysiological activity. The results reveal the differences in connectivity and activity patterns between the two types of neurons, and the influence of the physical environment on the development and maturation of neuronal networks.
Article
Neurosciences
Wolfgang J. Streit, Jonas Rotter, Karsten Winter, Wolf Mueller, Habibeh Khoshbouei, Ingo Bechmann
Summary: This study explores the pathogenesis of neuritic plaques, finding that accumulations of iron and ferroptosis in the central nervous system trigger the formation of plaques. Microglial ferritin expression and A beta deposition both contribute to this process. Neurofibrillary tangles, on the other hand, are unlikely to involve the release of neuronal iron extracellularly.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Chemistry, Analytical
Francesca Callegari, Martina Brofiga, Fabio Poggio, Paolo Massobrio
Summary: The present study investigated the effects of low-frequency electrical stimulation on cortical and hippocampal networks. The results showed that cortical assemblies were more reactive than hippocampal ones, and that the response to stimulation was delayed in the cortical assemblies.
Article
Pharmacology & Pharmacy
Chunli Li, Haipeng Wang, Min Wang, Chunyun Chen, Fei Bai, Mengqi Ban, Chunfu Wu
Summary: The study demonstrated that oxytocin can prevent the damage to rat hippocampal neurons induced by methamphetamine, including protection of mitochondrial membrane potential, reduction of oxidative stress, and inhibition of neuron apoptosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Microbiology
S. P. Venkata Subbaiah, Patil Pranita Uttamrao, Uttam Das, Sruthi Sundaresan, Thenmalarchelvi Rathinavelan
Summary: Saccharomyces cerevisiae Stm1 protein plays an important role in ribosome preservation and apoptosis-like cell death. It can recognize specific DNA structures and its conformation and fibrillation are influenced by protein concentration and salt concentration.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiaoyi Wang, Xiaomeng Yu, Yujuan Li, Fengxia Liu, Liyuan Du, Nanchang Xie, Cui Wang
Summary: The research reveals that ATF5-regulated mtUPR plays a protective role in neuronal injury induced by magnesium deficiency, possibly by maintaining mitochondrial function.
NEUROCHEMICAL RESEARCH
(2023)
Article
Clinical Neurology
Kai Chen, Riya Gupta, Alejandro Martin-Avila, Meng Cui, Zhongcong Xie, Guang Yang
Summary: This study reveals the underlying mechanisms of anesthesia-induced remote memory impairment and identifies the hyperactivity of pyramidal neurons and increased tau phosphorylation as significant factors. Inhibiting these abnormal activities may improve memory recall in individuals with Alzheimer's disease after anesthesia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Immunology
Maria Carolina Barbosa-Silva, Raquel Maria P. Campos, Ingrid Del Castilo, Julia Franca, Paula S. Frost, Carmen Penido, Julia R. Clarke, Claudio Canetti, Victor T. Ribeiro-Resende
Summary: Neural-immune interactions play a role in the functioning of the nervous system, with potential consequences for cognitive, sensory, and motor abilities. However, the specific impact of immune factors on nervous system homeostasis remains unclear.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Damian M. Janecki, Agata Swiatkowska, Joanna Szpotkowska, Anna Urbanowicz, Martyna Kabacinska, Kamil Szpotkowski, Jerzy Ciesiolka
Summary: The protein PCBP2 has been shown to directly bind to the 5' terminus of p53 mRNA and is involved in both stability and translation control of p53 mRNA, especially under stress conditions. This dual function factor plays a crucial role in modulating p53 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Martina Lorenzati, Enrica Boda, Roberta Parolisi, Martino Bonato, Tiziana Borsello, Thomas Herdegen, Annalisa Buffo, Alessandro Vercelli
Summary: The genetic ablation of MAPK JNK1 results in reduced myelination in the brain, accompanied by increased OPC density and proliferation. Additionally, JNK1 plays a crucial role in regulating OPC branching architecture and growth.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Damijana Mojca Juric, Klara Bulc Rozman, Metoda Lipnik-Stangelj, Dusan Suput, Miran Brvar
Summary: The influence of cannabidiol (CBD) on brain development is not well understood, but it may interfere with the endogenous cannabinoid system during critical periods, leading to apoptosis and necroptosis in neurons and astrocytes.
Article
Neurosciences
Yadong Zhou, Xianjing Zhang, Hui Yang, Bo Chu, Maochuan Zhen, Junli Zhang, Lin Yang
Summary: This study explores the role of the CREB1/DAPK1 axis in brain injury after CPR. Overexpression of CREB1 improves rat neurological function, inhibits neuron apoptosis, and reduces Caspase-3 expression. CREB1 suppresses hippocampal neuron apoptosis by inhibiting DAPK1 expression. Therefore, CREB1 can mitigate brain injury after CPR.
