Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 76, Issue -, Pages 17-23Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2015.10.010
Keywords
p75 neurotrophin receptor; Neurotrophic factor; Neurological disorder; Therapeutic target
Funding
- National Natural Science Foundation of China [81372040]
- Innovative Foundation for Postgraduates from Chongqing University of Technology [YCX2014230]
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As a low-affinity neurotrophins receptor, p75 neurotrophin receptor (p75NTR) is a transmembrane receptor involved in a diverse array of cellular responses, including apoptosis, survival, neurite outgrowth, migration, and cell cycle arrest, which may be related to some neurological disorders, such as Alzheimer's disease (AD), schizophrenia, major depressive disorder (MDD), posttraumatic stress disorder (PTSD), amyotrophic lateral sclerosis (ALS), and Parkinson's disease (PD). Indeed, a series of studies during the last decade has demonstrated that the p75NTR signaling plays key roles in most aspects of the neurological disorder diseases. In spite of the limited information available, this review still tried to summary the relationship between p75NTR and diverse neurological disorder diseases, and tried to further clarify the possible mechanism, which may provide a novel therapeutic target for the treatment of neurological disorders. (C) 2015 Elsevier Masson SAS. All rights reserved.
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