Journal
NATURAL PRODUCT RESEARCH
Volume 35, Issue 7, Pages 1115-1121Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1641807
Keywords
Cladosporium sp; indole diterpenoid alkaloid; cladosporine A; antimicrobial activities
Categories
Funding
- National Natural Science Foundation of China [3171101305]
- Chang Jiang Scholars from the Program Ministry of Education of China [2017]
- Guangdong Special Support Program [2016TX03R280]
- Young Elite Scientists Sponsorship Program by China Association of Chinese Medicine [QNRC2-B06]
- Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme [2014]
- Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program [2017BT01Y036]
- K. C. Wong Education Foundation [2016]
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A new indole diterpenoid alkaloid, Cladosporine A (1), was isolated from the extract of a fungal strain Cladosporium sp. JNU17DTH12-9-01. Its structure was determined by spectroscopic analysis, and it showed antimicrobial activities against Staphylococcus aureus and Candida albicans.
Cladosporine A (1), a new indole diterpenoid alkaloid, was isolated from the extract of a fungal strain Cladosporium sp. JNU17DTH12-9-01. Its structure was elucidated by extensive spectroscopic analysis, and the absolute configurations were determined by electronic circular dichroism (ECD) experiments. This is the first report of the presence of indole diterpenoid alkaloid in the genus Cladosporium. The antimicrobial activities against Staphylococcus aureus 209P, Escherichia coli ATCC0111, Aspergillus niger R330, and Candida albicans FIM709 were evaluated. Compound 1 showed MICs of 4 mu g/mL and 16 mu g/mL against S. aureus 209P and C. albicans FIM709, respectively. [GRAPHICS] .
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