Journal
NATURAL PRODUCT RESEARCH
Volume 35, Issue 3, Pages 377-383Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2019.1633649
Keywords
Amomum villosum var; xanthioides; Zingiberaceae; sesquiterpene; NO inhibitory activity
Categories
Funding
- National Natural Science Foundation of China [31600275, 31600265]
- Natural Science Foundation of Guangxi Zhuang Autonomous Region of China [2017GXNSFAA198077, AD18281032]
- Doctoral Starting Fund of Xinxiang Medical University [XYBSKYZZ201813]
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A new bergamotane-type sesquiterpene, axanthiol A, was isolated from the rhizomes of Amomum villosum var. xanthioides, along with six known compounds. Compound 5 showed effective inhibitory activity on LPS-induced nitric oxide production, with an IC50 value of 34.81 μM.
A new bergamotane-type sesquiterpene, named axanthiol A (1), and six known compounds (2-7) were isolated from the rhizomes of Amomum villosum var. xanthioides. Their structures were established on the basis of extensive spectroscopic analysis and the absolute configuration of 1 was confirmed by the Mosher ester method. Moreover, all the isolates were evaluated for their effects on LPS-induced nitric oxide (NO) production, and compound 5 showed efficacious inhibitory activity with IC50 value of 34.81 mu M. [GRAPHICS] .
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