Systems approach reveals photosensitivity and PER 2 level as determinants of clock‐modulator efficacy

Temporal dynamics of circadian phase shifting response to consecutive night shifts in healthcare workers: role of light-dark exposure

(2018) Julia E. Stone et al.   JOURNAL OF PHYSIOLOGY-LONDON

Reentrainment of the circadian pacemaker during jet lag: East-west asymmetry and the effects of north-south travel

(2018) Casey O. Diekman et al.   JOURNAL OF THEORETICAL BIOLOGY

CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch

(2018) Rajesh Narasimamurthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhythms: The dark side meets the light

(2018) Arthur Millius et al.   SCIENCE

Diurnal transcriptome atlas of a primate across major neural and peripheral tissues

(2018) Ludovic S. Mure et al.   SCIENCE

Efficacy of melatonin with behavioural sleep-wake scheduling for delayed sleep-wake phase disorder: A double-blind, randomised clinical trial

(2018) Tracey L. Sletten et al.   PLOS MEDICINE

Delayed sleep-wake phase disorder

(2018) Alexander D. Nesbitt   Journal of Thoracic Disease

High-accuracy determination of internal circadian time from a single blood sample

(2018) Nicole Wittenbrink et al.   JOURNAL OF CLINICAL INVESTIGATION

Training the Circadian Clock, Clocking the Drugs, and Drugging the Clock to Prevent, Manage, and Treat Chronic Diseases

(2018) Gabriele Sulli et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Increased sensitivity of the circadian system to light in delayed sleep–wake phase disorder

(2018) Lauren A. Watson et al.   JOURNAL OF PHYSIOLOGY-LONDON

Macromolecular Assemblies of the Mammalian Circadian Clock

(2017) Rajindra P. Aryal et al.   MOLECULAR CELL

Temperature-Sensitive Substrate and Product Binding Underlie Temperature-Compensated Phosphorylation in the Clock

(2017) Yuta Shinohara et al.   MOLECULAR CELL

Precision medicine in circadian rhythm sleep–wake disorders: current state and future perspectives

(2017) Henry Keijzer et al.   Personalized Medicine

Design Principles of Phosphorylation-Dependent Timekeeping in Eukaryotic Circadian Clocks

(2017) Koji L. Ode et al.   Cold Spring Harbor Perspectives in Biology

Sleep Pharmacogenetics: Personalized Sleep-Wake Therapy

(2016) Sebastian C. Holst et al.   Annual Review of Pharmacology and Toxicology

Insights From an Integrated Physiologically Based Pharmacokinetic Model for Brain Penetration

(2016) Patrick E. Trapa et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Transcriptional architecture of the mammalian circadian clock

(2016) Joseph S. Takahashi   NATURE REVIEWS GENETICS

Model-driven experimental approach reveals the complex regulatory distribution of p53 by the circadian factor Period 2

(2016) Tetsuya Gotoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Individual Differences in Sleep Timing Relate to Melanopsin-Based Phototransduction in Healthy Adolescents and Young Adults

(2016) Wisse P. van der Meijden et al.   SLEEP

A global quantification of "normal" sleep schedules using smartphone data

(2016) O. J. Walch et al.   Science Advances

Individual Differences in Sleep Timing Relate to Melanopsin-Based Phototransduction in Healthy Adolescents and Young Adults

(2016) Wisse P. van der Meijden et al.   SLEEP

PER2 Differentially Regulates Clock Phosphorylation versus Transcription by Reciprocal Switching of CK1ε Activity

(2015) Ximing Qin et al.   JOURNAL OF BIOLOGICAL RHYTHMS

A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period

(2015) Min Zhou et al.   MOLECULAR CELL

Defining digital medicine

(2015) Eric Elenko et al.   NATURE BIOTECHNOLOGY

Light-regulated translational control of circadian behavior by eIF4E phosphorylation

(2015) Ruifeng Cao et al.   NATURE NEUROSCIENCE

Personalized medicine for pathological circadian dysfunctions

(2015) Rachel L. Skelton et al.   Frontiers in Pharmacology

Aripiprazole Is Effective for Treatment of Delayed Sleep Phase Syndrome

(2014) Manabu Takaki et al.   CLINICAL NEUROPHARMACOLOGY

A Novel Mechanism Controlling Resetting Speed of the Circadian Clock to Environmental Stimuli

(2014) Violetta Pilorz et al.   CURRENT BIOLOGY

Light Stimulates the Mouse Adrenal through a Retinohypothalamic Pathway Independent of an Effect on the Clock in the Suprachiasmatic Nucleus

(2014) Silke Kiessling et al.   PLoS One

A circadian gene expression atlas in mammals: Implications for biology and medicine

(2014) Ray Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The CRTC1-SIK1 Pathway Regulates Entrainment of the Circadian Clock

(2013) Aarti Jagannath et al.   CELL

Glucose Sensor O-GlcNAcylation Coordinates with Phosphorylation to Regulate Circadian Clock

(2013) Krista Kaasik et al.   Cell Metabolism

Entrainment of the Human Circadian Clock to the Natural Light-Dark Cycle

(2013) Kenneth P. Wright et al.   CURRENT BIOLOGY

Human phase response curve to a single 6.5 h pulse of short-wavelength light

(2012) Melanie Rüger et al.   JOURNAL OF PHYSIOLOGY-LONDON

Human phase response curve to a 1 h pulse of bright white light

(2012) Melissa A. St Hilaire et al.   JOURNAL OF PHYSIOLOGY-LONDON

A mechanism for robust circadian timekeeping via stoichiometric balance

(2012) Jae Kyoung Kim et al.   Molecular Systems Biology

Circadian Rhythm Sleep Disorders

(2012) Lirong Zhu et al.   NEUROLOGIC CLINICS

Human blood metabolite timetable indicates internal body time

(2012) T. Kasukawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Small Molecule Activators of Cryptochrome

(2012) T. Hirota et al.   SCIENCE

Circadian Timing in Cancer Treatments

(2010) Francis Lévi et al.   Annual Review of Pharmacology and Toxicology

Systems Biology of Mammalian Circadian Clocks

(2010) Hideki Ukai et al.   Annual Review of Physiology

The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks

(2010) Charna Dibner et al.   Annual Review of Physiology

The Substructure of the Suprachiasmatic Nucleus: Similarities between Nocturnal and Diurnal Spiny Mice

(2010) Rotem Cohen et al.   BRAIN BEHAVIOR AND EVOLUTION

Human Phase Response Curves to Three Days of Daily Melatonin: 0.5 mgVersus3.0 mg

(2010) Helen J. Burgess et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adrenal glucocorticoids have a key role in circadian resynchronization in a mouse model of jet lag

(2010) Silke Kiessling et al.   JOURNAL OF CLINICAL INVESTIGATION

Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes

(2010) Q.-J. Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic treatment with a selective inhibitor of casein kinase I δ/ε yields cumulative phase delays in circadian rhythms

(2010) Jeffrey Sprouse et al.   PSYCHOPHARMACOLOGY

Selective Inhibition of Casein Kinase 1  Minimally Alters Circadian Clock Period

(2009) K. M. Walton et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Inhibition of casein kinase I ε/δ produces phase shifts in the circadian rhythms of Cynomolgus monkeys

(2009) Jeffrey Sprouse et al.   PSYCHOPHARMACOLOGY

Period gene expression in the diurnal degu (Octodon degus) differs from the nocturnal laboratory rat (Rattus norvegicus)

(2008) Andrew M. Vosko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Identifying mechanisms of chronotolerance and chronoefficacy for the anticancer drugs 5-fluorouracil and oxaliplatin by computational modeling

(2008) Atilla Altinok et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

A practical approach to circadian rhythm sleep disorders

(2008) Bjørn Bjorvatn et al.   SLEEP MEDICINE REVIEWS