NMR-Based Metabolomics in Metal-Based Drug Research

Pharmacometabonomics Analysis Reveals Serum Formate and Acetate Potentially Associated with Varying Response to Gemcitabine-Carboplatin Chemotherapy in Metastatic Breast Cancer Patients

(2018) Limiao Jiang et al.   JOURNAL OF PROTEOME RESEARCH

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Response of Cisplatin Resistant Skov-3 Cells to [Pt(O,O′-Acac)(γ-Acac)(DMS)] Treatment Revealed by a Metabolomic 1H-NMR Study

(2018) Federica De Castro et al.   MOLECULES

Impact of the Pd2Spermine Chelate on Osteosarcoma Metabolism: An NMR Metabolomics Study

(2017) Inês Lamego et al.   JOURNAL OF PROTEOME RESEARCH

The reverse Warburg effect is likely to be an Achilles’ heel of cancer that can be exploited for cancer therapy

(2017) Yaojie Fu et al.   Oncotarget

Ovarian Cancer Cell Survival and Proliferation Is Mediated by the Warburg Effect.

(2017) Sara Elizabeth Ladley et al.   BIOLOGY OF REPRODUCTION

Serum Metabolic Profile Alteration Reveals Response to Platinum-Based Combination Chemotherapy for Lung Cancer: Sensitive Patients Distinguished from Insensitive ones

(2017) Shan Xu et al.   Scientific Reports

The Warburg effect: 80 years on

(2016) Michelle Potter et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

1H HR-MAS NMR Based Metabolic Profiling of Cells in Response to Treatment with a Hexacationic Ruthenium Metallaprism as Potential Anticancer Drug

(2015) Martina Vermathen et al.   PLoS One

Principal component analysis

(2014) Rasmus Bro et al.   Analytical Methods

Carriers for metal complexes on tumour cells: the effect of cyclodextrins vs CNTs on the model guest phenanthroline-5,6-dione trithiacyclononane ruthenium(II) chloride

(2014) Susana S. Braga et al.   BIOMETALS

Metabolic Markers of MG-63 Osteosarcoma Cell Line Response to Doxorubicin and Methotrexate Treatment: Comparison to Cisplatin

(2014) Inês Lamego et al.   JOURNAL OF PROTEOME RESEARCH

Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer

(2013) Di Zhao et al.   CANCER CELL

A Novel Serum Metabolomics-Based Diagnostic Approach to Pancreatic Cancer

(2013) T. Kobayashi et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

The mode of action of anticancer gold-based drugs: a structural perspective

(2013) Luigi Messori et al.   CHEMICAL COMMUNICATIONS

Dose responsive effects of cisplatin in L02 cells using NMR-based metabolomics

(2013) Shu Liu et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Targeting lactate metabolism for cancer therapeutics

(2013) Joanne R. Doherty et al.   JOURNAL OF CLINICAL INVESTIGATION

Potential Markers of Cisplatin Treatment Response Unveiled by NMR Metabolomics of Human Lung Cells

(2013) I. F. Duarte et al.   MOLECULAR PHARMACEUTICS

Nodal regulates energy metabolism in glioma cells by inducing expression of hypoxia-inducible factor 1 

(2013) J.-H. Lai et al.   NEURO-ONCOLOGY

A Polyamine-Deficient Diet Prevents Oxaliplatin-Induced Acute Cold and Mechanical Hypersensitivity in Rats

(2013) Jérémy Ferrier et al.   PLoS One

Targeting cellular metabolism to improve cancer therapeutics

(2013) Y Zhao et al.   Cell Death & Disease

Titanium and Vanadium Complexes as Anticancer Agents

(2012) Irena Kostova   Anti-Cancer Agents in Medicinal Chemistry

Targeting glucose metabolism for cancer therapy: Figure 1.

(2012) Robert B. Hamanaka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The state-of-the-art determination of urinary nucleosides using chromatographic techniques “hyphenated” with advanced bioinformatic methods

(2011) Wiktoria Struck et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Serum metabolomics as a novel diagnostic approach for gastrointestinal cancer

(2011) Atsuki Ikeda et al.   BIOMEDICAL CHROMATOGRAPHY

Identification of Urinary Biomarkers Related to Cisplatin-Induced Acute Renal Toxicity Using NMR-Based Metabolomics

(2011) He Wen et al.   Biomolecules & Therapeutics

Mechanism matters

(2010)   NATURE MEDICINE

Metabolic Modulation of Glioblastoma with Dichloroacetate

(2010) E. D. Michelakis et al.   Science Translational Medicine

Arginine Deiminase as a Novel Therapy for Prostate Cancer Induces Autophagy and Caspase-Independent Apoptosis

(2009) R. H. Kim et al.   CANCER RESEARCH

Non-traditional platinum compounds for improved accumulation, oral bioavailability, and tumor targeting

(2009) Katherine S. Lovejoy et al.   DALTON TRANSACTIONS

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

A new rule-based algorithm for identifying metabolic markers in prostate cancer using tandem mass spectrometry

(2008) M. Osl et al.   BIOINFORMATICS

Mass spectrometry based metabolomic approaches in urinary biomarker study of women's cancers

(2008) Han Min Woo et al.   CLINICA CHIMICA ACTA

Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study

(2008) Rachelle S Doody et al.   LANCET

Systems biology: Metabonomics

(2008) Jeremy K. Nicholson et al.   NATURE

A metabonomic approach to the diagnosis of oral squamous cell carcinoma, oral lichen planus and oral leukoplakia

(2007) Shi-Kai Yan et al.   ORAL ONCOLOGY