Article
Surgery
Yujin Zhang, Ying Li, Qing Tang, Haizhen Wang, Youhua Peng, Meijunzi Luo, Jie Gao, Pan Huang, Bijun Zeng, Zhibo Yang
Summary: The study found that Dendrobium officinale polysaccharide (DOP) can improve testosterone-induced hair loss, possibly through affecting the Wnt signaling and hair follicle stem cell functions.
AESTHETIC PLASTIC SURGERY
(2023)
Article
Plant Sciences
Zhengfei Luo, Lian Liu, Qiong Nie, Mingjin Huang, Chunlii Luo, Yedong Sun, Yongyan Ma, Jianxin Yu, Fuqiang Du
Summary: This study analyzed the secondary metabolites and antioxidant activity of D. officinale from three regions using a metabolomics approach. A total of 411 metabolites were identified, including 136 differential metabolites. These differential metabolites were mainly enriched in secondary metabolic pathways, particularly flavonoids, phenolic acids, and amines. Furthermore, correlation analysis revealed that 48 differential metabolites were significantly positively correlated with antioxidant capacity, with flavonoids being the main influencing factors. These findings provide valuable guidance for variety screening, quality control, and product development of D. officinale.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Plant Sciences
Chengchong Huang, Jiali Yu, Jingjing Da, Rong Dong, Lu Dai, Yuqi Yang, Yiyao Deng, Jing Yuan
Summary: DOP, a primary active component of Dendrobium officinale Kimura & Migo, has been found to have a significant therapeutic effect on renal fibrosis in diabetic kidney disease (DKD). It can protect renal function by inhibiting fibrosis and also has hypoglycemic and anti-inflammatory effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Wenhao Liao, Yueqiang Wen, Jing Wang, Maoyuan Zhao, Shangbin Lv, Nianzhi Chen, Yuchen Li, Lina Wan, Qiao Zheng, Yu Mou, Ziyi Zhao, Jianyuan Tang, Jinhao Zeng
Summary: This study aims to investigate the role and potential mechanism of GA on gastric precancerous lesions (GPL), the key turning point of gastritis to gastric cancer, with the aim of delaying, blocking or reversing the dynamic overall process of inflammation-cancer transformation and thus blocking GPL to prevent the development of gastric cancer.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Xiaoyang Zhang, Yanfeng Yan, Yunxia Lv, Xin Li, Leiyao Chen, Zihui Huang, Junbo Zhou, Yong Wang, Xiaoming Wang, Xu Wang, Hongwei Gu
Summary: Urinary tract infections (UTI) caused by uropathogenic Escherichia coli (UPEC) can be attenuated by Dendrobium officinale polysaccharides (DOPs), which possess anti-inflammatory properties and inhibit the activation of NLRP3 pathway and ROS signal. DOPs effectively mitigate UPEC-induced pyroptosis in macrophage cells by reducing cell damage and pro-inflammatory cytokine secretion.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Food Science & Technology
Chuanbo Sun, Nuo Zhang, Guangpei Xu, Ping Jiang, Shiping Huang, Qun Zhao, Yanfei He
Summary: This study demonstrates that Dendrobium officinale polysaccharides (DOP) have antitumor and immunomodulatory activities, inhibiting tumor growth through multiple pathways.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Biochemistry & Molecular Biology
Wen-hua Chen, Jian-jun Wu, Xue-fei Li, Jie-miao Lu, Wei Wu, Yi-qi Sun, Bo Zhu, Lu-ping Qin
Summary: Dendrobium officinale polysaccharides exhibit a variety of biological effects, including immunomodulatory, anti-tumor, and gastro-protective effects. Further research is needed to explore extraction, purification, and structural characteristics of these polysaccharides.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Environmental Sciences
Yi Mu, Bangwei Che, Kaifa Tang, Wenjun Zhang, Shenghan Xu, Wei Li, Jun He, Miao Liu, Peng Chen, Siwen Zhong, Guangyu Li
Summary: This study explored the protective effect of Dendrobium officinale polysaccharides (DOPs) on reproductive oxidative stress injury in male mice and its mechanism. The results showed that DOPs effectively reduced the oxidative stress injury of testicular tissue and improved sperm quality and hormone levels. The protective effect of DOPs was mediated by reducing oxidative stress levels, improving the hormone environment in testes, and regulating the expression of specific genes in Sertoli cells and spermatogenic cells.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Food Science & Technology
Chen Li, Yunwei Wang, Zijia Huang, Yi Zhang, Jiao Li, Qing Zhang, Benjamin Kofi Simpson, Jingxue Wang
Summary: This study investigated the hypoglycemic and hypolipidemic effects of polysaccharides of Dendrobium officinale compound (DOCP) on streptozotocin induced type 2 diabetic mice. DOCP significantly decreased fasting blood glucose and insulin resistance, increased serum insulin content, reduced lipid levels, improved antioxidant capability, and protected liver and pancreas. DOCP also increased the diversity of intestinal flora and up-regulated the expression of key genes related to glucose metabolism.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Nutrition & Dietetics
Nkwachukwu Oziamara Okoro, Arome Solomon Odiba, Qi Yu, Bin He, Guiyan Liao, Cheng Jin, Wenxia Fang, Bin Wang
Summary: Dendrobium officinale, a widely used medicinal herb, has gained attention for its polysaccharide content and its potential medicinal properties. In this study, the anti-aging potential of polysaccharides extracted from D. officinale grown in different environments was investigated using Caenorhabditis elegans as a model. The findings showed that greenhouse-grown D. officinale polysaccharides had the optimal effect of extending lifespan and enhancing stress resistance. These results provide valuable information for the cultivation and medicinal applications of D. officinale.
Article
Food Science & Technology
Hang Chen, Xueqin Shi, Lanyan Cen, Lin Zhang, Yifeng Dai, Shuyi Qiu, Xiangyong Zeng, Chaoyang Wei
Summary: In this study, different fermentations were conducted on Dendrobium officinale polysaccharides, and it was found that yeast fermentation could effectively reduce the molecular weight and improve the antioxidant activity of the polysaccharides, indicating a potential way to enhance their antioxidant activity. Additionally, four homogeneous polysaccharides with different compositions and molecular weights were obtained. These findings are significant for further research on Dendrobium officinale polysaccharides.
Review
Nutrition & Dietetics
Weijie Wu, Ziqi Zhao, Zhaoer Zhao, Dandan Zhang, Qianyi Zhang, Jiayu Zhang, Zhengyi Fang, Yiling Bai, Xiaohui Guo
Summary: In this review, the extraction, structure, health benefits, and related mechanisms of Dendrobium officinale polysaccharides (DOPs) were summarized. It was proposed that DOPs are potential prebiotics, influencing the composition of gut microbiota and providing health benefits. This has important implications for the development of functional foods and health products.
Article
Biotechnology & Applied Microbiology
Li Hao, Xin Shi, Shunwang Qin, Jiahong Dong, Huan Shi, Yuehua Wang, Yi Zhang
Summary: In this study, 25 DoSWEET genes were identified and analyzed in D. officinale. The research revealed the evolutionary relationship, conserved motifs, chromosomal location, and expression patterns of DoSWEETs. Different DoSWEET genes play different roles in sugar transport, and some genes are regulated under stress conditions. The correlation analysis and interaction network prediction provide a foundation for further functional verification.
Article
Medicine, Research & Experimental
Yingmin Liang, Ruixuan Du, Rui Chen, Pak Hin Chu, Mary Sau Man Ip, Kalin Yan Bo Zhang, Judith Choi Wo Mak
Summary: DOPs extracted from Dendrobium officinale showed therapeutic effects in reducing cigarette smoke-induced airway inflammation by decreasing oxidative stress and inflammatory cell infiltration, as well as inhibiting the activation of MAPK and NF-kappa B signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Food Science & Technology
Yongtao Zhang, Shiquan You, Dongdong Wang, Dan Zhao, Jiachan Zhang, Quan An, Meng Li, Changtao Wang
Summary: In this study, the molecular characteristics of fermented Dendrobium officinale polysaccharides (FDOP) by Lactobacillus delbrueckil bulgaricus were analyzed using FT-IR, GPC-LC, and SEM. FDOP showed a smaller molecular structure and better water solubility. The protective effect of FDOP on human skin fibroblasts (HSF) damaged by UV radiation was investigated, and it was found that FDOP improved the antioxidant capacity of HSF and reduced the breakdown of collagen, elastin, and hyaluronic acid. The antioxidative and antiaging properties of FDOP were explored, and it was observed that FDOP could up-regulate the Nrf2/Keapl and TGF-beta/Smads pathways to reduce oxidative damage and aging effects.
FOOD SCIENCE & NUTRITION
(2022)
Article
Integrative & Complementary Medicine
Yi Zhao, Yan Liu, Xi-Ming Lan, Guo-Liang Xu, You-Zhi Sun, Fei Li, Hong-Ning Liu
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2016)
Article
Cell Biology
Yi Zhao, Youzhi Sun, Gaoyu Wang, Shucao Ge, Hongning Liu
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Integrative & Complementary Medicine
Yi Zhao, Hong-Xia Huang, Su-Yuan Tang, You-Zhi Sun
Summary: The study found that Dendrobium officinale polysaccharides (DOP) inhibit the development of precancerous lesions of gastric cancer (PLGC) by upregulating the PER3 and AQP4 gene and protein expression. The mechanism of action also involves modulating the Circadian Rhythm Signaling pathway.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
