Editorial Material
Medicine, General & Internal
Maximilian F. Konig, Vasanth Sathiyakumar, Casey M. Phan, Steven P. Schulman, Allan C. Gelber
Summary: A 38-year-old female mail carrier experienced sudden chest pain and shortness of breath on her way home from work, with examination revealing abnormalities in her heart.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Chemistry, Physical
Seth C. Martin, Hendrik Hansen-Goos, Roland Roth, Brian B. Laird
Summary: By using simulations and theoretical calculations, we investigated the influence of wall curvature on the interfacial thermodynamics of solid-fluid interfaces. Our results show that the surface thermodynamics of the system is consistent with the predictions of morphometric thermodynamics for both positive and negative wall curvatures.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Review
Chemistry, Physical
Shuobo Wang, Xu Han, Yihe Zhang, Na Tian, Tianyi Ma, Hongwei Huang
Summary: This article provides a timely and comprehensive review focusing on recent advances in the design strategies for photocatalytic CO2 conversion. It emphasizes the importance of key parameters in tailoring the size, morphology, bandgap, and other properties of photocatalysts to improve CO2 conversion efficiency and selectivity. New trends and strategies in structural design to meet the demands for prominent CO2 photoreduction activity are also introduced, offering a comprehensive guideline for designing state-of-the-art photocatalysts with well-defined structures for CO2 conversion.
Editorial Material
Medicine, General & Internal
MaryAnn Dakkak
Summary: In this narrative medicine essay, a family medicine physician shares her personal story as someone who is obese and disabled. She talks about her own process of addressing stigma and bias around obesity and how she is now helping patients work toward improved physical function and overall health goals.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Editorial Material
Engineering, Biomedical
Ke Huang, Ke Cheng
Summary: Inflamed heart tissue can be repaired after a heart attack by using a degradable matrix that can be infused intravascularly and binds to leaky blood vessels.
NATURE BIOMEDICAL ENGINEERING
(2023)
Review
Biochemistry & Molecular Biology
Claudio Hetz
Summary: Maintaining neuronal proteostasis is crucial for brain function throughout our lifespan. As we age, the decline in proteostasis network activity may increase the risk of neurodegenerative diseases characterized by abnormal protein aggregates.
Editorial Material
Hematology
Geoffrey L. Uy
Summary: The study demonstrates a novel T-cell-bispecific antibody (TCB) targeting intracellular WT1 in AML, resulting in T-cell activation and killing of leukemia cells with minimal effect on normal hematopoietic cells.
Review
Chemistry, Inorganic & Nuclear
Tomoki Tateishi, Masahiko Yoshimura, Shun Tokuda, Fuyuki Matsuda, Daishi Fujita, Shuhei Furukawa
Summary: Cage-like molecules formed by the coordination of metal ions and organic links have unique chemical properties and design flexibility, and are pushing the boundaries of science. This review article compares coordination cages (CCs) and metal-organic cages (MOCs) from two distinct chemistry communities, highlighting their similarities and differences. The article provides insights into synthetic conditions and identifies new research directions in the field.
COORDINATION CHEMISTRY REVIEWS
(2022)
Review
Immunology
Martin Kolev, Madhumita Das, Monica Gerber, Scott Baver, Pascal Deschatelets, Maciej M. Markiewski
Summary: Recent studies have shown that complement plays a role in accelerating cancer progression by suppressing antitumor immunity in the tumor microenvironment. Activation of intracellular complement is crucial for the survival of immune cells, making it important for tumor cell survival and growth. Additionally, intracellular complement activation is essential for priming antitumor T cell responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Chemistry, Physical
Hosni Meddeb, Maximilian Goetz-Koehler, Nils Neugebohrn, Udayan Banik, Norbert Osterthun, Oleg Sergeev, Dennis Berends, Colleen Lattyak, Kai Gehrke, Martin Vehse
Summary: Solar photovoltaics play a crucial role in meeting the growing energy demand and addressing climate challenges. The diversity and customization options of tunable solar cells offer unique opportunities for various applications by adjusting intrinsic properties like bandgap energy and transparency.
ADVANCED ENERGY MATERIALS
(2022)
Article
Chemistry, Analytical
Yusi Bu, Xiaolin Zhang, Aihong Zhu, Linhao Li, Xiaoyu Xie, Sicen Wang
Summary: Inside-out cell membrane-coated nanoparticles were prepared for screening tyrosine kinase inhibitors and successfully targeted potential antitumor compounds from lung adenocarcinoma. This novel approach enhances drug screening efficiency and broadens possibilities for drug lead discovery in the future.
ANALYTICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Ramesh Koirala, Andrew Vae Priest, Chi-Fu Yen, Joleen S. Cheah, Willem-Jan Pannekoek, Martijn Gloerich, Soichiro Yamada, Sanjeevi Sivasankar
Summary: Cadherin cell-cell adhesion proteins are crucial for tissue morphogenesis and wound healing. Research has shown that vinculin can convert weak X-dimers of cadherin into strong strand-swap dimers, thereby regulating cell-cell adhesion. This process is mediated by myosin II-dependent changes in cytoskeletal tension, providing insight into the mechanisms of cadherin conformational regulation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Plant Sciences
Leander Ehmke, Gerd Hause, Ralf Bernd Kloesgen, Bationa Bennewitz
Summary: The inner membrane of mitochondria serves as a major barrier between cytosol and mitochondrial matrix, facilitating the controlled exchange of metabolites, ions, and proteins. Inside-out inner membrane vesicles are a useful tool for studying the export of substances from the matrix to the intermembrane space. This article presents a protocol for isolating inside-out vesicles of the inner membrane of plant mitochondria and demonstrates their physiological activity.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Computer Science, Artificial Intelligence
Wei Sun, Dong Gong, Qinfeng Shi, Anton van den Hengel, Yanning Zhang
Summary: The article discusses the domain gap between learning-based super-resolution methods on synthetic and real data, proposing a new approach that does not require image pairing and alignment. By generating realistic LR images and learning a degradation adaptive SR network, state-of-the-art SR results on real-world images are achieved without the need for paired-learning methods.
IEEE TRANSACTIONS ON IMAGE PROCESSING
(2021)
Editorial Material
Biochemistry & Molecular Biology
Kazunori Yamamoto, Fumio Motegi
Summary: Two new studies provide insights into the intricate process of Caenorhabditis elegans embryo patterning by revealing the adaptations of conserved PAR proteins' interaction and crosstalk to perceive distinct cues, which ultimately shape unique asymmetries in form and function.
Meeting Abstract
Oncology
David Schaer, Richard Beckmann, Jack Dempsey, Lysiane Huber, Amelie Forest, Nelusha Amaladas, Ying Cindy Wang, Erik Rasmussen, Darin Chin, Yanxia Li, Andrew Capen, Marianne Deroose, Carmine Carpenito, Xueqian Gong, Kirk Staschke, Linda Chung, Farhana Merzoug, Trent Stewart, Lacey Litchfield, Philip Iversen, Sean Buchanan, Alfonso de Dios, Ruslan Novosiadly, Michael Kalos
Review
Biochemistry & Molecular Biology
Leonardo Augusto, Ronald C. Wek, William J. Sullivan
Summary: Toxoplasma gondii is an intracellular parasite that infects a wide range of warm-blooded vertebrates and can transition between different life cycle stages in various hosts, impacting different tissues and hosts. Understanding the mechanisms behind these stage transitions is crucial for therapeutic interventions aimed at preventing parasite transmission and pathogenesis.
MOLECULAR MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jagannath Misra, Michael J. Holmes, Emily T. Mirek, Michael Langevin, Hyeong-Geug Kim, Kenneth R. Carlson, Malcolm Watford, X. Charlie Dong, Tracy G. Anthony, Ronald C. Wek
Summary: Proper regulation of the Integrated stress response (ISR) and mTORC1 signaling is crucial for cell adaptation to amino acid starvation. Halofuginone (HF) inhibits aminoacylation of tRNA(Pro) and increases free amino acids, promoting translation of genes involved in protein biogenesis. Deletion of GCN2 reduces cell survival to HF, while inhibition of mTORC1 provides protection.
NUCLEIC ACIDS RESEARCH
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Ricardo Cordova, Jagannath Misra, Parth H. Amin, Nur P. Damayanti, Kenneth R. Carlson, Angela J. Klunk, Emily T. Mirek, Marcus J. Miller, Tracy G. Anthony, Roberto Pili, Ronald C. Wek, Kirk A. Staschke
Article
Biochemistry & Molecular Biology
Sankalpip Srivastava, Jie Jiang, Jagannath Misra, Gretchen Seim, Kirk A. Staschke, Minghua Zhong, Leonardo Zhou, Yu Liu, Chong Chen, Utpal Dave, Reuben Kapur, Sandeep Batra, Chi Zhang, Jiehao Zhou, Jing Fan, Ronald C. Wek, Ji Zhang
Summary: Amino acid restriction can inhibit tumor growth by reducing the expression and translation of c-MYC protein, a critical oncogene, in lymphoid cancer cells. This study demonstrates a molecular connection between MYC mRNA translation and the availability of asparagine, providing a potential post-transcriptional target for MYC oncogene through asparagine restriction.
Article
Biology
Ricardo A. Cordova, Jagannath Misra, Parth H. Amin, Anglea J. Klunk, Nur P. Damayanti, Kenneth R. Carlson, Andrew J. Elmendorf, Hyeong-Geug Kim, Emily T. Mirek, Bennet D. Elzey, Marcus J. Miller, X. Charlie Dong, Liang Cheng, Tracy G. Anthony, Robero Pili, Ronald C. Wek, Kirk A. Staschke
Summary: The eIF2 kinase GCN2 plays a crucial role in prostate cancer by regulating the expression of solute carrier genes, affecting amino acid import and levels, and ultimately impacting tumor growth. The use of a small molecule inhibitor of GCN2 shows promising therapeutic potential in mouse models of prostate cancer.
Article
Genetics & Heredity
Danni Jin, Sheree A. A. Wek, Ricardo A. A. Cordova, Ronald C. C. Wek, Didier Lacombe, Vincent Michaud, Karin Musier-Forsyth
Summary: In this study, compound heterozygous variants in the EPRS1 gene were identified in a 4-year-old female patient with developmental delay, seizures, and deafness. Functional studies of the identified missense mutations confirmed significant defects in enzymatic function in vitro and contributed to the diagnosis confirmation.
Article
Biochemistry & Molecular Biology
Ronald C. Wek, Tracy G. Anthony, Kirk A. Staschke
Summary: Organisms adapt to changing environments by engaging cellular stress response pathways, such as the integrated stress response (ISR). This review focuses on the mechanisms of eIF2 alpha kinases as first responders of stress, the regulation of eIF2 alpha phosphorylation and other stress signals, and the differential mRNA translation triggered by the ISR. It also discusses the synergy between the ISR and mTORC1 in amino acid insufficiency, as well as the pathological conditions and therapeutic strategies related to aberrant regulation of the ISR.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Kenneth R. Carlson, Millie M. Georgiadis, Feven Tameire, Kirk A. Staschke, Ronald C. Wek
Summary: The integrated stress response (ISR) is a mechanism that cells use to protect against environmental stresses. Protein kinases such as Gcn2 play a central role in the ISR by monitoring stress conditions and regulating protein synthesis. While Gcn2 is important for cell protection, it can also contribute to the progression of diseases. In this study, a Gcn2 inhibitor was found to activate Gcn2 and further investigation was conducted to understand the mechanism of this activation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Meeting Abstract
Oncology
Ricardo Cordova, Jagannath Misra, Nur P. Damayanti, Parth H. Amin, Kenneth R. Carlson, Angela J. Klunk, Emily T. Mirek, Marcus J. Miller, Tracy G. Anthony, Roberto Pili, Ronald C. Wek, Kirk A. Staschke
Meeting Abstract
Biochemistry & Molecular Biology
Parth Amin, Emily Mirek, Kirk Staschke, Tracy Anthony, Ronald Wek
