SNCA and mTOR Pathway Single Nucleotide Polymorphisms Interact to Modulate the Age at Onset of Parkinson's Disease

α-synuclein (SNCA ) but not dynamin 3 (DNM3 ) influences age at onset of leucine-rich repeat kinase 2 (LRRK2) Parkinson's disease in Spain

(2018) Rubén Fernández-Santiago et al.   MOVEMENT DISORDERS

Investigating Statistical Epistasis in Complex Disorders

(2018) James C. Turton et al.   JOURNAL OF ALZHEIMERS DISEASE

Analysis of Epistasis in Natural Traits Using Model Organisms

(2018) Richard F. Campbell et al.   TRENDS IN GENETICS

Predicting progression in patients with Parkinson's disease

(2017) Cornelis Blauwendraat et al.   LANCET NEUROLOGY

Nomenclature of genetic movement disorders: Recommendations of the International Parkinson and Movement Disorder Society task force

(2017) Connie Marras et al.   MOVEMENT DISORDERS

Variants in SNCA Gene Are Associated with Parkinson’s Disease Risk and Cognitive Symptoms in a Brazilian Sample

(2017) Clarissa L.C Campêlo et al.   Frontiers in Aging Neuroscience

Genetics of Parkinson's disease

(2016) Christina M. Lill   MOLECULAR AND CELLULAR PROBES

Absence ofLRRK2mutations in a cohort of patients with idiopathic REM sleep behavior disorder

(2016) Rubén Fernández-Santiago et al.   NEUROLOGY

Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium

(2016) Shefali Setia Verma et al.   PLoS Genetics

Altered machinery of protein synthesis is region- and stage-dependent and is associated with α-synuclein oligomers in Parkinson’s disease

(2015) Paula Garcia-Esparcia et al.   Acta Neuropathologica Communications

The Onset of Nonmotor Symptoms in Parkinson's disease (The ONSET PDStudy)

(2014) Claustre Pont-Sunyer et al.   MOVEMENT DISORDERS

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

Rotenone Induction of Hydrogen Peroxide Inhibits mTOR-mediated S6K1 and 4E-BP1/eIF4E Pathways, Leading to Neuronal Apoptosis

(2014) Qian Zhou et al.   TOXICOLOGICAL SCIENCES

SNCA rs356219 variant increases risk of sporadic Parkinson's disease in ethnic Chinese

(2013) Nan-Nan Li et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

SNCA: Major genetic modifier of age at onset of Parkinson's disease

(2013) Kathrin Brockmann et al.   MOVEMENT DISORDERS

TFEB-mediated autophagy rescues midbrain dopamine neurons from  -synuclein toxicity

(2013) M. Decressac et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Search for SNCA 3′ UTR Variants Identified SNP rs356165 as a Determinant of Disease Risk and Onset Age in Parkinson’s Disease

(2011) Lucía F. Cardo et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Replication of MAPT and SNCA, but not PARK16-18, as susceptibility genes for Parkinson's disease

(2011) Ignacio F. Mata et al.   MOVEMENT DISORDERS

Independent and joint effects of the MAPT and SNCA genes in Parkinson disease

(2010) Alexis Elbaz et al.   ANNALS OF NEUROLOGY

SNCA Variant Associated With Parkinson Disease and Plasma α-Synuclein Level

(2010) Ignacio F. Mata et al.   ARCHIVES OF NEUROLOGY

Lack of interaction of SNCA and MAPT genotypes in Parkinson's disease

(2010) T. Botta-Orfila et al.   EUROPEAN JOURNAL OF NEUROLOGY

Rapamycin Protects against Neuron Death in In Vitro andIn Vivo Models of Parkinson's Disease

(2010) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Pathogenic Lysosomal Depletion in Parkinson's Disease

(2010) B. Dehay et al.   JOURNAL OF NEUROSCIENCE

Cell death pathways in Parkinson’s disease: proximal triggers, distal effectors, and final steps

(2009) Oren A. Levy et al.   APOPTOSIS

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation

(2009) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria

(2009) Dennis W Dickson et al.   LANCET NEUROLOGY

Genome-wide association study reveals genetic risk underlying Parkinson's disease

(2009) Javier Simón-Sánchez et al.   NATURE GENETICS

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss

(2009) Luke S Tain et al.   NATURE NEUROSCIENCE

Oncogenic MAPK Signaling Stimulates mTORC1 Activity by Promoting RSK-Mediated Raptor Phosphorylation

(2008) Audrey Carrière et al.   CURRENT BIOLOGY

A computationally efficient hypothesis testing method for epistasis analysis using multifactor dimensionality reduction

(2008) Kristine A. Pattin et al.   GENETIC EPIDEMIOLOGY

The S18Y polymorphic variant of UCH-L1 confers an antioxidant function to neuronal cells

(2008) Elli Kyratzi et al.   HUMAN MOLECULAR GENETICS

Genetic variability in the SNCA gene influences α-synuclein levels in the blood and brain

(2007) Julia Fuchs et al.   FASEB JOURNAL