Journal
NANOMEDICINE
Volume 14, Issue 11, Pages 1429-1442Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2018-0484
Keywords
cell migration; cytokines release; immunosuppression; MAPK signaling; peripheral blood mononuclear cells; polymorphonuclear cells
Funding
- Sao Paulo Research Foundation [2014/07328-4]
- Coordination for the Improvement of Higher Level -or Education-Personnel (CAPES) [1569289]
- Research Support Foundation of the State of Rio Grande do Sul (FAPERGS: PRONEX)
- National Council of Technological and Scientific Development (CNPq)
- CAPES [001]
- CNPq
- Research Support Foundation of the State of Rio Grande do Sul (FAPERGS: Pesquisador Gaucho)
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Aim: Poly(epsilon-caprolactone) lipid-core nanocapsules (LNCs) are efficient drug carriers and drug-free LNCs display therapeutic effects, inhibiting tumor growth and neutrophil activities. Herein, we investigated the direct actions of LNCs on human immune cells, to guide their therapeutic application. Materials & methods: LNC's uptake, cytokine release, cell migration, proliferation and intracellular pathways under inflammatory stimulation were investigated. Results & conclusion: LNCs quickly penetrated leukocytes without cytotoxicity; inhibited mitogen-induced lymphocyte proliferation, cytokine release and leukocyte migration under inflammatory stimulation, which were associated with inhibition of the MAP kinase pathway and intracellular calcium influx. Hence, we showed LNCs as a down-regulatory agent on immune cells, suggesting that either the particles themselves or their application as a drug carrier can halt non-desired inflammatory processes.
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